Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerFlavivirusesSARS-COV-2DengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions TF
Localizations Stress granucleNucleoli
BulkPerturb-seq DataSet_01_348 DataSet_01_98

Description

Ensembl ID ENSG00000187772 Gene ID 389421 Accession 32207
Symbol LIN28B Alias CSDD2 Full Name lin-28 homolog B
Status Confidence Length 146717 bases Strand Plus strand
Position 6 : 104936616 - 105083332 RNA binding domain CSD , zf-CCHC
Summary The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000489735 CSD PF00313 3.6e-16 1
ENSP00000489735 zf-CCHC PF00098 3e-08 2
ENSP00000489735 zf-CCHC PF00098 3e-08 3
ENSP00000344401 CSD PF00313 5.3e-16 1
ENSP00000344401 zf-CCHC PF00098 4.6e-08 2
ENSP00000344401 zf-CCHC PF00098 4.6e-08 3
ENSP00000490468 CSD PF00313 5.6e-16 1
ENSP00000490468 zf-CCHC PF00098 5.1e-08 2
ENSP00000490468 zf-CCHC PF00098 5.1e-08 3

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
24972138 PKM2: the thread linking energy metabolism reprogramming with epigenetics in cancer. Ling Chen 2014-06-26 International journal of molecular sciences
32923517 RNA Binding Protein LIN28B: a prime time player shaping neuroblastoma aggression and metastasis. Dongdong Chen 2020-07-01 Oncoscience
26028027 MacroH2A1 downregulation enhances the stem-like properties of bladder cancer cells by transactivation of Lin28B. S-J Park 2016-03-10 Oncogene
29707103 NF-κB promotes the stem-like properties of leukemia cells by activation of LIN28B. Jianbiao Zhou 2018-04-26 World journal of stem cells
29099484 Lin28B and miR-142-3p regulate neuronal differentiation by modulating Staufen1 expression. Younseo Oh 2018-02-01 Cell death and differentiation
37304235 The role of LIN28B in tumor progression and metastasis in solid tumor entities. Tabea Gewalt 2023-01-01 Oncology research
23481595 Identification of mRNAs bound and regulated by human LIN28 proteins and molecular requirements for RNA recognition. Markus Hafner 2013-05-01 RNA (New York, N.Y.)
24885919 Lin28B expression correlates with aggressive clinicopathological characteristics in breast invasive ductal carcinoma. Ruilian Xie 2014-06-01 Cancer biotherapy & radiopharmaceuticals
24386298 Increased expression of Lin28B associates with poor prognosis in patients with oral squamous cell carcinoma. Tianfu Wu 2013-01-01 PloS one
34591242 Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer. F Lorenzo Sempere 2021-09-01 Cancer metastasis reviews
28573150 Notch/Hes signaling and miR-9 engage in complex feedback interactions controlling neural progenitor cell proliferation and differentiation. Beate Roese-Koerner 2017-01-01 Neurogenesis (Austin, Tex.)
34638330 Pancreatic Cancer Small Extracellular Vesicles (Exosomes): A Tale of Short- and Long-Distance Communication. Mareike Waldenmaier 2021-09-28 Cancers
31215730 LIN28B regulates androgen receptor in human trophoblast cells through Let-7c. S Erin McWhorter 2019-09-01 Molecular reproduction and development
27320042 LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Jin Zhang 2016-07-07 Cell stem cell
28693523 Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia. Jianbiao Zhou 2017-07-11 Journal of hematology & oncology
27180906 SIRT6 Suppresses Pancreatic Cancer through Control of Lin28b. Sita Kugel 2016-06-02 Cell
33107691 The KRAS/Lin28B axis maintains stemness of pancreatic cancer cells via the let-7i/TET3 pathway. Yawen Liu 2021-01-01 Molecular oncology
32284747 LIN28B gene polymorphisms modify hepatoblastoma susceptibility in Chinese children. Zhonghua Yang 2020-01-01 Journal of Cancer
24599217 The prenatal origins of cancer. M Glenn Marshall 2014-04-01 Nature reviews. Cancer
37370851 LIN28B and Let-7 in Diffuse Midline Glioma: A Review. Truman Knowles 2023-06-19 Cancers
20525879 Lin-28B expression promotes transformation and invasion in human hepatocellular carcinoma. Yun-Chu Wang 2010-09-01 Carcinogenesis
36524131 Occurrence and role of lung megakaryocytes in infection and inflammation. Lucie Gelon 2022-01-01 Frontiers in immunology
36059274 The OTUD6B-LIN28B-MYC axis determines the proliferative state in multiple myeloma. Carmen Paulmann 2022-10-17 The EMBO journal
27793996 Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-β Signaling. Yelena Bronevetsky 2016-12-01 Journal of immunology (Baltimore, Md. : 1950)
26851235 Hepatic Premalignant Alterations Triggered by Human Nephrotoxin Aristolochic Acid I in Canines. Ke Jin 2016-04-01 Cancer prevention research (Philadelphia, Pa.)
35819951 RNANetMotif: Identifying sequence-structure RNA network motifs in RNA-protein binding sites. Hongli Ma 2022-07-01 PLoS computational biology
23770886 Identification of LIN28B-bound mRNAs reveals features of target recognition and regulation. Robin Graf 2013-07-01 RNA biology
31816633 The human fetal thymus generates invariant effector γδ T cells. Paola Tieppo 2020-03-02 The Journal of experimental medicine

Transcripts

Name Transcript ID bp Protein Translation ID
LIN28B-202 ENST00000635857 912 209aa ENSP00000489735
LIN28B-203 ENST00000637759 2635 258aa ENSP00000490468
LIN28B-201 ENST00000345080 5446 250aa ENSP00000344401

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
17010Neuroblastoma6.85e-00523222812
21842Personality6.434e-005-
22847Body Height9.9780000E-006-
22848Body Height3.6880000E-005-
23216Body Height8.8940000E-006-
23218Body Height2.3110000E-005-
24720Waist Circumference2.3950000E-008-
24721Waist Circumference4.2420000E-008-
24722Waist Circumference4.2030000E-008-
24821Waist Circumference6.1860000E-006-
24943Waist Circumference8.4360000E-005-
36678Platelet Function Tests8.1000000E-006-
61718Body Mass Index1E-1525673412
61719Waist Circumference1E-1525673412
61832Body Mass Index2E-625673412
61833Waist Circumference2E-625673412
71912Neuroblastoma1E-822941191
79221Puberty2E-824770850
81065Schizophrenia10E-726198764
81871Body Height8E-718391951
82840Menarche3E-1319448621
83449Menarche2E-1419448622
88786Menarche5E-723667675
97300Androgens2E-620303062
102992Body Mass Index2E-1225673412
102993Waist Circumference2E-1225673412
105425Body Height1E-818391950
106697Menarche4E-1619448623

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000187772homo_sapiensENSP0000000769923.901118.4066homo_sapiensENSP0000034440134.826.8
ENSG00000187772homo_sapiensENSP0000036162634.876525.6173homo_sapiensENSP0000034440145.233.2
ENSG00000187772homo_sapiensENSP0000022825124.193516.3979homo_sapiensENSP000003444013624.4
ENSG00000187772homo_sapiensENSP0000036331472.248865.0718homo_sapiensENSP0000034440160.454.4

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000187772homo_sapiensENSP0000034440198.498.4nomascus_leucogenysENSNLEP0000003794395.348895.3488
ENSG00000187772homo_sapiensENSP0000034440198.898.8pan_paniscusENSPPAP0000003158395.736495.7364
ENSG00000187772homo_sapiensENSP0000034440198.498.4pongo_abeliiENSPPYP0000004171595.348895.3488
ENSG00000187772homo_sapiensENSP0000034440198.898.8pan_troglodytesENSPTRP0000007067395.736495.7364
ENSG00000187772homo_sapiensENSP000003444019898gorilla_gorillaENSGGOP0000004002194.961294.9612
ENSG00000187772homo_sapiensENSP0000034440173.268.4ornithorhynchus_anatinusENSOANP0000004734249.863846.594
ENSG00000187772homo_sapiensENSP0000034440190.886.4sarcophilus_harrisiiENSSHAP0000003713881.654777.6978
ENSG00000187772homo_sapiensENSP0000034440179.674notamacropus_eugeniiENSMEUP0000000279581.557475.8197
ENSG00000187772homo_sapiensENSP0000034440165.664choloepus_hoffmanniENSCHOP0000000148693.181890.9091
ENSG00000187772homo_sapiensENSP0000034440195.294dasypus_novemcinctusENSDNOP0000001186296.356395.1417
ENSG00000187772homo_sapiensENSP0000034440190.887.2erinaceus_europaeusENSEEUP0000000329490.438286.8526
ENSG00000187772homo_sapiensENSP0000034440194.491.6echinops_telfairiENSETEP0000001243294.491.6
ENSG00000187772homo_sapiensENSP0000034440196.496callithrix_jacchusENSCJAP0000005492692.692392.3077
ENSG00000187772homo_sapiensENSP0000034440197.297.2cercocebus_atysENSCATP0000002931094.921994.9219
ENSG00000187772homo_sapiensENSP0000034440197.297.2macaca_fascicularisENSMFAP0000005348994.921994.9219
ENSG00000187772homo_sapiensENSP0000034440196.896.8macaca_mulattaENSMMUP0000006930692.366492.3664
ENSG00000187772homo_sapiensENSP0000034440197.297.2macaca_nemestrinaENSMNEP0000002935594.921994.9219
ENSG00000187772homo_sapiensENSP0000034440197.297.2papio_anubisENSPANP0000002840291.011291.0112
ENSG00000187772homo_sapiensENSP0000034440197.297.2mandrillus_leucophaeusENSMLEP0000000941194.921994.9219
ENSG00000187772homo_sapiensENSP0000034440193.291.6tursiops_truncatusENSTTRP0000001413684.727383.2727
ENSG00000187772homo_sapiensENSP0000034440191.288vulpes_vulpesENSVVUP0000000474388.030984.9421
ENSG00000187772homo_sapiensENSP000003444019085.2mus_spretusMGP_SPRETEiJ_P002396883.025878.5978
ENSG00000187772homo_sapiensENSP0000034440193.692.8equus_asinusENSEASP0000504770883.27482.5623
ENSG00000187772homo_sapiensENSP000003444019290capra_hircusENSCHIP0000000771390.196188.2353
ENSG00000187772homo_sapiensENSP0000034440195.294loxodonta_africanaENSLAFP0000002309387.179586.0806
ENSG00000187772homo_sapiensENSP0000034440192.491.6panthera_leoENSPLOP0000000092289.534988.7597
ENSG00000187772homo_sapiensENSP0000034440194.493.6ailuropoda_melanoleucaENSAMEP0000001203991.472990.6977
ENSG00000187772homo_sapiensENSP0000034440192.490.8bos_indicus_hybridENSBIXP0000502785790.588289.0196
ENSG00000187772homo_sapiensENSP0000034440192.891.2oryctolagus_cuniculusENSOCUP0000001533089.922588.3721
ENSG00000187772homo_sapiensENSP0000034440193.292.4equus_caballusENSECAP0000005563782.918282.2064
ENSG00000187772homo_sapiensENSP0000034440191.287.6canis_lupus_familiarisENSCAFP0084501023488.030984.556
ENSG00000187772homo_sapiensENSP0000034440192.491.6panthera_pardusENSPPRP0000002580789.534988.7597
ENSG00000187772homo_sapiensENSP0000034440191.690balaenoptera_musculusENSBMSP0001001193189.105187.5486
ENSG00000187772homo_sapiensENSP0000034440189.687.6cavia_porcellusENSCPOP0000000557189.687.6
ENSG00000187772homo_sapiensENSP0000034440192.491.6felis_catusENSFCAP0000004904489.534988.7597
ENSG00000187772homo_sapiensENSP0000034440193.692.8ursus_americanusENSUAMP0000002967292.12691.3386
ENSG00000187772homo_sapiensENSP0000034440191.286.8monodelphis_domesticaENSMODP0000002248777.288173.5593
ENSG00000187772homo_sapiensENSP0000034440192.490.8bison_bison_bisonENSBBBP0000000145290.588289.0196
ENSG00000187772homo_sapiensENSP0000034440192.490.8monodon_monocerosENSMMNP0001501378289.883388.3269
ENSG00000187772homo_sapiensENSP0000034440193.692.8sus_scrofaENSSSCP0000005428590.697789.9225
ENSG00000187772homo_sapiensENSP0000034440195.695.2microcebus_murinusENSMICP0000005012992.635792.2481
ENSG00000187772homo_sapiensENSP000003444019490.8octodon_degusENSODEP0000001841194.377591.1647
ENSG00000187772homo_sapiensENSP0000034440183.279.2jaculus_jaculusENSJJAP0000000632591.6387.2247
ENSG00000187772homo_sapiensENSP0000034440191.689.6ovis_aries_rambouilletENSOARP0002000399685.767883.8951
ENSG00000187772homo_sapiensENSP0000034440193.692.8ursus_maritimusENSUMAP0000002879992.12691.3386
ENSG00000187772homo_sapiensENSP0000034440188.887.2ochotona_princepsENSOPRP0000000579890.243988.6179
ENSG00000187772homo_sapiensENSP000003444019290delphinapterus_leucasENSDLEP0000002380783.333381.5217
ENSG00000187772homo_sapiensENSP0000034440191.289.6physeter_catodonENSPCTP0000502190288.71687.1595
ENSG00000187772homo_sapiensENSP0000034440190.886mus_caroliMGP_CAROLIEiJ_P002282783.763879.3358
ENSG00000187772homo_sapiensENSP000003444019085.6mus_musculusENSMUSP0000007836183.025878.9668
ENSG00000187772homo_sapiensENSP0000034440191.288.4dipodomys_ordiiENSDORP0000002380693.442690.5738
ENSG00000187772homo_sapiensENSP0000034440193.691.2dipodomys_ordiiENSDORP0000000900794.736892.3077
ENSG00000187772homo_sapiensENSP0000034440195.294mustela_putorius_furoENSMPUP0000000941395.294
ENSG00000187772homo_sapiensENSP0000034440195.694.8aotus_nancymaaeENSANAP0000002925890.188789.434
ENSG00000187772homo_sapiensENSP000003444019695.6aotus_nancymaaeENSANAP0000003848194.861794.4664
ENSG00000187772homo_sapiensENSP0000034440197.296.8saimiri_boliviensis_boliviensisENSSBOP0000001731997.296.8
ENSG00000187772homo_sapiensENSP0000034440186.483.2vicugna_pacosENSVPAP0000001043087.804984.5528
ENSG00000187772homo_sapiensENSP000003444018282chlorocebus_sabaeusENSCSAP0000001082698.557798.5577
ENSG00000187772homo_sapiensENSP000003444017068.4tupaia_belangeriENSTBEP0000000504070.281168.6747
ENSG00000187772homo_sapiensENSP0000034440168.466mesocricetus_auratusENSMAUP0000000483293.95690.6593
ENSG00000187772homo_sapiensENSP0000034440192.490.4phocoena_sinusENSPSNP0000002011889.883387.9377
ENSG00000187772homo_sapiensENSP0000034440192.490camelus_dromedariusENSCDRP0000501613689.534987.2093
ENSG00000187772homo_sapiensENSP0000034440182.878.4carlito_syrichtaENSTSYP0000001854873.928670
ENSG00000187772homo_sapiensENSP0000034440195.693.6carlito_syrichtaENSTSYP0000001884792.635790.6977
ENSG00000187772homo_sapiensENSP0000034440190.890panthera_tigris_altaicaENSPTIP0000000789389.723388.9328
ENSG00000187772homo_sapiensENSP0000034440190.485.2rattus_norvegicusENSRNOP0000003778883.394878.5978
ENSG00000187772homo_sapiensENSP000003444019695.6prolemur_simusENSPSMP0000000471890.225689.8496
ENSG00000187772homo_sapiensENSP000003444019287.2microtus_ochrogasterENSMOCP0000001674784.870880.4428
ENSG00000187772homo_sapiensENSP0000034440193.689.6sorex_araneusENSSARP0000000756193.689.6
ENSG00000187772homo_sapiensENSP0000034440189.686.4peromyscus_maniculatus_bairdiiENSPEMP0000001652482.656879.7048
ENSG00000187772homo_sapiensENSP0000034440192.490.8bos_mutusENSBMUP0000003084690.588289.0196
ENSG00000187772homo_sapiensENSP0000034440190.485.6mus_spicilegusENSMSIP0000003634183.394878.9668
ENSG00000187772homo_sapiensENSP000003444019087.2cricetulus_griseus_chok1gshdENSCGRP0000102689483.955281.3433
ENSG00000187772homo_sapiensENSP0000034440194.493.6pteropus_vampyrusENSPVAP0000000830385.507284.7826
ENSG00000187772homo_sapiensENSP0000034440170.468.4myotis_lucifugusENSMLUP0000000627795.135192.4324
ENSG00000187772homo_sapiensENSP0000034440190.886.4vombatus_ursinusENSVURP0001001292787.984583.7209
ENSG00000187772homo_sapiensENSP0000034440194.893.6rhinolophus_ferrumequinumENSRFEP0001000487891.860590.6977
ENSG00000187772homo_sapiensENSP0000034440194.493.2neovison_visonENSNVIP0000000462791.472990.3101
ENSG00000187772homo_sapiensENSP000003444019290.4bos_taurusENSBTAP0000005365193.117491.498
ENSG00000187772homo_sapiensENSP0000034440193.291.2heterocephalus_glaber_femaleENSHGLP0000003546982.918281.1388
ENSG00000187772homo_sapiensENSP0000034440196.896.4rhinopithecus_bietiENSRBIP0000002468594.531294.1406
ENSG00000187772homo_sapiensENSP0000034440190.487.2canis_lupus_dingoENSCAFP0002002228588.976485.8268
ENSG00000187772homo_sapiensENSP0000034440196.495.2sciurus_vulgarisENSSVLP0000501012393.410992.2481
ENSG00000187772homo_sapiensENSP0000034440191.286.4phascolarctos_cinereusENSPCIP0000005046188.372183.7209
ENSG00000187772homo_sapiensENSP0000034440192.889.2nannospalax_galiliENSNGAP0000002459393.548489.9194
ENSG00000187772homo_sapiensENSP000003444019088bos_grunniensENSBGRP0000000767492.592690.535
ENSG00000187772homo_sapiensENSP0000034440193.291.6chinchilla_lanigeraENSCLAP0000001530093.291.6
ENSG00000187772homo_sapiensENSP0000034440188.887.2cervus_hanglu_yarkandensisENSCHYP0000003500687.058885.4902
ENSG00000187772homo_sapiensENSP0000034440193.292.8catagonus_wagneriENSCWAP0000002476588.593288.2129
ENSG00000187772homo_sapiensENSP0000034440196.895.2ictidomys_tridecemlineatusENSSTOP0000000240088.321286.8613
ENSG00000187772homo_sapiensENSP000003444019694.8otolemur_garnettiiENSOGAP000000098839694.8
ENSG00000187772homo_sapiensENSP0000034440196.896.4cebus_imitatorENSCCAP0000000631092.366491.9847
ENSG00000187772homo_sapiensENSP0000034440196.895.6urocitellus_parryiiENSUPAP0001001564688.321287.2263
ENSG00000187772homo_sapiensENSP000003444019290.4moschus_moschiferusENSMMSP0000001387890.196188.6274
ENSG00000187772homo_sapiensENSP0000034440196.496rhinopithecus_roxellanaENSRROP0000001915394.140693.75
ENSG00000187772homo_sapiensENSP000003444019085.6mus_pahariMGP_PahariEiJ_P008600683.025878.9668
ENSG00000187772homo_sapiensENSP0000034440196.496propithecus_coquereliENSPCOP0000001078793.410993.0233
ENSG00000187772homo_sapiensENSP000003444013220.4caenorhabditis_elegansY39A1C.3.127.210917.3469
ENSG00000187772homo_sapiensENSP0000034440128.818.4caenorhabditis_elegansF46F11.2.126.966317.2285
ENSG00000187772homo_sapiensENSP0000034440128.419.2caenorhabditis_elegansM01E11.5.126.792518.1132
ENSG00000187772homo_sapiensENSP0000034440143.632.8drosophila_melanogasterFBpp007679855.897442.0513
ENSG00000187772homo_sapiensENSP0000034440146.434.4ciona_intestinalisENSCINP0000003271559.793844.3299
ENSG00000187772homo_sapiensENSP0000034440147.235.6eptatretus_burgeriENSEBUP0000001315958.706544.2786
ENSG00000187772homo_sapiensENSP0000034440185.277.6callorhinchus_miliiENSCMIP0000001812280.988673.7643
ENSG00000187772homo_sapiensENSP0000034440187.682.8latimeria_chalumnaeENSLACP0000000455378.494674.1936
ENSG00000187772homo_sapiensENSP000003444018676.4lepisosteus_oculatusENSLOCP0000002042587.044577.3279
ENSG00000187772homo_sapiensENSP0000034440165.258.4clupea_harengusENSCHAP0000005542271.17963.7555
ENSG00000187772homo_sapiensENSP0000034440167.259.2clupea_harengusENSCHAP000000283387061.6667
ENSG00000187772homo_sapiensENSP0000034440164.856.4danio_rerioENSDARP0000010253777.142967.1429
ENSG00000187772homo_sapiensENSP0000034440164.855.6carassius_auratusENSCARP0000005765475.700964.9533
ENSG00000187772homo_sapiensENSP000003444016456carassius_auratusENSCARP0000007813677.294767.6329
ENSG00000187772homo_sapiensENSP0000034440165.256carassius_auratusENSCARP0000008638776.886866.0377
ENSG00000187772homo_sapiensENSP000003444016456carassius_auratusENSCARP0000001435750.156743.8871
ENSG00000187772homo_sapiensENSP0000034440167.256.8astyanax_mexicanusENSAMXP0000000192575.336363.6771
ENSG00000187772homo_sapiensENSP0000034440166.455.6astyanax_mexicanusENSAMXP0000000146268.032856.9672
ENSG00000187772homo_sapiensENSP0000034440160.854ictalurus_punctatusENSIPUP0000001993074.876866.5025
ENSG00000187772homo_sapiensENSP0000034440162.852.8ictalurus_punctatusENSIPUP0000002110367.672456.8966
ENSG00000187772homo_sapiensENSP0000034440167.661.2esox_luciusENSELUP0000001599676.818269.5455
ENSG00000187772homo_sapiensENSP000003444015446electrophorus_electricusENSEEEP0000002909163.679254.2453
ENSG00000187772homo_sapiensENSP0000034440165.255.6electrophorus_electricusENSEEEP0000004401069.658159.4017
ENSG00000187772homo_sapiensENSP0000034440164.860.8oncorhynchus_kisutchENSOKIP0000500785371.365666.9604
ENSG00000187772homo_sapiensENSP0000034440163.651.2oncorhynchus_kisutchENSOKIP0000500465864.112951.6129
ENSG00000187772homo_sapiensENSP0000034440166.462oncorhynchus_kisutchENSOKIP0000504508071.861567.0996
ENSG00000187772homo_sapiensENSP000003444016452oncorhynchus_kisutchENSOKIP0000504822864.516152.4194
ENSG00000187772homo_sapiensENSP0000034440163.651.6oncorhynchus_mykissENSOMYP0000000090263.095251.1905
ENSG00000187772homo_sapiensENSP0000034440166.862oncorhynchus_mykissENSOMYP0000001213572.294467.0996
ENSG00000187772homo_sapiensENSP0000034440165.661.6oncorhynchus_mykissENSOMYP0000001214472.246767.8414
ENSG00000187772homo_sapiensENSP0000034440164.852.8oncorhynchus_mykissENSOMYP0000006324465.322653.2258
ENSG00000187772homo_sapiensENSP000003444016661.2salmo_salarENSSSAP0000016650168.7563.75
ENSG00000187772homo_sapiensENSP0000034440162.850.8salmo_salarENSSSAP0000012201255.087744.5614
ENSG00000187772homo_sapiensENSP0000034440162.450.4salmo_salarENSSSAP0000006226159.54248.0916
ENSG00000187772homo_sapiensENSP0000034440165.261.2salmo_salarENSSSAP0000015730861.048757.3034
ENSG00000187772homo_sapiensENSP0000034440165.661.2salmo_truttaENSSTUP0000004876372.246767.4009
ENSG00000187772homo_sapiensENSP0000034440163.651.2salmo_truttaENSSTUP0000001061363.095250.7937
ENSG00000187772homo_sapiensENSP0000034440160.849.2salmo_truttaENSSTUP0000005567459.607848.2353
ENSG00000187772homo_sapiensENSP0000034440165.661.6salmo_truttaENSSTUP0000010297061.423257.6779
ENSG00000187772homo_sapiensENSP0000034440167.258.8gadus_morhuaENSGMOP0000005800050.602444.2771
ENSG00000187772homo_sapiensENSP0000034440169.662fundulus_heteroclitusENSFHEP0000002066672.803364.8536
ENSG00000187772homo_sapiensENSP0000034440156.849.2poecilia_reticulataENSPREP0000000901267.942658.8517
ENSG00000187772homo_sapiensENSP0000034440169.662.8xiphophorus_maculatusENSXMAP0000000345273.417766.2447
ENSG00000187772homo_sapiensENSP0000034440164.857.6oryzias_latipesENSORLP0000003023563.03556.0311
ENSG00000187772homo_sapiensENSP0000034440168.860cyclopterus_lumpusENSCLMP0000503569673.819764.3777
ENSG00000187772homo_sapiensENSP0000034440170.862.8oreochromis_niloticusENSONIP0000001851275.64167.094
ENSG00000187772homo_sapiensENSP000003444017062haplochromis_burtoniENSHBUP0000002962672.614164.3154
ENSG00000187772homo_sapiensENSP000003444017062astatotilapia_callipteraENSACLP0000003180174.152565.678
ENSG00000187772homo_sapiensENSP0000034440170.462.8sparus_aurataENSSAUP0001003739274.576366.5254
ENSG00000187772homo_sapiensENSP000003444017062.4lates_calcariferENSLCAP0001003936672.614164.7303
ENSG00000187772homo_sapiensENSP0000034440187.279.2xenopus_tropicalisENSXETP0000010827983.206175.5725
ENSG00000187772homo_sapiensENSP0000034440189.684.4chrysemys_picta_belliiENSCPBP0000000509389.959884.739
ENSG00000187772homo_sapiensENSP0000034440189.685.2sphenodon_punctatusENSSPUP0000001708289.24384.8606
ENSG00000187772homo_sapiensENSP0000034440188.482.8crocodylus_porosusENSCPRP0000500132964.619960.5263
ENSG00000187772homo_sapiensENSP0000034440186.479.6notechis_scutatusENSNSUP0000002480383.720977.1318
ENSG00000187772homo_sapiensENSP0000034440180.874.8pseudonaja_textilisENSPTXP0000000967184.518878.2427
ENSG00000187772homo_sapiensENSP0000034440187.282anas_platyrhynchos_platyrhynchosENSAPLP0000002813176.760672.1831
ENSG00000187772homo_sapiensENSP0000034440187.281.2gallus_gallusENSGALP0001001890484.496178.6822
ENSG00000187772homo_sapiensENSP0000034440186.880.8meleagris_gallopavoENSMGAP0000001430284.108578.2946
ENSG00000187772homo_sapiensENSP0000034440188.884serinus_canariaENSSCAP0000000110188.884
ENSG00000187772homo_sapiensENSP0000034440188.483.6parus_majorENSPMJP0000000033085.658981.0078
ENSG00000187772homo_sapiensENSP0000034440187.682anolis_carolinensisENSACAP0000000385162.215958.2386
ENSG00000187772homo_sapiensENSP0000034440170.862.4neolamprologus_brichardiENSNBRP0000002632573.140564.4628
ENSG00000187772homo_sapiensENSP0000034440180.474.8naja_najaENSNNAP0000000231884.453878.5714
ENSG00000187772homo_sapiensENSP0000034440185.679.6podarcis_muralisENSPMRP0000001168883.593877.7344
ENSG00000187772homo_sapiensENSP000003444018882.8geospiza_fortisENSGFOP0000000500988.353483.1325
ENSG00000187772homo_sapiensENSP0000034440187.682.8taeniopygia_guttataENSTGUP0000002337384.883780.2326
ENSG00000187772homo_sapiensENSP000003444016457.6erpetoichthys_calabaricusENSECRP0000000288977.294769.5652
ENSG00000187772homo_sapiensENSP000003444016860.4kryptolebias_marmoratusENSKMAP0000002200171.129763.1799
ENSG00000187772homo_sapiensENSP0000034440186.480salvator_merianaeENSSMRP0000001712678.260972.4638
ENSG00000187772homo_sapiensENSP0000034440167.660.8oryzias_javanicusENSOJAP0000004773473.478366.087
ENSG00000187772homo_sapiensENSP0000034440169.661.6amphilophus_citrinellusENSACIP0000001257069.879561.8474
ENSG00000187772homo_sapiensENSP0000034440170.462.8dicentrarchus_labraxENSDLAP0000507436374.576366.5254
ENSG00000187772homo_sapiensENSP0000034440166.861.2amphiprion_perculaENSAPEP0000003089970.762764.8305
ENSG00000187772homo_sapiensENSP0000034440166.861.2amphiprion_perculaENSAPEP0000003074070.762764.8305
ENSG00000187772homo_sapiensENSP0000034440168.462oryzias_sinensisENSOSIP0000002035870.370463.786
ENSG00000187772homo_sapiensENSP0000034440189.284.8pelodiscus_sinensisENSPSIP0000000270289.558285.1406
ENSG00000187772homo_sapiensENSP0000034440189.282.8gopherus_evgoodeiENSGEVP0000500527585.114579.0076
ENSG00000187772homo_sapiensENSP0000034440189.282.4chelonoidis_abingdoniiENSCABP0000000980185.114578.626
ENSG00000187772homo_sapiensENSP0000034440166.860.4seriola_dumeriliENSSDUP0000000072972.294465.368
ENSG00000187772homo_sapiensENSP0000034440170.462.4cottoperca_gobioENSCGOP0000005689875.536566.9528
ENSG00000187772homo_sapiensENSP0000034440188.483.2struthio_camelus_australisENSSCUP0000001198385.992280.9339
ENSG00000187772homo_sapiensENSP0000034440188.884anser_brachyrhynchusENSABRP0000000336386.381381.7121
ENSG00000187772homo_sapiensENSP0000034440168.461.6gasterosteus_aculeatusENSGACP0000001243072.457665.2542
ENSG00000187772homo_sapiensENSP000003444017062.8cynoglossus_semilaevisENSCSEP0000000043074.152566.5254
ENSG00000187772homo_sapiensENSP0000034440170.463.2poecilia_formosaENSPFOP0000001946974.261666.6667
ENSG00000187772homo_sapiensENSP0000034440168.861.6myripristis_murdjanENSMMDP0000504925173.819766.0944
ENSG00000187772homo_sapiensENSP0000034440168.861.6sander_luciopercaENSSLUP0000001280173.819766.0944
ENSG00000187772homo_sapiensENSP000003444018883.6strigops_habroptilaENSSHBP0000500818987.301682.9365
ENSG00000187772homo_sapiensENSP0000034440166.861.2amphiprion_ocellarisENSAOCP0000002671570.762764.8305
ENSG00000187772homo_sapiensENSP0000034440189.684.4terrapene_carolina_triunguisENSTMTP0000000152889.959884.739
ENSG00000187772homo_sapiensENSP0000034440164.860.4hucho_huchoENSHHUP0000003116864.541860.1594
ENSG00000187772homo_sapiensENSP0000034440165.252.4hucho_huchoENSHHUP0000001756865.725852.8226
ENSG00000187772homo_sapiensENSP0000034440144.840hucho_huchoENSHHUP0000002346471.794964.1026
ENSG00000187772homo_sapiensENSP000003444015446hucho_huchoENSHHUP0000005334072.192561.4973
ENSG00000187772homo_sapiensENSP000003444017063.2betta_splendensENSBSLP0000002075674.468167.234
ENSG00000187772homo_sapiensENSP000003444016857.6pygocentrus_nattereriENSPNAP0000002767775.555664
ENSG00000187772homo_sapiensENSP0000034440165.655.2pygocentrus_nattereriENSPNAP0000001054666.396855.8704
ENSG00000187772homo_sapiensENSP0000034440169.663.2anabas_testudineusENSATEP0000002031575.324768.3983
ENSG00000187772homo_sapiensENSP0000034440140.828.4ciona_savignyiENSCSAVP0000001116258.285740.5714
ENSG00000187772homo_sapiensENSP0000034440165.658.8seriola_lalandi_dorsalisENSSLDP0000000228564.822158.1028
ENSG00000187772homo_sapiensENSP0000034440170.463.2labrus_bergyltaENSLBEP0000002530971.544764.2276
ENSG00000187772homo_sapiensENSP0000034440170.862.4pundamilia_nyerereiENSPNYP0000002995973.140564.4628
ENSG00000187772homo_sapiensENSP0000034440170.862.8mastacembelus_armatusENSMAMP0000000999775.64167.094
ENSG00000187772homo_sapiensENSP0000034440167.259.6stegastes_partitusENSSPAP0000001302772.413864.2241
ENSG00000187772homo_sapiensENSP0000034440166.862.4oncorhynchus_tshawytschaENSOTSP0000502055573.568368.7225
ENSG00000187772homo_sapiensENSP000003444015847.2oncorhynchus_tshawytschaENSOTSP0000508737059.917448.7603
ENSG00000187772homo_sapiensENSP0000034440163.651.6oncorhynchus_tshawytschaENSOTSP0000507089457.608746.7391
ENSG00000187772homo_sapiensENSP0000034440163.651.6oncorhynchus_tshawytschaENSOTSP0000507512357.608746.7391
ENSG00000187772homo_sapiensENSP0000034440165.661.6oncorhynchus_tshawytschaENSOTSP0000501100070.386366.0944
ENSG00000187772homo_sapiensENSP0000034440169.261.2acanthochromis_polyacanthusENSAPOP0000001145570.040561.9433
ENSG00000187772homo_sapiensENSP0000034440187.683.2aquila_chrysaetos_chrysaetosENSACCP0002001081287.25182.8685
ENSG00000187772homo_sapiensENSP0000034440170.462.8nothobranchius_furzeriENSNFUP0001502569075.862167.6724
ENSG00000187772homo_sapiensENSP0000034440169.662.4cyprinodon_variegatusENSCVAP0000000091974.35966.6667
ENSG00000187772homo_sapiensENSP000003444016254denticeps_clupeoidesENSDCDP0000002026868.281959.4714
ENSG00000187772homo_sapiensENSP000003444016254.4denticeps_clupeoidesENSDCDP0000000911768.584160.177
ENSG00000187772homo_sapiensENSP0000034440169.261.6larimichthys_croceaENSLCRP0000501494962.909156
ENSG00000187772homo_sapiensENSP0000034440169.262takifugu_rubripesENSTRUP0000008578075.217467.3913
ENSG00000187772homo_sapiensENSP0000034440176.869.6ficedula_albicollisENSFALP0000002275556.140450.8772
ENSG00000187772homo_sapiensENSP0000034440168.459.6hippocampus_comesENSHCOP0000000857271.548162.3431
ENSG00000187772homo_sapiensENSP0000034440165.656.8cyprinus_carpio_carpioENSCCRP0000014368069.198359.9156
ENSG00000187772homo_sapiensENSP0000034440156.849.6cyprinus_carpio_carpioENSCCRP0000008061354.198547.3282
ENSG00000187772homo_sapiensENSP0000034440186.881.2coturnix_japonicaENSCJPP0000501094584.435878.9883
ENSG00000187772homo_sapiensENSP000003444017063.2poecilia_latipinnaENSPLAP0000002360273.839766.6667
ENSG00000187772homo_sapiensENSP000003444014035.2sinocyclocheilus_grahamiENSSGRP0000011080471.428662.8571
ENSG00000187772homo_sapiensENSP000003444016656.4sinocyclocheilus_grahamiENSSGRP0000008420377.830266.5094
ENSG00000187772homo_sapiensENSP0000034440171.263.2maylandia_zebraENSMZEP0000502431676.068467.5214
ENSG00000187772homo_sapiensENSP0000034440167.660.4tetraodon_nigroviridisENSTNIP0000001527073.478365.6522
ENSG00000187772homo_sapiensENSP0000034440171.266.4paramormyrops_kingsleyaeENSPKIP0000003368873.25168.3128
ENSG00000187772homo_sapiensENSP000003444017266.8scleropages_formosusENSSFOP0001501636866.420761.6236
ENSG00000187772homo_sapiensENSP000003444018882leptobrachium_leishanenseENSLLEP0000002677287.649481.6733
ENSG00000187772homo_sapiensENSP0000034440168.460.8scophthalmus_maximusENSSMAP0000004115174.347866.087
ENSG00000187772homo_sapiensENSP0000034440165.658oryzias_melastigmaENSOMEP0000000540773.214364.7321

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding2HDA,IDAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1IDAHomo_sapiens(9606)Component
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0010587involved_in miRNA catabolic process1IMPHomo_sapiens(9606)Process
GO:0031054involved_in pre-miRNA processing2IBA,IMPHomo_sapiens(9606)Process
GO:0031123involved_in RNA 3-end processing1IMPHomo_sapiens(9606)Process
GO:0050779involved_in RNA destabilization1IDAHomo_sapiens(9606)Process
GO:1990837enables sequence-specific double-stranded DNA binding1IDAHomo_sapiens(9606)Function
GO:2000627involved_in positive regulation of miRNA catabolic process1IMPHomo_sapiens(9606)Process
GO:2000632involved_in negative regulation of pre-miRNA processing1IDAHomo_sapiens(9606)Process
GO:2000635involved_in negative regulation of primary miRNA processing1IDAHomo_sapiens(9606)Process

Expression