Ensembl ID ENSG00000187772 Gene ID 389421 Accession 32207
Gene Symbol LIN28B Alias CSDD2 Full Name lin-28 homolog B
Position 6 : 104936616 - 105083332 Length 146717 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]

ENSG00000187772 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000187772 LIN28B 6.33 6.24e-15 HNSC
ENSG00000187772 LIN28B 4.88 2.57e-14 BRCA
ENSG00000187772 LIN28B 6.87 2.79e-29 LUSC
ENSG00000187772 LIN28B 10.9 9.21e-38 LIHC
ENSG00000187772 LIN28B 6.52 1.43e-25 UCEC
ENSG00000187772 LIN28B 7.98 4.92e-23 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000187772 LIN28B tumor 16971064
ENSG00000187772 LIN28B tumor 19211792
ENSG00000187772 LIN28B epithelial ovarian cancer 19477633
ENSG00000187772 LIN28B tumors 19483683
ENSG00000187772 LIN28B cancer 19557079
ENSG00000187772 LIN28B tumours 19578360
ENSG00000187772 LIN28B cancers 19713958
ENSG00000187772 LIN28B lung cancer 19745602
ENSG00000187772 LIN28B cancer 20512147
ENSG00000187772 LIN28B tumor 20525879
ENSG00000187772 LIN28B tumor 20805998
ENSG00000187772 LIN28B tumor 20827722
ENSG00000187772 LIN28B epithelial ovarian cancer 21482675
ENSG00000187772 LIN28B colon cancer 21512136
ENSG00000187772 LIN28B ovarian cancers 21533284
ENSG00000187772 LIN28B tumors 21552419
ENSG00000187772 LIN28B colon cancer 21625210
ENSG00000187772 LIN28B tumor 21853155
ENSG00000187772 LIN28B tumor 21963849
ENSG00000187772 LIN28B cancer 22013165
ENSG00000187772 LIN28B breast cancer 22081076
ENSG00000187772 LIN28B tumor 22114584
ENSG00000187772 LIN28B breast tumors 22118463
ENSG00000187772 LIN28B cancer 22129484
ENSG00000187772 LIN28B tumors 22225612
ENSG00000187772 LIN28B cancer 22433967
ENSG00000187772 LIN28B tumor 22713243
ENSG00000187772 LIN28B epithelial ovarian cancer 22822098
ENSG00000187772 LIN28B tumors 22941191
ENSG00000187772 LIN28B cancer 22974476
ENSG00000187772 LIN28B cancer 22976955
ENSG00000187772 LIN28B tumor 23042116
ENSG00000187772 LIN28B colon cancer 23052130
ENSG00000187772 LIN28B tumor 23161096
ENSG00000187772 LIN28B breast cancer 23318420
ENSG00000187772 LIN28B cancer 23420006
ENSG00000187772 LIN28B cancer 23449627
ENSG00000187772 LIN28B breast cancer 23494474
ENSG00000187772 LIN28B cancer 23770886
ENSG00000187772 LIN28B GBM 23846349
ENSG00000187772 LIN28B tumors 24040120
ENSG00000187772 LIN28B tumor 24056962
ENSG00000187772 LIN28B colon cancer 24213119
ENSG00000187772 LIN28B tumors 24244607
ENSG00000187772 LIN28B gastric cancer 24276240
ENSG00000187772 LIN28B oral cancer 24386298
ENSG00000187772 LIN28B tumors 24498170
ENSG00000187772 LIN28B Wilms tumor 24732380
ENSG00000187772 LIN28B non-small cell lung cancer 24780874
ENSG00000187772 LIN28B tumor 24839957
ENSG00000187772 LIN28B breast cancers 24885919
ENSG00000187772 LIN28B tumor 24958470
ENSG00000187772 LIN28B tumor 25165876
ENSG00000187772 LIN28B gastric cancer 25197381
ENSG00000187772 LIN28B prostate cancer 25201220
ENSG00000187772 LIN28B tumor 25277326
ENSG00000187772 LIN28B cancer 25301052
ENSG00000187772 LIN28B tumour 25360631
ENSG00000187772 LIN28B oral cavity cancer 25503985
ENSG00000187772 LIN28B gastric cancer 25633261
ENSG00000187772 LIN28B cancers 25638158
ENSG00000187772 LIN28B tumor 25726847
ENSG00000187772 LIN28B Cancer 25744721
ENSG00000187772 LIN28B cancers 25858147
ENSG00000187772 LIN28B tumor 25861255
ENSG00000187772 LIN28B tumor 25925570
ENSG00000187772 LIN28B tumor 25956904
ENSG00000187772 LIN28B cancer 26028027
ENSG00000187772 LIN28B cancer 26080928
ENSG00000187772 LIN28B cancer 26123544
ENSG00000187772 LIN28B tumor 26123663
ENSG00000187772 LIN28B tumours 26158423
ENSG00000187772 LIN28B cancers 26244988
ENSG00000187772 LIN28B breast cancers 26379447
ENSG00000187772 LIN28B cancer 26399619
ENSG00000187772 LIN28B oral cancers 26478718
ENSG00000187772 LIN28B prostate cancer 26501150
ENSG00000187772 LIN28B pancreatic cancer 26609473
ENSG00000187772 LIN28B childhood tumor 26674877
ENSG00000187772 LIN28B tumor 26733615
ENSG00000187772 LIN28B cancer 26851235
ENSG00000187772 LIN28B pancreatic cancer 26910839
ENSG00000187772 LIN28B cancer 26917013
ENSG00000187772 LIN28B Tumor 26997273
ENSG00000187772 LIN28B malignant tumors 27007052
ENSG00000187772 LIN28B cancer 27021521
ENSG00000187772 LIN28B tumor 27039094
ENSG00000187772 LIN28B embryonal tumors 27095948
ENSG00000187772 LIN28B tumor 27102443
ENSG00000187772 LIN28B prostate cancer 27197175
ENSG00000187772 LIN28B tumor 27197189
ENSG00000187772 LIN28B cancer 27248826
ENSG00000187772 LIN28B tumors 27296804
ENSG00000187772 LIN28B tumor 27383785
ENSG00000187772 LIN28B gastric cancer 27513187
ENSG00000187772 LIN28B tumor 27562754
ENSG00000187772 LIN28B cancer 27713163
ENSG00000187772 LIN28B tumors 27773931
ENSG00000187772 LIN28B colon cancer 27793004
ENSG00000187772 LIN28B tumor 27821801
ENSG00000187772 LIN28B Cancer 28011885
ENSG00000187772 LIN28B lung cancer 28218277
ENSG00000187772 LIN28B Wilms tumor 28301057
ENSG00000187772 LIN28B Liver Cancer 28367203
ENSG00000187772 LIN28B tumors 28400788
ENSG00000187772 LIN28B cancer 28404969
ENSG00000187772 LIN28B cancer 28482074
ENSG00000187772 LIN28B lung cancer 28486418
ENSG00000187772 LIN28B lung cancer 28603287
ENSG00000187772 LIN28B cancer 28693523
ENSG00000187772 LIN28B Cancer 28710315
ENSG00000187772 LIN28B Cancer 28741513
ENSG00000187772 LIN28B tumors 28825729
ENSG00000187772 LIN28B cancer 28910332
ENSG00000187772 LIN28B pancreatic cancer 28947981
ENSG00000187772 LIN28B cancer 28949784
ENSG00000187772 LIN28B tumor 28950674
ENSG00000187772 LIN28B tumor 29222745
ENSG00000187772 LIN28B lung cancer 29301498
ENSG00000187772 LIN28B tumour 29315268
ENSG00000187772 LIN28B colorectal cancers 29330293
ENSG00000187772 LIN28B tumor 29336272
ENSG00000187772 LIN28B tumor 29383160
ENSG00000187772 LIN28B acute myeloid leukemia (AML) 29437595
ENSG00000187772 LIN28B Cancer 29466730
ENSG00000187772 LIN28B tumor 29492199
ENSG00000187772 LIN28B tumor 29503447
ENSG00000187772 LIN28B cancer 29576613
ENSG00000187772 LIN28B tumor 29587439
ENSG00000187772 LIN28B tumor 29660014
ENSG00000187772 LIN28B colon cancer 29669301
ENSG00000187772 LIN28B AML 29707103
ENSG00000187772 LIN28B colon cancer 29725425
ENSG00000187772 LIN28B gastric cancer 29787985
ENSG00000187772 LIN28B gastric cancers 29802314
ENSG00000187772 LIN28B lung cancer 29950144
ENSG00000187772 LIN28B Tumours 29972883
ENSG00000187772 LIN28B tumor 30027143
ENSG00000187772 LIN28B cancer 30046338
ENSG00000187772 LIN28B cancer 30057901
ENSG00000187772 LIN28B cancer 30060526
ENSG00000187772 LIN28B tumor 30154460
ENSG00000187772 LIN28B ovarian cancer 30174831
ENSG00000187772 LIN28B cancer 30353165
ENSG00000187772 LIN28B cancer 30429015
ENSG00000187772 LIN28B tumors 30504901
ENSG00000187772 LIN28B tumors 30530054
ENSG00000187772 LIN28B cancer 30615673
ENSG00000187772 LIN28B tumor 30635573
ENSG00000187772 LIN28B cancer 30742065
ENSG00000187772 LIN28B tumor 30760980
ENSG00000187772 LIN28B pediatric tumor 30867811
ENSG00000187772 LIN28B breast cancer 30917918
ENSG00000187772 LIN28B lung cancer 30926969
ENSG00000187772 LIN28B Cancer 30953666
ENSG00000187772 LIN28B small cell lung cancer 31079917
ENSG00000187772 LIN28B cancer 31085453
ENSG00000187772 LIN28B Cancer 31147574
ENSG00000187772 LIN28B cancer 31215730
ENSG00000187772 LIN28B cancer 31240246
ENSG00000187772 LIN28B cancer 31413760
ENSG00000187772 LIN28B cancer 31440515
ENSG00000187772 LIN28B cancer 31484926
ENSG00000187772 LIN28B cancer 31485601
ENSG00000187772 LIN28B tumor 31510013
ENSG00000187772 LIN28B tumor 31601998
ENSG00000187772 LIN28B tumor 31638206
ENSG00000187772 LIN28B colon cancer 31692974
ENSG00000187772 LIN28B cancer 31705593
ENSG00000187772 LIN28B colorectal cancer 31713927
ENSG00000187772 LIN28B breast cancer 31754343
ENSG00000187772 LIN28B tumor 31762817
ENSG00000187772 LIN28B lung tumor 31766078
ENSG00000187772 LIN28B breast cancer 31907362
ENSG00000187772 LIN28B cancer 31925101
ENSG00000187772 LIN28B tumor 31970774
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000187772 LIN28B MESO 0.025 high
ENSG00000187772 LIN28B SARC 0.048 high
ENSG00000187772 LIN28B STAD 0.0042 high
ENSG00000187772 LIN28B CHOL 0.00063 high
ENSG00000187772 LIN28B UCEC 0.00017 high
ENSG00000187772 LIN28B ACC 0.0059 high
ENSG00000187772 LIN28B LGG 0.0026 high
ENSG00000187772 LIN28B KIRP 0.0033 high
ENSG00000187772 LIN28B PCPG 0.0089 high
ENSG00000187772 LIN28B OV 0.022 high
ENSG00000187772 LIN28B TGCT 0.013 high
ENSG00000187772 LIN28B BLCA 0.0022 high
ENSG00000187772 LIN28B GBM 0.041 high
ENSG00000187772 LIN28B LIHC 0.00011 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000187772 LIN28B LUAD Del 1.151475 0.057490 0.378931 0.501938
ENSG00000187772 LIN28B SKCM Del 4.476889 0.116525 0.567551 0.577657
ENSG00000187772 LIN28B LIHC Del 1.732792 0.081930 0.607019 0.337838
ENSG00000187772 LIN28B DLBC Del 3.886310 0.299984 0.598820 0.395833
ENSG00000187772 LIN28B BLCA Del 2.551717 0.105877 0.386594 0.446078
ENSG00000187772 LIN28B BRCA Amp 3.420045 0.191254 0.715489 0.174074
ENSG00000187772 LIN28B BRCA Del 4.413345 0.089519 0.486758 0.314815
ENSG00000187772 LIN28B STAD Del 1.470788 0.071686 0.395230 0.190476
ENSG00000187772 LIN28B PRAD Del 42.812035 0.302790 0.545560 0.323171
ENSG00000187772 LIN28B MESO Del 1.255423 0.146842 0.521416 0.471264
ENSG00000187772 LIN28B KIRC Del 1.283770 0.028502 0.443852 0.267045
ENSG00000187772 LIN28B OV Del 2.100276 0.204376 0.616651 0.521589