Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerFlavivirusesHIVRVSARS-COV-2SINVDengue
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Nucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000168496 Gene ID 2237 Accession 3650
Symbol FEN1 Alias MF1;RAD2;FEN-1 Full Name flap structure-specific endonuclease 1
Status Confidence Length 4328 bases Strand Plus strand
Position 11 : 61792911 - 61797238 RNA binding domain N.A.
Summary The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
27867099 Risky repair: DNA-protein crosslinks formed by mitochondrial base excision DNA repair enzymes acting on free radical lesions. Audrey Rachel Caston 2017-06-01 Free radical biology & medicine
35883563 Small-Molecule Inhibitors Targeting FEN1 for Cancer Therapy. Fan Yang 2022-07-20 Biomolecules
23675412 A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties. Lawrence Kazak 2013-01-01 PloS one
30184152 SUMO-1 modification of FEN1 facilitates its interaction with Rad9-Rad1-Hus1 to counteract DNA replication stress. Xiaoli Xu 2018-10-01 Journal of molecular cell biology
17038322 Flap endonuclease disengages Dna2 helicase/nuclease from Okazaki fragment flaps. A Jason Stewart 2006-12-15 The Journal of biological chemistry
23451868 Flap endonuclease 1. Lata Balakrishnan 2013-01-01 Annual review of biochemistry
27926991 Human mitochondrial nucleases. Francesco Bruni 2017-06-01 The FEBS journal
36829835 RNA G-Quadruplex within the 5'-UTR of FEN1 Regulates mRNA Stability under Oxidative Stress. Ying Ma 2023-01-26 Antioxidants (Basel, Switzerland)
36030671 Lighting-up aptamer transcriptional amplification for highly sensitive and label-free FEN1 detection. Lei Liao 2023-01-05 Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

Transcripts

Name Transcript ID bp Protein Translation ID
FEN1-201 ENST00000305885 2016 380aa ENSP00000305480
FEN1-203 ENST00000535723 776 165aa ENSP00000445692
FEN1-202 ENST00000535307 768 154aa ENSP00000460402

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
57338alpha-Linolenic Acid8.5920000E-06021829377
57389Docosahexaenoic Acids5.2470000E-00621829377
57437docosapentaenoic acid1.3800000E-13921829377
57483Eicosapentaenoic Acid5.9610000E-05521829377
61380Metabolism9E-1424816252
62155Platelet Count3E-1022139419
69931Eicosapentaenoic Acid6E-5521829377
76215Eicosapentaenoic Acid5E-5821829377
83484alpha-Linolenic Acid9E-6021829377
83574docosapentaenoic acid1E-13921829377
87347Trans Fatty Acids5E-1325646338
88695Trans Fatty Acids1E-1225646338
89746Insulin Resistance3E-923378610
99853Inflammatory Bowel Diseases2E-1523128233
100051Fatty Acids1E-925500335
100052Linoleic Acid1E-925500335
100656Trans Fatty Acids4E-1325646338
101872Crohn Disease9E-728067908
103354Fatty Acids3E-1925500335

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000168496homo_sapiensENSP0000035550618.676111.2293homo_sapiensENSP0000030548041.578925
ENSG00000168496homo_sapiensENSP0000037065319.16310.793homo_sapiensENSP0000030548045.789525.7895

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000168496homo_sapiensENSP0000030548099.736899.4737nomascus_leucogenysENSNLEP0000000378399.736899.4737
ENSG00000168496homo_sapiensENSP00000305480100100pan_paniscusENSPPAP00000006842100100
ENSG00000168496homo_sapiensENSP0000030548093.947492.6316pongo_abeliiENSPPYP0000000366992.010390.7216
ENSG00000168496homo_sapiensENSP00000305480100100pan_troglodytesENSPTRP00000006454100100
ENSG00000168496homo_sapiensENSP00000305480100100gorilla_gorillaENSGGOP00000012253100100
ENSG00000168496homo_sapiensENSP0000030548095.526388.9474ornithorhynchus_anatinusENSOANP0000004404095.026288.4817
ENSG00000168496homo_sapiensENSP0000030548094.473788.6842sarcophilus_harrisiiENSSHAP0000000421394.473788.6842
ENSG00000168496homo_sapiensENSP0000030548095.526389.7368notamacropus_eugeniiENSMEUP0000000385395.526389.7368
ENSG00000168496homo_sapiensENSP0000030548097.631696.5789choloepus_hoffmanniENSCHOP0000001033797.631696.5789
ENSG00000168496homo_sapiensENSP0000030548097.368495.2632dasypus_novemcinctusENSDNOP0000002609497.625395.5145
ENSG00000168496homo_sapiensENSP0000030548098.157995.7895echinops_telfairiENSETEP0000000598798.157995.7895
ENSG00000168496homo_sapiensENSP0000030548099.736898.9474callithrix_jacchusENSCJAP0000007368799.736898.9474
ENSG00000168496homo_sapiensENSP0000030548010099.2105cercocebus_atysENSCATP0000000144610099.2105
ENSG00000168496homo_sapiensENSP0000030548010099.2105macaca_fascicularisENSMFAP0000001073410099.2105
ENSG00000168496homo_sapiensENSP0000030548010099.2105macaca_mulattaENSMMUP0000000875410099.2105
ENSG00000168496homo_sapiensENSP0000030548010099.2105macaca_nemestrinaENSMNEP0000000397310099.2105
ENSG00000168496homo_sapiensENSP0000030548010099.2105papio_anubisENSPANP0000001816710099.2105
ENSG00000168496homo_sapiensENSP0000030548099.736898.9474mandrillus_leucophaeusENSMLEP0000000302599.736898.9474
ENSG00000168496homo_sapiensENSP0000030548099.210597.6316tursiops_truncatusENSTTRP0000001065599.210597.6316
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579vulpes_vulpesENSVVUP0000000533199.210598.1579
ENSG00000168496homo_sapiensENSP0000030548098.157996.8421mus_spretusMGP_SPRETEiJ_P005008598.157996.8421
ENSG00000168496homo_sapiensENSP0000030548098.947498.1579equus_asinusENSEASP0000504909494.235693.4837
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579capra_hircusENSCHIP0000000501799.210598.1579
ENSG00000168496homo_sapiensENSP0000030548098.157996.8421panthera_leoENSPLOP0000001005898.157996.8421
ENSG00000168496homo_sapiensENSP0000030548099.210598.4211bos_indicus_hybridENSBIXP0000503002099.210598.4211
ENSG00000168496homo_sapiensENSP0000030548099.210597.6316oryctolagus_cuniculusENSOCUP0000000285199.210597.6316
ENSG00000168496homo_sapiensENSP0000030548098.947498.1579equus_caballusENSECAP0000006798798.947498.1579
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579canis_lupus_familiarisENSCAFP0084501574699.210598.1579
ENSG00000168496homo_sapiensENSP0000030548098.157996.8421panthera_pardusENSPPRP0000002621898.157996.8421
ENSG00000168496homo_sapiensENSP0000030548099.210598.4211marmota_marmota_marmotaENSMMMP0000000220999.210598.4211
ENSG00000168496homo_sapiensENSP0000030548099.210597.6316balaenoptera_musculusENSBMSP0001000986399.210597.6316
ENSG00000168496homo_sapiensENSP0000030548097.368494.4737cavia_porcellusENSCPOP0000003222397.368494.4737
ENSG00000168496homo_sapiensENSP0000030548098.421197.1053felis_catusENSFCAP0000001269398.421197.1053
ENSG00000168496homo_sapiensENSP0000030548098.684297.6316ursus_americanusENSUAMP0000002364498.684297.6316
ENSG00000168496homo_sapiensENSP0000030548093.157985.5263monodelphis_domesticaENSMODP0000002707793.157985.5263
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579bison_bison_bisonENSBBBP0000001067799.210598.1579
ENSG00000168496homo_sapiensENSP0000030548099.210597.6316monodon_monocerosENSMMNP0001502508799.210597.6316
ENSG00000168496homo_sapiensENSP0000030548098.421196.8421sus_scrofaENSSSCP0000007972498.421196.8421
ENSG00000168496homo_sapiensENSP0000030548082.894778.9474microcebus_murinusENSMICP0000004212386.301482.1918
ENSG00000168496homo_sapiensENSP0000030548097.105392.8947octodon_degusENSODEP0000002604697.105392.8947
ENSG00000168496homo_sapiensENSP0000030548098.684297.6316jaculus_jaculusENSJJAP0000000891598.684297.6316
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579ovis_aries_rambouilletENSOARP0002002203399.210598.1579
ENSG00000168496homo_sapiensENSP0000030548098.684297.3684ursus_maritimusENSUMAP0000001637998.684297.3684
ENSG00000168496homo_sapiensENSP0000030548099.210597.8947delphinapterus_leucasENSDLEP0000000047899.210597.8947
ENSG00000168496homo_sapiensENSP0000030548099.210597.8947physeter_catodonENSPCTP0000501190899.210597.8947
ENSG00000168496homo_sapiensENSP0000030548098.157996.5789mus_caroliMGP_CAROLIEiJ_P004810798.157996.5789
ENSG00000168496homo_sapiensENSP0000030548097.894796.5789mus_musculusENSMUSP0000011724697.894796.5789
ENSG00000168496homo_sapiensENSP0000030548098.947496.8421dipodomys_ordiiENSDORP0000000190998.947496.8421
ENSG00000168496homo_sapiensENSP0000030548098.421196.3158mustela_putorius_furoENSMPUP0000001986598.421196.3158
ENSG00000168496homo_sapiensENSP0000030548099.736898.9474aotus_nancymaaeENSANAP0000000387899.736898.9474
ENSG00000168496homo_sapiensENSP0000030548099.473798.6842saimiri_boliviensis_boliviensisENSSBOP0000000474899.473798.6842
ENSG00000168496homo_sapiensENSP0000030548091.052690.2632chlorocebus_sabaeusENSCSAP0000000275110099.1329
ENSG00000168496homo_sapiensENSP0000030548099.736898.1579tupaia_belangeriENSTBEP0000001188999.736898.1579
ENSG00000168496homo_sapiensENSP0000030548098.421197.3684mesocricetus_auratusENSMAUP0000001196098.421197.3684
ENSG00000168496homo_sapiensENSP0000030548099.210597.8947phocoena_sinusENSPSNP0000002209399.210597.8947
ENSG00000168496homo_sapiensENSP0000030548099.210597.8947camelus_dromedariusENSCDRP0000501048399.210597.8947
ENSG00000168496homo_sapiensENSP0000030548098.947498.4211carlito_syrichtaENSTSYP0000002571698.947498.4211
ENSG00000168496homo_sapiensENSP0000030548098.157996.8421panthera_tigris_altaicaENSPTIP0000000060998.157996.8421
ENSG00000168496homo_sapiensENSP0000030548098.421196.3158rattus_norvegicusENSRNOP0000002784298.421196.3158
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579prolemur_simusENSPSMP0000003116099.210598.1579
ENSG00000168496homo_sapiensENSP0000030548098.421197.3684microtus_ochrogasterENSMOCP0000001311998.421197.3684
ENSG00000168496homo_sapiensENSP0000030548098.421197.6316peromyscus_maniculatus_bairdiiENSPEMP0000000800798.421197.6316
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579bos_mutusENSBMUP0000000031999.210598.1579
ENSG00000168496homo_sapiensENSP0000030548098.157996.8421mus_spicilegusENSMSIP0000003171498.157996.8421
ENSG00000168496homo_sapiensENSP0000030548098.421197.6316cricetulus_griseus_chok1gshdENSCGRP0000100747798.421197.6316
ENSG00000168496homo_sapiensENSP0000030548098.684296.8421pteropus_vampyrusENSPVAP0000001164198.425296.5879
ENSG00000168496homo_sapiensENSP0000030548098.684297.1053myotis_lucifugusENSMLUP0000000946198.684297.1053
ENSG00000168496homo_sapiensENSP0000030548095.789590.2632vombatus_ursinusENSVURP0001000374095.789590.2632
ENSG00000168496homo_sapiensENSP0000030548098.157996.8421rhinolophus_ferrumequinumENSRFEP0001000079598.677297.3545
ENSG00000168496homo_sapiensENSP0000030548098.684296.5789neovison_visonENSNVIP0000002778498.684296.5789
ENSG00000168496homo_sapiensENSP0000030548099.210598.4211bos_taurusENSBTAP0000000007199.210598.4211
ENSG00000168496homo_sapiensENSP0000030548097.105394.7368heterocephalus_glaber_femaleENSHGLP0000003819695.103192.7835
ENSG00000168496homo_sapiensENSP0000030548010099.4737rhinopithecus_bietiENSRBIP0000000315210099.4737
ENSG00000168496homo_sapiensENSP0000030548099.473798.4211sciurus_vulgarisENSSVLP0000500910799.473798.4211
ENSG00000168496homo_sapiensENSP0000030548092.368483.9474phascolarctos_cinereusENSPCIP0000001321393.850385.2941
ENSG00000168496homo_sapiensENSP0000030548092.631691.0526procavia_capensisENSPCAP0000001598597.777896.1111
ENSG00000168496homo_sapiensENSP0000030548099.210597.1053nannospalax_galiliENSNGAP0000000058599.210597.1053
ENSG00000168496homo_sapiensENSP0000030548097.631694.4737chinchilla_lanigeraENSCLAP0000001251897.631694.4737
ENSG00000168496homo_sapiensENSP0000030548099.210598.4211cervus_hanglu_yarkandensisENSCHYP0000001862199.210598.4211
ENSG00000168496homo_sapiensENSP0000030548098.421196.5789catagonus_wagneriENSCWAP0000002640998.421196.5789
ENSG00000168496homo_sapiensENSP0000030548099.210598.4211ictidomys_tridecemlineatusENSSTOP0000000302199.210598.4211
ENSG00000168496homo_sapiensENSP0000030548099.736898.1579otolemur_garnettiiENSOGAP0000001886299.736898.1579
ENSG00000168496homo_sapiensENSP0000030548090.263289.7368cebus_imitatorENSCCAP0000001256099.420398.8406
ENSG00000168496homo_sapiensENSP0000030548098.947498.1579urocitellus_parryiiENSUPAP0001000590498.947498.1579
ENSG00000168496homo_sapiensENSP0000030548099.473798.6842moschus_moschiferusENSMMSP0000001873799.473798.6842
ENSG00000168496homo_sapiensENSP0000030548010099.4737rhinopithecus_roxellanaENSRROP0000000452010099.4737
ENSG00000168496homo_sapiensENSP0000030548097.894796.5789mus_pahariMGP_PahariEiJ_P002110397.894796.5789
ENSG00000168496homo_sapiensENSP0000030548099.210598.1579propithecus_coquereliENSPCOP0000000455599.210598.1579
ENSG00000168496homo_sapiensENSP0000030548076.578961.8421caenorhabditis_elegansY47G6A.8.176.17861.5183
ENSG00000168496homo_sapiensENSP0000030548079.473763.4211drosophila_melanogasterFBpp008622378.441662.5974
ENSG00000168496homo_sapiensENSP0000030548052.631641.0526petromyzon_marinusENSPMAP0000001038988.495669.0266
ENSG00000168496homo_sapiensENSP0000030548087.631675eptatretus_burgeriENSEBUP0000000226287.172874.6073
ENSG00000168496homo_sapiensENSP0000030548046.315838.4211callorhinchus_miliiENSCMIP000000036588066.3636
ENSG00000168496homo_sapiensENSP0000030548021.315814.4737callorhinchus_miliiENSCMIP0000000316576.415151.8868
ENSG00000168496homo_sapiensENSP0000030548075.789564.7368latimeria_chalumnaeENSLACP0000000175190.851777.6025
ENSG00000168496homo_sapiensENSP0000030548084.210571.5789clupea_harengusENSCHAP0000006196083.989571.3911
ENSG00000168496homo_sapiensENSP0000030548088.947476.8421danio_rerioENSDARP0000014422288.947476.8421
ENSG00000168496homo_sapiensENSP0000030548088.684275.7895carassius_auratusENSCARP0000009803388.684275.7895
ENSG00000168496homo_sapiensENSP0000030548088.684277.1053carassius_auratusENSCARP0000011793480.815370.2638
ENSG00000168496homo_sapiensENSP0000030548084.736872.1053astyanax_mexicanusENSAMXP0000003016878.536666.8293
ENSG00000168496homo_sapiensENSP0000030548088.157975ictalurus_punctatusENSIPUP0000000186488.157975
ENSG00000168496homo_sapiensENSP0000030548088.157976.0526esox_luciusENSELUP0000004028388.157976.0526
ENSG00000168496homo_sapiensENSP0000030548088.157975.2632electrophorus_electricusENSEEEP0000003287588.157975.2632
ENSG00000168496homo_sapiensENSP0000030548039.210531.3158oncorhynchus_kisutchENSOKIP0000505713065.350952.193
ENSG00000168496homo_sapiensENSP0000030548088.421175oncorhynchus_kisutchENSOKIP0000505749488.421175
ENSG00000168496homo_sapiensENSP0000030548039.210531.3158oncorhynchus_kisutchENSOKIP0000505724165.350952.193
ENSG00000168496homo_sapiensENSP0000030548024.210518.6842oncorhynchus_kisutchENSOKIP0000510330056.097643.2927
ENSG00000168496homo_sapiensENSP0000030548042.368430.7895oncorhynchus_mykissENSOMYP0000011425066.528948.3471
ENSG00000168496homo_sapiensENSP0000030548088.684275oncorhynchus_mykissENSOMYP0000000814880.815368.3453
ENSG00000168496homo_sapiensENSP0000030548087.894774.2105salmo_salarENSSSAP0000017332679.713667.3031
ENSG00000168496homo_sapiensENSP0000030548048.157937.3684salmo_truttaENSSTUP0000000133365.124650.5338
ENSG00000168496homo_sapiensENSP0000030548087.894773.9474salmo_truttaENSSTUP0000002497684.343470.9596
ENSG00000168496homo_sapiensENSP0000030548087.631675.2632gadus_morhuaENSGMOP0000000185587.631675.2632
ENSG00000168496homo_sapiensENSP0000030548082.368470.5263fundulus_heteroclitusENSFHEP0000000803085.054372.8261
ENSG00000168496homo_sapiensENSP0000030548083.684271.0526poecilia_reticulataENSPREP0000002621080.30368.1818
ENSG00000168496homo_sapiensENSP0000030548087.368474.4737xiphophorus_maculatusENSXMAP0000000613687.368474.4737
ENSG00000168496homo_sapiensENSP0000030548086.578976.0526oryzias_latipesENSORLP0000003668176.157466.8981
ENSG00000168496homo_sapiensENSP0000030548086.578975.2632cyclopterus_lumpusENSCLMP0000501920686.578975.2632
ENSG00000168496homo_sapiensENSP0000030548086.052675oreochromis_niloticusENSONIP0000007656085.378674.4125
ENSG00000168496homo_sapiensENSP0000030548087.368475.5263haplochromis_burtoniENSHBUP0000002854287.368475.5263
ENSG00000168496homo_sapiensENSP0000030548085.263272.3684astatotilapia_callipteraENSACLP0000002866885.039472.1785
ENSG00000168496homo_sapiensENSP0000030548087.894776.5789sparus_aurataENSSAUP0001001463287.894776.5789
ENSG00000168496homo_sapiensENSP0000030548087.894776.5789sparus_aurataENSSAUP0001002707187.894776.5789
ENSG00000168496homo_sapiensENSP0000030548087.631676.0526lates_calcariferENSLCAP0001002010687.631676.0526
ENSG00000168496homo_sapiensENSP0000030548091.578980.5263xenopus_tropicalisENSXETP0000001466391.099580.1047
ENSG00000168496homo_sapiensENSP0000030548093.947485.5263chrysemys_picta_belliiENSCPBP0000002478393.455585.0785
ENSG00000168496homo_sapiensENSP0000030548092.368485.5263sphenodon_punctatusENSSPUP0000001707991.644984.8564
ENSG00000168496homo_sapiensENSP0000030548093.421184.7368crocodylus_porosusENSCPRP0000501446592.931984.2932
ENSG00000168496homo_sapiensENSP0000030548092.894782.3684laticauda_laticaudataENSLLTP0000001146392.408481.9372
ENSG00000168496homo_sapiensENSP0000030548093.421182.6316notechis_scutatusENSNSUP0000000422692.931982.199
ENSG00000168496homo_sapiensENSP0000030548093.421182.6316pseudonaja_textilisENSPTXP0000001840792.931982.199
ENSG00000168496homo_sapiensENSP0000030548092.894783.9474anas_platyrhynchos_platyrhynchosENSAPLP0000000114790.281381.5857
ENSG00000168496homo_sapiensENSP0000030548093.421184.4737gallus_gallusENSGALP0001003059193.175884.252
ENSG00000168496homo_sapiensENSP0000030548093.157984.2105meleagris_gallopavoENSMGAP0000002280558.223752.6316
ENSG00000168496homo_sapiensENSP0000030548092.368483.6842serinus_canariaENSSCAP0000001341990.932682.3834
ENSG00000168496homo_sapiensENSP0000030548093.157983.1579parus_majorENSPMJP0000000826591.709881.8653
ENSG00000168496homo_sapiensENSP0000030548090.526381.5789anolis_carolinensisENSACAP0000001915184.520976.1671
ENSG00000168496homo_sapiensENSP0000030548038.421133.9474neolamprologus_brichardiENSNBRP0000003192580.66371.2707
ENSG00000168496homo_sapiensENSP0000030548093.421182.6316naja_najaENSNNAP0000000090792.931982.199
ENSG00000168496homo_sapiensENSP0000030548093.947484.4737podarcis_muralisENSPMRP0000000232393.455584.0314
ENSG00000168496homo_sapiensENSP0000030548092.631683.4211geospiza_fortisENSGFOP0000001638691.191782.1244
ENSG00000168496homo_sapiensENSP0000030548092.368482.8947taeniopygia_guttataENSTGUP0000002162788.636479.5455
ENSG00000168496homo_sapiensENSP000003054809080.2632erpetoichthys_calabaricusENSECRP0000001702089.763880.0525
ENSG00000168496homo_sapiensENSP0000030548086.315875.2632kryptolebias_marmoratusENSKMAP0000000625686.315875.2632
ENSG00000168496homo_sapiensENSP0000030548092.631683.9474salvator_merianaeENSSMRP0000000402692.146683.5079
ENSG00000168496homo_sapiensENSP0000030548085.789575.5263oryzias_javanicusENSOJAP0000002089483.589773.5897
ENSG00000168496homo_sapiensENSP0000030548087.368476.0526amphilophus_citrinellusENSACIP0000002896387.368476.0526
ENSG00000168496homo_sapiensENSP0000030548086.315873.6842dicentrarchus_labraxENSDLAP0000501015584.974172.5389
ENSG00000168496homo_sapiensENSP0000030548087.894775.7895amphiprion_perculaENSAPEP0000000335987.894775.7895
ENSG00000168496homo_sapiensENSP0000030548027.368422.3684oryzias_sinensisENSOSIP0000002562075.912462.0438
ENSG00000168496homo_sapiensENSP0000030548093.947486.0526pelodiscus_sinensisENSPSIP0000001796685.817378.6058
ENSG00000168496homo_sapiensENSP0000030548093.421184.7368gopherus_evgoodeiENSGEVP0000502407192.931984.2932
ENSG00000168496homo_sapiensENSP0000030548093.421184.7368chelonoidis_abingdoniiENSCABP0000001401992.931984.2932
ENSG00000168496homo_sapiensENSP0000030548087.368475.2632seriola_dumeriliENSSDUP0000002446687.368475.2632
ENSG00000168496homo_sapiensENSP0000030548082.105370.5263cottoperca_gobioENSCGOP0000001228279.591868.3673
ENSG00000168496homo_sapiensENSP0000030548093.421183.1579struthio_camelus_australisENSSCUP0000000016992.931982.7225
ENSG00000168496homo_sapiensENSP0000030548093.157983.6842anser_brachyrhynchusENSABRP0000001664492.913483.4646
ENSG00000168496homo_sapiensENSP0000030548086.842174.7368gasterosteus_aculeatusENSGACP0000000294186.842174.7368
ENSG00000168496homo_sapiensENSP0000030548087.894775cynoglossus_semilaevisENSCSEP0000001503087.894775
ENSG00000168496homo_sapiensENSP0000030548087.368475poecilia_formosaENSPFOP0000000976686.458374.2188
ENSG00000168496homo_sapiensENSP0000030548087.894775.7895myripristis_murdjanENSMMDP0000504055087.894775.7895
ENSG00000168496homo_sapiensENSP0000030548087.105373.9474sander_luciopercaENSSLUP0000004496687.105373.9474
ENSG00000168496homo_sapiensENSP0000030548093.421182.6316strigops_habroptilaENSSHBP0000502208092.931982.199
ENSG00000168496homo_sapiensENSP0000030548087.894775.2632amphiprion_ocellarisENSAOCP0000000175987.894775.2632
ENSG00000168496homo_sapiensENSP0000030548093.684285.2632terrapene_carolina_triunguisENSTMTP0000001915093.193784.8168
ENSG00000168496homo_sapiensENSP0000030548085.526371.5789hucho_huchoENSHHUP0000000729784.856471.0183
ENSG00000168496homo_sapiensENSP0000030548046.578937.3684hucho_huchoENSHHUP0000004877877.292662.0087
ENSG00000168496homo_sapiensENSP0000030548085.263273.6842betta_splendensENSBSLP0000000837383.505272.1649
ENSG00000168496homo_sapiensENSP0000030548087.368475.2632pygocentrus_nattereriENSPNAP0000002069887.368475.2632
ENSG00000168496homo_sapiensENSP0000030548082.105371.0526anabas_testudineusENSATEP0000002487878.39267.8392
ENSG00000168496homo_sapiensENSP0000030548073.684256.5789saccharomyces_cerevisiaeYKL113C73.298456.2827
ENSG00000168496homo_sapiensENSP0000030548087.368475seriola_lalandi_dorsalisENSSLDP0000000465187.368475
ENSG00000168496homo_sapiensENSP0000030548087.631675.7895labrus_bergyltaENSLBEP0000003293887.631675.7895
ENSG00000168496homo_sapiensENSP0000030548087.368475.5263pundamilia_nyerereiENSPNYP0000000431187.368475.5263
ENSG00000168496homo_sapiensENSP0000030548087.105375mastacembelus_armatusENSMAMP0000003263987.105375
ENSG00000168496homo_sapiensENSP0000030548084.473772.1053stegastes_partitusENSSPAP0000001142884.25271.916
ENSG00000168496homo_sapiensENSP0000030548024.736819.2105oncorhynchus_tshawytschaENSOTSP0000504703155.621343.1953
ENSG00000168496homo_sapiensENSP0000030548078.421165.2632oncorhynchus_tshawytschaENSOTSP0000501075579.679166.3102
ENSG00000168496homo_sapiensENSP0000030548087.368475.7895acanthochromis_polyacanthusENSAPOP0000002886783.627272.5441
ENSG00000168496homo_sapiensENSP0000030548093.421183.4211aquila_chrysaetos_chrysaetosENSACCP0002001872192.931982.9843
ENSG00000168496homo_sapiensENSP0000030548085.263274.2105nothobranchius_furzeriENSNFUP0001500934580.19869.802
ENSG00000168496homo_sapiensENSP0000030548087.105375.2632cyprinodon_variegatusENSCVAP0000002074087.105375.2632
ENSG00000168496homo_sapiensENSP0000030548084.736873.1579denticeps_clupeoidesENSDCDP0000000437882.564171.2821
ENSG00000168496homo_sapiensENSP0000030548088.157974.4737larimichthys_croceaENSLCRP0000503507488.157974.4737
ENSG00000168496homo_sapiensENSP000003054808573.9474takifugu_rubripesENSTRUP0000005169284.776973.7533
ENSG00000168496homo_sapiensENSP0000030548092.368483.4211ficedula_albicollisENSFALP0000001229984.172776.0192
ENSG00000168496homo_sapiensENSP000003054806048.6842hippocampus_comesENSHCOP0000002627174.509860.4575
ENSG00000168496homo_sapiensENSP0000030548084.736872.1053hippocampus_comesENSHCOP0000000333486.792473.8544
ENSG00000168496homo_sapiensENSP0000030548088.157976.0526cyprinus_carpio_carpioENSCCRP0000015082688.157976.0526
ENSG00000168496homo_sapiensENSP0000030548084.473771.8421cyprinus_carpio_carpioENSCCRP0000000760482.73270.3608
ENSG00000168496homo_sapiensENSP0000030548093.157983.4211coturnix_japonicaENSCJPP0000501600592.913483.2021
ENSG00000168496homo_sapiensENSP0000030548087.368475poecilia_latipinnaENSPLAP0000002988087.368475
ENSG00000168496homo_sapiensENSP0000030548085.263272.6316sinocyclocheilus_grahamiENSSGRP0000002117882.442770.229
ENSG00000168496homo_sapiensENSP0000030548068.421155.7895sinocyclocheilus_grahamiENSSGRP0000010962686.092770.1987
ENSG00000168496homo_sapiensENSP0000030548024.736822.6316sinocyclocheilus_grahamiENSSGRP0000000548391.262183.4951
ENSG00000168496homo_sapiensENSP0000030548085.263272.3684maylandia_zebraENSMZEP0000503239385.039472.1785
ENSG00000168496homo_sapiensENSP0000030548071.315858.4211tetraodon_nigroviridisENSTNIP0000000549473.243260
ENSG00000168496homo_sapiensENSP0000030548088.421176.8421paramormyrops_kingsleyaeENSPKIP0000002498588.421176.8421
ENSG00000168496homo_sapiensENSP0000030548088.421175.5263scleropages_formosusENSSFOP0001501932785.496273.028
ENSG00000168496homo_sapiensENSP000003054808573.6842leptobrachium_leishanenseENSLLEP0000002875589.226577.3481
ENSG00000168496homo_sapiensENSP0000030548087.368473.6842scophthalmus_maximusENSSMAP0000003270282.79369.8254
ENSG00000168496homo_sapiensENSP0000030548086.578976.3158oryzias_melastigmaENSOMEP0000001479186.578976.3158

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000287enables magnesium ion binding1IBAHomo_sapiens(9606)Function
GO:0000724involved_in double-strand break repair via homologous recombination1TASHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region2HDA,IDAHomo_sapiens(9606)Component
GO:0003677enables DNA binding1IMPHomo_sapiens(9606)Function
GO:0003684enables damaged DNA binding1TASHomo_sapiens(9606)Function
GO:0003690enables double-stranded DNA binding1TASHomo_sapiens(9606)Function
GO:0004519enables endonuclease activity1TASHomo_sapiens(9606)Function
GO:0004523enables RNA-DNA hybrid ribonuclease activity2IBA,IDAHomo_sapiens(9606)Function
GO:0004527enables exonuclease activity1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0006260involved_in DNA replication1TASHomo_sapiens(9606)Process
GO:0006281involved_in DNA repair1TASHomo_sapiens(9606)Process
GO:0006287involved_in base-excision repair, gap-filling1TASHomo_sapiens(9606)Process
GO:0006302involved_in double-strand break repair1TASHomo_sapiens(9606)Process
GO:0007613involved_in memory1IEAHomo_sapiens(9606)Process
GO:0008309enables double-stranded DNA exodeoxyribonuclease activity1TASHomo_sapiens(9606)Function
GO:0008409enables 5-3 exonuclease activity2IBA,IDAHomo_sapiens(9606)Function
GO:0009650involved_in UV protection1TASHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0017108enables 5-flap endonuclease activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0030145enables manganese ion binding1IBAHomo_sapiens(9606)Function
GO:0032201involved_in telomere maintenance via semi-conservative replication1TASHomo_sapiens(9606)Process
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0043137involved_in DNA replication, removal of RNA primer1IDAHomo_sapiens(9606)Process
GO:0045876involved_in positive regulation of sister chromatid cohesion1IMPHomo_sapiens(9606)Process
GO:0048256enables flap endonuclease activity1IDAHomo_sapiens(9606)Function
GO:0090305involved_in nucleic acid phosphodiester bond hydrolysis1IDAHomo_sapiens(9606)Process

Expression