Ensembl ID ENSG00000198900 Gene ID 7150 Accession 11986
Gene Symbol TOP1 Alias TOPI Full Name DNA topoisomerase I
Position 20 : 41028822 - 41124487 Length 95666 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq, Jul 2008]

ENSG00000198900 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000198900 TOP1 0.56 3.02e-31 BRCA
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000198900 TOP1 cancer 10021292
ENSG00000198900 TOP1 cancer 10077164
ENSG00000198900 TOP1 colorectal cancer 10353756
ENSG00000198900 TOP1 tumors 10426671
ENSG00000198900 TOP1 colorectal cancer 10533483
ENSG00000198900 TOP1 cancer 10547719
ENSG00000198900 TOP1 ovarian cancer 10550825
ENSG00000198900 TOP1 cancer 10573208
ENSG00000198900 TOP1 tumor 10819166
ENSG00000198900 TOP1 brain tumors 10982004
ENSG00000198900 TOP1 tumors 11084429
ENSG00000198900 TOP1 cancers 11205246
ENSG00000198900 TOP1 tumours 11299781
ENSG00000198900 TOP1 tumor 11321439
ENSG00000198900 TOP1 cancer 11361337
ENSG00000198900 TOP1 tumor 11395247
ENSG00000198900 TOP1 tumor 11479235
ENSG00000198900 TOP1 ovarian cancer 11697485
ENSG00000198900 TOP1 Esophageal Squamous Cell Cancer 11749700
ENSG00000198900 TOP1 colorectal cancer 11751522
ENSG00000198900 TOP1 ovarian cancer 11774743
ENSG00000198900 TOP1 cancer 12027807
ENSG00000198900 TOP1 germ cell tumours 12237772
ENSG00000198900 TOP1 tumor 12369944
ENSG00000198900 TOP1 malignant tumor 12520736
ENSG00000198900 TOP1 tumor 12529968
ENSG00000198900 TOP1 cancer 12570765
ENSG00000198900 TOP1 prostate cancer 12750860
ENSG00000198900 TOP1 breast tumors 12833450
ENSG00000198900 TOP1 AML 12874791
ENSG00000198900 TOP1 pediatric cancer 12882743
ENSG00000198900 TOP1 cancer 12894548
ENSG00000198900 TOP1 cancer 12907247
ENSG00000198900 TOP1 tumors 1309380
ENSG00000198900 TOP1 pancreatic tumor 1315526
ENSG00000198900 TOP1 tumor 1317858
ENSG00000198900 TOP1 tumor 1332623
ENSG00000198900 TOP1 cancer 1332948
ENSG00000198900 TOP1 cancer 14519980
ENSG00000198900 TOP1 tumor 14565655
ENSG00000198900 TOP1 colorectal cancer 14648715
ENSG00000198900 TOP1 tumor 14679002
ENSG00000198900 TOP1 AML 15036893
ENSG00000198900 TOP1 Cancer 15132777
ENSG00000198900 TOP1 cancer 15157660
ENSG00000198900 TOP1 cancer 15170677
ENSG00000198900 TOP1 breast cancer 15215569
ENSG00000198900 TOP1 cancer 15255290
ENSG00000198900 TOP1 tumor 15274350
ENSG00000198900 TOP1 childhood cancers 15503024
ENSG00000198900 TOP1 tumor 15514562
ENSG00000198900 TOP1 colon tumor 15678378
ENSG00000198900 TOP1 tumor 15689163
ENSG00000198900 TOP1 cancers 15713902
ENSG00000198900 TOP1 tumors 15864388
ENSG00000198900 TOP1 cancer 15923621
ENSG00000198900 TOP1 Cancer 15930305
ENSG00000198900 TOP1 colorectal cancer 15948034
ENSG00000198900 TOP1 tumor 16132345
ENSG00000198900 TOP1 gastric cancer 16158947
ENSG00000198900 TOP1 colorectal cancer 16184927
ENSG00000198900 TOP1 cancer 16248431
ENSG00000198900 TOP1 tumor 16368568
ENSG00000198900 TOP1 cancer 16508919
ENSG00000198900 TOP1 breast cancer 16819197
ENSG00000198900 TOP1 benign tumors of the ovary 1682037
ENSG00000198900 TOP1 tumor 16939812
ENSG00000198900 TOP1 cancer 16965765
ENSG00000198900 TOP1 tumour 16983402
ENSG00000198900 TOP1 tumour 16990856
ENSG00000198900 TOP1 prostate cancer 17135786
ENSG00000198900 TOP1 tumors 17143621
ENSG00000198900 TOP1 cancers 17336444
ENSG00000198900 TOP1 cancer 17531144
ENSG00000198900 TOP1 cancer 17604595
ENSG00000198900 TOP1 cancer 17613819
ENSG00000198900 TOP1 cancers 17624531
ENSG00000198900 TOP1 cancer 17638905
ENSG00000198900 TOP1 small cell lung cancer 17645849
ENSG00000198900 TOP1 cancer 17666793
ENSG00000198900 TOP1 cancers 17722653
ENSG00000198900 TOP1 cancers 17943230
ENSG00000198900 TOP1 colorectal cancer 18208837
ENSG00000198900 TOP1 tumor 18223676
ENSG00000198900 TOP1 tumour 18489530
ENSG00000198900 TOP1 breast cancer 18520043
ENSG00000198900 TOP1 tumor 18566215
ENSG00000198900 TOP1 cancer 18676842
ENSG00000198900 TOP1 cancer 18991627
ENSG00000198900 TOP1 tumours 18998135
ENSG00000198900 TOP1 tumor 19303306
ENSG00000198900 TOP1 cancer 19445707
ENSG00000198900 TOP1 tumor 19531625
ENSG00000198900 TOP1 cancer 19604089
ENSG00000198900 TOP1 tumors 20017204
ENSG00000198900 TOP1 breast cancer 20164500
ENSG00000198900 TOP1 Cancer 20215517
ENSG00000198900 TOP1 tumours 20465595
ENSG00000198900 TOP1 tumour 20544499
ENSG00000198900 TOP1 cancer 20600288
ENSG00000198900 TOP1 cancers 20704988
ENSG00000198900 TOP1 oral cancer 20738175
ENSG00000198900 TOP1 tumors 20811674
ENSG00000198900 TOP1 breast cancer 21533497
ENSG00000198900 TOP1 tumor 21619602
ENSG00000198900 TOP1 tumor 2170010
ENSG00000198900 TOP1 tumor 2174551
ENSG00000198900 TOP1 tumour 21966440
ENSG00000198900 TOP1 tumor 22113577
ENSG00000198900 TOP1 cancers 22140093
ENSG00000198900 TOP1 colorectal cancer 22171973
ENSG00000198900 TOP1 cancer 22797812
ENSG00000198900 TOP1 tumors 22917641
ENSG00000198900 TOP1 lung cancer 22934142
ENSG00000198900 TOP1 cancer 23006513
ENSG00000198900 TOP1 cancer 23029106
ENSG00000198900 TOP1 colorectal cancer 23110915
ENSG00000198900 TOP1 breast cancer 23152011
ENSG00000198900 TOP1 cancer 23169295
ENSG00000198900 TOP1 cancer 23314103
ENSG00000198900 TOP1 tumour 23347980
ENSG00000198900 TOP1 bladder cancer 23365634
ENSG00000198900 TOP1 tumor 23432590
ENSG00000198900 TOP1 cancer 23503598
ENSG00000198900 TOP1 tumor 23532891
ENSG00000198900 TOP1 Colorectal Cancer 23577133
ENSG00000198900 TOP1 colorectal cancer 23597015
ENSG00000198900 TOP1 tumour 23805307
ENSG00000198900 TOP1 colon cancer 23836376
ENSG00000198900 TOP1 cancer 24013388
ENSG00000198900 TOP1 tumor 24024505
ENSG00000198900 TOP1 cancer 24103454
ENSG00000198900 TOP1 cancer 24194914
ENSG00000198900 TOP1 tumor 24216996
ENSG00000198900 TOP1 cancer 24252850
ENSG00000198900 TOP1 metastatic colorectal cancer 24256029
ENSG00000198900 TOP1 breast cancer 24400218
ENSG00000198900 TOP1 cancer 24429698
ENSG00000198900 TOP1 tumors 24516563
ENSG00000198900 TOP1 tumor 24525588
ENSG00000198900 TOP1 cancer 24637157
ENSG00000198900 TOP1 cancer 24758386
ENSG00000198900 TOP1 colon cancer 24886433
ENSG00000198900 TOP1 cancer 24992598
ENSG00000198900 TOP1 cancer 25036042
ENSG00000198900 TOP1 tumor 25179828
ENSG00000198900 TOP1 Small Cell Lung Cancer 25232464
ENSG00000198900 TOP1 tumor 25253693
ENSG00000198900 TOP1 tumor 25295459
ENSG00000198900 TOP1 cancer 25404338
ENSG00000198900 TOP1 tumor 2548199
ENSG00000198900 TOP1 AML 25510486
ENSG00000198900 TOP1 colorectal cancer 25522766
ENSG00000198900 TOP1 cancer 25539742
ENSG00000198900 TOP1 colon cancer 2555920
ENSG00000198900 TOP1 tumor 2557245
ENSG00000198900 TOP1 cancers 25615400
ENSG00000198900 TOP1 prostate cancer 25619691
ENSG00000198900 TOP1 tumors 25777966
ENSG00000198900 TOP1 cancer 25879470
ENSG00000198900 TOP1 cancer 25881826
ENSG00000198900 TOP1 ovarian cancer 25884494
ENSG00000198900 TOP1 breast cancer 25885574
ENSG00000198900 TOP1 DLBCL 25931012
ENSG00000198900 TOP1 tumor 25987486
ENSG00000198900 TOP1 breast cancer 26029013
ENSG00000198900 TOP1 breast cancer 26042602
ENSG00000198900 TOP1 gastric cancer 26050197
ENSG00000198900 TOP1 tumor 26159926
ENSG00000198900 TOP1 ovarian cancers 26207989
ENSG00000198900 TOP1 tumor 26257065
ENSG00000198900 TOP1 cancer 26287259
ENSG00000198900 TOP1 colon cancer 26460955
ENSG00000198900 TOP1 cancers 26463633
ENSG00000198900 TOP1 Colon Cancer 26542057
ENSG00000198900 TOP1 tumors 26676887
ENSG00000198900 TOP1 cancer 26801089
ENSG00000198900 TOP1 breast cancer 26801902
ENSG00000198900 TOP1 ovarian cancers 26949094
ENSG00000198900 TOP1 colon cancer 27029323
ENSG00000198900 TOP1 lung cancer 27121056
ENSG00000198900 TOP1 Cancer 27138759
ENSG00000198900 TOP1 lung cancer 27141638
ENSG00000198900 TOP1 cancer 27181710
ENSG00000198900 TOP1 tumors 27220325
ENSG00000198900 TOP1 cancer 27301177
ENSG00000198900 TOP1 tumor 27315793
ENSG00000198900 TOP1 breast cancer 27566577
ENSG00000198900 TOP1 gastric cancer 27638859
ENSG00000198900 TOP1 cancer 27641670
ENSG00000198900 TOP1 cancer 27825117
ENSG00000198900 TOP1 cancers 27825797
ENSG00000198900 TOP1 tumour 27875523
ENSG00000198900 TOP1 colorectal cancer 27888622
ENSG00000198900 TOP1 tumors 27990691
ENSG00000198900 TOP1 tumor 28030910
ENSG00000198900 TOP1 tumors 28077117
ENSG00000198900 TOP1 breast cancer 28127549
ENSG00000198900 TOP1 cancer 28180300
ENSG00000198900 TOP1 tumor 28355294
ENSG00000198900 TOP1 breast cancer 28360015
ENSG00000198900 TOP1 tumor 28503091
ENSG00000198900 TOP1 colon cancer 28556593
ENSG00000198900 TOP1 gastric cancer 28677116
ENSG00000198900 TOP1 tumor 28882690
ENSG00000198900 TOP1 tumor 28961713
ENSG00000198900 TOP1 gastric cancer 29125991
ENSG00000198900 TOP1 tumor 29170084
ENSG00000198900 TOP1 tumor 29177742
ENSG00000198900 TOP1 gastric cancer 29237470
ENSG00000198900 TOP1 tumors 29252124
ENSG00000198900 TOP1 Non-Small Cell Lung Cancer 29453962
ENSG00000198900 TOP1 Cancer 29748210
ENSG00000198900 TOP1 AML 29781401
ENSG00000198900 TOP1 tumors 29869738
ENSG00000198900 TOP1 cancer 29898404
ENSG00000198900 TOP1 cancer 29899822
ENSG00000198900 TOP1 cancer 30052267
ENSG00000198900 TOP1 tumor 30061364
ENSG00000198900 TOP1 Cancer 30132517
ENSG00000198900 TOP1 tumor 30157947
ENSG00000198900 TOP1 cancer 30336023
ENSG00000198900 TOP1 endometrial cancer 30341503
ENSG00000198900 TOP1 cancers 30555231
ENSG00000198900 TOP1 lung cancer 30605652
ENSG00000198900 TOP1 tumors 30622252
ENSG00000198900 TOP1 cancer 30663574
ENSG00000198900 TOP1 tumor 30675254
ENSG00000198900 TOP1 cancers 30708024
ENSG00000198900 TOP1 tumor 30907213
ENSG00000198900 TOP1 lung cancer 30983992
ENSG00000198900 TOP1 breast cancer 31059050
ENSG00000198900 TOP1 cancer 31067275
ENSG00000198900 TOP1 Breast Cancer 31072044
ENSG00000198900 TOP1 cancers 31138113
ENSG00000198900 TOP1 cancer 31176097
ENSG00000198900 TOP1 tumor 31196001
ENSG00000198900 TOP1 tumor 31227499
ENSG00000198900 TOP1 colon cancer 31242600
ENSG00000198900 TOP1 Cancer 31409613
ENSG00000198900 TOP1 malignant peripheral nerve sheath tumors 31444410
ENSG00000198900 TOP1 Tumor 31547492
ENSG00000198900 TOP1 cancer 31602296
ENSG00000198900 TOP1 breast cancer 31695042
ENSG00000198900 TOP1 breast cancer 31783818
ENSG00000198900 TOP1 tumour 31922440
ENSG00000198900 TOP1 cancer 31930190
ENSG00000198900 TOP1 cancers 7494232
ENSG00000198900 TOP1 cancer 7519727
ENSG00000198900 TOP1 cancer 7523352
ENSG00000198900 TOP1 tumor 7613087
ENSG00000198900 TOP1 small-cell lung cancer 7640225
ENSG00000198900 TOP1 cancer 7641181
ENSG00000198900 TOP1 cancer 7796407
ENSG00000198900 TOP1 tumor 7935175
ENSG00000198900 TOP1 tumor 8061056
ENSG00000198900 TOP1 tumor 8144677
ENSG00000198900 TOP1 bladder cancer 8205547
ENSG00000198900 TOP1 cancer 8226741
ENSG00000198900 TOP1 tumor 8271279
ENSG00000198900 TOP1 cancer 8383888
ENSG00000198900 TOP1 cancer 8387398
ENSG00000198900 TOP1 tumour 8529198
ENSG00000198900 TOP1 tumor 8565133
ENSG00000198900 TOP1 lung cancer 8630122
ENSG00000198900 TOP1 tumors 8734332
ENSG00000198900 TOP1 tumour 8761367
ENSG00000198900 TOP1 small cell lung cancer 8853931
ENSG00000198900 TOP1 tumours 8922198
ENSG00000198900 TOP1 tumors 8993513
ENSG00000198900 TOP1 colon-cancer 9033637
ENSG00000198900 TOP1 lung tumors 9045964
ENSG00000198900 TOP1 Cancer 9092822
ENSG00000198900 TOP1 tumor 9334824
ENSG00000198900 TOP1 cancer 9342501
ENSG00000198900 TOP1 cancer 9391066
ENSG00000198900 TOP1 non-small cell lung cancer 9414664
ENSG00000198900 TOP1 breast cancer 9499438
ENSG00000198900 TOP1 epithelial ovarian cancer 9602266
ENSG00000198900 TOP1 tumor 9637775
ENSG00000198900 TOP1 small-cell lung cancer 9649127
ENSG00000198900 TOP1 tumours 9702210
ENSG00000198900 TOP1 colon cancer 9748119
ENSG00000198900 TOP1 cancer 9914787
ENSG00000198900 TOP1 cancer 9929504
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000198900 TOP1 lung adenocarcinoma missense_variant 0.8143% (21/2579) 4 entries
ENSG00000198900 TOP1 colon adenocarcinoma missense_variant 1.376% (18/1308) 4 entries
ENSG00000198900 TOP1 female breast carcinoma sequence_alteration 1.023% (4/391) 1 entry
ENSG00000198900 TOP1 clear cell renal carcinoma missense_variant 0.5054% (8/1583) 4 entries
ENSG00000198900 TOP1 prostate adenocarcinoma frameshift_variant 1.908% (41/2149) 1 entry
ENSG00000198900 TOP1 melanoma missense_variant 2.759% (4/145) 3 entries
ENSG00000198900 TOP1 hepatocellular carcinoma sequence_alteration 0.8105% (8/987) 1 entry
ENSG00000198900 TOP1 esophageal squamous cell carcinoma missense_variant 0.4386% (3/684) 1 entry
ENSG00000198900 TOP1 leiomyosarcoma missense_variant 4.0% (4/100) 1 entry
ENSG00000198900 TOP1 breast carcinoma missense_variant 0.4749% (7/1474) 1 entry
ENSG00000198900 TOP1 breast ductal adenocarcinoma missense_variant 3.032% (49/1616) 2 entries
ENSG00000198900 TOP1 colon adenocarcinoma stop_gained 1.376% (18/1308) 1 entry
ENSG00000198900 TOP1 squamous cell lung carcinoma missense_variant 0.804% (8/995) 1 entry
ENSG00000198900 TOP1 lobular breast carcinoma missense_variant 2.372% (6/253) 1 entry
ENSG00000198900 TOP1 gastric adenocarcinoma missense_variant 1.073% (9/839) 1 entry
ENSG00000198900 TOP1 urothelial carcinoma missense_variant 2.326% (2/86) 1 entry
ENSG00000198900 TOP1 rectal adenocarcinoma missense_variant 1.444% (8/554) 4 entries
ENSG00000198900 TOP1 prostate carcinoma sequence_alteration 1.446% (7/484) 2 entries
ENSG00000198900 TOP1 myelodysplastic syndrome sequence_alteration 4.054% (3/74) 2 entries
ENSG00000198900 TOP1 brain glioblastoma sequence_alteration 0.2475% (3/1212) 2 entries
ENSG00000198900 TOP1 female breast carcinoma missense_variant 1.023% (4/391) 2 entries
ENSG00000198900 TOP1 cecum adenocarcinoma missense_variant 2.963% (8/270) 1 entry
ENSG00000198900 TOP1 bladder transitional cell carcinoma missense_variant 0.8969% (4/446) 2 entries
ENSG00000198900 TOP1 pancreatic ductal adenocarcinoma missense_variant 1.724% (29/1682) 1 entry
ENSG00000198900 TOP1 diffuse large B-cell lymphoma missense_variant 0.8108% (3/370) 1 entry
ENSG00000198900 TOP1 gastric intestinal type adenocarcinoma missense_variant 2.353% (2/85) 1 entry
ENSG00000198900 TOP1 non-small cell lung carcinoma missense_variant 1.905% (2/105) 2 entries
ENSG00000198900 TOP1 small cell lung carcinoma sequence_alteration 1.345% (6/446) 2 entries
ENSG00000198900 TOP1 esophageal adenocarcinoma missense_variant 4.22% (23/545) 1 entry
ENSG00000198900 TOP1 central nervous system primitive neuroectodermal neoplasm sequence_alteration 0.4464% (2/448) 1 entry
ENSG00000198900 TOP1 colorectal adenocarcinoma sequence_alteration 2.061% (25/1213) 1 entry
ENSG00000198900 TOP1 colorectal adenocarcinoma stop_gained 2.061% (25/1213) 1 entry
ENSG00000198900 TOP1 prostate adenocarcinoma sequence_alteration 1.908% (41/2149) 1 entry
ENSG00000198900 TOP1 skin melanoma stop_gained 1.553% (18/1159) 3 entries
ENSG00000198900 TOP1 Endometrial Endometrioid Adenocarcinoma stop_gained 2.477% (16/646) 1 entry
ENSG00000198900 TOP1 colorectal adenocarcinoma missense_variant 2.061% (25/1213) 2 entries
ENSG00000198900 TOP1 skin melanoma missense_variant 1.553% (18/1159) 3 entries
ENSG00000198900 TOP1 gastric adenocarcinoma stop_gained 1.073% (9/839) 1 entry
ENSG00000198900 TOP1 Pancreatic Acinar Cell Carcinoma missense_variant 5.882% (2/34) 2 entries
ENSG00000198900 TOP1 Endometrial Endometrioid Adenocarcinoma missense_variant 2.477% (16/646) 1 entry
ENSG00000198900 TOP1 colon adenocarcinoma sequence_alteration 1.376% (18/1308) 3 entries
ENSG00000198900 TOP1 adenosquamous lung carcinoma missense_variant 4.545% (1/22) 1 entry
ENSG00000198900 TOP1 prostate carcinoma missense_variant 1.446% (7/484) 1 entry
ENSG00000198900 TOP1 endometrial carcinoma missense_variant 4.167% (1/24) 1 entry
ENSG00000198900 TOP1 Anal Squamous Cell Carcinoma missense_variant 1.22% (1/82) 1 entry
ENSG00000198900 TOP1 ovarian serous adenocarcinoma missense_variant 0.1131% (1/884) 1 entry
ENSG00000198900 TOP1 clear cell renal carcinoma sequence_alteration 0.5054% (8/1583) 1 entry
ENSG00000198900 TOP1 Uveal Melanoma missense_variant 0.7812% (1/128) 1 entry
ENSG00000198900 TOP1 small intestinal adenocarcinoma missense_variant 4.762% (1/21) 1 entry
ENSG00000198900 TOP1 undifferentiated pleomorphic sarcoma missense_variant 1.639% (1/61) 1 entry
ENSG00000198900 TOP1 brain glioblastoma conservative_inframe_deletion 0.2475% (3/1212) 1 entry
ENSG00000198900 TOP1 bladder transitional cell carcinoma stop_gained 0.8969% (4/446) 1 entry
ENSG00000198900 TOP1 lung adenocarcinoma frameshift_variant 0.8143% (21/2579) 1 entry
ENSG00000198900 TOP1 laryngeal squamous cell carcinoma missense_variant 2.439% (1/41) 1 entry
ENSG00000198900 TOP1 small cell lung carcinoma stop_gained 1.345% (6/446) 1 entry
ENSG00000198900 TOP1 prostate adenocarcinoma missense_variant 1.908% (41/2149) 1 entry
ENSG00000198900 TOP1 Tonsillar Squamous Cell Carcinoma missense_variant 11.11% (1/9) 1 entry
ENSG00000198900 TOP1 large cell lung carcinoma missense_variant 5.263% (1/19) 1 entry
ENSG00000198900 TOP1 rectal adenocarcinoma conservative_inframe_deletion 1.444% (8/554) 1 entry
ENSG00000198900 TOP1 Merkel cell skin cancer missense_variant 1.064% (1/94) 1 entry
ENSG00000198900 TOP1 chondroblastoma sequence_alteration 14.29% (1/7) 1 entry
ENSG00000198900 TOP1 Pleural Epithelioid Mesothelioma sequence_alteration 0.7407% (1/135) 1 entry
ENSG00000198900 TOP1 Appendix Adenocarcinoma missense_variant 1.351% (1/74) 1 entry
ENSG00000198900 TOP1 cecum adenocarcinoma stop_gained 2.963% (8/270) 1 entry
ENSG00000198900 TOP1 ovarian clear cell adenocarcinoma missense_variant 2.857% (1/35) 1 entry
ENSG00000198900 TOP1 small cell lung carcinoma missense_variant 1.345% (6/446) 1 entry
ENSG00000198900 TOP1 nasopharyngeal squamous cell carcinoma missense_variant 0.5556% (1/180) 1 entry
ENSG00000198900 TOP1 Duodenal Adenocarcinoma frameshift_variant 5.882% (1/17) 1 entry
ENSG00000198900 TOP1 hepatocellular carcinoma missense_variant 0.8105% (8/987) 1 entry
ENSG00000198900 TOP1 cervical squamous cell carcinoma stop_gained 0.3086% (1/324) 1 entry
ENSG00000198900 TOP1 small cell lung carcinoma frameshift_variant 1.345% (6/446) 1 entry
ENSG00000198900 TOP1 bile duct adenocarcinoma missense_variant 0.2597% (1/385) 1 entry
ENSG00000198900 TOP1 colon adenocarcinoma frameshift_variant 1.376% (18/1308) 1 entry
ENSG00000198900 TOP1 cecum adenocarcinoma sequence_alteration 2.963% (8/270) 1 entry
ENSG00000198900 TOP1 Mast Cell Neoplasm sequence_alteration 25.0% (1/4) 1 entry
ENSG00000198900 TOP1 lung adenocarcinoma stop_gained 0.8143% (21/2579) 1 entry
ENSG00000198900 TOP1 neoplasm of mature B-cells sequence_alteration 1.667% (1/60) 1 entry
ENSG00000198900 TOP1 esophageal squamous cell carcinoma sequence_alteration 0.4386% (3/684) 1 entry
ENSG00000198900 TOP1 head and neck squamous cell carcinoma missense_variant 0.1508% (1/663) 1 entry
ENSG00000198900 TOP1 Breast Carcinoma by Gene Expression Profile missense_variant 4.082% (2/49) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000198900 TOP1 MESO 0.014 low
ENSG00000198900 TOP1 STAD 0.027 low
ENSG00000198900 TOP1 UVM 0.00047 high
ENSG00000198900 TOP1 PAAD 0.0054 high
ENSG00000198900 TOP1 UCEC 0.0014 high
ENSG00000198900 TOP1 HNSC 0.0016 high
ENSG00000198900 TOP1 KIRP 0.021 high
ENSG00000198900 TOP1 KICH 0.031 high
ENSG00000198900 TOP1 LUAD 0.037 high
ENSG00000198900 TOP1 PCPG 0.00024 low
ENSG00000198900 TOP1 THYM 0.0024 low
ENSG00000198900 TOP1 BRCA 0.044 high
ENSG00000198900 TOP1 COAD 0.04 low
ENSG00000198900 TOP1 ESCA 0.00035 high
ENSG00000198900 TOP1 KIRC 0.0026 low
ENSG00000198900 TOP1 PRAD 0.017 low
ENSG00000198900 TOP1 SKCM 0.00044 low
ENSG00000198900 TOP1 LIHC 0.00049 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000198900 TOP1 READ Amp 18.952265 0.647788 1.306954 0.890909
ENSG00000198900 TOP1 COAD Amp 32.408549 0.432168 1.160950 0.720621
ENSG00000198900 TOP1 UCS Amp 0.664109 0.486592 0.815123 0.803571