Ensembl ID ENSG00000167862 Gene ID 3396 Accession 5359
Gene Symbol MRPL58 Alias DS1;DS-1;ICT1;mL62;MRP-L58 Full Name mitochondrial ribosomal protein L58
Position 17 : 75012670 - 75021261 Length 8592 bases Strand Plus strand
Status Confidence Main interacting RNAstRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]

ENSG00000167862 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000167862 MRPL58 0.86 2.16e-35 BRCA
ENSG00000167862 MRPL58 0.77 4.02e-15 COAD
ENSG00000167862 MRPL58 0.90 2.33e-20 LUSC
ENSG00000167862 MRPL58 0.48 7.83e-12 PRAD
ENSG00000167862 MRPL58 0.73 1.09e-11 KIRP
ENSG00000167862 MRPL58 0.83 9.67e-18 UCEC
ENSG00000167862 MRPL58 0.81 6.77e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000167862 MRPL58 tumor 10349310
ENSG00000167862 MRPL58 cancer 11597542
ENSG00000167862 MRPL58 pancreatic cancer 25274283
ENSG00000167862 MRPL58 GBM 26056476
ENSG00000167862 MRPL58 prostate cancer 26186090
ENSG00000167862 MRPL58 breast cancer 26469889
ENSG00000167862 MRPL58 Colorectal Cancer 27411551
ENSG00000167862 MRPL58 breast cancer 28290601
ENSG00000167862 MRPL58 gastric cancer 28987942
ENSG00000167862 MRPL58 gastric cancer 29036264
ENSG00000167862 MRPL58 tumor 29130100
ENSG00000167862 MRPL58 tumors 29383182
ENSG00000167862 MRPL58 cancer 29577649
ENSG00000167862 MRPL58 breast cancer 29951881
ENSG00000167862 MRPL58 pancreatic cancer 8123488
ENSG00000167862 MRPL58 cancer 9530044
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000167862 MRPL58 SARC 0.0051 low
ENSG00000167862 MRPL58 CHOL 0.05 high
ENSG00000167862 MRPL58 PAAD 0.028 low
ENSG00000167862 MRPL58 UCEC 0.015 low
ENSG00000167862 MRPL58 THCA 0.023 low
ENSG00000167862 MRPL58 LGG 0.018 high
ENSG00000167862 MRPL58 LUSC 0.049 low
ENSG00000167862 MRPL58 HNSC 0.036 high
ENSG00000167862 MRPL58 READ 0.025 low
ENSG00000167862 MRPL58 KIRP 0.037 low
ENSG00000167862 MRPL58 KICH 0.00092 high
ENSG00000167862 MRPL58 PCPG 0.047 low
ENSG00000167862 MRPL58 COAD 0.00068 low
ENSG00000167862 MRPL58 ESCA 0.016 high
ENSG00000167862 MRPL58 OV 0.0027 low
ENSG00000167862 MRPL58 KIRC 0.00057 high
ENSG00000167862 MRPL58 LAML 0.00011 high
ENSG00000167862 MRPL58 GBM 0.029 high
ENSG00000167862 MRPL58 CESC 0.013 low
ENSG00000167862 MRPL58 LIHC 0.0026 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000167862 MRPL58 LUSC Amp 1.936474 0.233702 0.450176 0.469062
ENSG00000167862 MRPL58 LUAD Amp 2.711302 0.163966 0.406713 0.496124
ENSG00000167862 MRPL58 LGG Amp 2.338820 0.067725 0.570625 0.079922
ENSG00000167862 MRPL58 CESC Amp 3.507040 0.226198 0.693776 0.237288
ENSG00000167862 MRPL58 PAAD Del 3.317897 0.091201 0.350607 0.222826
ENSG00000167862 MRPL58 SKCM Amp 5.715045 0.259825 0.559237 0.348774
ENSG00000167862 MRPL58 LIHC Amp 8.678241 0.268693 0.679866 0.378378
ENSG00000167862 MRPL58 BLCA Amp 2.332550 0.219915 0.473341 0.473039
ENSG00000167862 MRPL58 BRCA Amp 23.767203 0.377607 0.661719 0.372222
ENSG00000167862 MRPL58 UCEC Amp 3.696529 0.162423 0.583235 0.170686
ENSG00000167862 MRPL58 OV Amp 1.377800 0.353684 0.527590 0.348877