RBP Type
Non-canonical_RBPs
Diseases
Drug
Main interacting RNAs
N.A.
Moonlighting functions
Kinase
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000167258 Gene ID
51755 Accession
24224
Symbol
CDK12
Alias
CRK7;CRKR;CRKRS
Full Name
cyclin dependent kinase 12
Status
Confidence
Length
89656 bases
Strand
Plus strand
Position
17 : 39461486 - 39551141
RNA binding domain
N.A.
Summary
Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
34316683 CDK12: cellular functions and therapeutic potential of versatile player in cancer.
Kveta Pilarova
2020-03-01
NAR cancer
29090014 The emerging roles of CDK12 in tumorigenesis.
Hana Paculová
2017-01-01
Cell division
30409083 Therapeutic targeting of transcriptional cyclin-dependent kinases.
D Matthew Galbraith
2019-04-01
Transcription
31652541 CDK12 Activity-Dependent Phosphorylation Events in Human Cells.
Bartlomiej Bartkowiak
2019-10-22
Biomolecules
25429106 Expression, purification, and identification of associated proteins of the full-length hCDK12/CyclinK complex.
Bartlomiej Bartkowiak
2015-01-16
The Journal of biological chemistry
28334900 CDK12 regulates alternative last exon mRNA splicing and promotes breast cancer cell invasion.
F Jerry Tien
2017-06-20
Nucleic acids research
30988284 CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Malgorzata Krajewska
2019-04-15
Nature communications
32805052 CDK12 globally stimulates RNA polymerase II transcription elongation and carboxyl-terminal domain phosphorylation.
Michael Tellier
2020-08-20
Nucleic acids research
36463205 The mechanism of BUD13 m6A methylation mediated MBNL1-phosphorylation by CDK12 regulating the vasculogenic mimicry in glioblastoma cells.
Meichen Liu
2022-12-03
Cell death & disease
34898046 Analysis of CDK12 alterations in a pan-cancer database.
Elizabeth Pan
2022-02-01
Cancer medicine
35732832 Immunomodulation therapy offers new molecular strategies to treat UTI.
Daniel Butler
2022-07-01
Nature reviews. Urology
29358035 EWS/FLI Confers Tumor Cell Synthetic Lethality to CDK12 Inhibition in Ewing Sarcoma.
Balboni Amanda Iniguez
2018-02-12
Cancer cell
Name
Transcript ID
bp
Protein
Translation ID
CDK12-202
ENST00000447079
8287
1490aa
ENSP00000398880
CDK12-204
ENST00000559663
6018
1262aa
ENSP00000453329
CDK12-208
ENST00000584632
4165
1201aa
ENSP00000464641
CDK12-201
ENST00000430627
5918
1481aa
ENSP00000407720
CDK12-205
ENST00000581593
559
186aa
ENSP00000499389
CDK12-207
ENST00000584336
1963
No protein
-
CDK12-206
ENST00000581963
436
No protein
-
CDK12-209
ENST00000585161
2036
No protein
-
CDK12-203
ENST00000558240
555
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
70648 Arthritis, Rheumatoid 2E-8 24390342 72134 Glomerular Filtration Rate 9E-6 27588450 84279 Forced Expiratory Volume 1E-7 28166213 95097 Polycystic Ovary Syndrome 1E-6 26416764 98278 Urine 4E-26 26352407
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000167258 homo_sapiens ENSP00000337194 33.863 20.5561 homo_sapiens ENSP00000398880 22.8859 13.8926 ENSG00000167258 homo_sapiens ENSP00000181839 51.0582 41.6667 homo_sapiens ENSP00000398880 51.8121 42.2819 ENSG00000167258 homo_sapiens ENSP00000498608 49.4253 31.954 homo_sapiens ENSP00000398880 14.4295 9.32886 ENSG00000167258 homo_sapiens ENSP00000485244 26.1458 17.0833 homo_sapiens ENSP00000398880 16.8456 11.0067 ENSG00000167258 homo_sapiens ENSP00000261211 52.5813 32.1224 homo_sapiens ENSP00000398880 18.4564 11.2752 ENSG00000167258 homo_sapiens ENSP00000370938 48.2759 29.9569 homo_sapiens ENSP00000398880 15.0336 9.32886 ENSG00000167258 homo_sapiens ENSP00000362361 64.2473 45.1613 homo_sapiens ENSP00000398880 16.0403 11.2752 ENSG00000167258 homo_sapiens ENSP00000266970 62.7517 44.2953 homo_sapiens ENSP00000398880 12.5503 8.85906 ENSG00000167258 homo_sapiens ENSP00000322343 55.7803 36.1272 homo_sapiens ENSP00000398880 12.953 8.38926 ENSG00000167258 homo_sapiens ENSP00000349762 52.8226 33.2661 homo_sapiens ENSP00000398880 17.5839 11.0738 ENSG00000167258 homo_sapiens ENSP00000338673 56.9444 39.1667 homo_sapiens ENSP00000398880 13.7584 9.46309 ENSG00000167258 homo_sapiens ENSP00000463048 42.8389 25.7033 homo_sapiens ENSP00000398880 22.4832 13.4899 ENSG00000167258 homo_sapiens ENSP00000384442 42.6923 25.5128 homo_sapiens ENSP00000398880 22.349 13.3557 ENSG00000167258 homo_sapiens ENSP00000257904 55.4455 40.264 homo_sapiens ENSP00000398880 11.2752 8.18792 ENSG00000167258 homo_sapiens ENSP00000306340 38.2456 22.807 homo_sapiens ENSP00000398880 14.6309 8.72483 ENSG00000167258 homo_sapiens ENSP00000256443 56.9364 37.8613 homo_sapiens ENSP00000398880 13.2215 8.79195 ENSG00000167258 homo_sapiens ENSP00000265334 35.3041 18.9189 homo_sapiens ENSP00000398880 14.0268 7.51678 ENSG00000167258 homo_sapiens ENSP00000397087 55.8282 38.3436 homo_sapiens ENSP00000398880 12.2148 8.38926 ENSG00000167258 homo_sapiens ENSP00000514486 51.1696 32.1637 homo_sapiens ENSP00000398880 11.745 7.38255 ENSG00000167258 homo_sapiens ENSP00000419782 63.3562 41.0959 homo_sapiens ENSP00000398880 12.4161 8.05369 ENSG00000167258 homo_sapiens ENSP00000399082 51.4768 32.2785 homo_sapiens ENSP00000398880 16.3758 10.2685 ENSG00000167258 homo_sapiens ENSP00000369390 48.4009 29.2111 homo_sapiens ENSP00000398880 15.2349 9.19463 ENSG00000167258 homo_sapiens ENSP00000400088 61.3115 41.9672 homo_sapiens ENSP00000398880 12.5503 8.5906 ENSG00000167258 homo_sapiens ENSP00000378699 63.9731 42.4242 homo_sapiens ENSP00000398880 12.7517 8.45638 ENSG00000167258 homo_sapiens ENSP00000379176 49.2997 32.2129 homo_sapiens ENSP00000398880 11.8121 7.71812 ENSG00000167258 homo_sapiens ENSP00000357907 44.4223 28.0877 homo_sapiens ENSP00000398880 14.9664 9.46309
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000167258 homo_sapiens ENSP00000398880 96.1074 95.5705 nomascus_leucogenys ENSNLEP00000024301 97.5477 97.0027 ENSG00000167258 homo_sapiens ENSP00000398880 100 99.6644 pan_paniscus ENSPPAP00000019671 100 99.6644 ENSG00000167258 homo_sapiens ENSP00000398880 99.6644 99.4631 pongo_abelii ENSPPYP00000025434 99.6644 99.4631 ENSG00000167258 homo_sapiens ENSP00000398880 100 99.7987 pan_troglodytes ENSPTRP00000068079 100 99.7987 ENSG00000167258 homo_sapiens ENSP00000398880 99.6644 99.2617 gorilla_gorilla ENSGGOP00000018001 99.6644 99.2617 ENSG00000167258 homo_sapiens ENSP00000398880 85.8389 78.8591 ornithorhynchus_anatinus ENSOANP00000006585 85.2099 78.2811 ENSG00000167258 homo_sapiens ENSP00000398880 93.0201 87.5168 sarcophilus_harrisii ENSSHAP00000018495 92.5234 87.0494 ENSG00000167258 homo_sapiens ENSP00000398880 72.5503 68.0537 notamacropus_eugenii ENSMEUP00000008061 72.6967 68.191 ENSG00000167258 homo_sapiens ENSP00000398880 76.443 74.8993 choloepus_hoffmanni ENSCHOP00000004590 76.5457 75 ENSG00000167258 homo_sapiens ENSP00000398880 97.2483 94.8993 dasypus_novemcinctus ENSDNOP00000021438 97.118 94.7721 ENSG00000167258 homo_sapiens ENSP00000398880 81.5436 78.6577 erinaceus_europaeus ENSEEUP00000013103 81.2166 78.3422 ENSG00000167258 homo_sapiens ENSP00000398880 70 67.1812 echinops_telfairi ENSETEP00000008086 69.953 67.1361 ENSG00000167258 homo_sapiens ENSP00000398880 98.9933 98.1879 callithrix_jacchus ENSCJAP00000015986 98.9269 98.1221 ENSG00000167258 homo_sapiens ENSP00000398880 98.3893 97.7181 cercocebus_atys ENSCATP00000025596 98.9872 98.312 ENSG00000167258 homo_sapiens ENSP00000398880 99.3289 98.7248 macaca_fascicularis ENSMFAP00000030208 99.3289 98.7248 ENSG00000167258 homo_sapiens ENSP00000398880 98.6577 98.0537 macaca_mulatta ENSMMUP00000066906 99.2573 98.6496 ENSG00000167258 homo_sapiens ENSP00000398880 99.2617 98.6577 macaca_nemestrina ENSMNEP00000007499 99.2617 98.6577 ENSG00000167258 homo_sapiens ENSP00000398880 99.2617 98.5235 papio_anubis ENSPANP00000020543 99.2617 98.5235 ENSG00000167258 homo_sapiens ENSP00000398880 95.906 95.1678 mandrillus_leucophaeus ENSMLEP00000030218 98.4838 97.7257 ENSG00000167258 homo_sapiens ENSP00000398880 93.1544 91.2081 tursiops_truncatus ENSTTRP00000008008 96.6574 94.6379 ENSG00000167258 homo_sapiens ENSP00000398880 90.2685 88.5906 vulpes_vulpes ENSVVUP00000001814 96.693 94.8958 ENSG00000167258 homo_sapiens ENSP00000398880 94.8993 91.4094 mus_spretus MGP_SPRETEiJ_P0031051 95.283 91.779 ENSG00000167258 homo_sapiens ENSP00000398880 97.047 94.8322 equus_asinus ENSEASP00005002789 96.9819 94.7686 ENSG00000167258 homo_sapiens ENSP00000398880 96.3087 94.2953 capra_hircus ENSCHIP00000014477 96.3087 94.2953 ENSG00000167258 homo_sapiens ENSP00000398880 96.3758 94.4966 loxodonta_africana ENSLAFP00000009568 96.1822 94.3068 ENSG00000167258 homo_sapiens ENSP00000398880 97.3154 95.6376 panthera_leo ENSPLOP00000011796 97.185 95.5094 ENSG00000167258 homo_sapiens ENSP00000398880 97.047 95.1678 ailuropoda_melanoleuca ENSAMEP00000004181 96.9819 95.104 ENSG00000167258 homo_sapiens ENSP00000398880 95.7047 93.6242 bos_indicus_hybrid ENSBIXP00005045971 96.2863 94.1931 ENSG00000167258 homo_sapiens ENSP00000398880 97.5168 95.5705 oryctolagus_cuniculus ENSOCUP00000000677 97.3861 95.4424 ENSG00000167258 homo_sapiens ENSP00000398880 92.2148 89.6644 equus_caballus ENSECAP00000019089 96.2859 93.623 ENSG00000167258 homo_sapiens ENSP00000398880 96.443 94.698 canis_lupus_familiaris ENSCAFP00845017999 97.029 95.2735 ENSG00000167258 homo_sapiens ENSP00000398880 97.3826 95.6376 panthera_pardus ENSPPRP00000021301 97.252 95.5094 ENSG00000167258 homo_sapiens ENSP00000398880 93.3557 91.4765 marmota_marmota_marmota ENSMMMP00000022322 97.1369 95.1816 ENSG00000167258 homo_sapiens ENSP00000398880 92.349 90.0671 balaenoptera_musculus ENSBMSP00010030511 96.0223 93.6497 ENSG00000167258 homo_sapiens ENSP00000398880 95.8389 93.0872 cavia_porcellus ENSCPOP00000007545 95.8389 93.0872 ENSG00000167258 homo_sapiens ENSP00000398880 92.6174 90 felis_catus ENSFCAP00000009183 94.6502 91.9753 ENSG00000167258 homo_sapiens ENSP00000398880 93.557 90.9396 ursus_americanus ENSUAMP00000034042 94.5085 91.8644 ENSG00000167258 homo_sapiens ENSP00000398880 93.0201 87.651 monodelphis_domestica ENSMODP00000052554 92.4616 87.1247 ENSG00000167258 homo_sapiens ENSP00000398880 15.5705 14.094 monodelphis_domestica ENSMODP00000049180 87.218 78.9474 ENSG00000167258 homo_sapiens ENSP00000398880 96.3087 94.2282 bison_bison_bison ENSBBBP00000015322 96.3087 94.2282 ENSG00000167258 homo_sapiens ENSP00000398880 96.6443 94.698 monodon_monoceros ENSMMNP00015025720 96.6443 94.698 ENSG00000167258 homo_sapiens ENSP00000398880 96.8456 94.7651 sus_scrofa ENSSSCP00000055304 96.7158 94.6381 ENSG00000167258 homo_sapiens ENSP00000398880 97.5168 95.3691 microcebus_murinus ENSMICP00000048800 97.5168 95.3691 ENSG00000167258 homo_sapiens ENSP00000398880 95.0336 92.0805 octodon_degus ENSODEP00000024039 95.6111 92.6401 ENSG00000167258 homo_sapiens ENSP00000398880 96.0403 93.3557 jaculus_jaculus ENSJJAP00000023723 96.1048 93.4184 ENSG00000167258 homo_sapiens ENSP00000398880 96.1074 94.1611 ovis_aries_rambouillet ENSOARP00020019137 96.1074 94.1611 ENSG00000167258 homo_sapiens ENSP00000398880 91.2081 89.1275 ursus_maritimus ENSUMAP00000023821 95.5696 93.3896 ENSG00000167258 homo_sapiens ENSP00000398880 59.3289 56.1074 ochotona_princeps ENSOPRP00000014977 59.4086 56.1828 ENSG00000167258 homo_sapiens ENSP00000398880 90.4698 88.5906 delphinapterus_leucas ENSDLEP00000019564 96.4925 94.4882 ENSG00000167258 homo_sapiens ENSP00000398880 96.6443 94.4966 physeter_catodon ENSPCTP00005010857 96.6443 94.4966 ENSG00000167258 homo_sapiens ENSP00000398880 95.0336 91.5436 mus_caroli MGP_CAROLIEiJ_P0029628 95.4178 91.9137 ENSG00000167258 homo_sapiens ENSP00000398880 94.8993 91.3423 mus_musculus ENSMUSP00000103162 95.283 91.7116 ENSG00000167258 homo_sapiens ENSP00000398880 95.7718 93.4228 dipodomys_ordii ENSDORP00000016611 96.2239 93.8638 ENSG00000167258 homo_sapiens ENSP00000398880 81.8792 80 mustela_putorius_furo ENSMPUP00000014898 95.1638 92.9797 ENSG00000167258 homo_sapiens ENSP00000398880 99.0604 98.1879 aotus_nancymaae ENSANAP00000018751 98.994 98.1221 ENSG00000167258 homo_sapiens ENSP00000398880 93.557 91.8792 saimiri_boliviensis_boliviensis ENSSBOP00000011770 97.0077 95.2679 ENSG00000167258 homo_sapiens ENSP00000398880 82.8188 81.2081 vicugna_pacos ENSVPAP00000010291 97.0126 95.1258 ENSG00000167258 homo_sapiens ENSP00000398880 92.0805 91.6778 chlorocebus_sabaeus ENSCSAP00000015351 99.1329 98.6994 ENSG00000167258 homo_sapiens ENSP00000398880 75.6376 74.0268 tupaia_belangeri ENSTBEP00000010465 75.6884 74.0766 ENSG00000167258 homo_sapiens ENSP00000398880 91.6778 88.5906 mesocricetus_auratus ENSMAUP00000022745 95.0592 91.858 ENSG00000167258 homo_sapiens ENSP00000398880 96.0403 94.094 phocoena_sinus ENSPSNP00000008771 96.6892 94.7297 ENSG00000167258 homo_sapiens ENSP00000398880 96.1074 94.0268 camelus_dromedarius ENSCDRP00005006384 96.6914 94.5982 ENSG00000167258 homo_sapiens ENSP00000398880 95.7047 93.4228 carlito_syrichta ENSTSYP00000009032 96.2863 93.9905 ENSG00000167258 homo_sapiens ENSP00000398880 97.3826 95.6376 panthera_tigris_altaica ENSPTIP00000008946 97.252 95.5094 ENSG00000167258 homo_sapiens ENSP00000398880 95.1678 91.8792 rattus_norvegicus ENSRNOP00000008256 95.617 92.3129 ENSG00000167258 homo_sapiens ENSP00000398880 97.2483 94.698 prolemur_simus ENSPSMP00000013290 97.1831 94.6345 ENSG00000167258 homo_sapiens ENSP00000398880 94.2282 90.9396 microtus_ochrogaster ENSMOCP00000027558 94.4818 91.1844 ENSG00000167258 homo_sapiens ENSP00000398880 69.3289 67.651 sorex_araneus ENSSARP00000012575 90.6936 88.4987 ENSG00000167258 homo_sapiens ENSP00000398880 95.5034 92.0805 peromyscus_maniculatus_bairdii ENSPEMP00000007400 95.6317 92.2043 ENSG00000167258 homo_sapiens ENSP00000398880 96.3087 94.2953 bos_mutus ENSBMUP00000002444 96.3087 94.2953 ENSG00000167258 homo_sapiens ENSP00000398880 94.9664 91.2752 mus_spicilegus ENSMSIP00000019669 95.3504 91.6442 ENSG00000167258 homo_sapiens ENSP00000398880 89.4631 85.9732 cricetulus_griseus_chok1gshd ENSCGRP00001023186 95.0107 91.3043 ENSG00000167258 homo_sapiens ENSP00000398880 90.9396 88.6577 pteropus_vampyrus ENSPVAP00000008033 91.4922 89.1965 ENSG00000167258 homo_sapiens ENSP00000398880 96.5101 93.8926 myotis_lucifugus ENSMLUP00000006077 96.3807 93.7668 ENSG00000167258 homo_sapiens ENSP00000398880 92.953 87.5168 vombatus_ursinus ENSVURP00010007888 92.3949 86.9913 ENSG00000167258 homo_sapiens ENSP00000398880 92.0134 89.2617 rhinolophus_ferrumequinum ENSRFEP00010018981 92.0134 89.2617 ENSG00000167258 homo_sapiens ENSP00000398880 90.2685 87.7852 neovison_vison ENSNVIP00000005466 94.9188 92.3077 ENSG00000167258 homo_sapiens ENSP00000398880 96.3087 94.2282 bos_taurus ENSBTAP00000002005 96.3087 94.2282 ENSG00000167258 homo_sapiens ENSP00000398880 95.8389 93.0872 heterocephalus_glaber_female ENSHGLP00000036906 95.9033 93.1498 ENSG00000167258 homo_sapiens ENSP00000398880 89.5302 86.9799 rhinopithecus_bieti ENSRBIP00000014440 92.9617 90.3136 ENSG00000167258 homo_sapiens ENSP00000398880 90.604 88.5235 canis_lupus_dingo ENSCAFP00020029167 95.9488 93.7456 ENSG00000167258 homo_sapiens ENSP00000398880 96.9799 95.3691 sciurus_vulgaris ENSSVLP00005017426 97.6351 96.0135 ENSG00000167258 homo_sapiens ENSP00000398880 92.6846 87.3826 phascolarctos_cinereus ENSPCIP00000038693 92.1281 86.8579 ENSG00000167258 homo_sapiens ENSP00000398880 69.4631 68.1208 procavia_capensis ENSPCAP00000009313 90.5512 88.8014 ENSG00000167258 homo_sapiens ENSP00000398880 92.5503 88.4564 nannospalax_galili ENSNGAP00000020218 93.8095 89.6599 ENSG00000167258 homo_sapiens ENSP00000398880 96.3087 94.2953 bos_grunniens ENSBGRP00000018847 96.3087 94.2953 ENSG00000167258 homo_sapiens ENSP00000398880 93.1544 90.4698 chinchilla_lanigera ENSCLAP00000023974 96.1885 93.4165 ENSG00000167258 homo_sapiens ENSP00000398880 95.8389 94.094 cervus_hanglu_yarkandensis ENSCHYP00000003581 95.8389 94.094 ENSG00000167258 homo_sapiens ENSP00000398880 96.5101 94.2282 catagonus_wagneri ENSCWAP00000002182 96.4453 94.165 ENSG00000167258 homo_sapiens ENSP00000398880 96.9799 95.2349 ictidomys_tridecemlineatus ENSSTOP00000013738 97.045 95.2989 ENSG00000167258 homo_sapiens ENSP00000398880 97.3826 94.7651 otolemur_garnettii ENSOGAP00000009437 97.3172 94.7015 ENSG00000167258 homo_sapiens ENSP00000398880 92.4832 91.0067 cebus_imitator ENSCCAP00000021292 96.8377 95.2916 ENSG00000167258 homo_sapiens ENSP00000398880 95.8389 94.094 urocitellus_parryii ENSUPAP00010009300 97.1429 95.3742 ENSG00000167258 homo_sapiens ENSP00000398880 89.5302 87.7181 moschus_moschiferus ENSMMSP00000028629 96.5268 94.5731 ENSG00000167258 homo_sapiens ENSP00000398880 93.1544 91.9463 rhinopithecus_roxellana ENSRROP00000032713 97.7465 96.4789 ENSG00000167258 homo_sapiens ENSP00000398880 95.0336 91.6778 mus_pahari MGP_PahariEiJ_P0036350 95.6111 92.235 ENSG00000167258 homo_sapiens ENSP00000398880 97.1141 94.8993 propithecus_coquereli ENSPCOP00000000324 97.1141 94.8993 ENSG00000167258 homo_sapiens ENSP00000398880 49.1275 40.6711 petromyzon_marinus ENSPMAP00000000847 56.9207 47.1229 ENSG00000167258 homo_sapiens ENSP00000398880 10.2685 7.65101 eptatretus_burgeri ENSEBUP00000017934 58.6207 43.6782 ENSG00000167258 homo_sapiens ENSP00000398880 30.6711 23.1544 eptatretus_burgeri ENSEBUP00000014087 52.8324 39.8844 ENSG00000167258 homo_sapiens ENSP00000398880 68.7248 56.2416 callorhinchus_milii ENSCMIP00000017307 66.4504 54.3803 ENSG00000167258 homo_sapiens ENSP00000398880 76.6443 66.443 latimeria_chalumnae ENSLACP00000019217 75.83 65.7371 ENSG00000167258 homo_sapiens ENSP00000398880 48.255 40.4027 lepisosteus_oculatus ENSLOCP00000015703 56.7482 47.5138 ENSG00000167258 homo_sapiens ENSP00000398880 55.1678 46.3087 clupea_harengus ENSCHAP00000015963 59.0093 49.5334 ENSG00000167258 homo_sapiens ENSP00000398880 52.349 44.2282 danio_rerio ENSDARP00000087834 60.3248 50.9667 ENSG00000167258 homo_sapiens ENSP00000398880 52.0134 43.8255 carassius_auratus ENSCARP00000078228 60.9277 51.3365 ENSG00000167258 homo_sapiens ENSP00000398880 51.2752 43.4899 carassius_auratus ENSCARP00000066610 61.2179 51.9231 ENSG00000167258 homo_sapiens ENSP00000398880 52.6175 43.7584 carassius_auratus ENSCARP00000116070 61.25 50.9375 ENSG00000167258 homo_sapiens ENSP00000398880 52.6175 43.6913 carassius_auratus ENSCARP00000006100 61.25 50.8594 ENSG00000167258 homo_sapiens ENSP00000398880 53.1544 43.8255 astyanax_mexicanus ENSAMXP00000030963 60.4119 49.8093 ENSG00000167258 homo_sapiens ENSP00000398880 52.4832 43.4899 ictalurus_punctatus ENSIPUP00000017743 61.0461 50.5855 ENSG00000167258 homo_sapiens ENSP00000398880 56.7785 47.9195 esox_lucius ENSELUP00000038153 60.4718 51.0365 ENSG00000167258 homo_sapiens ENSP00000398880 49.5973 41.745 electrophorus_electricus ENSEEEP00000036423 62.1531 52.3129 ENSG00000167258 homo_sapiens ENSP00000398880 57.047 48.1879 oncorhynchus_kisutch ENSOKIP00005098261 60.3265 50.9581 ENSG00000167258 homo_sapiens ENSP00000398880 57.3825 48.1879 oncorhynchus_kisutch ENSOKIP00005070585 60.5953 50.8859 ENSG00000167258 homo_sapiens ENSP00000398880 57.047 48.1208 oncorhynchus_mykiss ENSOMYP00000041246 60.4552 50.9957 ENSG00000167258 homo_sapiens ENSP00000398880 57.3154 48.255 oncorhynchus_mykiss ENSOMYP00000010455 60.5245 50.9568 ENSG00000167258 homo_sapiens ENSP00000398880 57.1141 47.9866 salmo_salar ENSSSAP00000003861 58.6088 49.2424 ENSG00000167258 homo_sapiens ENSP00000398880 52.6175 44.6309 salmo_salar ENSSSAP00000042750 61.1068 51.8316 ENSG00000167258 homo_sapiens ENSP00000398880 56.7114 47.7852 salmo_trutta ENSSTUP00000040472 59.9291 50.4965 ENSG00000167258 homo_sapiens ENSP00000398880 57.1812 48.1208 salmo_trutta ENSSTUP00000081762 60.727 51.1048 ENSG00000167258 homo_sapiens ENSP00000398880 54.4966 46.1745 gadus_morhua ENSGMOP00000025589 56.9425 48.2468 ENSG00000167258 homo_sapiens ENSP00000398880 24.7651 22.6846 fundulus_heteroclitus ENSFHEP00000011438 81.0989 74.2857 ENSG00000167258 homo_sapiens ENSP00000398880 54.698 46.3087 poecilia_reticulata ENSPREP00000016181 60.2811 51.0355 ENSG00000167258 homo_sapiens ENSP00000398880 55.0336 46.5772 xiphophorus_maculatus ENSXMAP00000008734 60.0733 50.8425 ENSG00000167258 homo_sapiens ENSP00000398880 54.7651 46.0403 oryzias_latipes ENSORLP00000004297 59.9559 50.4041 ENSG00000167258 homo_sapiens ENSP00000398880 48.9262 42.0134 cyclopterus_lumpus ENSCLMP00005010132 62.6827 53.8263 ENSG00000167258 homo_sapiens ENSP00000398880 55.5705 46.6443 oreochromis_niloticus ENSONIP00000001285 61.2879 51.4434 ENSG00000167258 homo_sapiens ENSP00000398880 55.2349 46.1745 haplochromis_burtoni ENSHBUP00000000578 60.8728 50.8876 ENSG00000167258 homo_sapiens ENSP00000398880 55.1678 46.1745 astatotilapia_calliptera ENSACLP00000002898 60.8438 50.9252 ENSG00000167258 homo_sapiens ENSP00000398880 56.3758 47.1141 sparus_aurata ENSSAUP00010049992 61.5385 51.4286 ENSG00000167258 homo_sapiens ENSP00000398880 56.6443 47.8523 lates_calcarifer ENSLCAP00010044495 61.6508 52.0818 ENSG00000167258 homo_sapiens ENSP00000398880 76.1074 66.7785 xenopus_tropicalis ENSXETP00000075166 77.3533 67.8718 ENSG00000167258 homo_sapiens ENSP00000398880 88.0537 80.604 chrysemys_picta_bellii ENSCPBP00000005312 88.3502 80.8754 ENSG00000167258 homo_sapiens ENSP00000398880 86.7785 78.5235 sphenodon_punctatus ENSSPUP00000009387 87.247 78.9474 ENSG00000167258 homo_sapiens ENSP00000398880 86.3758 78.4564 crocodylus_porosus ENSCPRP00005003684 88.3929 80.2885 ENSG00000167258 homo_sapiens ENSP00000398880 81.8121 73.3557 laticauda_laticaudata ENSLLTP00000022515 82.1429 73.6523 ENSG00000167258 homo_sapiens ENSP00000398880 21.1409 20.1342 notechis_scutatus ENSNSUP00000000728 91.5698 87.2093 ENSG00000167258 homo_sapiens ENSP00000398880 75.3691 67.7852 notechis_scutatus ENSNSUP00000023486 82.4523 74.1557 ENSG00000167258 homo_sapiens ENSP00000398880 81.6107 73.0872 pseudonaja_textilis ENSPTXP00000011976 81.5013 72.9893 ENSG00000167258 homo_sapiens ENSP00000398880 62.5503 55.3691 pseudonaja_textilis ENSPTXP00000024196 81.4685 72.1154 ENSG00000167258 homo_sapiens ENSP00000398880 27.5168 26.2416 anas_platyrhynchos_platyrhynchos ENSAPLP00000013099 94.2529 89.8851 ENSG00000167258 homo_sapiens ENSP00000398880 85.4362 77.047 gallus_gallus ENSGALP00010039322 86.1299 77.6725 ENSG00000167258 homo_sapiens ENSP00000398880 76.3758 68.7248 meleagris_gallopavo ENSMGAP00000022119 84.7988 76.304 ENSG00000167258 homo_sapiens ENSP00000398880 78.7919 71.2081 serinus_canaria ENSSCAP00000010873 86.5144 78.1872 ENSG00000167258 homo_sapiens ENSP00000398880 85.1007 76.443 parus_major ENSPMJP00000024329 86.2585 77.483 ENSG00000167258 homo_sapiens ENSP00000398880 77.7852 70 anolis_carolinensis ENSACAP00000035282 81.2763 73.1417 ENSG00000167258 homo_sapiens ENSP00000398880 23.1544 21.5436 neolamprologus_brichardi ENSNBRP00000025616 85.8209 79.8507 ENSG00000167258 homo_sapiens ENSP00000398880 81.5436 73.0872 naja_naja ENSNNAP00000021139 82.2057 73.6806 ENSG00000167258 homo_sapiens ENSP00000398880 45.7047 41.4765 naja_naja ENSNNAP00000019073 83.2518 75.5501 ENSG00000167258 homo_sapiens ENSP00000398880 82.0805 73.9597 podarcis_muralis ENSPMRP00000023081 83.882 75.583 ENSG00000167258 homo_sapiens ENSP00000398880 75.7047 67.9195 geospiza_fortis ENSGFOP00000014351 84.6847 75.976 ENSG00000167258 homo_sapiens ENSP00000398880 84.4295 75.9732 taeniopygia_guttata ENSTGUP00000002283 86.5199 77.8542 ENSG00000167258 homo_sapiens ENSP00000398880 52.5503 44.5638 erpetoichthys_calabaricus ENSECRP00000023939 65.3044 55.3795 ENSG00000167258 homo_sapiens ENSP00000398880 55.4362 45.906 kryptolebias_marmoratus ENSKMAP00000027729 60.9145 50.4425 ENSG00000167258 homo_sapiens ENSP00000398880 83.6913 75.1678 salvator_merianae ENSSMRP00000007381 83.1333 74.6667 ENSG00000167258 homo_sapiens ENSP00000398880 47.9195 40.6711 oryzias_javanicus ENSOJAP00000035787 63.354 53.7711 ENSG00000167258 homo_sapiens ENSP00000398880 24.5638 22.6846 amphilophus_citrinellus ENSACIP00000012739 83.7529 77.3455 ENSG00000167258 homo_sapiens ENSP00000398880 55.906 47.3154 amphiprion_percula ENSAPEP00000005681 61.7953 52.2997 ENSG00000167258 homo_sapiens ENSP00000398880 54.698 46.0403 oryzias_sinensis ENSOSIP00000021348 59.8824 50.4041 ENSG00000167258 homo_sapiens ENSP00000398880 87.4497 79.6644 pelodiscus_sinensis ENSPSIP00000008518 87.8624 80.0405 ENSG00000167258 homo_sapiens ENSP00000398880 87.8523 79.7987 gopherus_evgoodei ENSGEVP00005020020 88.2076 80.1213 ENSG00000167258 homo_sapiens ENSP00000398880 88.1879 80.2685 chelonoidis_abingdonii ENSCABP00000030378 88.5445 80.593 ENSG00000167258 homo_sapiens ENSP00000398880 56.9128 48.0537 seriola_dumerili ENSSDUP00000031762 62.4448 52.7246 ENSG00000167258 homo_sapiens ENSP00000398880 86.9799 78.3893 struthio_camelus_australis ENSSCUP00000017250 87.3315 78.7062 ENSG00000167258 homo_sapiens ENSP00000398880 85.4362 77.3154 anser_brachyrhynchus ENSABRP00000000479 85.6662 77.5236 ENSG00000167258 homo_sapiens ENSP00000398880 54.8322 46.2416 cynoglossus_semilaevis ENSCSEP00000025860 60.1177 50.699 ENSG00000167258 homo_sapiens ENSP00000398880 52.8188 44.8322 poecilia_formosa ENSPFOP00000024829 61.3406 52.0655 ENSG00000167258 homo_sapiens ENSP00000398880 56.5772 47.4497 myripristis_murdjan ENSMMDP00005023690 61.3091 51.4182 ENSG00000167258 homo_sapiens ENSP00000398880 86.1745 77.2483 strigops_habroptila ENSSHBP00005010108 86.3484 77.4042 ENSG00000167258 homo_sapiens ENSP00000398880 55.8389 47.2483 amphiprion_ocellaris ENSAOCP00000005012 61.8128 52.3031 ENSG00000167258 homo_sapiens ENSP00000398880 88.1208 80.6711 terrapene_carolina_triunguis ENSTMTP00000012865 88.4175 80.9428 ENSG00000167258 homo_sapiens ENSP00000398880 56.8456 48.0537 hucho_hucho ENSHHUP00000046163 60.3276 50.9972 ENSG00000167258 homo_sapiens ENSP00000398880 57.1812 48.255 hucho_hucho ENSHHUP00000080476 60.127 50.741 ENSG00000167258 homo_sapiens ENSP00000398880 55.0336 46.443 betta_splendens ENSBSLP00000025196 62.1683 52.464 ENSG00000167258 homo_sapiens ENSP00000398880 53.8255 44.8322 pygocentrus_nattereri ENSPNAP00000001507 60.7116 50.5678 ENSG00000167258 homo_sapiens ENSP00000398880 55.302 46.2416 anabas_testudineus ENSATEP00000001572 60.4549 50.5503 ENSG00000167258 homo_sapiens ENSP00000398880 18.3893 14.7651 ciona_savignyi ENSCSAVP00000015892 70.801 56.8475 ENSG00000167258 homo_sapiens ENSP00000398880 56.7785 47.9866 seriola_lalandi_dorsalis ENSSLDP00000002872 62.2059 52.5735 ENSG00000167258 homo_sapiens ENSP00000398880 23.8255 22.349 labrus_bergylta ENSLBEP00000006451 88.75 83.25 ENSG00000167258 homo_sapiens ENSP00000398880 55.1678 46.1074 pundamilia_nyererei ENSPNYP00000015466 60.9792 50.9644 ENSG00000167258 homo_sapiens ENSP00000398880 56.3758 47.2483 mastacembelus_armatus ENSMAMP00000033083 61.7193 51.7267 ENSG00000167258 homo_sapiens ENSP00000398880 24.4966 22.6174 stegastes_partitus ENSSPAP00000021290 87.53 80.8153 ENSG00000167258 homo_sapiens ENSP00000398880 56.9799 48.1208 oncorhynchus_tshawytscha ENSOTSP00005035340 59.0403 49.8609 ENSG00000167258 homo_sapiens ENSP00000398880 56.1074 47.3154 oncorhynchus_tshawytscha ENSOTSP00005095649 60.9774 51.4223 ENSG00000167258 homo_sapiens ENSP00000398880 56.0403 47.4497 acanthochromis_polyacanthus ENSAPOP00000016952 62.0357 52.526 ENSG00000167258 homo_sapiens ENSP00000398880 86.9128 78.3893 aquila_chrysaetos_chrysaetos ENSACCP00020006815 87.2054 78.6532 ENSG00000167258 homo_sapiens ENSP00000398880 54.0268 44.9664 nothobranchius_furzeri ENSNFUP00015000402 60.1644 50.0747 ENSG00000167258 homo_sapiens ENSP00000398880 55.1007 46.2416 cyprinodon_variegatus ENSCVAP00000028905 60.7698 50.9993 ENSG00000167258 homo_sapiens ENSP00000398880 54.698 46.0403 denticeps_clupeoides ENSDCDP00000008140 60.0147 50.5155 ENSG00000167258 homo_sapiens ENSP00000398880 57.1812 48.0537 larimichthys_crocea ENSLCRP00005039695 61.0315 51.2894 ENSG00000167258 homo_sapiens ENSP00000398880 54.8993 46.5101 takifugu_rubripes ENSTRUP00000069106 60.6375 51.3714 ENSG00000167258 homo_sapiens ENSP00000398880 84.2953 75.8389 ficedula_albicollis ENSFALP00000000573 84.0696 75.6359 ENSG00000167258 homo_sapiens ENSP00000398880 22.7517 20.5369 hippocampus_comes ENSHCOP00000004325 83.4975 75.3695 ENSG00000167258 homo_sapiens ENSP00000398880 52.8859 43.8255 cyprinus_carpio_carpio ENSCCRP00000166813 61.2277 50.7382 ENSG00000167258 homo_sapiens ENSP00000398880 52.349 44.094 cyprinus_carpio_carpio ENSCCRP00000041213 61.2245 51.5699 ENSG00000167258 homo_sapiens ENSP00000398880 85.8389 77.2483 coturnix_japonica ENSCJPP00005002189 86.4773 77.8229 ENSG00000167258 homo_sapiens ENSP00000398880 54.2282 45.8389 poecilia_latipinna ENSPLAP00000017637 60.7519 51.3534 ENSG00000167258 homo_sapiens ENSP00000398880 52.6846 43.8255 sinocyclocheilus_grahami ENSSGRP00000109417 60.8999 50.6594 ENSG00000167258 homo_sapiens ENSP00000398880 52.2148 43.9597 sinocyclocheilus_grahami ENSSGRP00000034303 60.8764 51.252 ENSG00000167258 homo_sapiens ENSP00000398880 55.1678 46.1745 maylandia_zebra ENSMZEP00005030623 60.8438 50.9252 ENSG00000167258 homo_sapiens ENSP00000398880 52.5503 45.0336 tetraodon_nigroviridis ENSTNIP00000014668 63.2472 54.2003 ENSG00000167258 homo_sapiens ENSP00000398880 59.3289 49.9329 paramormyrops_kingsleyae ENSPKIP00000003890 61.0076 51.3458 ENSG00000167258 homo_sapiens ENSP00000398880 58.8591 49.5973 scleropages_formosus ENSSFOP00015075070 59.5384 50.1697 ENSG00000167258 homo_sapiens ENSP00000398880 73.3557 63.4899 leptobrachium_leishanense ENSLLEP00000044511 75.4834 65.3315 ENSG00000167258 homo_sapiens ENSP00000398880 55.6376 46.2416 scophthalmus_maximus ENSSMAP00000059638 59.6832 49.604 ENSG00000167258 homo_sapiens ENSP00000398880 36.3087 29.6644 oryzias_melastigma ENSOMEP00000020737 57.6145 47.0714 ENSG00000167258 homo_sapiens ENSP00000398880 5.36913 5.10067 oryzias_melastigma ENSOMEP00000012737 86.9565 82.6087
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0002944 part_of cyclin K-CDK12 complex 1 IPI Homo_sapiens(9606) Component GO:0004672 enables protein kinase activity 1 IDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005524 enables ATP binding 1 IEA Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 1 IBA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 2 IDA,TAS Homo_sapiens(9606) Component GO:0006366 involved_in transcription by RNA polymerase II 1 IDA Homo_sapiens(9606) Process GO:0006397 involved_in mRNA processing 1 IEA Homo_sapiens(9606) Process GO:0006468 involved_in protein phosphorylation 1 IBA Homo_sapiens(9606) Process GO:0008024 part_of cyclin/CDK positive transcription elongation factor complex 1 IBA Homo_sapiens(9606) Component GO:0008353 enables RNA polymerase II CTD heptapeptide repeat kinase activity 3 IBA,IDA,IMP Homo_sapiens(9606) Function GO:0008380 involved_in RNA splicing 1 ISS Homo_sapiens(9606) Process GO:0016607 located_in nuclear speck 1 IDA Homo_sapiens(9606) Component GO:0019901 enables protein kinase binding 1 IEA Homo_sapiens(9606) Function GO:0019908 part_of nuclear cyclin-dependent protein kinase holoenzyme complex 1 ISS Homo_sapiens(9606) Component GO:0030332 enables cyclin binding 2 IBA,IPI Homo_sapiens(9606) Function GO:0032968 involved_in positive regulation of transcription elongation by RNA polymerase II 1 IBA Homo_sapiens(9606) Process GO:0043405 involved_in regulation of MAP kinase activity 1 IMP Homo_sapiens(9606) Process GO:0045944 involved_in positive regulation of transcription by RNA polymerase II 1 IMP Homo_sapiens(9606) Process GO:0046777 involved_in protein autophosphorylation 1 IDA Homo_sapiens(9606) Process GO:0051726 involved_in regulation of cell cycle 1 IEA Homo_sapiens(9606) Process GO:0106310 enables protein serine kinase activity 1 IEA Homo_sapiens(9606) Function GO:2000737 involved_in negative regulation of stem cell differentiation 1 IEA Homo_sapiens(9606) Process
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