Ensembl ID ENSG00000149428 Gene ID 10525 Accession 16931
Gene Symbol HYOU1 Alias IMD59;Grp170;HSP12A;ORP150;GRP-170;ORP-150 Full Name hypoxia up-regulated 1
Position 11 : 119044188 - 119057227 Length 13040 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

ENSG00000149428 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000149428 HYOU1 0.76 1.11e-26 BRCA
ENSG00000149428 HYOU1 0.91 2.10e-20 LUSC
ENSG00000149428 HYOU1 1.14 5.31e-20 UCEC
ENSG00000149428 HYOU1 1.12 2.80e-31 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000149428 HYOU1 Tumors 11358846
ENSG00000149428 HYOU1 prostate cancer 11690552
ENSG00000149428 HYOU1 tumor 11771177
ENSG00000149428 HYOU1 bladder cancer 12175409
ENSG00000149428 HYOU1 prostate cancer 12445237
ENSG00000149428 HYOU1 tumour 16519738
ENSG00000149428 HYOU1 tumour 16543725
ENSG00000149428 HYOU1 cancer 16861902
ENSG00000149428 HYOU1 tumors 17167033
ENSG00000149428 HYOU1 breast cancer 17968289
ENSG00000149428 HYOU1 tumors 19360299
ENSG00000149428 HYOU1 tumor 19812200
ENSG00000149428 HYOU1 tumor 20637304
ENSG00000149428 HYOU1 thyroid cancer 20719828
ENSG00000149428 HYOU1 tumor 21339366
ENSG00000149428 HYOU1 tumor 23127963
ENSG00000149428 HYOU1 cancer 23363441
ENSG00000149428 HYOU1 cancer 23757447
ENSG00000149428 HYOU1 tumor 24039668
ENSG00000149428 HYOU1 tumor 24920810
ENSG00000149428 HYOU1 Cancer 25629003
ENSG00000149428 HYOU1 cancer 25684010
ENSG00000149428 HYOU1 pancreatic cancer 25987888
ENSG00000149428 HYOU1 tumor 26388988
ENSG00000149428 HYOU1 cancer 26636034
ENSG00000149428 HYOU1 thyroid cancer 26700459
ENSG00000149428 HYOU1 tumor 26918051
ENSG00000149428 HYOU1 mammary cancer 27160935
ENSG00000149428 HYOU1 cancer 27713320
ENSG00000149428 HYOU1 tumor 27799870
ENSG00000149428 HYOU1 tumor 28468249
ENSG00000149428 HYOU1 cancer 28846078
ENSG00000149428 HYOU1 cancer 28914774
ENSG00000149428 HYOU1 tumour 29098793
ENSG00000149428 HYOU1 tumor 29285267
ENSG00000149428 HYOU1 prostate cancer 29997385
ENSG00000149428 HYOU1 epithelial ovarian cancer 31173282
ENSG00000149428 HYOU1 tumor 9645760
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000149428 HYOU1 SARC 0.01 high
ENSG00000149428 HYOU1 STAD 0.045 low
ENSG00000149428 HYOU1 UVM 0.0014 high
ENSG00000149428 HYOU1 PAAD 0.031 low
ENSG00000149428 HYOU1 UCEC 0.00024 low
ENSG00000149428 HYOU1 THCA 0.00035 high
ENSG00000149428 HYOU1 LUSC 0.041 high
ENSG00000149428 HYOU1 HNSC 0.011 high
ENSG00000149428 HYOU1 KIRP 0.019 high
ENSG00000149428 HYOU1 KICH 0.025 high
ENSG00000149428 HYOU1 BRCA 0.043 low
ENSG00000149428 HYOU1 UCS 0.025 high
ENSG00000149428 HYOU1 KIRC 0.00013 high
ENSG00000149428 HYOU1 TGCT 0.00027 high
ENSG00000149428 HYOU1 BLCA 0.029 high
ENSG00000149428 HYOU1 LAML 7e-04 low
ENSG00000149428 HYOU1 SKCM 0.032 low
ENSG00000149428 HYOU1 CESC 0.018 high
ENSG00000149428 HYOU1 LIHC 0.0022 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000149428 HYOU1 LUSC Del 2.435993 0.088168 0.349323 0.347305
ENSG00000149428 HYOU1 LUAD Del 2.487741 0.072177 0.326874 0.215116
ENSG00000149428 HYOU1 LGG Amp 1.736394 0.059131 0.461468 0.163743
ENSG00000149428 HYOU1 CESC Del 27.575413 0.304610 0.574917 0.545763
ENSG00000149428 HYOU1 KIRP Del 3.401020 0.051877 0.572737 0.100694
ENSG00000149428 HYOU1 SARC Del 6.370556 0.239278 0.551043 0.470817
ENSG00000149428 HYOU1 ESCA Del 1.429005 0.117679 0.432056 0.418478
ENSG00000149428 HYOU1 SKCM Del 22.136448 0.252815 0.554061 0.547684
ENSG00000149428 HYOU1 HNSC Del 16.937186 0.157212 0.439335 0.467433
ENSG00000149428 HYOU1 LIHC Del 2.262766 0.089245 0.481205 0.251351
ENSG00000149428 HYOU1 PCPG Del 0.881565 0.062152 0.614542 0.283951
ENSG00000149428 HYOU1 TGCT Del 5.036716 0.140744 0.477357 0.806667
ENSG00000149428 HYOU1 BLCA Del 3.141529 0.113307 0.406314 0.372549
ENSG00000149428 HYOU1 BRCA Del 47.980360 0.221542 0.518078 0.495370
ENSG00000149428 HYOU1 STAD Del 1.282005 0.068985 0.359024 0.206349
ENSG00000149428 HYOU1 PRAD Del 1.069966 0.077018 0.494217 0.075203
ENSG00000149428 HYOU1 UCEC Del 0.979410 0.051622 0.496810 0.152134
ENSG00000149428 HYOU1 UVM Del 1.063142 0.073079 0.581446 0.075000