RBP Type
Non-canonical_RBPs
Diseases
SARS-COV-2 Dengue Zika
Drug
N.A.
Main interacting RNAs
N.A.
Moonlighting functions
Metabolic enzyme
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000188612 Gene ID
6613 Accession
11125
Symbol
SUMO2
Alias
HSMT3;SMT3B;SUMO3;Smt3A;SMT3H2
Full Name
small ubiquitin like modifier 2
Status
Confidence
Length
17374 bases
Strand
Minus strand
Position
17 : 75165586 - 75182959
RNA binding domain
N.A.
Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last two amino acids of the carboxy-terminus have been cleaved off. Numerous pseudogenes have been reported for this gene. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
29979787 A genome-wide screen of Epstein-Barr virus proteins that modulate host SUMOylation identifies a SUMO E3 ligase conserved in herpesviruses.
F Carlos CF Cruz-Herrera De
2018-07-01
PLoS pathogens
36346822 A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines.
Xinyu Gu
2022-11-01
PLoS computational biology
32369911 Oxidative Stress in DNA Repeat Expansion Disorders: A Focus on NRF2 Signaling Involvement.
Piergiorgio P La
2020-05-01
Biomolecules
34638970 The Function of SUMOylation and Its Critical Roles in Cardiovascular Diseases and Potential Clinical Implications.
Congcong Du
2021-09-30
International journal of molecular sciences
21698343 An intranucleolar body associated with rDNA.
Saskia Hutten
2011-10-01
Chromosoma
32176739 STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.
Yuyan Wang
2020-03-01
PLoS pathogens
26259101 Global SUMOylation on active chromatin is an acute heat stress response restricting transcription.
A Einari Niskanen
2015-07-28
Genome biology
Name
Transcript ID
bp
Protein
Translation ID
SUMO2-202
ENST00000420826
3166
95aa
ENSP00000405965
SUMO2-201
ENST00000314523
809
71aa
ENSP00000400886
SUMO2-203
ENST00000578238
490
52aa
ENSP00000461997
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000188612 homo_sapiens ENSP00000324792 11.6945 7.63723 homo_sapiens ENSP00000405965 51.5789 33.6842 ENSG00000188612 homo_sapiens ENSP00000318635 91.5789 85.2632 homo_sapiens ENSP00000405965 91.5789 85.2632 ENSG00000188612 homo_sapiens ENSP00000330343 90.2913 88.3495 homo_sapiens ENSP00000405965 97.8947 95.7895
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000188612 homo_sapiens ENSP00000405965 100 100 nomascus_leucogenys ENSNLEP00000040203 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 100 98.9474 gorilla_gorilla ENSGGOP00000016811 60.5096 59.8726 ENSG00000188612 homo_sapiens ENSP00000405965 100 98.9474 sarcophilus_harrisii ENSSHAP00000041229 48.9691 48.4536 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 dasypus_novemcinctus ENSDNOP00000026529 68.3453 68.3453 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 cercocebus_atys ENSCATP00000033143 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 macaca_nemestrina ENSMNEP00000030819 69.3431 69.3431 ENSG00000188612 homo_sapiens ENSP00000405965 71.5789 68.4211 vulpes_vulpes ENSVVUP00000016420 95.7747 91.5493 ENSG00000188612 homo_sapiens ENSP00000405965 94.7368 90.5263 vulpes_vulpes ENSVVUP00000016417 88.2353 84.3137 ENSG00000188612 homo_sapiens ENSP00000405965 80 71.5789 capra_hircus ENSCHIP00000020238 59.8425 53.5433 ENSG00000188612 homo_sapiens ENSP00000405965 85.2632 81.0526 loxodonta_africana ENSLAFP00000026107 85.2632 81.0526 ENSG00000188612 homo_sapiens ENSP00000405965 96.8421 93.6842 panthera_leo ENSPLOP00000026916 96.8421 93.6842 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 equus_caballus ENSECAP00000087665 42.6009 42.6009 ENSG00000188612 homo_sapiens ENSP00000405965 96.8421 93.6842 panthera_pardus ENSPPRP00000027322 96.8421 93.6842 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 balaenoptera_musculus ENSBMSP00010027674 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 57.8947 52.6316 ursus_americanus ENSUAMP00000012385 87.3016 79.3651 ENSG00000188612 homo_sapiens ENSP00000405965 100 98.9474 monodelphis_domestica ENSMODP00000008950 30.8442 30.5195 ENSG00000188612 homo_sapiens ENSP00000405965 88.4211 84.2105 monodon_monoceros ENSMMNP00015009677 88.4211 84.2105 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 sus_scrofa ENSSSCP00000018235 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 microcebus_murinus ENSMICP00000029190 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 73.6842 72.6316 octodon_degus ENSODEP00000012549 95.8904 94.5205 ENSG00000188612 homo_sapiens ENSP00000405965 97.8947 93.6842 jaculus_jaculus ENSJJAP00000011318 97.8947 93.6842 ENSG00000188612 homo_sapiens ENSP00000405965 88.4211 84.2105 delphinapterus_leucas ENSDLEP00000021227 88.4211 84.2105 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 physeter_catodon ENSPCTP00005010376 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 72.6316 71.5789 dipodomys_ordii ENSDORP00000025984 86.25 85 ENSG00000188612 homo_sapiens ENSP00000405965 98.9474 98.9474 saimiri_boliviensis_boliviensis ENSSBOP00000005709 98.9474 98.9474 ENSG00000188612 homo_sapiens ENSP00000405965 88.4211 86.3158 saimiri_boliviensis_boliviensis ENSSBOP00000007076 84.8485 82.8283 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 chlorocebus_sabaeus ENSCSAP00000001037 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 73.6842 67.3684 tupaia_belangeri ENSTBEP00000004355 89.7436 82.0513 ENSG00000188612 homo_sapiens ENSP00000405965 90.5263 85.2632 phocoena_sinus ENSPSNP00000002957 90.5263 85.2632 ENSG00000188612 homo_sapiens ENSP00000405965 97.8947 90.5263 camelus_dromedarius ENSCDRP00005017185 97.8947 90.5263 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 microtus_ochrogaster ENSMOCP00000005352 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 53.6842 51.5789 peromyscus_maniculatus_bairdii ENSPEMP00000034519 78.4615 75.3846 ENSG00000188612 homo_sapiens ENSP00000405965 54.7368 54.7368 peromyscus_maniculatus_bairdii ENSPEMP00000031395 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 53.6842 50.5263 mus_spicilegus ENSMSIP00000017761 98.0769 92.3077 ENSG00000188612 homo_sapiens ENSP00000405965 52.6316 50.5263 mus_spicilegus ENSMSIP00000019299 96.1538 92.3077 ENSG00000188612 homo_sapiens ENSP00000405965 52.6316 50.5263 mus_spicilegus ENSMSIP00000000287 96.1538 92.3077 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 rhinolophus_ferrumequinum ENSRFEP00010000259 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 53.6842 51.5789 heterocephalus_glaber_female ENSHGLP00000000699 100 96.0784 ENSG00000188612 homo_sapiens ENSP00000405965 50.5263 50.5263 canis_lupus_dingo ENSCAFP00020023984 97.9592 97.9592 ENSG00000188612 homo_sapiens ENSP00000405965 98.9474 98.9474 sciurus_vulgaris ENSSVLP00005008036 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 94.7368 91.5789 phascolarctos_cinereus ENSPCIP00000033600 94.7368 91.5789 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 nannospalax_galili ENSNGAP00000025680 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 bos_grunniens ENSBGRP00000027078 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 87.3684 87.3684 ictidomys_tridecemlineatus ENSSTOP00000032392 97.6471 97.6471 ENSG00000188612 homo_sapiens ENSP00000405965 52.6316 52.6316 urocitellus_parryii ENSUPAP00010005297 96.1538 96.1538 ENSG00000188612 homo_sapiens ENSP00000405965 52.6316 49.4737 urocitellus_parryii ENSUPAP00010001984 96.1538 90.3846 ENSG00000188612 homo_sapiens ENSP00000405965 73.6842 69.4737 moschus_moschiferus ENSMMSP00000019149 73.6842 69.4737 ENSG00000188612 homo_sapiens ENSP00000405965 100 98.9474 mus_pahari MGP_PahariEiJ_P0037665 100 98.9474 ENSG00000188612 homo_sapiens ENSP00000405965 77.8947 67.3684 drosophila_melanogaster FBpp0078984 82.2222 71.1111 ENSG00000188612 homo_sapiens ENSP00000405965 84.2105 76.8421 ciona_intestinalis ENSCINP00000032913 80.8081 73.7374 ENSG00000188612 homo_sapiens ENSP00000405965 87.3684 82.1053 eptatretus_burgeri ENSEBUP00000001657 41.7085 39.196 ENSG00000188612 homo_sapiens ENSP00000405965 73.6842 63.1579 xiphophorus_maculatus ENSXMAP00000015392 47.619 40.8163 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 crocodylus_porosus ENSCPRP00005004555 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 98.9474 97.8947 pseudonaja_textilis ENSPTXP00000001147 98.9474 97.8947 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 anas_platyrhynchos_platyrhynchos ENSAPLP00000006410 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 46.3158 45.2632 meleagris_gallopavo ENSMGAP00000030977 84.6154 82.6923 ENSG00000188612 homo_sapiens ENSP00000405965 98.9474 97.8947 naja_naja ENSNNAP00000029962 98.9474 97.8947 ENSG00000188612 homo_sapiens ENSP00000405965 98.9474 98.9474 salvator_merianae ENSSMRP00000030258 98.9474 98.9474 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 pelodiscus_sinensis ENSPSIP00000006876 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 anser_brachyrhynchus ENSABRP00000018444 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 strigops_habroptila ENSSHBP00005017144 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 49.4737 44.2105 hucho_hucho ENSHHUP00000024978 95.9184 85.7143 ENSG00000188612 homo_sapiens ENSP00000405965 83.1579 75.7895 ciona_savignyi ENSCSAVP00000004278 79.798 72.7273 ENSG00000188612 homo_sapiens ENSP00000405965 75.7895 68.4211 labrus_bergylta ENSLBEP00000007592 77.4194 69.8925 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 aquila_chrysaetos_chrysaetos ENSACCP00020002981 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 100 100 coturnix_japonica ENSCJPP00005027877 100 100 ENSG00000188612 homo_sapiens ENSP00000405965 51.5789 50.5263 leptobrachium_leishanense ENSLLEP00000000943 94.2308 92.3077
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 2 IBA,IDA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 TAS Homo_sapiens(9606) Component GO:0016605 located_in PML body 1 IDA Homo_sapiens(9606) Component GO:0016925 involved_in protein sumoylation 2 IBA,IDA Homo_sapiens(9606) Process GO:0031386 enables protein tag activity 1 IBA Homo_sapiens(9606) Function GO:0031625 enables ubiquitin protein ligase binding 1 IPI Homo_sapiens(9606) Function GO:0032436 involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process 1 IDA Homo_sapiens(9606) Process GO:0044389 enables ubiquitin-like protein ligase binding 1 IBA Homo_sapiens(9606) Function
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