RBP Type	Non-canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	N.A.
Moonlighting functions	Transmemebrane
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000149428	Gene ID	10525	Accession	16931
Symbol	HYOU1	Alias	IMD59;Grp170;HSP12A;ORP150;GRP-170;ORP-150	Full Name	hypoxia up-regulated 1
Status	Confidence	Length	13040 bases	Strand	Minus strand
Position	11 : 119044188 - 119057227	RNA binding domain	N.A.
Summary	The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
HYOU1-218	ENST00000617285	4598	999aa	ENSP00000480150
HYOU1-222	ENST00000694928	1710	72aa	ENSP00000511596
HYOU1-216	ENST00000612687	4360	937aa	ENSP00000483106
HYOU1-212	ENST00000533381	4570	No protein	-
HYOU1-206	ENST00000530473	4560	999aa	ENSP00000431874
HYOU1-213	ENST00000534233	4371	999aa	ENSP00000462951
HYOU1-223	ENST00000694929	4887	No protein	-
HYOU1-224	ENST00000694930	4664	No protein	-
HYOU1-217	ENST00000614711	4415	999aa	ENSP00000480248
HYOU1-225	ENST00000694932	4360	1000aa	ENSP00000511598
HYOU1-226	ENST00000694933	4501	904aa	ENSP00000511599
HYOU1-227	ENST00000694934	4467	946aa	ENSP00000511600
HYOU1-228	ENST00000694935	4475	1000aa	ENSP00000511601
HYOU1-211	ENST00000532519	4359	946aa	ENSP00000467866
HYOU1-221	ENST00000652093	4367	1000aa	ENSP00000498353
HYOU1-229	ENST00000694937	3972	158aa	ENSP00000511603
HYOU1-219	ENST00000621959	3358	937aa	ENSP00000484186
HYOU1-203	ENST00000527738	809	No protein	-
HYOU1-207	ENST00000531682	319	No protein	-
HYOU1-214	ENST00000543287	2464	38aa	ENSP00000442727
HYOU1-210	ENST00000532421	2077	653aa	ENSP00000463515
HYOU1-205	ENST00000530467	2050	602aa	ENSP00000479845
HYOU1-215	ENST00000610597	2021	602aa	ENSP00000484622
HYOU1-202	ENST00000527038	1988	602aa	ENSP00000463742
HYOU1-208	ENST00000531694	542	No protein	-
HYOU1-209	ENST00000531968	550	38aa	ENSP00000464026
HYOU1-220	ENST00000622474	549	No protein	-
HYOU1-204	ENST00000529174	549	No protein	-
HYOU1-201	ENST00000526354	564	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
67772	Bronchodilator Agents	1E-6	26634245
67773	Lung Volume Measurements	1E-6	26634245

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000149428	homo_sapiens	ENSP00000324173	49.0826	27.8287	homo_sapiens	ENSP00000480150	32.1321	18.2182
ENSG00000149428	homo_sapiens	ENSP00000367623	43.6149	26.7191	homo_sapiens	ENSP00000480150	22.2222	13.6136
ENSG00000149428	homo_sapiens	ENSP00000285667	43.7367	22.7176	homo_sapiens	ENSP00000480150	20.6206	10.7107
ENSG00000149428	homo_sapiens	ENSP00000297185	42.8571	23.7113	homo_sapiens	ENSP00000480150	29.1291	16.1161
ENSG00000149428	homo_sapiens	ENSP00000364805	50.702	29.0172	homo_sapiens	ENSP00000480150	32.5325	18.6186
ENSG00000149428	homo_sapiens	ENSP00000247207	51.1737	28.6385	homo_sapiens	ENSP00000480150	32.7327	18.3183
ENSG00000149428	homo_sapiens	ENSP00000310219	50.2333	29.86	homo_sapiens	ENSP00000480150	32.3323	19.2192
ENSG00000149428	homo_sapiens	ENSP00000302961	50.119	29.0476	homo_sapiens	ENSP00000480150	42.1421	24.4244
ENSG00000149428	homo_sapiens	ENSP00000318687	48.0186	27.0396	homo_sapiens	ENSP00000480150	41.2412	23.2232
ENSG00000149428	homo_sapiens	ENSP00000432083	52.1672	29.8762	homo_sapiens	ENSP00000480150	33.7337	19.3193
ENSG00000149428	homo_sapiens	ENSP00000296464	49.5828	28.1287	homo_sapiens	ENSP00000480150	41.6416	23.6236
ENSG00000149428	homo_sapiens	ENSP00000364801	51.3261	28.7051	homo_sapiens	ENSP00000480150	32.9329	18.4184
ENSG00000149428	homo_sapiens	ENSP00000364802	51.3261	28.7051	homo_sapiens	ENSP00000480150	32.9329	18.4184
ENSG00000149428	homo_sapiens	ENSP00000498859	99.9	99.9	homo_sapiens	ENSP00000480150	100	100

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000149428	homo_sapiens	ENSP00000480150	95.2953	95.0951	nomascus_leucogenys	ENSNLEP00000039021	99.5816	99.3724
ENSG00000149428	homo_sapiens	ENSP00000480150	99.6997	99.3994	pan_paniscus	ENSPPAP00000002224	99.6997	99.3994
ENSG00000149428	homo_sapiens	ENSP00000480150	99.3994	98.999	pongo_abelii	ENSPPYP00000004526	99.3	98.9
ENSG00000149428	homo_sapiens	ENSP00000480150	99.6997	99.2993	pan_troglodytes	ENSPTRP00000007480	99.6997	99.2993
ENSG00000149428	homo_sapiens	ENSP00000480150	99.6997	99.3994	gorilla_gorilla	ENSGGOP00000007855	99.6997	99.3994
ENSG00000149428	homo_sapiens	ENSP00000480150	81.2813	73.6737	ornithorhynchus_anatinus	ENSOANP00000040361	78.9883	71.5953
ENSG00000149428	homo_sapiens	ENSP00000480150	89.7898	83.1832	sarcophilus_harrisii	ENSSHAP00000034462	78.5464	72.7671
ENSG00000149428	homo_sapiens	ENSP00000480150	80.0801	73.3734	notamacropus_eugenii	ENSMEUP00000014059	79.2864	72.6462
ENSG00000149428	homo_sapiens	ENSP00000480150	45.3453	43.8438	choloepus_hoffmanni	ENSCHOP00000004165	46.8944	45.3416
ENSG00000149428	homo_sapiens	ENSP00000480150	95.4955	93.3934	dasypus_novemcinctus	ENSDNOP00000004663	95.5912	93.487
ENSG00000149428	homo_sapiens	ENSP00000480150	90.1902	87.2873	erinaceus_europaeus	ENSEEUP00000002893	91.1943	88.2591
ENSG00000149428	homo_sapiens	ENSP00000480150	86.0861	82.3824	echinops_telfairi	ENSETEP00000010415	88.4774	84.6708
ENSG00000149428	homo_sapiens	ENSP00000480150	98.1982	97.2973	callithrix_jacchus	ENSCJAP00000051860	98.1	97.2
ENSG00000149428	homo_sapiens	ENSP00000480150	98.3984	97.5976	cercocebus_atys	ENSCATP00000033991	98.2018	97.4026
ENSG00000149428	homo_sapiens	ENSP00000480150	98.8989	98.3984	macaca_fascicularis	ENSMFAP00000056582	94.4551	93.9771
ENSG00000149428	homo_sapiens	ENSP00000480150	98.7988	98.3984	macaca_mulatta	ENSMMUP00000036656	98.7988	98.3984
ENSG00000149428	homo_sapiens	ENSP00000480150	98.999	98.5986	macaca_nemestrina	ENSMNEP00000046206	98.999	98.5986
ENSG00000149428	homo_sapiens	ENSP00000480150	97.4975	96.7968	papio_anubis	ENSPANP00000006741	96.3403	95.6479
ENSG00000149428	homo_sapiens	ENSP00000480150	99.0991	98.6987	mandrillus_leucophaeus	ENSMLEP00000015715	99.0991	98.6987
ENSG00000149428	homo_sapiens	ENSP00000480150	94.4945	91.3914	tursiops_truncatus	ENSTTRP00000002805	94.7791	91.6667
ENSG00000149428	homo_sapiens	ENSP00000480150	94.6947	92.3924	vulpes_vulpes	ENSVVUP00000033259	88.164	86.0205
ENSG00000149428	homo_sapiens	ENSP00000480150	95.2953	91.6917	mus_spretus	MGP_SPRETEiJ_P0091129	95.2953	91.6917
ENSG00000149428	homo_sapiens	ENSP00000480150	95.4955	92.993	equus_asinus	ENSEASP00005006661	95.3047	92.8072
ENSG00000149428	homo_sapiens	ENSP00000480150	92.8929	89.99	capra_hircus	ENSCHIP00000017986	89.8354	87.0281
ENSG00000149428	homo_sapiens	ENSP00000480150	93.4935	90.4905	loxodonta_africana	ENSLAFP00000015566	93.0279	90.0398
ENSG00000149428	homo_sapiens	ENSP00000480150	91.2913	89.4895	panthera_leo	ENSPLOP00000006959	89.8522	88.0788
ENSG00000149428	homo_sapiens	ENSP00000480150	94.3944	92.0921	ailuropoda_melanoleuca	ENSAMEP00000000043	88.4615	86.3039
ENSG00000149428	homo_sapiens	ENSP00000480150	91.6917	89.0891	bos_indicus_hybrid	ENSBIXP00005043911	89.716	87.1694
ENSG00000149428	homo_sapiens	ENSP00000480150	94.2943	91.2913	oryctolagus_cuniculus	ENSOCUP00000003670	94.2943	91.2913
ENSG00000149428	homo_sapiens	ENSP00000480150	95.3954	92.8929	equus_caballus	ENSECAP00000058010	94.6375	92.1549
ENSG00000149428	homo_sapiens	ENSP00000480150	94.3944	92.1922	canis_lupus_familiaris	ENSCAFP00845001038	78.9782	77.1357
ENSG00000149428	homo_sapiens	ENSP00000480150	94.3944	92.5926	panthera_pardus	ENSPPRP00000002902	94.489	92.6854
ENSG00000149428	homo_sapiens	ENSP00000480150	94.5946	92.3924	marmota_marmota_marmota	ENSMMMP00000025679	94.7844	92.5777
ENSG00000149428	homo_sapiens	ENSP00000480150	94.8949	91.6917	balaenoptera_musculus	ENSBMSP00010016672	94.8949	91.6917
ENSG00000149428	homo_sapiens	ENSP00000480150	94.995	91.6917	cavia_porcellus	ENSCPOP00000005811	95.1856	91.8756
ENSG00000149428	homo_sapiens	ENSP00000480150	94.6947	92.8929	felis_catus	ENSFCAP00000001069	94.6947	92.8929
ENSG00000149428	homo_sapiens	ENSP00000480150	94.2943	92.0921	ursus_americanus	ENSUAMP00000036621	94.5783	92.3695
ENSG00000149428	homo_sapiens	ENSP00000480150	85.8859	79.6797	monodelphis_domestica	ENSMODP00000041411	84.8665	78.7339
ENSG00000149428	homo_sapiens	ENSP00000480150	92.2923	89.8899	bison_bison_bison	ENSBBBP00000025157	92.1079	89.7103
ENSG00000149428	homo_sapiens	ENSP00000480150	94.8949	91.992	monodon_monoceros	ENSMMNP00015029388	94.8949	91.992
ENSG00000149428	homo_sapiens	ENSP00000480150	95.2953	91.992	sus_scrofa	ENSSSCP00000037024	90.237	87.109
ENSG00000149428	homo_sapiens	ENSP00000480150	95.6957	92.4925	microcebus_murinus	ENSMICP00000040719	95.6	92.4
ENSG00000149428	homo_sapiens	ENSP00000480150	90.6907	86.987	octodon_degus	ENSODEP00000011925	91.5152	87.7778
ENSG00000149428	homo_sapiens	ENSP00000480150	48.2482	47.047	jaculus_jaculus	ENSJJAP00000022393	95.6349	93.254
ENSG00000149428	homo_sapiens	ENSP00000480150	93.7938	91.3914	ovis_aries_rambouillet	ENSOARP00020016744	93.513	91.1178
ENSG00000149428	homo_sapiens	ENSP00000480150	94.2943	92.0921	ursus_maritimus	ENSUMAP00000000544	94.5783	92.3695
ENSG00000149428	homo_sapiens	ENSP00000480150	92.6927	89.2893	ochotona_princeps	ENSOPRP00000014847	92.8786	89.4684
ENSG00000149428	homo_sapiens	ENSP00000480150	94.995	92.0921	delphinapterus_leucas	ENSDLEP00000027536	95.0902	92.1844
ENSG00000149428	homo_sapiens	ENSP00000480150	94.4945	91.4915	physeter_catodon	ENSPCTP00005014782	94.4945	91.4915
ENSG00000149428	homo_sapiens	ENSP00000480150	21.7217	21.3213	mus_caroli	MGP_CAROLIEiJ_P0087544	95.5947	93.8326
ENSG00000149428	homo_sapiens	ENSP00000480150	95.4955	91.992	mus_musculus	ENSMUSP00000123700	95.4955	91.992
ENSG00000149428	homo_sapiens	ENSP00000480150	21.7217	21.3213	dipodomys_ordii	ENSDORP00000026704	95.5947	93.8326
ENSG00000149428	homo_sapiens	ENSP00000480150	94.6947	92.3924	mustela_putorius_furo	ENSMPUP00000004961	94.9799	92.6707
ENSG00000149428	homo_sapiens	ENSP00000480150	98.4985	97.5976	aotus_nancymaae	ENSANAP00000023984	98.4985	97.5976
ENSG00000149428	homo_sapiens	ENSP00000480150	97.8979	96.8969	saimiri_boliviensis_boliviensis	ENSSBOP00000018298	97.8979	96.8969
ENSG00000149428	homo_sapiens	ENSP00000480150	45.045	43.1431	vicugna_pacos	ENSVPAP00000009340	46.9729	44.9896
ENSG00000149428	homo_sapiens	ENSP00000480150	98.7988	98.4985	chlorocebus_sabaeus	ENSCSAP00000015500	98.7988	98.4985
ENSG00000149428	homo_sapiens	ENSP00000480150	95.1952	91.8919	mesocricetus_auratus	ENSMAUP00000012839	95.2906	91.984
ENSG00000149428	homo_sapiens	ENSP00000480150	94.6947	91.5916	phocoena_sinus	ENSPSNP00000003259	94.6947	91.5916
ENSG00000149428	homo_sapiens	ENSP00000480150	94.2943	91.4915	camelus_dromedarius	ENSCDRP00005030072	94.2943	91.4915
ENSG00000149428	homo_sapiens	ENSP00000480150	95.7958	93.4935	carlito_syrichta	ENSTSYP00000025735	95.988	93.681
ENSG00000149428	homo_sapiens	ENSP00000480150	92.3924	89.6897	panthera_tigris_altaica	ENSPTIP00000018370	90.8465	88.189
ENSG00000149428	homo_sapiens	ENSP00000480150	95.0951	91.992	rattus_norvegicus	ENSRNOP00000039172	95.0951	91.992
ENSG00000149428	homo_sapiens	ENSP00000480150	95.2953	92.7928	prolemur_simus	ENSPSMP00000004508	95.2	92.7
ENSG00000149428	homo_sapiens	ENSP00000480150	95.0951	91.992	microtus_ochrogaster	ENSMOCP00000006900	95.0951	91.992
ENSG00000149428	homo_sapiens	ENSP00000480150	69.5696	64.965	sorex_araneus	ENSSARP00000005101	69.7091	65.0953
ENSG00000149428	homo_sapiens	ENSP00000480150	95.1952	91.992	peromyscus_maniculatus_bairdii	ENSPEMP00000006913	95.1952	91.992
ENSG00000149428	homo_sapiens	ENSP00000480150	93.7938	91.2913	bos_mutus	ENSBMUP00000015038	93.6064	91.1089
ENSG00000149428	homo_sapiens	ENSP00000480150	95.4955	91.7918	mus_spicilegus	ENSMSIP00000007982	95.4955	91.7918
ENSG00000149428	homo_sapiens	ENSP00000480150	95.0951	91.7918	cricetulus_griseus_chok1gshd	ENSCGRP00001003324	95.0951	91.7918
ENSG00000149428	homo_sapiens	ENSP00000480150	84.2843	81.8819	pteropus_vampyrus	ENSPVAP00000012772	84.6231	82.2111
ENSG00000149428	homo_sapiens	ENSP00000480150	92.993	89.4895	myotis_lucifugus	ENSMLUP00000004355	93.1795	89.669
ENSG00000149428	homo_sapiens	ENSP00000480150	88.7888	82.0821	vombatus_ursinus	ENSVURP00010005179	88.523	81.8363
ENSG00000149428	homo_sapiens	ENSP00000480150	94.0941	91.4915	rhinolophus_ferrumequinum	ENSRFEP00010022936	94.5674	91.9517
ENSG00000149428	homo_sapiens	ENSP00000480150	94.5946	92.1922	neovison_vison	ENSNVIP00000004729	93.4718	91.0979
ENSG00000149428	homo_sapiens	ENSP00000480150	91.6917	89.1892	bos_taurus	ENSBTAP00000074586	89.716	87.2674
ENSG00000149428	homo_sapiens	ENSP00000480150	93.5936	90.7908	heterocephalus_glaber_female	ENSHGLP00000009674	95.0203	92.1748
ENSG00000149428	homo_sapiens	ENSP00000480150	98.8989	98.4985	rhinopithecus_bieti	ENSRBIP00000034589	98.8989	98.4985
ENSG00000149428	homo_sapiens	ENSP00000480150	93.6937	91.1912	canis_lupus_dingo	ENSCAFP00020016268	90.4348	88.0193
ENSG00000149428	homo_sapiens	ENSP00000480150	95.6957	93.2933	sciurus_vulgaris	ENSSVLP00005018454	95.8877	93.4804
ENSG00000149428	homo_sapiens	ENSP00000480150	88.989	81.8819	phascolarctos_cinereus	ENSPCIP00000030719	87.1569	80.1961
ENSG00000149428	homo_sapiens	ENSP00000480150	83.4835	81.3814	procavia_capensis	ENSPCAP00000011893	89.1026	86.859
ENSG00000149428	homo_sapiens	ENSP00000480150	48.6486	47.2472	nannospalax_galili	ENSNGAP00000010296	96.4286	93.6508
ENSG00000149428	homo_sapiens	ENSP00000480150	90.991	88.0881	bos_grunniens	ENSBGRP00000030264	89.8221	86.9565
ENSG00000149428	homo_sapiens	ENSP00000480150	95.0951	92.0921	chinchilla_lanigera	ENSCLAP00000021753	95.0951	92.0921
ENSG00000149428	homo_sapiens	ENSP00000480150	94.2943	91.5916	cervus_hanglu_yarkandensis	ENSCHYP00000008696	94.012	91.3174
ENSG00000149428	homo_sapiens	ENSP00000480150	94.2943	91.0911	catagonus_wagneri	ENSCWAP00000019001	92.3529	89.2157
ENSG00000149428	homo_sapiens	ENSP00000480150	94.5946	92.1922	ictidomys_tridecemlineatus	ENSSTOP00000012867	94.7844	92.3771
ENSG00000149428	homo_sapiens	ENSP00000480150	87.3874	83.5836	otolemur_garnettii	ENSOGAP00000006518	87.3874	83.5836
ENSG00000149428	homo_sapiens	ENSP00000480150	97.8979	96.7968	cebus_imitator	ENSCCAP00000017093	97.8	96.7
ENSG00000149428	homo_sapiens	ENSP00000480150	94.7948	92.4925	urocitellus_parryii	ENSUPAP00010023112	94.985	92.678
ENSG00000149428	homo_sapiens	ENSP00000480150	93.3934	90.991	moschus_moschiferus	ENSMMSP00000021690	93.1138	90.7186
ENSG00000149428	homo_sapiens	ENSP00000480150	97.2973	96.7968	rhinopithecus_roxellana	ENSRROP00000023976	96.1424	95.6479
ENSG00000149428	homo_sapiens	ENSP00000480150	94.8949	91.3914	mus_pahari	MGP_PahariEiJ_P0023198	94.8949	91.3914
ENSG00000149428	homo_sapiens	ENSP00000480150	95.7958	93.3934	propithecus_coquereli	ENSPCOP00000004628	95.988	93.5807
ENSG00000149428	homo_sapiens	ENSP00000480150	40.2402	22.2222	caenorhabditis_elegans	T14G8.3.1	43.6482	24.1042
ENSG00000149428	homo_sapiens	ENSP00000480150	50.4505	36.036	drosophila_melanogaster	FBpp0290016	54.6045	39.0033
ENSG00000149428	homo_sapiens	ENSP00000480150	58.0581	41.9419	ciona_intestinalis	ENSCINP00000031737	65.9091	47.6136
ENSG00000149428	homo_sapiens	ENSP00000480150	22.1221	12.1121	petromyzon_marinus	ENSPMAP00000003647	45.3799	24.846
ENSG00000149428	homo_sapiens	ENSP00000480150	41.6416	27.7277	eptatretus_burgeri	ENSEBUP00000010334	52.327	34.8428
ENSG00000149428	homo_sapiens	ENSP00000480150	66.7668	55.0551	callorhinchus_milii	ENSCMIP00000036276	74.1111	61.1111
ENSG00000149428	homo_sapiens	ENSP00000480150	76.5766	63.5636	latimeria_chalumnae	ENSLACP00000020014	77.0393	63.9476
ENSG00000149428	homo_sapiens	ENSP00000480150	54.7548	47.4474	lepisosteus_oculatus	ENSLOCP00000006812	84.6749	73.3746
ENSG00000149428	homo_sapiens	ENSP00000480150	74.2743	62.4625	clupea_harengus	ENSCHAP00000030348	75.6371	63.6086
ENSG00000149428	homo_sapiens	ENSP00000480150	76.4765	65.1652	danio_rerio	ENSDARP00000090804	77.9592	66.4286
ENSG00000149428	homo_sapiens	ENSP00000480150	76.5766	64.4645	carassius_auratus	ENSCARP00000095642	77.665	65.3807
ENSG00000149428	homo_sapiens	ENSP00000480150	77.0771	65.4655	carassius_auratus	ENSCARP00000134682	75.9369	64.497
ENSG00000149428	homo_sapiens	ENSP00000480150	77.1772	65.6657	astyanax_mexicanus	ENSAMXP00000049057	74.8544	63.6893
ENSG00000149428	homo_sapiens	ENSP00000480150	75.6757	64.8649	ictalurus_punctatus	ENSIPUP00000009114	76.3636	65.4545
ENSG00000149428	homo_sapiens	ENSP00000480150	76.1762	65.7658	esox_lucius	ENSELUP00000016623	73.9553	63.8484
ENSG00000149428	homo_sapiens	ENSP00000480150	74.8749	63.964	electrophorus_electricus	ENSEEEP00000031412	73.913	63.1423
ENSG00000149428	homo_sapiens	ENSP00000480150	72.8729	60.6607	oncorhynchus_kisutch	ENSOKIP00005008459	71.3726	59.4118
ENSG00000149428	homo_sapiens	ENSP00000480150	73.974	61.8619	oncorhynchus_kisutch	ENSOKIP00005104095	72.451	60.5882
ENSG00000149428	homo_sapiens	ENSP00000480150	74.975	62.8629	oncorhynchus_mykiss	ENSOMYP00000028836	74.8252	62.7373
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	61.5616	oncorhynchus_mykiss	ENSOMYP00000098659	72.3529	60.2941
ENSG00000149428	homo_sapiens	ENSP00000480150	75.976	63.8639	salmo_salar	ENSSSAP00000096347	73.8327	62.0623
ENSG00000149428	homo_sapiens	ENSP00000480150	74.2743	62.7628	salmo_salar	ENSSSAP00000048047	72.6027	61.3503
ENSG00000149428	homo_sapiens	ENSP00000480150	72.6727	62.4625	salmo_trutta	ENSSTUP00000012371	75.3894	64.7975
ENSG00000149428	homo_sapiens	ENSP00000480150	73.7738	62.963	salmo_trutta	ENSSTUP00000038261	72.1841	61.6063
ENSG00000149428	homo_sapiens	ENSP00000480150	73.7738	60.961	gadus_morhua	ENSGMOP00000046424	72.7542	60.1185
ENSG00000149428	homo_sapiens	ENSP00000480150	73.3734	60.8609	fundulus_heteroclitus	ENSFHEP00000027295	75.334	62.4872
ENSG00000149428	homo_sapiens	ENSP00000480150	74.0741	62.5626	poecilia_reticulata	ENSPREP00000020322	75.8197	64.0369
ENSG00000149428	homo_sapiens	ENSP00000480150	74.2743	61.962	xiphophorus_maculatus	ENSXMAP00000025134	73.6842	61.4697
ENSG00000149428	homo_sapiens	ENSP00000480150	71.6717	59.0591	oryzias_latipes	ENSORLP00000024083	75.1312	61.9098
ENSG00000149428	homo_sapiens	ENSP00000480150	74.8749	63.8639	cyclopterus_lumpus	ENSCLMP00005023722	73.913	63.0435
ENSG00000149428	homo_sapiens	ENSP00000480150	74.2743	63.0631	oreochromis_niloticus	ENSONIP00000033785	75.7916	64.3514
ENSG00000149428	homo_sapiens	ENSP00000480150	70.0701	59.96	haplochromis_burtoni	ENSHBUP00000019547	74.6269	63.8593
ENSG00000149428	homo_sapiens	ENSP00000480150	74.0741	62.7628	astatotilapia_calliptera	ENSACLP00000006452	75.6646	64.1104
ENSG00000149428	homo_sapiens	ENSP00000480150	74.1742	62.1622	sparus_aurata	ENSSAUP00010022701	74.9242	62.7907
ENSG00000149428	homo_sapiens	ENSP00000480150	75.6757	63.1632	lates_calcarifer	ENSLCAP00010023757	77.0642	64.3221
ENSG00000149428	homo_sapiens	ENSP00000480150	78.2783	65.1652	xenopus_tropicalis	ENSXETP00000072829	77.8109	64.7761
ENSG00000149428	homo_sapiens	ENSP00000480150	81.0811	70.4705	chrysemys_picta_bellii	ENSCPBP00000005503	70.619	61.3775
ENSG00000149428	homo_sapiens	ENSP00000480150	80.8809	68.3684	sphenodon_punctatus	ENSSPUP00000005484	79.6844	67.357
ENSG00000149428	homo_sapiens	ENSP00000480150	79.2793	68.3684	crocodylus_porosus	ENSCPRP00005009548	72.3949	62.4314
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	62.8629	laticauda_laticaudata	ENSLLTP00000014612	75.5374	64.2784
ENSG00000149428	homo_sapiens	ENSP00000480150	76.0761	64.4645	notechis_scutatus	ENSNSUP00000008377	71.028	60.1869
ENSG00000149428	homo_sapiens	ENSP00000480150	75.0751	63.964	pseudonaja_textilis	ENSPTXP00000007057	77.3196	65.8763
ENSG00000149428	homo_sapiens	ENSP00000480150	78.4785	68.2683	anas_platyrhynchos_platyrhynchos	ENSAPLP00000005679	79.272	68.9585
ENSG00000149428	homo_sapiens	ENSP00000480150	80.4805	70.3704	gallus_gallus	ENSGALP00010037488	77.4566	67.7264
ENSG00000149428	homo_sapiens	ENSP00000480150	77.8779	68.6687	meleagris_gallopavo	ENSMGAP00000004290	79.9589	70.5036
ENSG00000149428	homo_sapiens	ENSP00000480150	79.98	68.8689	serinus_canaria	ENSSCAP00000023989	80.3823	69.2153
ENSG00000149428	homo_sapiens	ENSP00000480150	80.1802	68.969	parus_major	ENSPMJP00000009411	80.5835	69.3159
ENSG00000149428	homo_sapiens	ENSP00000480150	78.979	68.6687	anolis_carolinensis	ENSACAP00000013983	79.6165	69.223
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	62.963	neolamprologus_brichardi	ENSNBRP00000006418	75.4601	64.3149
ENSG00000149428	homo_sapiens	ENSP00000480150	75.3754	64.1642	naja_naja	ENSNNAP00000019424	74.7024	63.5913
ENSG00000149428	homo_sapiens	ENSP00000480150	79.2793	67.4675	podarcis_muralis	ENSPMRP00000031189	79.8387	67.9436
ENSG00000149428	homo_sapiens	ENSP00000480150	71.2713	61.5616	geospiza_fortis	ENSGFOP00000005911	77.8993	67.2867
ENSG00000149428	homo_sapiens	ENSP00000480150	74.6747	65.1652	taeniopygia_guttata	ENSTGUP00000000047	82.6135	72.093
ENSG00000149428	homo_sapiens	ENSP00000480150	75.7758	64.2643	erpetoichthys_calabaricus	ENSECRP00000018261	75.9278	64.3932
ENSG00000149428	homo_sapiens	ENSP00000480150	73.4735	62.4625	kryptolebias_marmoratus	ENSKMAP00000021817	78.1683	66.4537
ENSG00000149428	homo_sapiens	ENSP00000480150	78.979	67.8679	salvator_merianae	ENSSMRP00000028245	78.664	67.5972
ENSG00000149428	homo_sapiens	ENSP00000480150	73.2733	61.1612	oryzias_javanicus	ENSOJAP00000037672	75	62.6025
ENSG00000149428	homo_sapiens	ENSP00000480150	72.4725	61.3614	amphilophus_citrinellus	ENSACIP00000024689	78.0172	66.056
ENSG00000149428	homo_sapiens	ENSP00000480150	75.0751	63.1632	dicentrarchus_labrax	ENSDLAP00005006356	76.0649	63.9959
ENSG00000149428	homo_sapiens	ENSP00000480150	74.975	64.3644	amphiprion_percula	ENSAPEP00000020328	75.9635	65.213
ENSG00000149428	homo_sapiens	ENSP00000480150	73.3734	60.1602	oryzias_sinensis	ENSOSIP00000033978	75.1795	61.641
ENSG00000149428	homo_sapiens	ENSP00000480150	78.3784	68.3684	pelodiscus_sinensis	ENSPSIP00000003337	78.3	68.3
ENSG00000149428	homo_sapiens	ENSP00000480150	73.3734	63.7638	gopherus_evgoodei	ENSGEVP00005030196	78.6481	68.3476
ENSG00000149428	homo_sapiens	ENSP00000480150	75.7758	65.4655	chelonoidis_abingdonii	ENSCABP00000014299	78.8542	68.125
ENSG00000149428	homo_sapiens	ENSP00000480150	75.8759	63.5636	seriola_dumerili	ENSSDUP00000029639	77.2681	64.7299
ENSG00000149428	homo_sapiens	ENSP00000480150	71.1712	59.8599	cottoperca_gobio	ENSCGOP00000037461	76.0428	63.9572
ENSG00000149428	homo_sapiens	ENSP00000480150	78.5786	68.6687	struthio_camelus_australis	ENSSCUP00000014162	80.7613	70.5761
ENSG00000149428	homo_sapiens	ENSP00000480150	75.3754	63.964	gasterosteus_aculeatus	ENSGACP00000026575	75.4509	64.0281
ENSG00000149428	homo_sapiens	ENSP00000480150	74.6747	62.963	cynoglossus_semilaevis	ENSCSEP00000030546	73.1373	61.6667
ENSG00000149428	homo_sapiens	ENSP00000480150	74.2743	62.4625	poecilia_formosa	ENSPFOP00000021214	75.5601	63.5438
ENSG00000149428	homo_sapiens	ENSP00000480150	75.5756	64.6647	myripristis_murdjan	ENSMMDP00005033454	76.8839	65.7841
ENSG00000149428	homo_sapiens	ENSP00000480150	72.0721	61.2613	sander_lucioperca	ENSSLUP00000020336	73.922	62.8337
ENSG00000149428	homo_sapiens	ENSP00000480150	79.4795	68.7688	strigops_habroptila	ENSSHBP00005022031	79.4	68.7
ENSG00000149428	homo_sapiens	ENSP00000480150	74.975	64.2643	amphiprion_ocellaris	ENSAOCP00000029817	75.9635	65.1116
ENSG00000149428	homo_sapiens	ENSP00000480150	78.0781	66.7668	terrapene_carolina_triunguis	ENSTMTP00000013361	78.629	67.2379
ENSG00000149428	homo_sapiens	ENSP00000480150	76.2763	63.964	hucho_hucho	ENSHHUP00000088153	73.1286	61.3244
ENSG00000149428	homo_sapiens	ENSP00000480150	72.2723	61.6617	hucho_hucho	ENSHHUP00000049694	75.523	64.4352
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	61.962	betta_splendens	ENSBSLP00000009930	74.5455	62.5253
ENSG00000149428	homo_sapiens	ENSP00000480150	77.1772	66.3664	pygocentrus_nattereri	ENSPNAP00000023659	77.9575	67.0374
ENSG00000149428	homo_sapiens	ENSP00000480150	74.8749	63.2633	anabas_testudineus	ENSATEP00000023213	76.0163	64.2276
ENSG00000149428	homo_sapiens	ENSP00000480150	58.0581	41.4414	ciona_savignyi	ENSCSAVP00000005549	59.1233	42.2018
ENSG00000149428	homo_sapiens	ENSP00000480150	35.3353	18.6186	saccharomyces_cerevisiae	YKL073W	40.0681	21.1124
ENSG00000149428	homo_sapiens	ENSP00000480150	75.1752	62.963	seriola_lalandi_dorsalis	ENSSLDP00000016251	76.5545	64.1182
ENSG00000149428	homo_sapiens	ENSP00000480150	74.7748	62.7628	labrus_bergylta	ENSLBEP00000027829	76.3024	64.0449
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	62.6627	pundamilia_nyererei	ENSPNYP00000002206	75.4601	64.0082
ENSG00000149428	homo_sapiens	ENSP00000480150	75.6757	63.964	mastacembelus_armatus	ENSMAMP00000002650	75.5245	63.8362
ENSG00000149428	homo_sapiens	ENSP00000480150	75.5756	64.1642	stegastes_partitus	ENSSPAP00000001252	76.572	65.0101
ENSG00000149428	homo_sapiens	ENSP00000480150	73.5736	61.3614	oncorhynchus_tshawytscha	ENSOTSP00005095264	70.8092	59.0559
ENSG00000149428	homo_sapiens	ENSP00000480150	74.7748	63.1632	oncorhynchus_tshawytscha	ENSOTSP00005086226	71.9653	60.79
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	61.4615	oncorhynchus_tshawytscha	ENSOTSP00005046977	72.2821	60.1371
ENSG00000149428	homo_sapiens	ENSP00000480150	71.0711	61.2613	acanthochromis_polyacanthus	ENSAPOP00000002493	74.6583	64.3533
ENSG00000149428	homo_sapiens	ENSP00000480150	79.1792	68.8689	aquila_chrysaetos_chrysaetos	ENSACCP00020009790	81.5464	70.9278
ENSG00000149428	homo_sapiens	ENSP00000480150	73.7738	62.7628	nothobranchius_furzeri	ENSNFUP00015036296	75.9011	64.5726
ENSG00000149428	homo_sapiens	ENSP00000480150	68.5686	54.2543	cyprinodon_variegatus	ENSCVAP00000000460	71.9538	56.9328
ENSG00000149428	homo_sapiens	ENSP00000480150	75.2753	63.5636	denticeps_clupeoides	ENSDCDP00000030387	76.1905	64.3364
ENSG00000149428	homo_sapiens	ENSP00000480150	75.5756	63.3634	larimichthys_crocea	ENSLCRP00005060454	75.5	63.3
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	61.1612	takifugu_rubripes	ENSTRUP00000009688	75.6923	62.6667
ENSG00000149428	homo_sapiens	ENSP00000480150	79.98	69.2693	ficedula_albicollis	ENSFALP00000010293	80.3823	69.6177
ENSG00000149428	homo_sapiens	ENSP00000480150	74.2743	61.0611	hippocampus_comes	ENSHCOP00000020829	76.259	62.6927
ENSG00000149428	homo_sapiens	ENSP00000480150	74.3744	63.2633	cyprinus_carpio_carpio	ENSCCRP00000014226	75.1264	63.9029
ENSG00000149428	homo_sapiens	ENSP00000480150	77.1772	65.3654	cyprinus_carpio_carpio	ENSCCRP00000147306	75.9606	64.335
ENSG00000149428	homo_sapiens	ENSP00000480150	79.7798	68.8689	coturnix_japonica	ENSCJPP00005014947	80.1005	69.1457
ENSG00000149428	homo_sapiens	ENSP00000480150	74.1742	62.4625	poecilia_latipinna	ENSPLAP00000002718	76.947	64.7975
ENSG00000149428	homo_sapiens	ENSP00000480150	76.977	65.6657	sinocyclocheilus_grahami	ENSSGRP00000046732	78.3096	66.8024
ENSG00000149428	homo_sapiens	ENSP00000480150	74.2743	63.5636	sinocyclocheilus_grahami	ENSSGRP00000026366	75.1012	64.2713
ENSG00000149428	homo_sapiens	ENSP00000480150	73.8739	62.8629	maylandia_zebra	ENSMZEP00005031553	75.4601	64.2127
ENSG00000149428	homo_sapiens	ENSP00000480150	19.8198	15.6156	tetraodon_nigroviridis	ENSTNIP00000004277	73.6059	57.9926
ENSG00000149428	homo_sapiens	ENSP00000480150	73.7738	60.8609	tetraodon_nigroviridis	ENSTNIP00000011439	77.5789	64
ENSG00000149428	homo_sapiens	ENSP00000480150	75.7758	64.4645	paramormyrops_kingsleyae	ENSPKIP00000018126	76.1569	64.7887
ENSG00000149428	homo_sapiens	ENSP00000480150	75.0751	64.0641	scleropages_formosus	ENSSFOP00015043770	75.3769	64.3216
ENSG00000149428	homo_sapiens	ENSP00000480150	77.0771	65.966	leptobrachium_leishanense	ENSLLEP00000029031	79.8755	68.361
ENSG00000149428	homo_sapiens	ENSP00000480150	69.8699	58.6587	leptobrachium_leishanense	ENSLLEP00000048530	76.7033	64.3956
ENSG00000149428	homo_sapiens	ENSP00000480150	75.7758	63.2633	scophthalmus_maximus	ENSSMAP00000050165	76.7748	64.0974
ENSG00000149428	homo_sapiens	ENSP00000480150	72.7728	60.8609	oryzias_melastigma	ENSOMEP00000028148	74.4115	62.2313

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000774	enables adenyl-nucleotide exchange factor activity	1	IBA	Homo_sapiens(9606)	Function
GO:0002931	involved_in response to ischemia	1	ISS	Homo_sapiens(9606)	Process
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005524	enables ATP binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	TAS	Homo_sapiens(9606)	Component
GO:0005783	located_in endoplasmic reticulum	1	NAS	Homo_sapiens(9606)	Component
GO:0005788	located_in endoplasmic reticulum lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0005790	located_in smooth endoplasmic reticulum	1	ISS	Homo_sapiens(9606)	Component
GO:0005925	located_in focal adhesion	1	HDA	Homo_sapiens(9606)	Component
GO:0006457	involved_in protein folding	1	IEA	Homo_sapiens(9606)	Process
GO:0006888	involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	1	IDA	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0034663	part_of endoplasmic reticulum chaperone complex	1	IBA	Homo_sapiens(9606)	Component
GO:0034976	involved_in response to endoplasmic reticulum stress	1	IEP	Homo_sapiens(9606)	Process
GO:0051082	enables unfolded protein binding	1	ISS	Homo_sapiens(9606)	Function
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0071456	involved_in cellular response to hypoxia	2	IDA,IEP	Homo_sapiens(9606)	Process
GO:0071682	located_in endocytic vesicle lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0140662	enables ATP-dependent protein folding chaperone	1	IEA	Homo_sapiens(9606)	Function
GO:1903298	involved_in negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:1903382	involved_in negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway	1	IEA	Homo_sapiens(9606)	Process