RBP Type	Non-canonical_RBPs
Diseases	CancerSARS-COV-OC43FlavivirusesHIVSARS-COV-2SINVDengueZika
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	Stress granucleFibrillar center
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000198900	Gene ID	7150	Accession	11986
Symbol	TOP1	Alias	TOPI	Full Name	DNA topoisomerase I
Status	Confidence	Length	95666 bases	Strand	Plus strand
Position	20 : 41028822 - 41124487	RNA binding domain	N.A.
Summary	This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]