Ensembl ID ENSG00000167258 Gene ID 51755 Accession 24224
Gene Symbol CDK12 Alias CRK7;CRKR;CRKRS Full Name cyclin dependent kinase 12
Position 17 : 39461486 - 39551141 Length 89656 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000167258 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167258 CDK12 0.66 2.35e-11 BRCA
ENSG00000167258 CDK12 0.56 6.65e-13 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167258 CDK12 breast cancer 17117180
ENSG00000167258 CDK12 ovarian cancer 21720365
ENSG00000167258 CDK12 tumor 22544022
ENSG00000167258 CDK12 cancers 23613755
ENSG00000167258 CDK12 tumor 24240700
ENSG00000167258 CDK12 breast cancers 24395524
ENSG00000167258 CDK12 Ovarian cancer 24554720
ENSG00000167258 CDK12 Tumor 25312711
ENSG00000167258 CDK12 tumor 25429106
ENSG00000167258 CDK12 tumor 25712099
ENSG00000167258 CDK12 tumor 26189575
ENSG00000167258 CDK12 tumors 26622941
ENSG00000167258 CDK12 Ovarian Cancers 26787835
ENSG00000167258 CDK12 tumors 27251275
ENSG00000167258 CDK12 triple-negative breast cancer 27491809
ENSG00000167258 CDK12 cancer 27571479
ENSG00000167258 CDK12 Cancer 27601596
ENSG00000167258 CDK12 ovarian cancer 27642590
ENSG00000167258 CDK12 cancers 27662623
ENSG00000167258 CDK12 Triple-Negative Breast Cancer 27880910
ENSG00000167258 CDK12 lung tumor 27900369
ENSG00000167258 CDK12 ovarian cancer 27905519
ENSG00000167258 CDK12 cancer 27935476
ENSG00000167258 CDK12 lung cancer 28230015
ENSG00000167258 CDK12 breast cancer 28334900
ENSG00000167258 CDK12 tumors 28832682
ENSG00000167258 CDK12 tumor 29025359
ENSG00000167258 CDK12 breast cancer 29090014
ENSG00000167258 CDK12 Breast Cancer 29133620
ENSG00000167258 CDK12 tumor 29338072
ENSG00000167258 CDK12 Tumor 29358035
ENSG00000167258 CDK12 tumors 29382369
ENSG00000167258 CDK12 tumors 29760377
ENSG00000167258 CDK12 tumor 29872499
ENSG00000167258 CDK12 Prostate Cancer 29906450
ENSG00000167258 CDK12 cancers 29992508
ENSG00000167258 CDK12 tumor 29996110
ENSG00000167258 CDK12 tumors 30017478
ENSG00000167258 CDK12 cancers 30062102
ENSG00000167258 CDK12 cancer 30067358
ENSG00000167258 CDK12 cancer 30104286
ENSG00000167258 CDK12 Prostate Cancer 30207914
ENSG00000167258 CDK12 prostate cancer 30245085
ENSG00000167258 CDK12 gastric cancer 30310315
ENSG00000167258 CDK12 tumor 30319007
ENSG00000167258 CDK12 cancer 30333958
ENSG00000167258 CDK12 cancers 30409083
ENSG00000167258 CDK12 ovarian cancer 30422115
ENSG00000167258 CDK12 tumours 30487607
ENSG00000167258 CDK12 tumour 30531873
ENSG00000167258 CDK12 tumor 30541755
ENSG00000167258 CDK12 tumours 30794536
ENSG00000167258 CDK12 cancer 30819820
ENSG00000167258 CDK12 cancer 30988284
ENSG00000167258 CDK12 Tumor 31040255
ENSG00000167258 CDK12 prostate cancer 31218271
ENSG00000167258 CDK12 Breast Cancer 31259151
ENSG00000167258 CDK12 ovariancancer 31287417
ENSG00000167258 CDK12 Cancer 31292271
ENSG00000167258 CDK12 Tumours 31345636
ENSG00000167258 CDK12 cancer 31347271
ENSG00000167258 CDK12 tumors 31360735
ENSG00000167258 CDK12 tumor 31366128
ENSG00000167258 CDK12 breast tumor 31468695
ENSG00000167258 CDK12 gastric cancer 31523177
ENSG00000167258 CDK12 metastatic prostate cancer 31592503
ENSG00000167258 CDK12 ovarian cancer 31619387
ENSG00000167258 CDK12 Prostate Cancer 31640893
ENSG00000167258 CDK12 tumor 31652541
ENSG00000167258 CDK12 Triple-Negative Breast Cancer 31668947
ENSG00000167258 CDK12 Triple-Negative Breast Cancer 31676489
ENSG00000167258 CDK12 Triple-Negative Breast Cancer 31715127
ENSG00000167258 CDK12 Breast Cancer 31744448
ENSG00000167258 CDK12 pancreatic cancer 31917448
ENSG00000167258 CDK12 Prostate cancers 31972048
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000167258 CDK12 colorectal adenocarcinoma frameshift_variant 4.226% (56/1325) 2 entries
ENSG00000167258 CDK12 HER2 Positive Breast Carcinoma missense_variant 8.466% (16/189) 2 entries
ENSG00000167258 CDK12 colon adenocarcinoma frameshift_variant 3.79% (49/1293) 3 entries
ENSG00000167258 CDK12 colorectal adenocarcinoma conservative_inframe_deletion 4.226% (56/1325) 2 entries
ENSG00000167258 CDK12 prostate adenocarcinoma missense_variant 4.634% (100/2158) 3 entries
ENSG00000167258 CDK12 prostate adenocarcinoma frameshift_variant 4.634% (100/2158) 3 entries
ENSG00000167258 CDK12 colorectal adenocarcinoma sequence_alteration 4.226% (56/1325) 2 entries
ENSG00000167258 CDK12 colon adenocarcinoma stop_gained 3.79% (49/1293) 2 entries
ENSG00000167258 CDK12 prostate adenocarcinoma amino_acid_insertion 4.634% (100/2158) 1 entry
ENSG00000167258 CDK12 prostate adenocarcinoma sequence_alteration 4.634% (100/2158) 2 entries
ENSG00000167258 CDK12 colorectal adenocarcinoma missense_variant 4.226% (56/1325) 3 entries
ENSG00000167258 CDK12 colon adenocarcinoma missense_variant 3.79% (49/1293) 6 entries
ENSG00000167258 CDK12 prostate adenocarcinoma stop_gained 4.634% (100/2158) 2 entries
ENSG00000167258 CDK12 ovarian serous adenocarcinoma stop_gained 2.086% (19/911) 2 entries
ENSG00000167258 CDK12 brain glioblastoma sequence_alteration 0.9076% (11/1212) 1 entry
ENSG00000167258 CDK12 prostate carcinoma stop_gained 3.512% (17/484) 1 entry
ENSG00000167258 CDK12 colorectal adenocarcinoma amino_acid_insertion 4.226% (56/1325) 1 entry
ENSG00000167258 CDK12 clear cell renal carcinoma missense_variant 0.6766% (10/1478) 2 entries
ENSG00000167258 CDK12 esophageal squamous cell carcinoma stop_gained 1.895% (13/686) 3 entries
ENSG00000167258 CDK12 prostate adenocarcinoma conservative_inframe_deletion 4.634% (100/2158) 1 entry
ENSG00000167258 CDK12 pancreatic ductal adenocarcinoma missense_variant 1.863% (32/1718) 1 entry
ENSG00000167258 CDK12 cecum adenocarcinoma missense_variant 3.704% (10/270) 1 entry
ENSG00000167258 CDK12 lung adenocarcinoma missense_variant 1.362% (38/2789) 6 entries
ENSG00000167258 CDK12 ovarian serous adenocarcinoma frameshift_variant 2.086% (19/911) 2 entries
ENSG00000167258 CDK12 embryonal rhabdomyosarcoma missense_variant 2.326% (2/86) 1 entry
ENSG00000167258 CDK12 skin melanoma stop_gained 2.238% (26/1162) 1 entry
ENSG00000167258 CDK12 Endometrial Endometrioid Adenocarcinoma missense_variant 2.615% (17/650) 2 entries
ENSG00000167258 CDK12 breast carcinoma sequence_alteration 1.584% (25/1578) 1 entry
ENSG00000167258 CDK12 ovarian neoplasm missense_variant 3.448% (2/58) 1 entry
ENSG00000167258 CDK12 basal cell carcinoma missense_variant 10.29% (7/68) 2 entries
ENSG00000167258 CDK12 rectal adenocarcinoma missense_variant 1.648% (9/546) 2 entries
ENSG00000167258 CDK12 prostate carcinoma sequence_alteration 3.512% (17/484) 1 entry
ENSG00000167258 CDK12 ovarian serous adenocarcinoma conservative_inframe_deletion 2.086% (19/911) 2 entries
ENSG00000167258 CDK12 melanoma missense_variant 5.517% (8/145) 3 entries
ENSG00000167258 CDK12 lobular breast carcinoma missense_variant 1.527% (4/262) 1 entry
ENSG00000167258 CDK12 breast carcinoma missense_variant 1.584% (25/1578) 3 entries
ENSG00000167258 CDK12 urothelial carcinoma missense_variant 8.14% (7/86) 1 entry
ENSG00000167258 CDK12 gastric adenocarcinoma missense_variant 2.019% (19/941) 2 entries
ENSG00000167258 CDK12 Thyroid Gland Undifferentiated (Anaplastic) Carcinoma missense_variant 1.515% (4/264) 2 entries
ENSG00000167258 CDK12 Endometrial Endometrioid Adenocarcinoma frameshift_variant 2.615% (17/650) 1 entry
ENSG00000167258 CDK12 prostate carcinoma missense_variant 3.512% (17/484) 1 entry
ENSG00000167258 CDK12 gastric intestinal type adenocarcinoma missense_variant 3.529% (3/85) 1 entry
ENSG00000167258 CDK12 breast ductal adenocarcinoma stop_gained 2.959% (49/1656) 1 entry
ENSG00000167258 CDK12 esophageal squamous cell carcinoma missense_variant 1.895% (13/686) 4 entries
ENSG00000167258 CDK12 Ovarian Carcinosarcoma frameshift_variant 14.29% (2/14) 1 entry
ENSG00000167258 CDK12 breast ductal adenocarcinoma sequence_alteration 2.959% (49/1656) 1 entry
ENSG00000167258 CDK12 squamous cell lung carcinoma missense_variant 0.7984% (8/1002) 3 entries
ENSG00000167258 CDK12 rectal adenocarcinoma frameshift_variant 1.648% (9/546) 1 entry
ENSG00000167258 CDK12 breast carcinoma stop_gained 1.584% (25/1578) 1 entry
ENSG00000167258 CDK12 basal cell carcinoma stop_gained 10.29% (7/68) 2 entries
ENSG00000167258 CDK12 breast ductal adenocarcinoma missense_variant 2.959% (49/1656) 3 entries
ENSG00000167258 CDK12 bile duct adenocarcinoma missense_variant 0.5115% (2/391) 1 entry
ENSG00000167258 CDK12 Malignant Ovarian Mixed Epithelial Tumor missense_variant 20.0% (2/10) 1 entry
ENSG00000167258 CDK12 hepatocellular carcinoma missense_variant 1.218% (12/985) 1 entry
ENSG00000167258 CDK12 colon adenocarcinoma conservative_inframe_deletion 3.79% (49/1293) 1 entry
ENSG00000167258 CDK12 brain glioblastoma missense_variant 0.9076% (11/1212) 1 entry
ENSG00000167258 CDK12 clear cell renal carcinoma sequence_alteration 0.6766% (10/1478) 1 entry
ENSG00000167258 CDK12 gastric adenocarcinoma stop_gained 2.019% (19/941) 1 entry
ENSG00000167258 CDK12 female breast carcinoma missense_variant 1.496% (6/401) 2 entries
ENSG00000167258 CDK12 colon adenocarcinoma sequence_alteration 3.79% (49/1293) 1 entry
ENSG00000167258 CDK12 ovarian serous adenocarcinoma missense_variant 2.086% (19/911) 2 entries
ENSG00000167258 CDK12 prostate carcinoma frameshift_variant 3.512% (17/484) 1 entry
ENSG00000167258 CDK12 non-small cell lung carcinoma missense_variant 2.632% (3/114) 3 entries
ENSG00000167258 CDK12 skin melanoma missense_variant 2.238% (26/1162) 4 entries
ENSG00000167258 CDK12 Invasive Breast Carcinoma missense_variant 4.444% (2/45) 1 entry
ENSG00000167258 CDK12 lung adenocarcinoma stop_gained 1.362% (38/2789) 3 entries
ENSG00000167258 CDK12 small cell lung carcinoma missense_variant 1.57% (7/446) 3 entries
ENSG00000167258 CDK12 melanoma frameshift_variant 5.517% (8/145) 2 entries
ENSG00000167258 CDK12 bladder transitional cell carcinoma missense_variant 4.113% (19/462) 3 entries
ENSG00000167258 CDK12 cecum adenocarcinoma frameshift_variant 3.704% (10/270) 2 entries
ENSG00000167258 CDK12 esophageal adenocarcinoma missense_variant 3.467% (19/548) 1 entry
ENSG00000167258 CDK12 bladder transitional cell carcinoma sequence_alteration 4.113% (19/462) 1 entry
ENSG00000167258 CDK12 squamous cell lung carcinoma stop_gained 0.7984% (8/1002) 1 entry
ENSG00000167258 CDK12 ovarian sarcoma missense_variant 100.0% (1/1) 1 entry
ENSG00000167258 CDK12 diffuse gastric adenocarcinoma missense_variant 1.22% (1/82) 1 entry
ENSG00000167258 CDK12 Extraskeletal Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor missense_variant 3.03% (1/33) 1 entry
ENSG00000167258 CDK12 Ampulla of Vater Carcinoma missense_variant 1.176% (1/85) 1 entry
ENSG00000167258 CDK12 melanoma sequence_alteration 5.517% (8/145) 1 entry
ENSG00000167258 CDK12 pharyngeal squamous cell carcinoma frameshift_variant 1.399% (2/143) 1 entry
ENSG00000167258 CDK12 ovarian carcinoma frameshift_variant 9.091% (1/11) 1 entry
ENSG00000167258 CDK12 small intestinal adenocarcinoma missense_variant 9.524% (2/21) 1 entry
ENSG00000167258 CDK12 skin melanoma frameshift_variant 2.238% (26/1162) 1 entry
ENSG00000167258 CDK12 basal cell carcinoma sequence_alteration 10.29% (7/68) 1 entry
ENSG00000167258 CDK12 leiomyosarcoma missense_variant 0.9901% (1/101) 1 entry
ENSG00000167258 CDK12 rectal adenocarcinoma stop_gained 1.648% (9/546) 1 entry
ENSG00000167258 CDK12 small cell lung carcinoma stop_gained 1.57% (7/446) 1 entry
ENSG00000167258 CDK12 urothelial carcinoma frameshift_variant 8.14% (7/86) 1 entry
ENSG00000167258 CDK12 cecum adenocarcinoma stop_gained 3.704% (10/270) 1 entry
ENSG00000167258 CDK12 meningioma (disease) missense_variant 1.37% (1/73) 1 entry
ENSG00000167258 CDK12 Thymic Carcinoma missense_variant 9.091% (1/11) 1 entry
ENSG00000167258 CDK12 undifferentiated pleomorphic sarcoma missense_variant 1.613% (1/62) 1 entry
ENSG00000167258 CDK12 neoplasm stop_gained 3.448% (1/29) 1 entry
ENSG00000167258 CDK12 testicular seminoma frameshift_variant 2.353% (2/85) 1 entry
ENSG00000167258 CDK12 gastric intestinal type adenocarcinoma frameshift_variant 3.529% (3/85) 1 entry
ENSG00000167258 CDK12 pancreatic ductal adenocarcinoma frameshift_variant 1.863% (32/1718) 1 entry
ENSG00000167258 CDK12 breast ductal adenocarcinoma conservative_inframe_deletion 2.959% (49/1656) 1 entry
ENSG00000167258 CDK12 female breast carcinoma stop_gained 1.496% (6/401) 1 entry
ENSG00000167258 CDK12 breast ductal adenocarcinoma frameshift_variant 2.959% (49/1656) 1 entry
ENSG00000167258 CDK12 Merkel cell skin cancer missense_variant 2.128% (2/94) 1 entry
ENSG00000167258 CDK12 pharyngeal squamous cell carcinoma missense_variant 1.399% (2/143) 1 entry
ENSG00000167258 CDK12 head and neck squamous cell carcinoma missense_variant 0.159% (1/629) 1 entry
ENSG00000167258 CDK12 gastric adenocarcinoma frameshift_variant 2.019% (19/941) 1 entry
ENSG00000167258 CDK12 Endometrial Clear Cell Adenocarcinoma missense_variant 3.704% (1/27) 1 entry
ENSG00000167258 CDK12 mucosal melanoma missense_variant 1.429% (1/70) 1 entry
ENSG00000167258 CDK12 ependymoma sequence_alteration 1.852% (1/54) 1 entry
ENSG00000167258 CDK12 papillary thyroid carcinoma missense_variant 0.2028% (1/493) 1 entry
ENSG00000167258 CDK12 brain glioblastoma frameshift_variant 0.9076% (11/1212) 1 entry
ENSG00000167258 CDK12 nasopharyngeal squamous cell carcinoma missense_variant 0.3247% (1/308) 1 entry
ENSG00000167258 CDK12 soft tissue sarcoma missense_variant 0.3401% (1/294) 1 entry
ENSG00000167258 CDK12 testicular seminoma sequence_alteration 2.353% (2/85) 1 entry
ENSG00000167258 CDK12 Gallbladder Adenocarcinoma sequence_alteration 0.6061% (1/165) 1 entry
ENSG00000167258 CDK12 oral squamous cell carcinoma missense_variant 0.3817% (1/262) 1 entry
ENSG00000167258 CDK12 Mediastinal Malignant Germ Cell Tumor stop_gained 6.667% (1/15) 1 entry
ENSG00000167258 CDK12 Lung Sarcomatoid Carcinoma missense_variant 7.143% (1/14) 1 entry
ENSG00000167258 CDK12 mucosal melanoma frameshift_variant 1.429% (1/70) 1 entry
ENSG00000167258 CDK12 adrenal cortex carcinoma missense_variant 0.5291% (1/189) 1 entry
ENSG00000167258 CDK12 hemangioblastoma sequence_alteration 2.857% (1/35) 1 entry
ENSG00000167258 CDK12 esophageal squamous cell carcinoma sequence_alteration 1.895% (13/686) 1 entry
ENSG00000167258 CDK12 large cell lung carcinoma missense_variant 4.0% (1/25) 1 entry
ENSG00000167258 CDK12 Pleural Epithelioid Mesothelioma missense_variant 0.4878% (1/205) 1 entry
ENSG00000167258 CDK12 small cell lung carcinoma frameshift_variant 1.57% (7/446) 1 entry
ENSG00000167258 CDK12 gastric adenocarcinoma conservative_inframe_deletion 2.019% (19/941) 1 entry
ENSG00000167258 CDK12 Merkel cell skin cancer stop_gained 2.128% (2/94) 1 entry
ENSG00000167258 CDK12 salivary gland carcinoma frameshift_variant 3.03% (1/33) 1 entry
ENSG00000167258 CDK12 lung adenocarcinoma frameshift_variant 1.362% (38/2789) 1 entry
ENSG00000167258 CDK12 cecum adenocarcinoma amino_acid_insertion 3.704% (10/270) 1 entry
ENSG00000167258 CDK12 endometrial carcinoma missense_variant 3.448% (1/29) 1 entry
ENSG00000167258 CDK12 lymphoid neoplasm missense_variant 6.599% (13/197) 1 entry
ENSG00000167258 CDK12 small intestinal adenocarcinoma frameshift_variant 9.524% (2/21) 1 entry
ENSG00000167258 CDK12 Adrenal Gland Neuroblastoma missense_variant 1.667% (1/60) 1 entry
ENSG00000167258 CDK12 neoplasm missense_variant 3.448% (1/29) 1 entry
ENSG00000167258 CDK12 clear cell renal carcinoma frameshift_variant 0.6766% (10/1478) 1 entry
ENSG00000167258 CDK12 pancreatic neuroendocrine tumor missense_variant 3.814% (9/236) 1 entry
ENSG00000167258 CDK12 small cell lung carcinoma sequence_alteration 1.57% (7/446) 1 entry
ENSG00000167258 CDK12 Pancreatic Acinar Cell Carcinoma missense_variant 2.941% (1/34) 1 entry
ENSG00000167258 CDK12 hepatocellular carcinoma frameshift_variant 1.218% (12/985) 1 entry
ENSG00000167258 CDK12 Uveal Melanoma missense_variant 0.7812% (1/128) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167258 CDK12 MESO 0.0018 high
ENSG00000167258 CDK12 SARC 0.043 high
ENSG00000167258 CDK12 CHOL 0.036 high
ENSG00000167258 CDK12 UVM 0.039 high
ENSG00000167258 CDK12 PAAD 0.0085 high
ENSG00000167258 CDK12 THCA 0.022 high
ENSG00000167258 CDK12 ACC 0.007 high
ENSG00000167258 CDK12 LGG 0.0016 high
ENSG00000167258 CDK12 READ 0.00057 low
ENSG00000167258 CDK12 KIRP 0.00014 high
ENSG00000167258 CDK12 KICH 0.00093 high
ENSG00000167258 CDK12 PCPG 0.041 low
ENSG00000167258 CDK12 OV 0.0013 high
ENSG00000167258 CDK12 KIRC 0.0051 low
ENSG00000167258 CDK12 BLCA 0.04 high
ENSG00000167258 CDK12 LAML 0.00027 low
ENSG00000167258 CDK12 GBM 0.015 high
ENSG00000167258 CDK12 SKCM 0.03 high
ENSG00000167258 CDK12 LIHC 0.0027 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167258 CDK12 LUAD Amp 2.342704 0.156498 0.431782 0.436047
ENSG00000167258 CDK12 CESC Amp 1.540004 0.161275 0.760537 0.169492
ENSG00000167258 CDK12 ACC Del 2.670751 0.169615 0.585419 0.300000
ENSG00000167258 CDK12 READ Amp 2.630177 0.216761 0.685100 0.260606
ENSG00000167258 CDK12 COAD Amp 9.387927 0.201910 0.674314 0.246120
ENSG00000167258 CDK12 UCS Amp 1.069216 0.556256 0.957871 0.392857
ENSG00000167258 CDK12 SARC Del 1.307159 0.139439 0.443235 0.272374
ENSG00000167258 CDK12 PAAD Amp 1.386381 0.104963 0.506451 0.163043
ENSG00000167258 CDK12 ESCA Amp 16.560850 0.892085 1.159289 0.396739
ENSG00000167258 CDK12 HNSC Amp 2.170222 0.151057 0.603125 0.168582
ENSG00000167258 CDK12 PCPG Del 4.107941 0.118290 0.642095 0.222222
ENSG00000167258 CDK12 BLCA Amp 2.604780 0.227759 0.543589 0.392157
ENSG00000167258 CDK12 BRCA Amp 108.173350 0.855459 1.449162 0.296296
ENSG00000167258 CDK12 BRCA Del 1.069839 0.066964 0.424365 0.262963
ENSG00000167258 CDK12 STAD Amp 41.386111 0.735686 1.146410 0.301587
ENSG00000167258 CDK12 UCEC Amp 20.263998 0.354887 1.362638 0.120594
ENSG00000167258 CDK12 UCEC Del 1.693062 0.060259 0.563436 0.183673