Ensembl ID ENSG00000181381 Gene ID 91351 Accession 26429
Gene Symbol DDX60L Alias NA Full Name DExD/H-box 60 like
Position 4 : 168356735 - 168480514 Length 123780 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This gene encodes a member of the DExD/H-box helicase family of proteins, a subset of the super family 2 helicases. Members of the DExD/H-box helicase family share a conserved functional core comprised of two RecA-like globular domains. These domains contain conserved motifs that mediate ATP binding, ATP hydrolysis, nucleic acid binding, and RNA unwinding. In addition to functions in RNA metabolism, members of this family are involved in anti-viral immunity and act as cytosolic sensors of viral nucleic acids. The protein encoded by this gene has been shown to inhibit hepatitis C virus replication in response to interferon stimulation in cell culture. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

ENSG00000181381 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000181381 DDX60L 0.95 5.89e-35 KIRC
ENSG00000181381 DDX60L 1.55 1.02e-20 HNSC
ENSG00000181381 DDX60L -0.8 2.41e-11 LUSC
ENSG00000181381 DDX60L 0.89 1.06e-16 KIRP
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000181381 DDX60L MESO 0.0088 low
ENSG00000181381 DDX60L SARC 0.017 low
ENSG00000181381 DDX60L UVM 0.0014 high
ENSG00000181381 DDX60L PAAD 2e-04 high
ENSG00000181381 DDX60L THCA 0.021 low
ENSG00000181381 DDX60L ACC 0.027 low
ENSG00000181381 DDX60L HNSC 0.034 high
ENSG00000181381 DDX60L READ 0.0013 low
ENSG00000181381 DDX60L LUAD 0.026 high
ENSG00000181381 DDX60L PCPG 0.006 low
ENSG00000181381 DDX60L THYM 0.028 low
ENSG00000181381 DDX60L COAD 0.034 low
ENSG00000181381 DDX60L UCS 0.014 low
ENSG00000181381 DDX60L DLBC 0.00079 high
ENSG00000181381 DDX60L KIRC 0.0041 high
ENSG00000181381 DDX60L LAML 0.03 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000181381 DDX60L LUSC Del 10.274865 0.151917 0.396163 0.666667
ENSG00000181381 DDX60L LUAD Del 3.349197 0.079940 0.306141 0.341085
ENSG00000181381 DDX60L LGG Del 10.280019 0.105732 0.463056 0.259259
ENSG00000181381 DDX60L CESC Del 2.357551 0.096521 0.471215 0.362712
ENSG00000181381 DDX60L COAD Del 4.261432 0.075137 0.427644 0.317073
ENSG00000181381 DDX60L SARC Del 3.151439 0.182408 0.489478 0.315175
ENSG00000181381 DDX60L GBM Del 0.893419 0.054414 0.422122 0.135182
ENSG00000181381 DDX60L HNSC Del 5.401819 0.094784 0.361379 0.350575
ENSG00000181381 DDX60L LIHC Del 3.540656 0.105046 0.553575 0.421622
ENSG00000181381 DDX60L BLCA Del 6.138353 0.145149 0.378274 0.404412
ENSG00000181381 DDX60L BRCA Del 2.909927 0.080798 0.392702 0.311111
ENSG00000181381 DDX60L STAD Del 3.681674 0.096481 0.346997 0.414966
ENSG00000181381 DDX60L UCEC Del 0.955054 0.051220 0.455051 0.211503
ENSG00000181381 DDX60L OV Del 11.103853 0.310210 0.630505 0.685665