RBP Type	Non-canonical_RBPs
Diseases	N.A.
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000159593	Gene ID	8883	Accession	621
Symbol	NAE1	Alias	HPP1;ula-1;APPBP1;NEDFIH;A-116A10.1	Full Name	NEDD8 activating enzyme E1 subunit 1
Status	Confidence	Length	70382 bases	Strand	Minus strand
Position	16 : 66802875 - 66873256	RNA binding domain	N.A.
Summary	The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
NAE1-207	ENST00000562428	473	112aa	ENSP00000463546
NAE1-202	ENST00000359087	1825	537aa	ENSP00000351990
NAE1-216	ENST00000566663	576	129aa	ENSP00000462937
NAE1-201	ENST00000290810	1813	534aa	ENSP00000290810
NAE1-210	ENST00000563221	532	No protein	-
NAE1-219	ENST00000568672	523	No protein	-
NAE1-203	ENST00000379463	1909	528aa	ENSP00000368776
NAE1-204	ENST00000394074	1654	445aa	ENSP00000377637
NAE1-206	ENST00000562074	571	No protein	-
NAE1-217	ENST00000567521	765	No protein	-
NAE1-218	ENST00000567743	1460	25aa	ENSP00000455562
NAE1-211	ENST00000563253	566	23aa	ENSP00000454471
NAE1-209	ENST00000563185	401	109aa	ENSP00000454506
NAE1-205	ENST00000561579	728	124aa	ENSP00000464119
NAE1-213	ENST00000564040	536	No protein	-
NAE1-221	ENST00000569388	562	85aa	ENSP00000456847
NAE1-215	ENST00000566336	686	162aa	ENSP00000462040
NAE1-214	ENST00000565535	580	167aa	ENSP00000455967
NAE1-220	ENST00000569348	567	64aa	ENSP00000456564
NAE1-208	ENST00000562757	585	No protein	-
NAE1-212	ENST00000563419	649	No protein	-
NAE1-222	ENST00000569963	719	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
8635	Blood Pressure	6.8050755579474E-5	17903302
10006	Blood Vessels	9.19147722232086E-5	17903301

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004839	enables ubiquitin activating enzyme activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	is_active_in nucleus	1	IBA	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	1	IBA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005886	located_in plasma membrane	1	IEA	Homo_sapiens(9606)	Component
GO:0006511	involved_in ubiquitin-dependent protein catabolic process	1	IBA	Homo_sapiens(9606)	Process
GO:0006974	involved_in DNA damage response	1	IBA	Homo_sapiens(9606)	Process
GO:0007165	involved_in signal transduction	1	TAS	Homo_sapiens(9606)	Process
GO:0016567	involved_in protein ubiquitination	1	IBA	Homo_sapiens(9606)	Process
GO:0019781	contributes_to NEDD8 activating enzyme activity	1	IDA	Homo_sapiens(9606)	Function
GO:0031625	enables ubiquitin protein ligase binding	1	IPI	Homo_sapiens(9606)	Function
GO:0032991	part_of protein-containing complex	1	IDA	Homo_sapiens(9606)	Component
GO:0033314	involved_in mitotic DNA replication checkpoint signaling	1	IDA	Homo_sapiens(9606)	Process
GO:0042981	involved_in regulation of apoptotic process	2	IDA,IMP	Homo_sapiens(9606)	Process
GO:0043523	involved_in regulation of neuron apoptotic process	1	IDA	Homo_sapiens(9606)	Process
GO:0045116	involved_in protein neddylation	3	IDA,IEA,IMP	Homo_sapiens(9606)	Process
GO:0046982	enables protein heterodimerization activity	1	IPI	Homo_sapiens(9606)	Function
GO:0051402	involved_in neuron apoptotic process	1	IDA	Homo_sapiens(9606)	Process