Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000181381 Gene ID 91351 Accession 26429
Symbol DDX60L Alias NA Full Name DExD/H-box 60 like
Status Confidence Length 123780 bases Strand Minus strand
Position 4 : 168356735 - 168480514 RNA binding domain ResIII , DEAD
Summary This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000422202 DEAD PF00270 1.4e-14 1
ENSP00000422202 ResIII PF04851 3.1e-10 2
ENSP00000422423 DEAD PF00270 2e-14 1
ENSP00000422423 ResIII PF04851 6.8e-10 2
ENSP00000507872 DEAD PF00270 2e-14 1
ENSP00000507872 ResIII PF04851 6.8e-10 2
ENSP00000421026 DEAD PF00270 3.5e-06 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
DDX60L-207 ENST00000510590 3509 No protein -
DDX60L-216 ENST00000682922 6759 1706aa ENSP00000507872
DDX60L-208 ENST00000511577 6781 1706aa ENSP00000422423
DDX60L-211 ENST00000513103 507 No protein -
DDX60L-206 ENST00000505890 4568 1308aa ENSP00000422202
DDX60L-213 ENST00000514580 813 195aa ENSP00000422920
DDX60L-201 ENST00000503190 562 No protein -
DDX60L-205 ENST00000505863 2605 868aa ENSP00000421026
DDX60L-202 ENST00000504793 549 No protein -
DDX60L-204 ENST00000505696 588 124aa ENSP00000424310
DDX60L-214 ENST00000514748 632 98aa ENSP00000424396
DDX60L-215 ENST00000515088 2652 No protein -
DDX60L-212 ENST00000513901 623 No protein -
DDX60L-209 ENST00000512371 428 77aa ENSP00000427386
DDX60L-203 ENST00000505150 655 No protein -
DDX60L-210 ENST00000512958 769 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
26755Blood Pressure8.5170000E-005-
59967Hypertension2.8164309E-005-
64277Liver Cirrhosis6E-720708005
64278Non-alcoholic Fatty Liver Disease6E-720708005
84032Energy Intake8E-623251661

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000181381homo_sapiensENSP0000026423312.85716.67954homo_sapiensENSP0000050787219.519310.1407
ENSG00000181381homo_sapiensENSP0000036454326.725515.0883homo_sapiensENSP0000050787219.519311.0199
ENSG00000181381homo_sapiensENSP0000031712317.50948.2397homo_sapiensENSP0000050787221.922610.3165
ENSG00000181381homo_sapiensENSP0000035945422.020910.1742homo_sapiensENSP0000050787218.52298.55803
ENSG00000181381homo_sapiensENSP0000029548830.88115.8038homo_sapiensENSP0000050787219.929710.1993
ENSG00000181381homo_sapiensENSP0000037734478.855165.479homo_sapiensENSP0000050787279.132565.7093
ENSG00000181381homo_sapiensENSP0000035815917.98378.03815homo_sapiensENSP0000050787223.212210.3751
ENSG00000181381homo_sapiensENSP0000023064026.679514.2994homo_sapiensENSP0000050787216.29548.73388

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000181381homo_sapiensENSP0000050787297.538195.7796nomascus_leucogenysENSNLEP0000000798597.48195.7235
ENSG00000181381homo_sapiensENSP0000050787299.003598.2415pan_paniscusENSPPAP0000000349398.48497.7259
ENSG00000181381homo_sapiensENSP0000050787297.655396.0727pongo_abeliiENSPPYP0000001696797.655396.0727
ENSG00000181381homo_sapiensENSP0000050787299.003598.3001pan_troglodytesENSPTRP0000007546398.48497.7843
ENSG00000181381homo_sapiensENSP0000050787298.47697.5967gorilla_gorillaENSGGOP0000001443697.959297.0845
ENSG00000181381homo_sapiensENSP0000050787289.390483.177callithrix_jacchusENSCJAP0000000869291.481785.123
ENSG00000181381homo_sapiensENSP0000050787295.310791.7937cercocebus_atysENSCATP0000004341994.976691.472
ENSG00000181381homo_sapiensENSP0000050787295.193491.6178macaca_fascicularisENSMFAP0000002800995.193491.6178
ENSG00000181381homo_sapiensENSP0000050787295.369391.6764macaca_mulattaENSMMUP0000004640794.758391.0891
ENSG00000181381homo_sapiensENSP0000050787295.486591.9695macaca_nemestrinaENSMNEP0000001032295.040891.5403
ENSG00000181381homo_sapiensENSP0000050787294.783191.442papio_anubisENSPANP0000001203795.005991.6569
ENSG00000181381homo_sapiensENSP0000050787295.017691.5006mandrillus_leucophaeusENSMLEP0000000698294.739991.2332
ENSG00000181381homo_sapiensENSP0000050787284.466675.1465equus_asinusENSEASP0000503188383.827874.5782
ENSG00000181381homo_sapiensENSP0000050787226.846422.9191loxodonta_africanaENSLAFP0000002453978.424766.9521
ENSG00000181381homo_sapiensENSP0000050787284.525275.4396equus_caballusENSECAP0000004299083.934874.9127
ENSG00000181381homo_sapiensENSP0000050787215.94377.32708marmota_marmota_marmotaENSMMMP0000000871126.904112.364
ENSG00000181381homo_sapiensENSP0000050787288.569883.0012aotus_nancymaaeENSANAP0000002932192.07886.2888
ENSG00000181381homo_sapiensENSP0000050787290.97385.4631saimiri_boliviensis_boliviensisENSSBOP0000003648890.760285.2632
ENSG00000181381homo_sapiensENSP0000050787295.017691.2075chlorocebus_sabaeusENSCSAP0000001489394.684690.8878
ENSG00000181381homo_sapiensENSP0000050787284.759774.7948carlito_syrichtaENSTSYP0000001208084.610974.6635
ENSG00000181381homo_sapiensENSP0000050787293.317789.5076rhinopithecus_bietiENSRBIP0000000602294.312890.4621
ENSG00000181381homo_sapiensENSP0000050787290.269684.5252cebus_imitatorENSCCAP0000002477591.016585.2246
ENSG00000181381homo_sapiensENSP0000050787295.545192.0281rhinopithecus_roxellanaENSRROP0000003199895.154791.6521
ENSG00000181381homo_sapiensENSP0000050787220.92619.61313caenorhabditis_elegansY46G5A.4.116.64347.64569
ENSG00000181381homo_sapiensENSP000005078721.05510.410317oncorhynchus_mykissENSOMYP0000000035917.30776.73077
ENSG00000181381homo_sapiensENSP000005078721.40680.410317pygocentrus_nattereriENSPNAP0000002989721.62166.30631
ENSG00000181381homo_sapiensENSP0000050787215.29896.6823saccharomyces_cerevisiaeYGL251C21.98829.60404
ENSG00000181381homo_sapiensENSP0000050787219.98838.85111saccharomyces_cerevisiaeYER172C15.76516.98104
ENSG00000181381homo_sapiensENSP000005078725.392732.8136poecilia_latipinnaENSPLAP0000000067628.571414.9068
ENSG00000181381homo_sapiensENSP000005078724.337632.34467sinocyclocheilus_grahamiENSSGRP0000007553522.769212.3077

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003724enables RNA helicase activity1IEAHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding1IBAHomo_sapiens(9606)Function
GO:0003727enables single-stranded RNA binding1IBAHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0016887enables ATP hydrolysis activity1IEAHomo_sapiens(9606)Function
GO:0051607involved_in defense response to virus1IBAHomo_sapiens(9606)Process

Expression