Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs tRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000167862 Gene ID 3396 Accession 5359
Symbol MRPL58 Alias DS1;DS-1;ICT1;mL62;MRP-L58 Full Name mitochondrial ribosomal protein L58
Status Confidence Length 8592 bases Strand Plus strand
Position 17 : 75012670 - 75021261 RNA binding domain RF-1
Summary The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000301585 RF-1 PF00472 1.9e-18 1
ENSP00000462256 RF-1 PF00472 1.1e-16 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
MRPL58-204 ENST00000584208 593 192aa ENSP00000462256
MRPL58-201 ENST00000301585 894 206aa ENSP00000301585
MRPL58-202 ENST00000580800 513 71aa ENSP00000464192
MRPL58-203 ENST00000583772 678 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
103408Alzheimer Disease2E-826913989
103409Stroke2E-826913989

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000167862homo_sapiensENSP0000036879317.75289.66292homo_sapiensENSP0000030158538.349520.8738
ENSG00000167862homo_sapiensENSP0000035620221.315812.6316homo_sapiensENSP0000030158539.320423.301

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000167862homo_sapiensENSP0000030158589.805888.835nomascus_leucogenysENSNLEP0000002574298.404397.3404
ENSG00000167862homo_sapiensENSP0000030158599.514698.5437pan_paniscusENSPPAP0000001821599.514698.5437
ENSG00000167862homo_sapiensENSP0000030158598.543796.6019pongo_abeliiENSPPYP0000002891395.305293.4272
ENSG00000167862homo_sapiensENSP0000030158599.514699.0291pan_troglodytesENSPTRP0000001636099.514699.0291
ENSG00000167862homo_sapiensENSP0000030158592.718492.7184gorilla_gorillaENSGGOP0000001203898.963798.9637
ENSG00000167862homo_sapiensENSP0000030158578.155365.0485ornithorhynchus_anatinusENSOANP0000001119778.536665.3659
ENSG00000167862homo_sapiensENSP0000030158583.980672.8155sarcophilus_harrisiiENSSHAP0000003153483.574972.4638
ENSG00000167862homo_sapiensENSP0000030158578.640866.5049notamacropus_eugeniiENSMEUP0000001041078.260966.1836
ENSG00000167862homo_sapiensENSP0000030158579.126272.8155choloepus_hoffmanniENSCHOP0000000340184.45677.7202
ENSG00000167862homo_sapiensENSP0000030158591.262184.466dasypus_novemcinctusENSDNOP0000001020891.262184.466
ENSG00000167862homo_sapiensENSP0000030158588.349580.0971erinaceus_europaeusENSEEUP0000001194688.349580.0971
ENSG00000167862homo_sapiensENSP0000030158589.320479.6116echinops_telfairiENSETEP0000000852588.888979.2271
ENSG00000167862homo_sapiensENSP0000030158596.116592.233callithrix_jacchusENSCJAP0000006252596.116592.233
ENSG00000167862homo_sapiensENSP0000030158595.631192.7184cercocebus_atysENSCATP0000003253694.711591.8269
ENSG00000167862homo_sapiensENSP0000030158596.601993.6893macaca_fascicularisENSMFAP0000001229496.601993.6893
ENSG00000167862homo_sapiensENSP0000030158596.601994.1748macaca_fascicularisENSMFAP0000001192296.601994.1748
ENSG00000167862homo_sapiensENSP0000030158597.087494.6602macaca_mulattaENSMMUP0000007367097.087494.6602
ENSG00000167862homo_sapiensENSP0000030158597.087494.6602macaca_mulattaENSMMUP0000001528497.087494.6602
ENSG00000167862homo_sapiensENSP0000030158597.087494.1748macaca_nemestrinaENSMNEP0000001351197.087494.1748
ENSG00000167862homo_sapiensENSP0000030158597.087494.6602papio_anubisENSPANP0000000993997.087494.6602
ENSG00000167862homo_sapiensENSP0000030158597.572895.1456papio_anubisENSPANP0000003204597.572895.1456
ENSG00000167862homo_sapiensENSP0000030158567.961265.0485mandrillus_leucophaeusENSMLEP0000002269281.871378.3626
ENSG00000167862homo_sapiensENSP0000030158583.495181.068mandrillus_leucophaeusENSMLEP0000000618396.629293.8202
ENSG00000167862homo_sapiensENSP0000030158580.582572.3301tursiops_truncatusENSTTRP0000000245580.582572.3301
ENSG00000167862homo_sapiensENSP0000030158591.747684.9515vulpes_vulpesENSVVUP0000001516791.747684.9515
ENSG00000167862homo_sapiensENSP0000030158589.320479.6116mus_spretusMGP_SPRETEiJ_P003233989.320479.6116
ENSG00000167862homo_sapiensENSP0000030158572.815567.4757equus_asinusENSEASP0000500022862.557.9167
ENSG00000167862homo_sapiensENSP0000030158588.83580.5825capra_hircusENSCHIP0000001902588.83580.5825
ENSG00000167862homo_sapiensENSP0000030158592.23384.9515loxodonta_africanaENSLAFP0000000022492.23384.9515
ENSG00000167862homo_sapiensENSP0000030158590.291385.4369panthera_leoENSPLOP0000002166290.291385.4369
ENSG00000167862homo_sapiensENSP0000030158574.271869.9029ailuropoda_melanoleucaENSAMEP0000003527456.457653.1365
ENSG00000167862homo_sapiensENSP0000030158588.349580.0971bos_indicus_hybridENSBIXP0000502741988.349580.0971
ENSG00000167862homo_sapiensENSP0000030158588.83581.068oryctolagus_cuniculusENSOCUP0000000069588.405880.6763
ENSG00000167862homo_sapiensENSP0000030158592.23386.8932equus_caballusENSECAP0000008711392.23386.8932
ENSG00000167862homo_sapiensENSP0000030158591.262184.466canis_lupus_familiarisENSCAFP0084502239491.262184.466
ENSG00000167862homo_sapiensENSP0000030158590.776785.9223panthera_pardusENSPPRP0000001597490.776785.9223
ENSG00000167862homo_sapiensENSP0000030158590.776785.4369marmota_marmota_marmotaENSMMMP0000001241890.776785.4369
ENSG00000167862homo_sapiensENSP0000030158591.262179.1262balaenoptera_musculusENSBMSP0001002740491.262179.1262
ENSG00000167862homo_sapiensENSP0000030158587.378679.1262cavia_porcellusENSCPOP0000002139287.378679.1262
ENSG00000167862homo_sapiensENSP0000030158567.475763.5922felis_catusENSFCAP0000005729850.915847.9853
ENSG00000167862homo_sapiensENSP0000030158592.23386.4078ursus_americanusENSUAMP0000001297892.23386.4078
ENSG00000167862homo_sapiensENSP0000030158583.009771.3592monodelphis_domesticaENSMODP0000005427182.211570.6731
ENSG00000167862homo_sapiensENSP0000030158585.436978.1553bison_bison_bisonENSBBBP0000002643188.888981.3131
ENSG00000167862homo_sapiensENSP0000030158591.262182.0388monodon_monocerosENSMMNP0001502955791.262182.0388
ENSG00000167862homo_sapiensENSP0000030158590.776781.068sus_scrofaENSSSCP0000003180091.219581.4634
ENSG00000167862homo_sapiensENSP0000030158593.203986.8932microcebus_murinusENSMICP0000000968693.203986.8932
ENSG00000167862homo_sapiensENSP0000030158584.46679.1262octodon_degusENSODEP000000137928781.5
ENSG00000167862homo_sapiensENSP0000030158589.805883.9806jaculus_jaculusENSJJAP0000000087089.805883.9806
ENSG00000167862homo_sapiensENSP0000030158588.83580.5825ovis_aries_rambouilletENSOARP0002000673888.83580.5825
ENSG00000167862homo_sapiensENSP0000030158563.592253.8835ursus_maritimusENSUMAP0000001144164.851554.9505
ENSG00000167862homo_sapiensENSP0000030158583.009776.2136ochotona_princepsENSOPRP0000000152283.009776.2136
ENSG00000167862homo_sapiensENSP0000030158591.262182.0388delphinapterus_leucasENSDLEP0000001412891.262182.0388
ENSG00000167862homo_sapiensENSP0000030158591.262181.068physeter_catodonENSPCTP0000500998691.262181.068
ENSG00000167862homo_sapiensENSP0000030158587.864178.1553mus_caroliMGP_CAROLIEiJ_P003089387.864178.1553
ENSG00000167862homo_sapiensENSP0000030158588.83579.6116mus_musculusENSMUSP0000011674688.83579.6116
ENSG00000167862homo_sapiensENSP0000030158589.320481.068dipodomys_ordiiENSDORP0000000602994.35985.641
ENSG00000167862homo_sapiensENSP0000030158583.980675.2427mustela_putorius_furoENSMPUP0000001397884.390275.6098
ENSG00000167862homo_sapiensENSP0000030158595.631191.7476aotus_nancymaaeENSANAP0000001184295.631191.7476
ENSG00000167862homo_sapiensENSP0000030158594.174889.3204saimiri_boliviensis_boliviensisENSSBOP0000004039794.174889.3204
ENSG00000167862homo_sapiensENSP0000030158554.854450.9709vicugna_pacosENSVPAP0000000246788.281282.0312
ENSG00000167862homo_sapiensENSP0000030158596.601995.1456chlorocebus_sabaeusENSCSAP0000000098796.601995.1456
ENSG00000167862homo_sapiensENSP0000030158582.524376.699tupaia_belangeriENSTBEP0000001081882.524376.699
ENSG00000167862homo_sapiensENSP0000030158581.553473.301mesocricetus_auratusENSMAUP000000148988475.5
ENSG00000167862homo_sapiensENSP0000030158591.262182.0388phocoena_sinusENSPSNP0000002817991.262182.0388
ENSG00000167862homo_sapiensENSP0000030158591.262183.0097camelus_dromedariusENSCDRP0000501149391.262183.0097
ENSG00000167862homo_sapiensENSP0000030158583.980675.2427carlito_syrichtaENSTSYP0000001214384.390275.6098
ENSG00000167862homo_sapiensENSP0000030158579.611674.7573panthera_tigris_altaicaENSPTIP0000001577688.17282.7957
ENSG00000167862homo_sapiensENSP0000030158589.320480.0971rattus_norvegicusENSRNOP0000008591571.595364.2023
ENSG00000167862homo_sapiensENSP0000030158595.145687.8641prolemur_simusENSPSMP0000000158095.145687.8641
ENSG00000167862homo_sapiensENSP0000030158588.83580.5825microtus_ochrogasterENSMOCP0000001685188.83580.5825
ENSG00000167862homo_sapiensENSP0000030158590.291381.068peromyscus_maniculatus_bairdiiENSPEMP0000000265990.291381.068
ENSG00000167862homo_sapiensENSP0000030158566.019459.2233bos_mutusENSBMUP0000001085866.019459.2233
ENSG00000167862homo_sapiensENSP0000030158589.320479.6116mus_spicilegusENSMSIP0000003401972.156964.3137
ENSG00000167862homo_sapiensENSP0000030158590.291382.5243cricetulus_griseus_chok1gshdENSCGRP0000102586990.291382.5243
ENSG00000167862homo_sapiensENSP0000030158585.436979.1262pteropus_vampyrusENSPVAP0000001516285.436979.1262
ENSG00000167862homo_sapiensENSP0000030158566.019461.165myotis_lucifugusENSMLUP0000000615875.138169.6133
ENSG00000167862homo_sapiensENSP0000030158583.495171.3592vombatus_ursinusENSVURP0001001579583.902471.7073
ENSG00000167862homo_sapiensENSP0000030158591.262185.9223rhinolophus_ferrumequinumENSRFEP0001001713791.262185.9223
ENSG00000167862homo_sapiensENSP0000030158589.320484.9515neovison_visonENSNVIP0000001310587.61983.3333
ENSG00000167862homo_sapiensENSP0000030158588.349580.0971bos_taurusENSBTAP0000000427688.349580.0971
ENSG00000167862homo_sapiensENSP0000030158572.815562.6214heterocephalus_glaber_femaleENSHGLP0000001084568.181858.6364
ENSG00000167862homo_sapiensENSP0000030158587.864183.4951rhinopithecus_bietiENSRBIP0000001823290.586
ENSG00000167862homo_sapiensENSP0000030158591.262184.466canis_lupus_dingoENSCAFP0002002788491.262184.466
ENSG00000167862homo_sapiensENSP0000030158589.805884.9515sciurus_vulgarisENSSVLP0000500846989.805884.9515
ENSG00000167862homo_sapiensENSP0000030158583.980672.3301phascolarctos_cinereusENSPCIP0000000559183.173171.6346
ENSG00000167862homo_sapiensENSP0000030158590.776783.9806procavia_capensisENSPCAP0000001427890.776783.9806
ENSG00000167862homo_sapiensENSP0000030158586.893278.1553nannospalax_galiliENSNGAP0000000624988.613979.703
ENSG00000167862homo_sapiensENSP0000030158589.320481.068bos_grunniensENSBGRP0000002539077.966170.7627
ENSG00000167862homo_sapiensENSP0000030158590.291382.5243chinchilla_lanigeraENSCLAP0000000346790.291382.5243
ENSG00000167862homo_sapiensENSP0000030158589.805879.6116cervus_hanglu_yarkandensisENSCHYP0000000469089.805879.6116
ENSG00000167862homo_sapiensENSP0000030158591.262184.466catagonus_wagneriENSCWAP0000002531991.707384.8781
ENSG00000167862homo_sapiensENSP0000030158590.776784.466ictidomys_tridecemlineatusENSSTOP0000003106990.776784.466
ENSG00000167862homo_sapiensENSP0000030158588.83583.4951otolemur_garnettiiENSOGAP0000000316788.405883.0918
ENSG00000167862homo_sapiensENSP0000030158595.631191.2621cebus_imitatorENSCCAP0000003406595.631191.2621
ENSG00000167862homo_sapiensENSP0000030158590.291385.4369urocitellus_parryiiENSUPAP0001003054290.291385.4369
ENSG00000167862homo_sapiensENSP0000030158587.378678.1553moschus_moschiferusENSMMSP0000001832987.378678.1553
ENSG00000167862homo_sapiensENSP0000030158597.572894.6602rhinopithecus_roxellanaENSRROP0000000267797.572894.6602
ENSG00000167862homo_sapiensENSP0000030158597.572894.1748rhinopithecus_roxellanaENSRROP0000000150897.572894.1748
ENSG00000167862homo_sapiensENSP0000030158588.349578.6408mus_pahariMGP_PahariEiJ_P003761888.349578.6408
ENSG00000167862homo_sapiensENSP0000030158594.174887.8641propithecus_coquereliENSPCOP0000000134394.174887.8641
ENSG00000167862homo_sapiensENSP0000030158555.825237.3786drosophila_melanogasterFBpp030793456.650237.931
ENSG00000167862homo_sapiensENSP0000030158553.398136.8932ciona_intestinalisENSCINP0000003083354.726437.8109
ENSG00000167862homo_sapiensENSP0000030158555.825241.2621eptatretus_burgeriENSEBUP0000000256867.647150
ENSG00000167862homo_sapiensENSP0000030158567.961253.8835callorhinchus_miliiENSCMIP0000004916448.780538.676
ENSG00000167862homo_sapiensENSP0000030158572.815558.7379latimeria_chalumnaeENSLACP0000000947474.257459.901
ENSG00000167862homo_sapiensENSP0000030158570.388455.3398lepisosteus_oculatusENSLOCP0000001410170.388455.3398
ENSG00000167862homo_sapiensENSP0000030158560.679642.7184oncorhynchus_kisutchENSOKIP0000510983964.102645.1282
ENSG00000167862homo_sapiensENSP0000030158561.650542.7184oncorhynchus_mykissENSOMYP0000002106865.128245.1282
ENSG00000167862homo_sapiensENSP0000030158561.16543.6893salmo_salarENSSSAP0000007693662.376244.5545
ENSG00000167862homo_sapiensENSP0000030158561.650543.2039salmo_truttaENSSTUP0000011149965.128245.641
ENSG00000167862homo_sapiensENSP0000030158561.16548.5437xiphophorus_maculatusENSXMAP0000001243165.968652.356
ENSG00000167862homo_sapiensENSP0000030158557.76743.6893oreochromis_niloticusENSONIP0000002467261.65846.6321
ENSG00000167862homo_sapiensENSP0000030158561.650546.1165lates_calcariferENSLCAP0001004722365.128248.7179
ENSG00000167862homo_sapiensENSP0000030158567.475752.4272xenopus_tropicalisENSXETP0000002736264.351950
ENSG00000167862homo_sapiensENSP0000030158572.330160.1942chrysemys_picta_belliiENSCPBP0000004099872.330160.1942
ENSG00000167862homo_sapiensENSP0000030158567.475759.7087sphenodon_punctatusENSSPUP0000001244468.811960.8911
ENSG00000167862homo_sapiensENSP0000030158559.223348.0583crocodylus_porosusENSCPRP0000500444469.318256.25
ENSG00000167862homo_sapiensENSP0000030158567.475752.4272laticauda_laticaudataENSLLTP0000002454167.149852.1739
ENSG00000167862homo_sapiensENSP0000030158568.446652.9126notechis_scutatusENSNSUP0000001840568.115952.657
ENSG00000167862homo_sapiensENSP0000030158568.93253.3981pseudonaja_textilisENSPTXP0000000111168.59953.1401
ENSG00000167862homo_sapiensENSP0000030158567.961253.8835gallus_gallusENSGALP0001004448069.651755.2239
ENSG00000167862homo_sapiensENSP0000030158565.53454.3689serinus_canariaENSSCAP0000000065867.839256.2814
ENSG00000167862homo_sapiensENSP0000030158566.504955.8252parus_majorENSPMJP0000000041068.844257.7889
ENSG00000167862homo_sapiensENSP0000030158567.961257.2816anolis_carolinensisENSACAP0000000589947.781640.273
ENSG00000167862homo_sapiensENSP0000030158557.76743.2039neolamprologus_brichardiENSNBRP0000001776661.65846.114
ENSG00000167862homo_sapiensENSP0000030158568.446652.9126naja_najaENSNNAP0000001026068.115952.657
ENSG00000167862homo_sapiensENSP0000030158566.504955.3398taeniopygia_guttataENSTGUP0000000904668.844257.2864
ENSG00000167862homo_sapiensENSP0000030158564.077747.5728erpetoichthys_calabaricusENSECRP0000002800562.559246.4455
ENSG00000167862homo_sapiensENSP0000030158568.93256.3107salvator_merianaeENSSMRP0000003027168.59956.0386
ENSG00000167862homo_sapiensENSP0000030158556.796145.1456amphilophus_citrinellusENSACIP0000002489265.730352.2472
ENSG00000167862homo_sapiensENSP0000030158559.708745.1456dicentrarchus_labraxENSDLAP0000506802258.571444.2857
ENSG00000167862homo_sapiensENSP0000030158573.30161.165pelodiscus_sinensisENSPSIP0000000507973.30161.165
ENSG00000167862homo_sapiensENSP0000030158571.844759.7087gopherus_evgoodeiENSGEVP0000502761670.476258.5714
ENSG00000167862homo_sapiensENSP0000030158571.359259.2233chelonoidis_abingdoniiENSCABP0000001566371.359259.2233
ENSG00000167862homo_sapiensENSP0000030158562.135947.0874cottoperca_gobioENSCGOP0000005125065.979450
ENSG00000167862homo_sapiensENSP0000030158559.223348.0583struthio_camelus_australisENSSCUP0000001551363.541751.5625
ENSG00000167862homo_sapiensENSP0000030158562.135944.6602cynoglossus_semilaevisENSCSEP0000003137865.979447.4227
ENSG00000167862homo_sapiensENSP0000030158562.621447.5728poecilia_formosaENSPFOP0000001870666.839450.7772
ENSG00000167862homo_sapiensENSP0000030158572.330160.6796terrapene_carolina_triunguisENSTMTP0000002072472.330160.6796
ENSG00000167862homo_sapiensENSP0000030158561.16543.6893hucho_huchoENSHHUP0000007968264.615446.1538
ENSG00000167862homo_sapiensENSP0000030158554.854435.4369ciona_savignyiENSCSAVP0000001954655.12235.6098
ENSG00000167862homo_sapiensENSP0000030158558.252443.2039pundamilia_nyerereiENSPNYP0000000961062.176246.114
ENSG00000167862homo_sapiensENSP0000030158560.679642.233oncorhynchus_tshawytschaENSOTSP0000501900164.102644.6154
ENSG00000167862homo_sapiensENSP0000030158560.679642.233oncorhynchus_tshawytschaENSOTSP0000505081264.102644.6154
ENSG00000167862homo_sapiensENSP0000030158568.446656.3107aquila_chrysaetos_chrysaetosENSACCP0002000318871.212158.5859
ENSG00000167862homo_sapiensENSP0000030158552.912636.8932larimichthys_croceaENSLCRP0000505420453.694637.4384
ENSG00000167862homo_sapiensENSP0000030158562.135946.1165takifugu_rubripesENSTRUP0000008841862.745146.5686
ENSG00000167862homo_sapiensENSP0000030158565.048552.9126coturnix_japonicaENSCJPP0000502787269.430156.4767
ENSG00000167862homo_sapiensENSP0000030158561.650547.5728poecilia_latipinnaENSPLAP0000001338564.795950
ENSG00000167862homo_sapiensENSP0000030158560.679643.6893leptobrachium_leishanenseENSLLEP0000004759355.803640.1786

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0004045enables aminoacyl-tRNA hydrolase activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IDAHomo_sapiens(9606)Component
GO:0005743located_in mitochondrial inner membrane2NAS,TASHomo_sapiens(9606)Component
GO:0005759located_in mitochondrial matrix1TASHomo_sapiens(9606)Component
GO:0005762part_of mitochondrial large ribosomal subunit3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016150enables translation release factor activity, codon nonspecific2IBA,IDAHomo_sapiens(9606)Function
GO:0032543involved_in mitochondrial translation1NASHomo_sapiens(9606)Process
GO:0070126involved_in mitochondrial translational termination2IBA,IDAHomo_sapiens(9606)Process

Expression