Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-OC43FlavivirusesHIVSARS-COV-2SINVDengueZika
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucleFibrillar center
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000198900 Gene ID 7150 Accession 11986
Symbol TOP1 Alias TOPI Full Name DNA topoisomerase I
Status Confidence Length 95666 bases Strand Plus strand
Position 20 : 41028822 - 41124487 RNA binding domain N.A.
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37626846 Understanding the Human RECQ5 Helicase-Connecting the Dots from DNA to Clinics. Chiefe Mo 2023-08-10 Cells
25851487 RECQ5-dependent SUMOylation of DNA topoisomerase I prevents transcription-associated genome instability. Min Li 2015-04-08 Nature communications
22121227 Quantitative model of R-loop forming structures reveals a novel level of RNA-DNA interactome complexity. Thidathip Wongsurawat 2012-01-01 Nucleic acids research
32059547 The Functional Consequences of Eukaryotic Topoisomerase 1 Interaction with G-Quadruplex DNA. Alexandra Berroyer 2020-02-12 Genes

Transcripts

Name Transcript ID bp Protein Translation ID
TOP1-201 ENST00000361337 3734 765aa ENSP00000354522
TOP1-203 ENST00000681058 8092 No protein -
TOP1-204 ENST00000681113 3938 204aa ENSP00000505788
TOP1-205 ENST00000681392 4782 No protein -
TOP1-206 ENST00000681884 4736 No protein -
TOP1-202 ENST00000680945 2532 296aa ENSP00000504935

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
8045Cystatins9.19147722232086E-517903292
71961Cholesterol, LDL3E-1920686565
89822Cholesterol1E-1624097068
94031Cholesterol, LDL5E-1824097068

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000198900homo_sapiensENSP0000032883582.196366.7221homo_sapiensENSP0000035452264.575252.4183

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000198900homo_sapiensENSP0000035452210099.7386nomascus_leucogenysENSNLEP0000000788099.739299.4785
ENSG00000198900homo_sapiensENSP00000354522100100pan_paniscusENSPPAP00000041129100100
ENSG00000198900homo_sapiensENSP0000035452210099.8693pongo_abeliiENSPPYP0000001229699.739299.6089
ENSG00000198900homo_sapiensENSP00000354522100100pan_troglodytesENSPTRP00000023175100100
ENSG00000198900homo_sapiensENSP00000354522100100gorilla_gorillaENSGGOP00000008808100100
ENSG00000198900homo_sapiensENSP0000035452284.052378.3007ornithorhynchus_anatinusENSOANP0000002262889.058282.964
ENSG00000198900homo_sapiensENSP0000035452297.516394.1176sarcophilus_harrisiiENSSHAP0000004546497.38993.9948
ENSG00000198900homo_sapiensENSP0000035452281.830176.4706notamacropus_eugeniiENSMEUP0000000983575.603970.6522
ENSG00000198900homo_sapiensENSP0000035452266.535965.3595choloepus_hoffmanniENSCHOP0000000077766.103964.9351
ENSG00000198900homo_sapiensENSP0000035452297.908596.3399dasypus_novemcinctusENSDNOP0000000416497.653296.0887
ENSG00000198900homo_sapiensENSP0000035452285.359583.7908erinaceus_europaeusENSEEUP0000000720588.124286.5047
ENSG00000198900homo_sapiensENSP0000035452271.503370.5882echinops_telfairiENSETEP0000000130973.521572.5806
ENSG00000198900homo_sapiensENSP0000035452299.869399.3464callithrix_jacchusENSCJAP0000003357299.608999.0874
ENSG00000198900homo_sapiensENSP0000035452299.869399.2157cercocebus_atysENSCATP0000004312699.608998.957
ENSG00000198900homo_sapiensENSP0000035452299.869399.3464macaca_fascicularisENSMFAP0000003094399.608999.0874
ENSG00000198900homo_sapiensENSP0000035452299.869399.3464macaca_mulattaENSMMUP0000001454799.608999.0874
ENSG00000198900homo_sapiensENSP0000035452299.869399.3464macaca_nemestrinaENSMNEP0000003143999.608999.0874
ENSG00000198900homo_sapiensENSP0000035452299.738699.085papio_anubisENSPANP0000001773999.478598.8266
ENSG00000198900homo_sapiensENSP0000035452297.516396.8627mandrillus_leucophaeusENSMLEP0000003686899.334298.6684
ENSG00000198900homo_sapiensENSP0000035452299.607898.4314tursiops_truncatusENSTTRP0000000437690.606489.5363
ENSG00000198900homo_sapiensENSP0000035452285.490284.3137vulpes_vulpesENSVVUP0000004107499.543498.1735
ENSG00000198900homo_sapiensENSP0000035452298.954297.2549mus_spretusMGP_SPRETEiJ_P005803798.696297.0013
ENSG00000198900homo_sapiensENSP0000035452299.477198.1699equus_asinusENSEASP0000505447099.217797.9139
ENSG00000198900homo_sapiensENSP0000035452299.607898.3007capra_hircusENSCHIP0000002868999.348198.0443
ENSG00000198900homo_sapiensENSP0000035452295.686392.6797loxodonta_africanaENSLAFP0000001830495.064992.0779
ENSG00000198900homo_sapiensENSP0000035452299.607898.6928panthera_leoENSPLOP0000000402099.348198.4355
ENSG00000198900homo_sapiensENSP0000035452299.477198.4314ailuropoda_melanoleucaENSAMEP0000001021398.959797.9194
ENSG00000198900homo_sapiensENSP0000035452299.738698.6928bos_indicus_hybridENSBIXP0000500791199.219898.1795
ENSG00000198900homo_sapiensENSP0000035452299.215797.3856oryctolagus_cuniculusENSOCUP0000000710798.95797.1317
ENSG00000198900homo_sapiensENSP0000035452298.169996.6013equus_caballusENSECAP0000007724093.640992.1446
ENSG00000198900homo_sapiensENSP0000035452299.346498.0392canis_lupus_familiarisENSCAFP0084504172898.701397.4026
ENSG00000198900homo_sapiensENSP0000035452299.607898.6928panthera_pardusENSPPRP0000001735799.348198.4355
ENSG00000198900homo_sapiensENSP0000035452297.385695.0327marmota_marmota_marmotaENSMMMP0000001699798.54596.164
ENSG00000198900homo_sapiensENSP0000035452299.607898.9542balaenoptera_musculusENSBMSP0001002891599.089798.4395
ENSG00000198900homo_sapiensENSP0000035452299.738697.7778cavia_porcellusENSCPOP0000000814999.34997.3958
ENSG00000198900homo_sapiensENSP0000035452299.607898.6928felis_catusENSFCAP0000000836999.348198.4355
ENSG00000198900homo_sapiensENSP0000035452285.359584.5752ursus_americanusENSUAMP0000001011499.542798.6281
ENSG00000198900homo_sapiensENSP0000035452297.516394.6405monodelphis_domesticaENSMODP0000000068895.396492.5831
ENSG00000198900homo_sapiensENSP0000035452299.738698.6928bison_bison_bisonENSBBBP0000000672499.219898.1795
ENSG00000198900homo_sapiensENSP0000035452299.607898.5621monodon_monocerosENSMMNP0001500292999.089798.0494
ENSG00000198900homo_sapiensENSP0000035452232.287626.2745sus_scrofaENSSSCP0000007537369.77456.7797
ENSG00000198900homo_sapiensENSP0000035452299.477198.5621sus_scrofaENSSSCP0000002357098.959798.0494
ENSG00000198900homo_sapiensENSP0000035452299.08597.7778microcebus_murinusENSMICP0000000644899.08597.7778
ENSG00000198900homo_sapiensENSP0000035452299.08597.1242octodon_degusENSODEP0000001950198.826696.8709
ENSG00000198900homo_sapiensENSP0000035452297.516395.817jaculus_jaculusENSJJAP0000000997697.262195.5671
ENSG00000198900homo_sapiensENSP0000035452297.908596.6013ovis_aries_rambouilletENSOARP0002001713599.205397.8808
ENSG00000198900homo_sapiensENSP0000035452295.947794.1176ovis_aries_rambouilletENSOARP0002000822797.218595.3642
ENSG00000198900homo_sapiensENSP0000035452285.490284.7059ursus_maritimusENSUMAP0000000382999.543498.6301
ENSG00000198900homo_sapiensENSP0000035452275.686374.902ochotona_princepsENSOPRP0000001356875.488974.7066
ENSG00000198900homo_sapiensENSP0000035452294.117693.2026delphinapterus_leucasENSDLEP0000000544399.173698.2094
ENSG00000198900homo_sapiensENSP0000035452297.124295.9477physeter_catodonENSPCTP0000502596898.021196.8338
ENSG00000198900homo_sapiensENSP0000035452228.496723.268mus_caroliMGP_CAROLIEiJ_P005587931.964826.0997
ENSG00000198900homo_sapiensENSP0000035452298.954297.2549mus_musculusENSMUSP0000010509498.696297.0013
ENSG00000198900homo_sapiensENSP0000035452297.124295.6863dipodomys_ordiiENSDORP0000001140198.934897.47
ENSG00000198900homo_sapiensENSP0000035452299.477198.5621mustela_putorius_furoENSMPUP0000001758998.959798.0494
ENSG00000198900homo_sapiensENSP0000035452299.869399.4771aotus_nancymaaeENSANAP0000003772899.608999.2177
ENSG00000198900homo_sapiensENSP0000035452299.869399.4771saimiri_boliviensis_boliviensisENSSBOP0000002421699.608999.2177
ENSG00000198900homo_sapiensENSP0000035452291.503390.1961vicugna_pacosENSVPAP0000001038583.234282.0452
ENSG00000198900homo_sapiensENSP0000035452299.869399.3464chlorocebus_sabaeusENSCSAP0000001008399.608999.0874
ENSG00000198900homo_sapiensENSP0000035452274.117673.4641tupaia_belangeriENSTBEP0000000217574.117673.4641
ENSG00000198900homo_sapiensENSP0000035452298.823597.3856mesocricetus_auratusENSMAUP0000001055998.565897.1317
ENSG00000198900homo_sapiensENSP0000035452298.169996.732phocoena_sinusENSPSNP0000000627297.279895.8549
ENSG00000198900homo_sapiensENSP0000035452299.738698.4314camelus_dromedariusENSCDRP0000501366699.219897.9194
ENSG00000198900homo_sapiensENSP0000035452299.607899.085carlito_syrichtaENSTSYP0000000314299.348198.8266
ENSG00000198900homo_sapiensENSP0000035452298.169997.2549panthera_tigris_altaicaENSPTIP0000001911397.913997.0013
ENSG00000198900homo_sapiensENSP0000035452297.908596.2092rattus_norvegicusENSRNOP0000007657598.682596.9697
ENSG00000198900homo_sapiensENSP0000035452298.692897.2549prolemur_simusENSPSMP0000001946198.692897.2549
ENSG00000198900homo_sapiensENSP0000035452298.692897.2549microtus_ochrogasterENSMOCP0000000655798.435597.0013
ENSG00000198900homo_sapiensENSP0000035452294.248492.9412sorex_araneusENSSARP0000000477496.519495.1807
ENSG00000198900homo_sapiensENSP0000035452266.535964.9673peromyscus_maniculatus_bairdiiENSPEMP0000002487394.962792.7239
ENSG00000198900homo_sapiensENSP0000035452298.954297.5163peromyscus_maniculatus_bairdiiENSPEMP0000000423798.825197.389
ENSG00000198900homo_sapiensENSP0000035452299.738698.6928bos_mutusENSBMUP0000003565599.219898.1795
ENSG00000198900homo_sapiensENSP0000035452298.954297.2549mus_spicilegusENSMSIP0000001792098.696297.0013
ENSG00000198900homo_sapiensENSP0000035452298.692897.2549cricetulus_griseus_chok1gshdENSCGRP0000101224298.435597.0013
ENSG00000198900homo_sapiensENSP0000035452293.856292.549pteropus_vampyrusENSPVAP0000000428986.194584.994
ENSG00000198900homo_sapiensENSP0000035452296.993595.6863myotis_lucifugusENSMLUP0000000276299.197997.861
ENSG00000198900homo_sapiensENSP0000035452292.54989.8039vombatus_ursinusENSVURP0001001842797.925395.0207
ENSG00000198900homo_sapiensENSP0000035452289.019680.5229vombatus_ursinusENSVURP0001000817788.441680
ENSG00000198900homo_sapiensENSP0000035452299.346498.3007rhinolophus_ferrumequinumENSRFEP0001001487898.829797.7893
ENSG00000198900homo_sapiensENSP0000035452299.477198.3007neovison_visonENSNVIP0000001636398.959797.7893
ENSG00000198900homo_sapiensENSP0000035452297.647196.2092bos_taurusENSBTAP0000001046698.67997.2259
ENSG00000198900homo_sapiensENSP0000035452299.346497.9085heterocephalus_glaber_femaleENSHGLP0000000144499.087497.6532
ENSG00000198900homo_sapiensENSP0000035452299.738699.085rhinopithecus_bietiENSRBIP0000000988399.608498.9556
ENSG00000198900homo_sapiensENSP0000035452280.261479.2157canis_lupus_dingoENSCAFP0002001597799.675398.3766
ENSG00000198900homo_sapiensENSP0000035452269.019667.8431sciurus_vulgarisENSSVLP0000502643297.777896.1111
ENSG00000198900homo_sapiensENSP0000035452298.300797.1242sciurus_vulgarisENSSVLP0000502544498.044396.8709
ENSG00000198900homo_sapiensENSP0000035452299.08598.0392sciurus_vulgarisENSSVLP0000502668698.826697.7836
ENSG00000198900homo_sapiensENSP0000035452286.274581.9608phascolarctos_cinereusENSPCIP0000003517186.049581.7471
ENSG00000198900homo_sapiensENSP0000035452263.790858.5621phascolarctos_cinereusENSPCIP0000005211292.599685.0095
ENSG00000198900homo_sapiensENSP0000035452292.941290.719procavia_capensisENSPCAP0000000659984.241782.2275
ENSG00000198900homo_sapiensENSP0000035452299.08598.1699nannospalax_galiliENSNGAP0000000411998.826697.9139
ENSG00000198900homo_sapiensENSP0000035452299.738698.6928bos_grunniensENSBGRP0000001095399.478598.4355
ENSG00000198900homo_sapiensENSP0000035452299.346497.7778chinchilla_lanigeraENSCLAP0000001256498.958397.3958
ENSG00000198900homo_sapiensENSP0000035452293.856292.1569cervus_hanglu_yarkandensisENSCHYP0000002089998.087496.3115
ENSG00000198900homo_sapiensENSP0000035452299.607898.4314cervus_hanglu_yarkandensisENSCHYP0000003591299.089797.9194
ENSG00000198900homo_sapiensENSP0000035452299.607898.4314catagonus_wagneriENSCWAP0000001265999.089797.9194
ENSG00000198900homo_sapiensENSP0000035452298.823596.4706ictidomys_tridecemlineatusENSSTOP0000000540898.565896.219
ENSG00000198900homo_sapiensENSP0000035452296.73295.4248otolemur_garnettiiENSOGAP0000000756396.479895.176
ENSG00000198900homo_sapiensENSP0000035452299.607899.3464cebus_imitatorENSCCAP0000002413299.348199.0874
ENSG00000198900homo_sapiensENSP0000035452298.823596.4706urocitellus_parryiiENSUPAP0001000274198.565896.219
ENSG00000198900homo_sapiensENSP0000035452299.738698.5621moschus_moschiferusENSMMSP0000002865099.219898.0494
ENSG00000198900homo_sapiensENSP0000035452299.869399.2157rhinopithecus_roxellanaENSRROP0000004000299.608998.957
ENSG00000198900homo_sapiensENSP0000035452298.954297.3856mus_pahariMGP_PahariEiJ_P006686198.696297.1317
ENSG00000198900homo_sapiensENSP0000035452298.692897.2549propithecus_coquereliENSPCOP0000001227499.081497.6378
ENSG00000198900homo_sapiensENSP0000035452282.222269.0196petromyzon_marinusENSPMAP0000000584782.545969.2913
ENSG00000198900homo_sapiensENSP0000035452259.738652.6797eptatretus_burgeriENSEBUP0000000108691.951781.0865
ENSG00000198900homo_sapiensENSP0000035452286.274579.2157callorhinchus_miliiENSCMIP0000003751886.842179.7368
ENSG00000198900homo_sapiensENSP0000035452289.019683.0065latimeria_chalumnaeENSLACP0000002069591.655485.4643
ENSG00000198900homo_sapiensENSP0000035452291.895483.5294lepisosteus_oculatusENSLOCP0000000544692.621984.1897
ENSG00000198900homo_sapiensENSP0000035452278.039268.2353clupea_harengusENSCHAP0000005097188.444477.3333
ENSG00000198900homo_sapiensENSP0000035452290.588281.5686danio_rerioENSDARP0000006594891.424882.3219
ENSG00000198900homo_sapiensENSP0000035452267.973961.6993danio_rerioENSDARP0000010619792.691684.1355
ENSG00000198900homo_sapiensENSP0000035452284.444473.0719carassius_auratusENSCARP0000002905786.248374.6328
ENSG00000198900homo_sapiensENSP0000035452289.934680.7843carassius_auratusENSCARP0000007791391.005381.746
ENSG00000198900homo_sapiensENSP0000035452288.627479.4771carassius_auratusENSCARP0000002565091.869982.3848
ENSG00000198900homo_sapiensENSP0000035452268.627461.8301astyanax_mexicanusENSAMXP0000002106093.085183.8652
ENSG00000198900homo_sapiensENSP0000035452281.568672.1569ictalurus_punctatusENSIPUP0000002379090.56680.1161
ENSG00000198900homo_sapiensENSP0000035452287.581776.732esox_luciusENSELUP0000002620887.467476.6319
ENSG00000198900homo_sapiensENSP0000035452289.542580esox_luciusENSELUP0000000354490.848881.1671
ENSG00000198900homo_sapiensENSP0000035452280.130772.549electrophorus_electricusENSEEEP0000002241084.551776.5517
ENSG00000198900homo_sapiensENSP0000035452288.235377.5163oncorhynchus_kisutchENSOKIP0000503739089.522578.6472
ENSG00000198900homo_sapiensENSP0000035452289.150378.1699oncorhynchus_kisutchENSOKIP0000506096688.227777.3609
ENSG00000198900homo_sapiensENSP0000035452287.843178.1699oncorhynchus_kisutchENSOKIP0000500310486.486576.9627
ENSG00000198900homo_sapiensENSP0000035452284.052373.8562oncorhynchus_mykissENSOMYP0000013475088.082277.3973
ENSG00000198900homo_sapiensENSP0000035452288.235377.6471oncorhynchus_mykissENSOMYP0000003820289.522578.7798
ENSG00000198900homo_sapiensENSP0000035452286.274576.3399oncorhynchus_mykissENSOMYP0000005602087.649477.5564
ENSG00000198900homo_sapiensENSP0000035452289.150378.8235salmo_salarENSSSAP0000001764187.435977.3077
ENSG00000198900homo_sapiensENSP0000035452288.496778.6928salmo_salarENSSSAP0000012021190.750780.6971
ENSG00000198900homo_sapiensENSP0000035452289.150378.3007salmo_salarENSSSAP0000001085787.886677.1907
ENSG00000198900homo_sapiensENSP0000035452289.411878.8235salmo_truttaENSSTUP0000004244391.280.4
ENSG00000198900homo_sapiensENSP0000035452288.235378.3007salmo_truttaENSSTUP0000007803590.482680.2949
ENSG00000198900homo_sapiensENSP0000035452289.150378.3007salmo_truttaENSSTUP0000009359488.227777.4903
ENSG00000198900homo_sapiensENSP0000035452280.653670.0654gadus_morhuaENSGMOP0000000794391.272279.2899
ENSG00000198900homo_sapiensENSP0000035452283.006572.8105gadus_morhuaENSGMOP0000005982784.10673.7748
ENSG00000198900homo_sapiensENSP0000035452289.28178.9542fundulus_heteroclitusENSFHEP0000003453289.164578.8512
ENSG00000198900homo_sapiensENSP0000035452289.934680.5229fundulus_heteroclitusENSFHEP0000001692691.489481.9149
ENSG00000198900homo_sapiensENSP0000035452266.535960.2614fundulus_heteroclitusENSFHEP0000000164991.055582.4687
ENSG00000198900homo_sapiensENSP0000035452269.934663.9216poecilia_reticulataENSPREP0000002722288.283880.6931
ENSG00000198900homo_sapiensENSP0000035452270.980464.8366poecilia_reticulataENSPREP0000003288694.764486.562
ENSG00000198900homo_sapiensENSP0000035452271.241865.2288xiphophorus_maculatusENSXMAP0000000965193.003485.1536
ENSG00000198900homo_sapiensENSP0000035452280.522972.8105xiphophorus_maculatusENSXMAP0000001540189.665281.0771
ENSG00000198900homo_sapiensENSP0000035452269.019662.8758oryzias_latipesENSORLP0000001168089.948981.9421
ENSG00000198900homo_sapiensENSP0000035452289.542580.6536oryzias_latipesENSORLP0000001745291.333382.2667
ENSG00000198900homo_sapiensENSP0000035452281.045871.7647cyclopterus_lumpusENSCLMP0000502712388.952778.7661
ENSG00000198900homo_sapiensENSP0000035452266.535960.5229cyclopterus_lumpusENSCLMP0000502354192.71484.3352
ENSG00000198900homo_sapiensENSP0000035452290.849781.1765oreochromis_niloticusENSONIP0000002558191.931282.1429
ENSG00000198900homo_sapiensENSP0000035452283.398774.902oreochromis_niloticusENSONIP0000005449288.611179.5833
ENSG00000198900homo_sapiensENSP0000035452268.888963.5294haplochromis_burtoniENSHBUP0000000432293.109585.8657
ENSG00000198900homo_sapiensENSP0000035452289.803980.3922haplochromis_burtoniENSHBUP0000002928591.682
ENSG00000198900homo_sapiensENSP0000035452290.457580.6536astatotilapia_callipteraENSACLP0000003097291.655681.7219
ENSG00000198900homo_sapiensENSP0000035452268.888963.5294astatotilapia_callipteraENSACLP0000003896092.945385.7143
ENSG00000198900homo_sapiensENSP0000035452288.888978.0392sparus_aurataENSSAUP0001003371089.709878.7599
ENSG00000198900homo_sapiensENSP0000035452287.320377.5163sparus_aurataENSSAUP0001003660286.866177.1131
ENSG00000198900homo_sapiensENSP0000035452284.18374.902lates_calcariferENSLCAP000100420349281.8571
ENSG00000198900homo_sapiensENSP0000035452289.411879.6078lates_calcariferENSLCAP0001004661889.062579.2969
ENSG00000198900homo_sapiensENSP0000035452290.980483.268xenopus_tropicalisENSXETP0000007112186.567279.2289
ENSG00000198900homo_sapiensENSP0000035452286.274582.8758chrysemys_picta_belliiENSCPBP0000002556096.632592.8258
ENSG00000198900homo_sapiensENSP0000035452261.830153.9869sphenodon_punctatusENSSPUP0000000468978.181868.2645
ENSG00000198900homo_sapiensENSP0000035452294.248489.9346crocodylus_porosusENSCPRP0000501781192.317588.0922
ENSG00000198900homo_sapiensENSP0000035452288.496784.3137notechis_scutatusENSNSUP0000000142691.486587.1622
ENSG00000198900homo_sapiensENSP0000035452294.509889.8039pseudonaja_textilisENSPTXP0000001062294.881990.1575
ENSG00000198900homo_sapiensENSP0000035452278.823573.3333anas_platyrhynchos_platyrhynchosENSAPLP0000000817986.266180.2575
ENSG00000198900homo_sapiensENSP0000035452295.947792.2876gallus_gallusENSGALP0001003328696.073392.4084
ENSG00000198900homo_sapiensENSP0000035452273.071970.1961meleagris_gallopavoENSMGAP0000000301296.048192.268
ENSG00000198900homo_sapiensENSP0000035452286.013181.8301serinus_canariaENSSCAP0000001713294.949590.3319
ENSG00000198900homo_sapiensENSP0000035452286.274581.8301parus_majorENSPMJP0000000451594.691589.8135
ENSG00000198900homo_sapiensENSP0000035452277.254971.7647anolis_carolinensisENSACAP0000004005586.656980.4985
ENSG00000198900homo_sapiensENSP0000035452268.627463.3987neolamprologus_brichardiENSNBRP0000001889392.756285.689
ENSG00000198900homo_sapiensENSP0000035452290.71980.6536neolamprologus_brichardiENSNBRP0000003041886.858677.2215
ENSG00000198900homo_sapiensENSP0000035452294.640589.6732naja_najaENSNNAP0000000354195.013190.0262
ENSG00000198900homo_sapiensENSP0000035452295.294190.9804podarcis_muralisENSPMRP0000003306295.169790.8616
ENSG00000198900homo_sapiensENSP0000035452280.653676.8627geospiza_fortisENSGFOP0000000593391.952387.6304
ENSG00000198900homo_sapiensENSP0000035452296.209292.2876taeniopygia_guttataENSTGUP0000000486596.335192.4084
ENSG00000198900homo_sapiensENSP0000035452270.849766.0131erpetoichthys_calabaricusENSECRP0000001405492.333986.0307
ENSG00000198900homo_sapiensENSP0000035452288.627479.085kryptolebias_marmoratusENSKMAP0000002482488.396378.8787
ENSG00000198900homo_sapiensENSP0000035452289.28180.3922kryptolebias_marmoratusENSKMAP0000002850691.310282.2193
ENSG00000198900homo_sapiensENSP0000035452276.601371.8954salvator_merianaeENSSMRP0000001933490.712185.1393
ENSG00000198900homo_sapiensENSP0000035452282.483774.2484oryzias_javanicusENSOJAP0000004533784.358375.9358
ENSG00000198900homo_sapiensENSP0000035452287.189576.9935oryzias_javanicusENSOJAP0000000445987.303777.0942
ENSG00000198900homo_sapiensENSP0000035452286.797478.0392amphilophus_citrinellusENSACIP0000001447689.247380.2419
ENSG00000198900homo_sapiensENSP0000035452269.803964.3137amphilophus_citrinellusENSACIP0000001229490.508583.3898
ENSG00000198900homo_sapiensENSP0000035452285.620976.4706dicentrarchus_labraxENSDLAP0000502744287.449978.1041
ENSG00000198900homo_sapiensENSP0000035452290.326879.7386dicentrarchus_labraxENSDLAP0000501024389.97479.4271
ENSG00000198900homo_sapiensENSP0000035452289.28179.085amphiprion_perculaENSAPEP0000001088788.586378.4695
ENSG00000198900homo_sapiensENSP0000035452291.111181.1765amphiprion_perculaENSAPEP0000003303592.195882.1429
ENSG00000198900homo_sapiensENSP0000035452289.542580.5229oryzias_sinensisENSOSIP0000002069891.333382.1333
ENSG00000198900homo_sapiensENSP0000035452273.856267.451oryzias_sinensisENSOSIP0000001984789.540481.775
ENSG00000198900homo_sapiensENSP0000035452296.209292.4183pelodiscus_sinensisENSPSIP0000000780696.083592.2977
ENSG00000198900homo_sapiensENSP0000035452284.705981.3072gopherus_evgoodeiENSGEVP0000501633897.443693.5338
ENSG00000198900homo_sapiensENSP0000035452271.764769.281chelonoidis_abingdoniiENSCABP0000002746197.86194.4742
ENSG00000198900homo_sapiensENSP0000035452269.542563.3987seriola_dumeriliENSSDUP0000002356290.78582.7645
ENSG00000198900homo_sapiensENSP0000035452288.627478.9542seriola_dumeriliENSSDUP0000002746592.244982.1769
ENSG00000198900homo_sapiensENSP0000035452274.509865.6209cottoperca_gobioENSCGOP0000005018286.363676.0606
ENSG00000198900homo_sapiensENSP0000035452287.189577.1242cottoperca_gobioENSCGOP0000000361290.135179.7297
ENSG00000198900homo_sapiensENSP0000035452294.640590.4575struthio_camelus_australisENSSCUP0000000796294.764490.5759
ENSG00000198900homo_sapiensENSP0000035452290.980486.6667anser_brachyrhynchusENSABRP0000000359593.927189.4737
ENSG00000198900homo_sapiensENSP0000035452280.392270.1961gasterosteus_aculeatusENSGACP0000001343984.246673.5616
ENSG00000198900homo_sapiensENSP0000035452272.026159.3464gasterosteus_aculeatusENSGACP0000000208474.560261.4344
ENSG00000198900homo_sapiensENSP0000035452289.673280.2614cynoglossus_semilaevisENSCSEP0000001527291.588881.976
ENSG00000198900homo_sapiensENSP0000035452289.803980.915poecilia_formosaENSPFOP0000001574191.844982.754
ENSG00000198900homo_sapiensENSP0000035452285.359575.817poecilia_formosaENSPFOP0000000837586.261676.6182
ENSG00000198900homo_sapiensENSP0000035452278.823569.281myripristis_murdjanENSMMDP0000504215188.416477.7126
ENSG00000198900homo_sapiensENSP0000035452290.980481.0458myripristis_murdjanENSMMDP0000501540891.699681.6864
ENSG00000198900homo_sapiensENSP0000035452287.843178.6928sander_luciopercaENSSLUP0000004991789.361780.0532
ENSG00000198900homo_sapiensENSP0000035452273.071965.6209sander_luciopercaENSSLUP0000000614387.207578.3151
ENSG00000198900homo_sapiensENSP0000035452296.078492.1569strigops_habroptilaENSSHBP0000500800196.204292.2775
ENSG00000198900homo_sapiensENSP0000035452269.803963.0065amphiprion_ocellarisENSAOCP0000001514789.148680.4674
ENSG00000198900homo_sapiensENSP0000035452290.849780.915amphiprion_ocellarisENSAOCP0000001580891.931281.8783
ENSG00000198900homo_sapiensENSP0000035452286.274582.8758terrapene_carolina_triunguisENSTMTP0000001957896.632592.8258
ENSG00000198900homo_sapiensENSP0000035452288.36678.0392hucho_huchoENSHHUP0000006642190.738380.1342
ENSG00000198900homo_sapiensENSP0000035452289.019678.1699hucho_huchoENSHHUP0000001124588.098377.3609
ENSG00000198900homo_sapiensENSP0000035452288.36678.8235hucho_huchoENSHHUP0000004748590.616680.8311
ENSG00000198900homo_sapiensENSP0000035452288.104677.9085betta_splendensENSBSLP0000001831888.451478.2152
ENSG00000198900homo_sapiensENSP0000035452290.065480betta_splendensENSBSLP0000005011491.622381.383
ENSG00000198900homo_sapiensENSP0000035452289.542579.7386pygocentrus_nattereriENSPNAP0000000312590.848880.9019
ENSG00000198900homo_sapiensENSP0000035452289.019677.2549pygocentrus_nattereriENSPNAP0000003450789.136177.356
ENSG00000198900homo_sapiensENSP0000035452284.313775.6863anabas_testudineusENSATEP0000005301188.720879.6424
ENSG00000198900homo_sapiensENSP0000035452274.640567.0588anabas_testudineusENSATEP0000005682985.47976.7964
ENSG00000198900homo_sapiensENSP0000035452261.960853.2026ciona_savignyiENSCSAVP0000000162473.831863.3956
ENSG00000198900homo_sapiensENSP0000035452290.849780.915seriola_lalandi_dorsalisENSSLDP0000001434392.543382.4234
ENSG00000198900homo_sapiensENSP0000035452269.150363.268seriola_lalandi_dorsalisENSSLDP0000003309889.358181.7568
ENSG00000198900homo_sapiensENSP0000035452266.928159.7386labrus_bergyltaENSLBEP0000000880786.195376.936
ENSG00000198900homo_sapiensENSP0000035452289.150377.6471labrus_bergyltaENSLBEP0000002331591.543679.7315
ENSG00000198900homo_sapiensENSP0000035452290.588280.915pundamilia_nyerereiENSPNYP0000002488291.788181.9868
ENSG00000198900homo_sapiensENSP0000035452269.019663.5294pundamilia_nyerereiENSPNYP0000000171291.986184.669
ENSG00000198900homo_sapiensENSP0000035452285.620975.9477mastacembelus_armatusENSMAMP0000003124191.352981.0321
ENSG00000198900homo_sapiensENSP0000035452289.28179.085mastacembelus_armatusENSMAMP0000001545289.28179.085
ENSG00000198900homo_sapiensENSP0000035452290.980480.6536stegastes_partitusENSSPAP0000002809792.185481.7219
ENSG00000198900homo_sapiensENSP0000035452270.196164.0523stegastes_partitusENSSPAP0000000124188.907381.1258
ENSG00000198900homo_sapiensENSP0000035452230.065425.8824oncorhynchus_tshawytschaENSOTSP0000505440484.558872.7941
ENSG00000198900homo_sapiensENSP0000035452213.071910.1961oncorhynchus_tshawytschaENSOTSP0000500542671.942456.1151
ENSG00000198900homo_sapiensENSP0000035452221.568620.3922oncorhynchus_tshawytschaENSOTSP0000504410597.633192.3077
ENSG00000198900homo_sapiensENSP0000035452216.73212.9412oncorhynchus_tshawytschaENSOTSP0000505440564.321649.7487
ENSG00000198900homo_sapiensENSP0000035452288.235377.5163oncorhynchus_tshawytschaENSOTSP0000509183789.522578.6472
ENSG00000198900homo_sapiensENSP0000035452290.980481.1765acanthochromis_polyacanthusENSAPOP0000000813092.430382.4701
ENSG00000198900homo_sapiensENSP0000035452269.673263.268acanthochromis_polyacanthusENSAPOP0000003019290.033881.7568
ENSG00000198900homo_sapiensENSP0000035452280.784377.1242aquila_chrysaetos_chrysaetosENSACCP0002001595491.964387.7976
ENSG00000198900homo_sapiensENSP0000035452288.104678.6928nothobranchius_furzeriENSNFUP0001503159991.327981.5718
ENSG00000198900homo_sapiensENSP0000035452278.300769.4118nothobranchius_furzeriENSNFUP0001502668286.063276.2931
ENSG00000198900homo_sapiensENSP0000035452275.947766.7974cyprinodon_variegatusENSCVAP0000000827879.58970
ENSG00000198900homo_sapiensENSP0000035452289.934680.5229cyprinodon_variegatusENSCVAP0000000024891.489481.9149
ENSG00000198900homo_sapiensENSP0000035452287.843176.3399denticeps_clupeoidesENSDCDP0000003208687.614176.1408
ENSG00000198900homo_sapiensENSP0000035452287.581777.9085denticeps_clupeoidesENSDCDP0000003586086.340276.8041
ENSG00000198900homo_sapiensENSP0000035452278.562169.1503larimichthys_croceaENSLCRP0000503731186.103175.788
ENSG00000198900homo_sapiensENSP0000035452279.869370.3268larimichthys_croceaENSLCRP0000506064287.285776.8571
ENSG00000198900homo_sapiensENSP0000035452287.712476.2092takifugu_rubripesENSTRUP0000000136988.405876.8116
ENSG00000198900homo_sapiensENSP0000035452288.888978.6928takifugu_rubripesENSTRUP0000003126378.250969.275
ENSG00000198900homo_sapiensENSP0000035452289.934686.0131ficedula_albicollisENSFALP0000000581797.175192.9379
ENSG00000198900homo_sapiensENSP0000035452281.830172.549hippocampus_comesENSHCOP0000000239384.823875.2033
ENSG00000198900homo_sapiensENSP0000035452289.673280.3922cyprinus_carpio_carpioENSCCRP0000007953389.439480.1825
ENSG00000198900homo_sapiensENSP0000035452288.627479.3464cyprinus_carpio_carpioENSCCRP0000007951589.210579.8684
ENSG00000198900homo_sapiensENSP0000035452283.921673.5948cyprinus_carpio_carpioENSCCRP0000017348185.828975.2674
ENSG00000198900homo_sapiensENSP0000035452285.09881.6993coturnix_japonicaENSCJPP0000502692293.669189.9281
ENSG00000198900homo_sapiensENSP0000035452283.26875.2941poecilia_latipinnaENSPLAP0000002935389.466380.8989
ENSG00000198900homo_sapiensENSP0000035452268.888962.8758poecilia_latipinnaENSPLAP0000000820791.972183.9442
ENSG00000198900homo_sapiensENSP0000035452290.196181.3072sinocyclocheilus_grahamiENSSGRP0000010724491.390782.3841
ENSG00000198900homo_sapiensENSP0000035452255.163448.1046sinocyclocheilus_grahamiENSSGRP0000010921981.941771.4563
ENSG00000198900homo_sapiensENSP0000035452290.326880.1307sinocyclocheilus_grahamiENSSGRP0000005775991.523281.1921
ENSG00000198900homo_sapiensENSP0000035452276.078466.6667sinocyclocheilus_grahamiENSSGRP0000006096377.393667.8191
ENSG00000198900homo_sapiensENSP0000035452268.888963.5294maylandia_zebraENSMZEP0000503557792.945385.7143
ENSG00000198900homo_sapiensENSP0000035452290.588280.7843maylandia_zebraENSMZEP0000501343491.788181.8543
ENSG00000198900homo_sapiensENSP0000035452288.36676.8627tetraodon_nigroviridisENSTNIP0000000647187.792276.3636
ENSG00000198900homo_sapiensENSP0000035452288.888980tetraodon_nigroviridisENSTNIP0000000365890.545981.4913
ENSG00000198900homo_sapiensENSP0000035452269.934663.5294paramormyrops_kingsleyaeENSPKIP0000002153591.924483.5052
ENSG00000198900homo_sapiensENSP0000035452214.771212.6797paramormyrops_kingsleyaeENSPKIP0000003954373.856263.3987
ENSG00000198900homo_sapiensENSP0000035452290.326879.4771paramormyrops_kingsleyaeENSPKIP0000002192390.682479.79
ENSG00000198900homo_sapiensENSP0000035452290.849781.8301scleropages_formosusENSSFOP0001503393191.809882.6948
ENSG00000198900homo_sapiensENSP0000035452277.124270.1961scleropages_formosusENSSFOP0001503302691.757483.5148
ENSG00000198900homo_sapiensENSP0000035452290.196182.3529leptobrachium_leishanenseENSLLEP0000004299585.927878.4558
ENSG00000198900homo_sapiensENSP0000035452282.614474.1176scophthalmus_maximusENSSMAP0000002255790.285781
ENSG00000198900homo_sapiensENSP0000035452279.869371.2418scophthalmus_maximusENSSMAP0000001407389.067179.4461
ENSG00000198900homo_sapiensENSP0000035452289.803981.0458oryzias_melastigmaENSOMEP0000003619391.47882.5566
ENSG00000198900homo_sapiensENSP0000035452262.352956.732oryzias_melastigmaENSOMEP0000002925194.83186.2823

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000228colocalizes_with nuclear chromosome1IDAHomo_sapiens(9606)Component
GO:0000932located_in P-body1IDAHomo_sapiens(9606)Component
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1IDAHomo_sapiens(9606)Function
GO:0001650located_in fibrillar center1IDAHomo_sapiens(9606)Component
GO:0001673located_in male germ cell nucleus1IEAHomo_sapiens(9606)Component
GO:0003677enables DNA binding3EXP,IDA,IMPHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1IDAHomo_sapiens(9606)Function
GO:0003690enables double-stranded DNA binding1IMPHomo_sapiens(9606)Function
GO:0003697enables single-stranded DNA binding1IMPHomo_sapiens(9606)Function
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003917enables DNA topoisomerase type I (single strand cut, ATP-independent) activity3IBA,IDA,IMPHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity1IMPHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IMPHomo_sapiens(9606)Function
GO:0005634located_in nucleus2HDA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm3IDA,IMP,TASHomo_sapiens(9606)Component
GO:0005730is_active_in nucleolus3IBA,IDA,IMPHomo_sapiens(9606)Component
GO:0006260involved_in DNA replication1IBAHomo_sapiens(9606)Process
GO:0006265involved_in DNA topological change3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0006338involved_in chromatin remodeling1IMPHomo_sapiens(9606)Process
GO:0007059involved_in chromosome segregation1IBAHomo_sapiens(9606)Process
GO:0007623involved_in circadian rhythm1IEPHomo_sapiens(9606)Process
GO:0008301enables DNA binding, bending1EXPHomo_sapiens(9606)Function
GO:0009410involved_in response to xenobiotic stimulus1IEPHomo_sapiens(9606)Process
GO:0012501involved_in programmed cell death1NASHomo_sapiens(9606)Process
GO:0016310involved_in phosphorylation1NASHomo_sapiens(9606)Process
GO:0018105involved_in peptidyl-serine phosphorylation1IMPHomo_sapiens(9606)Process
GO:0019904enables protein domain specific binding1IPIHomo_sapiens(9606)Function
GO:0032922involved_in circadian regulation of gene expression1IMPHomo_sapiens(9606)Process
GO:0032993part_of protein-DNA complex1IMPHomo_sapiens(9606)Component
GO:0040016involved_in embryonic cleavage1IEAHomo_sapiens(9606)Process
GO:0043204located_in perikaryon1IEAHomo_sapiens(9606)Component
GO:0097100enables supercoiled DNA binding1IMPHomo_sapiens(9606)Function

Expression