Ensembl ID
ENSG00000168496
Gene ID
2237
Accession
3650
Gene Symbol
FEN1
Alias
MF1;RAD2;FEN-1
Full Name
flap structure-specific endonuclease 1
Position
11 : 61792911 - 61797238
Length
4328 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
ENSG00000168496 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000168496
FEN1
0.50
5.77e-14
KIRC
ENSG00000168496
FEN1
1.24
1.34e-35
HNSC
ENSG00000168496
FEN1
1.47
9.42e-13
BLCA
ENSG00000168496
FEN1
1.62
5.92e-93
BRCA
ENSG00000168496
FEN1
0.97
1.11e-23
COAD
ENSG00000168496
FEN1
0.95
7.78e-15
KICH
ENSG00000168496
FEN1
2.25
2.07e-131
LUSC
ENSG00000168496
FEN1
0.49
9.27e-11
PRAD
ENSG00000168496
FEN1
1.61
6.36e-42
LIHC
ENSG00000168496
FEN1
1.07
7.18e-17
STAD
ENSG00000168496
FEN1
2.20
2.34e-62
UCEC
ENSG00000168496
FEN1
3.07
1.31e-23
CESC
ENSG00000168496
FEN1
1.57
2.35e-47
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000168496
FEN1
tumour
12878006
ENSG00000168496
FEN1
lung cancer
14562054
ENSG00000168496
FEN1
tumor
16170025
ENSG00000168496
FEN1
prostate cancer
16879693
ENSG00000168496
FEN1
tumor
1688517
ENSG00000168496
FEN1
cancer
17589521
ENSG00000168496
FEN1
breast cancer
18237428
ENSG00000168496
FEN1
cancer
18443037
ENSG00000168496
FEN1
breast cancer
18669164
ENSG00000168496
FEN1
cancer
18702299
ENSG00000168496
FEN1
cancers
19010819
ENSG00000168496
FEN1
cancer
19068479
ENSG00000168496
FEN1
tumor
19137021
ENSG00000168496
FEN1
colorectal cancer
19218431
ENSG00000168496
FEN1
breast cancer
19522845
ENSG00000168496
FEN1
cancer
19525235
ENSG00000168496
FEN1
brain tumors
19596913
ENSG00000168496
FEN1
lung cancer
19618370
ENSG00000168496
FEN1
cancer
20929870
ENSG00000168496
FEN1
cancer
20972458
ENSG00000168496
FEN1
cancers
21062821
ENSG00000168496
FEN1
cancer
21383776
ENSG00000168496
FEN1
cancer
21612397
ENSG00000168496
FEN1
ovarian tumor
2182406
ENSG00000168496
FEN1
ovarian cancer
2197240
ENSG00000168496
FEN1
esophageal cancer
22072618
ENSG00000168496
FEN1
lung cancer
22155171
ENSG00000168496
FEN1
cancers
22569363
ENSG00000168496
FEN1
cancer
22788768
ENSG00000168496
FEN1
gastric cancer
22894650
ENSG00000168496
FEN1
lung cancer
23184144
ENSG00000168496
FEN1
cancer
23382697
ENSG00000168496
FEN1
cancers
23427045
ENSG00000168496
FEN1
cancer
24202319
ENSG00000168496
FEN1
cancer
24349332
ENSG00000168496
FEN1
breast cancer
24440783
ENSG00000168496
FEN1
breast cancer
24486718
ENSG00000168496
FEN1
gastric cancer
24590400
ENSG00000168496
FEN1
cancers
24608430
ENSG00000168496
FEN1
cancer
24701133
ENSG00000168496
FEN1
cancer
24836286
ENSG00000168496
FEN1
ovarian cancer
24880630
ENSG00000168496
FEN1
breast cancer
25111287
ENSG00000168496
FEN1
cancer
25154853
ENSG00000168496
FEN1
tumors
25425972
ENSG00000168496
FEN1
breast cancer
25665066
ENSG00000168496
FEN1
breast cancer
25885449
ENSG00000168496
FEN1
cancer
25921062
ENSG00000168496
FEN1
cancer
25922071
ENSG00000168496
FEN1
tumour
26267318
ENSG00000168496
FEN1
lung cancer
26431531
ENSG00000168496
FEN1
breast cancers
26459098
ENSG00000168496
FEN1
tumor
26545110
ENSG00000168496
FEN1
gallbladder cancer
26668074
ENSG00000168496
FEN1
colorectal cancer
26708601
ENSG00000168496
FEN1
gastric cancer
26718738
ENSG00000168496
FEN1
cancer
26807246
ENSG00000168496
FEN1
lung cancer
26811808
ENSG00000168496
FEN1
cancer
27020684
ENSG00000168496
FEN1
breast cancer
27088617
ENSG00000168496
FEN1
cancer
27270424
ENSG00000168496
FEN1
primary cancer
27391345
ENSG00000168496
FEN1
tumor
27467592
ENSG00000168496
FEN1
colon cancer
27526030
ENSG00000168496
FEN1
Cancer
27655641
ENSG00000168496
FEN1
breast cancer
27699013
ENSG00000168496
FEN1
breast cancer
27801669
ENSG00000168496
FEN1
cancer
27832451
ENSG00000168496
FEN1
Breast Cancer
27852524
ENSG00000168496
FEN1
breast cancer
28034453
ENSG00000168496
FEN1
cancer
28187440
ENSG00000168496
FEN1
breast cancers
28254786
ENSG00000168496
FEN1
esophageal cancer
28319330
ENSG00000168496
FEN1
tumor
28371273
ENSG00000168496
FEN1
cancer
28628639
ENSG00000168496
FEN1
cancers
28653660
ENSG00000168496
FEN1
cancer
28685785
ENSG00000168496
FEN1
breast cancer
28724427
ENSG00000168496
FEN1
non-small-cell lung cancer
28861953
ENSG00000168496
FEN1
tumour
28903334
ENSG00000168496
FEN1
breast cancer
28912877
ENSG00000168496
FEN1
cancer
28918054
ENSG00000168496
FEN1
tumor
29033691
ENSG00000168496
FEN1
Non-Small-Cell Lung Cancer
29037854
ENSG00000168496
FEN1
cancer
29109095
ENSG00000168496
FEN1
tumor
29348864
ENSG00000168496
FEN1
cervical cancer
29358095
ENSG00000168496
FEN1
breast cancer
29541412
ENSG00000168496
FEN1
cancer
29718417
ENSG00000168496
FEN1
tumors
29735403
ENSG00000168496
FEN1
cancer
29741650
ENSG00000168496
FEN1
colorectal cancer
29869816
ENSG00000168496
FEN1
Wilms tumor
29937070
ENSG00000168496
FEN1
cancers
30011902
ENSG00000168496
FEN1
cancer
30184152
ENSG00000168496
FEN1
lung cancer
30260965
ENSG00000168496
FEN1
cancer
30295841
ENSG00000168496
FEN1
Cancer
30336066
ENSG00000168496
FEN1
tumors
30526646
ENSG00000168496
FEN1
cancers
30558228
ENSG00000168496
FEN1
Colon Cancer
30694659
ENSG00000168496
FEN1
breast cancer
30712236
ENSG00000168496
FEN1
cancer
30937972
ENSG00000168496
FEN1
breast cancer
31266372
ENSG00000168496
FEN1
Cancer
31272350
ENSG00000168496
FEN1
cancers
31402791
ENSG00000168496
FEN1
Cancer
31467180
ENSG00000168496
FEN1
breast cancer
31471584
ENSG00000168496
FEN1
liver cancer
31534853
ENSG00000168496
FEN1
tumours
31572192
ENSG00000168496
FEN1
cervical cancer
31670906
ENSG00000168496
FEN1
breast cancer
31777591
ENSG00000168496
FEN1
cancer
31937519
ENSG00000168496
FEN1
tumor
8144677
ENSG00000168496
FEN1
cancers
9778254
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000168496
FEN1
STAD
0.0011
low
show
ENSG00000168496
FEN1
UVM
0.00092
high
show
ENSG00000168496
FEN1
PAAD
0.0034
high
show
ENSG00000168496
FEN1
THCA
0.0041
low
show
ENSG00000168496
FEN1
LGG
0.00058
high
show
ENSG00000168496
FEN1
HNSC
0.023
low
show
ENSG00000168496
FEN1
READ
0.02
low
show
ENSG00000168496
FEN1
LUAD
0.00078
high
show
ENSG00000168496
FEN1
THYM
0.013
low
show
ENSG00000168496
FEN1
COAD
0.0054
high
show
ENSG00000168496
FEN1
OV
0.0011
low
show
ENSG00000168496
FEN1
DLBC
0.028
low
show
ENSG00000168496
FEN1
KIRC
0.0021
high
show
ENSG00000168496
FEN1
PRAD
0.013
high
show
ENSG00000168496
FEN1
BLCA
0.026
high
show
ENSG00000168496
FEN1
LAML
0.0012
high
show
ENSG00000168496
FEN1
GBM
0.03
high
show
ENSG00000168496
FEN1
SKCM
0.033
high
show
ENSG00000168496
FEN1
CESC
0.026
low
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000168496
FEN1
TGCT
Del
1.022825
0.063515
0.400881
0.753333
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