Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000146731 Gene ID 908 Accession 1620
Symbol CCT6A Alias CCT6;Cctz;HTR3;TCPZ;TCP20;MoDP-2;TTCP20;CCT-zeta;CCT-zeta-1;TCP-1-zeta Full Name chaperonin containing TCP1 subunit 6A
Status Confidence Length 12305 bases Strand Plus strand
Position 7 : 56051685 - 56063989 RNA binding domain N.A.
Summary The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
CCT6A-201 ENST00000275603 2584 531aa ENSP00000275603
CCT6A-202 ENST00000335503 2529 486aa ENSP00000352019
CCT6A-208 ENST00000493855 261 No protein -
CCT6A-206 ENST00000482776 765 No protein -
CCT6A-207 ENST00000492618 692 No protein -
CCT6A-205 ENST00000466572 686 No protein -
CCT6A-203 ENST00000462133 665 No protein -
CCT6A-209 ENST00000494736 411 No protein -
CCT6A-204 ENST00000466479 745 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000146731homo_sapiensENSP0000025809148.618827.0718homo_sapiensENSP0000027560349.717527.6836
ENSG00000146731homo_sapiensENSP0000024606235.087717.5439homo_sapiensENSP0000027560337.664818.8324
ENSG00000146731homo_sapiensENSP0000035304837.522421.3645homo_sapiensENSP0000027560339.359722.4105
ENSG00000146731homo_sapiensENSP0000031906226.478911.9718homo_sapiensENSP0000027560335.404916.0075
ENSG00000146731homo_sapiensENSP0000026438011.72555.86273homo_sapiensENSP0000027560346.327723.1638
ENSG00000146731homo_sapiensENSP0000032719194.339685.8491homo_sapiensENSP0000027560394.16285.6874
ENSG00000146731homo_sapiensENSP0000028678842.883224.635homo_sapiensENSP0000027560344.256125.4237
ENSG00000146731homo_sapiensENSP0000029930047.476624.486homo_sapiensENSP0000027560347.834324.6704
ENSG00000146731homo_sapiensENSP0000037795850.092828.3859homo_sapiensENSP0000027560350.847528.8136
ENSG00000146731homo_sapiensENSP0000029568851.743126.789homo_sapiensENSP0000027560353.107327.4953
ENSG00000146731homo_sapiensENSP0000028032650.092429.39homo_sapiensENSP0000027560351.035829.9435
ENSG00000146731homo_sapiensENSP0000031733447.661927.1583homo_sapiensENSP0000027560349.905828.4369
ENSG00000146731homo_sapiensENSP0000037362036.474720.4188homo_sapiensENSP0000027560339.359722.0339

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000146731homo_sapiensENSP00000275603100100nomascus_leucogenysENSNLEP00000037522100100
ENSG00000146731homo_sapiensENSP0000027560396.421896.4218pan_paniscusENSPPAP0000000516397.338497.3384
ENSG00000146731homo_sapiensENSP0000027560399.811799.8117pongo_abeliiENSPPYP0000002345799.811799.8117
ENSG00000146731homo_sapiensENSP00000275603100100pan_troglodytesENSPTRP0000006145694.148994.1489
ENSG00000146731homo_sapiensENSP00000275603100100pan_troglodytesENSPTRP0000008797794.148994.1489
ENSG00000146731homo_sapiensENSP0000027560399.246799.0584gorilla_gorillaENSGGOP0000002869993.605793.4281
ENSG00000146731homo_sapiensENSP0000027560399.246799.0584gorilla_gorillaENSGGOP0000004112493.605793.4281
ENSG00000146731homo_sapiensENSP00000275603100100gorilla_gorillaENSGGOP00000011156100100
ENSG00000146731homo_sapiensENSP0000027560393.785390.3955choloepus_hoffmanniENSCHOP0000000058299.00695.4274
ENSG00000146731homo_sapiensENSP0000027560365.536763.0885dasypus_novemcinctusENSDNOP0000002224899.428695.7143
ENSG00000146731homo_sapiensENSP0000027560369.114967.2316erinaceus_europaeusENSEEUP0000000496979.094876.9397
ENSG00000146731homo_sapiensENSP0000027560392.655489.4539echinops_telfairiENSETEP0000000761992.655489.4539
ENSG00000146731homo_sapiensENSP0000027560310098.6817callithrix_jacchusENSCJAP0000003961510098.6817
ENSG00000146731homo_sapiensENSP0000027560310099.2467cercocebus_atysENSCATP0000002399293.816393.1095
ENSG00000146731homo_sapiensENSP0000027560310099.2467macaca_fascicularisENSMFAP0000000626010099.2467
ENSG00000146731homo_sapiensENSP0000027560310099.2467macaca_mulattaENSMMUP0000002002610099.2467
ENSG00000146731homo_sapiensENSP0000027560357.250554.4256macaca_nemestrinaENSMNEP0000000734895.597590.8805
ENSG00000146731homo_sapiensENSP0000027560385.122481.9209macaca_nemestrinaENSMNEP0000000255485.28382.0755
ENSG00000146731homo_sapiensENSP0000027560373.069772.3164macaca_nemestrinaENSMNEP0000000088799.232798.2097
ENSG00000146731homo_sapiensENSP0000027560310099.2467papio_anubisENSPANP0000000585290.924790.2397
ENSG00000146731homo_sapiensENSP0000027560310099.2467mandrillus_leucophaeusENSMLEP0000002265793.157992.4561
ENSG00000146731homo_sapiensENSP0000027560387.19484.1808mandrillus_leucophaeusENSMLEP0000000636189.038585.9615
ENSG00000146731homo_sapiensENSP0000027560394.915392.6554tursiops_truncatusENSTTRP0000001437799.408397.0414
ENSG00000146731homo_sapiensENSP0000027560391.525487.7589vulpes_vulpesENSVVUP0000002265993.641689.7881
ENSG00000146731homo_sapiensENSP0000027560399.811796.9868equus_asinusENSEASP0000501269099.811796.9868
ENSG00000146731homo_sapiensENSP0000027560388.323984.9341capra_hircusENSCHIP0000001590397.101493.3747
ENSG00000146731homo_sapiensENSP0000027560384.180879.2844capra_hircusENSCHIP0000002533092.355486.9835
ENSG00000146731homo_sapiensENSP0000027560394.726991.1488capra_hircusENSCHIP0000002324498.242294.5312
ENSG00000146731homo_sapiensENSP0000027560396.421892.6554capra_hircusENSCHIP0000000238096.421892.6554
ENSG00000146731homo_sapiensENSP0000027560394.538691.7137capra_hircusENSCHIP0000002787598.431495.4902
ENSG00000146731homo_sapiensENSP0000027560399.623496.9868capra_hircusENSCHIP0000001511399.623496.9868
ENSG00000146731homo_sapiensENSP0000027560393.59789.2655loxodonta_africanaENSLAFP0000001919393.59789.2655
ENSG00000146731homo_sapiensENSP0000027560399.058496.9868panthera_leoENSPLOP0000002058510097.9087
ENSG00000146731homo_sapiensENSP0000027560399.811798.1168ailuropoda_melanoleucaENSAMEP0000001700999.811798.1168
ENSG00000146731homo_sapiensENSP0000027560363.276859.322bos_indicus_hybridENSBIXP0000500687693.074887.2576
ENSG00000146731homo_sapiensENSP0000027560399.623497.1751bos_indicus_hybridENSBIXP0000504422299.623497.1751
ENSG00000146731homo_sapiensENSP0000027560399.058496.7985oryctolagus_cuniculusENSOCUP0000001518099.058496.7985
ENSG00000146731homo_sapiensENSP0000027560395.668591.3371equus_caballusENSECAP0000001756096.946692.5573
ENSG00000146731homo_sapiensENSP0000027560399.811797.9284canis_lupus_familiarisENSCAFP0084501775899.811797.9284
ENSG00000146731homo_sapiensENSP0000027560399.058496.9868panthera_pardusENSPPRP0000000995110097.9087
ENSG00000146731homo_sapiensENSP0000027560393.220388.5122marmota_marmota_marmotaENSMMMP0000000457791.497286.8762
ENSG00000146731homo_sapiensENSP0000027560396.798594.7269balaenoptera_musculusENSBMSP0001002240499.612497.4806
ENSG00000146731homo_sapiensENSP0000027560389.453986.2524balaenoptera_musculusENSBMSP0001000697097.535994.0452
ENSG00000146731homo_sapiensENSP0000027560399.43596.6102cavia_porcellusENSCPOP0000000630499.43596.6102
ENSG00000146731homo_sapiensENSP0000027560376.271272.8814felis_catusENSFCAP0000005555194.405690.2098
ENSG00000146731homo_sapiensENSP0000027560399.811797.9284ursus_americanusENSUAMP0000000478686.03984.4156
ENSG00000146731homo_sapiensENSP0000027560396.986894.7269bison_bison_bisonENSBBBP0000002147699.613297.2921
ENSG00000146731homo_sapiensENSP0000027560396.610294.162monodon_monocerosENSMMNP0001501237099.418696.8992
ENSG00000146731homo_sapiensENSP0000027560399.811797.3635sus_scrofaENSSSCP0000002070799.811797.3635
ENSG00000146731homo_sapiensENSP0000027560386.252483.0508microcebus_murinusENSMICP0000003644192.712589.2713
ENSG00000146731homo_sapiensENSP0000027560381.544377.5895microcebus_murinusENSMICP0000002550084.077780
ENSG00000146731homo_sapiensENSP0000027560399.811797.9284microcebus_murinusENSMICP0000002619599.624197.7444
ENSG00000146731homo_sapiensENSP0000027560382.109275.7062octodon_degusENSODEP0000001024287.550280.7229
ENSG00000146731homo_sapiensENSP0000027560370.433167.42octodon_degusENSODEP0000002029798.421194.2105
ENSG00000146731homo_sapiensENSP0000027560382.297675.7062jaculus_jaculusENSJJAP0000001342993.978586.4516
ENSG00000146731homo_sapiensENSP0000027560392.278788.3239jaculus_jaculusENSJJAP0000001326394.412390.3661
ENSG00000146731homo_sapiensENSP0000027560399.246795.2919jaculus_jaculusENSJJAP0000000863999.246795.2919
ENSG00000146731homo_sapiensENSP0000027560374.952972.693ovis_aries_rambouilletENSOARP0002000293895.903693.012
ENSG00000146731homo_sapiensENSP0000027560393.785390.3955ursus_maritimusENSUMAP0000002159489.407586.1759
ENSG00000146731homo_sapiensENSP0000027560389.077283.6158ochotona_princepsENSOPRP0000000759492.927387.2299
ENSG00000146731homo_sapiensENSP0000027560390.018887.194ochotona_princepsENSOPRP0000000307990.188787.3585
ENSG00000146731homo_sapiensENSP0000027560399.43596.9868delphinapterus_leucasENSDLEP0000002590399.43596.9868
ENSG00000146731homo_sapiensENSP0000027560395.856993.9736physeter_catodonENSPCTP0000500761999.608697.6517
ENSG00000146731homo_sapiensENSP0000027560399.811796.6102mus_musculusENSMUSP0000015938599.811796.6102
ENSG00000146731homo_sapiensENSP0000027560399.43595.8569dipodomys_ordiiENSDORP0000002710899.43595.8569
ENSG00000146731homo_sapiensENSP0000027560395.668592.8437mustela_putorius_furoENSMPUP0000000132397.31894.4444
ENSG00000146731homo_sapiensENSP0000027560396.610294.3503mustela_putorius_furoENSMPUP0000001610694.128491.9266
ENSG00000146731homo_sapiensENSP0000027560310098.8701aotus_nancymaaeENSANAP0000001071693.816392.7562
ENSG00000146731homo_sapiensENSP0000027560380.979379.661saimiri_boliviensis_boliviensisENSSBOP0000001813599.078397.4654
ENSG00000146731homo_sapiensENSP0000027560386.817384.9341vicugna_pacosENSVPAP0000000470199.353497.1983
ENSG00000146731homo_sapiensENSP0000027560385.122484.3691chlorocebus_sabaeusENSCSAP0000001220699.779398.8962
ENSG00000146731homo_sapiensENSP0000027560373.069768.5499mesocricetus_auratusENSMAUP0000001894487.584682.167
ENSG00000146731homo_sapiensENSP0000027560376.271273.4463phocoena_sinusENSPSNP0000002775695.294191.7647
ENSG00000146731homo_sapiensENSP0000027560379.849376.2712phocoena_sinusENSPSNP0000002697290.792386.7238
ENSG00000146731homo_sapiensENSP0000027560399.43597.5518camelus_dromedariusENSCDRP0000502276599.43597.5518
ENSG00000146731homo_sapiensENSP0000027560399.811797.9284carlito_syrichtaENSTSYP0000001521194.812293.0233
ENSG00000146731homo_sapiensENSP0000027560382.485978.1544panthera_tigris_altaicaENSPTIP0000001687088.843884.1785
ENSG00000146731homo_sapiensENSP0000027560372.316470.2448rattus_norvegicusENSRNOP0000009658694.348991.6462
ENSG00000146731homo_sapiensENSP0000027560377.401172.8814rattus_norvegicusENSRNOP0000009196091.946386.5772
ENSG00000146731homo_sapiensENSP0000027560310096.7985rattus_norvegicusENSRNOP0000000122794.316291.2966
ENSG00000146731homo_sapiensENSP0000027560399.623498.1168prolemur_simusENSPSMP0000002125999.623498.1168
ENSG00000146731homo_sapiensENSP0000027560310097.1751microtus_ochrogasterENSMOCP0000002557910097.1751
ENSG00000146731homo_sapiensENSP0000027560382.862577.7778microtus_ochrogasterENSMOCP0000002155992.243286.5828
ENSG00000146731homo_sapiensENSP0000027560390.018887.194sorex_araneusENSSARP0000000939898.964895.8592
ENSG00000146731homo_sapiensENSP0000027560392.46790.5838peromyscus_maniculatus_bairdiiENSPEMP0000000418910097.9633
ENSG00000146731homo_sapiensENSP0000027560393.59789.6422bos_mutusENSBMUP0000003385193.245889.3058
ENSG00000146731homo_sapiensENSP0000027560364.971760.8286bos_mutusENSBMUP0000002509592.991987.062
ENSG00000146731homo_sapiensENSP0000027560388.888984.5574mus_spicilegusENSMSIP0000001604397.925393.1535
ENSG00000146731homo_sapiensENSP0000027560379.472775.1412cricetulus_griseus_chok1gshdENSCGRP0000101778592.543987.5
ENSG00000146731homo_sapiensENSP0000027560355.932252.5424cricetulus_griseus_chok1gshdENSCGRP0000101670591.950586.3777
ENSG00000146731homo_sapiensENSP0000027560399.43596.2335cricetulus_griseus_chok1gshdENSCGRP0000102138299.43596.2335
ENSG00000146731homo_sapiensENSP0000027560399.811796.6102pteropus_vampyrusENSPVAP0000000133899.811796.6102
ENSG00000146731homo_sapiensENSP0000027560399.43595.6685myotis_lucifugusENSMLUP0000001379499.43595.6685
ENSG00000146731homo_sapiensENSP0000027560399.623497.1751rhinolophus_ferrumequinumENSRFEP0001000053299.623497.1751
ENSG00000146731homo_sapiensENSP0000027560310097.9284neovison_visonENSNVIP0000001193710097.9284
ENSG00000146731homo_sapiensENSP0000027560399.623497.1751bos_taurusENSBTAP0000006925199.623497.1751
ENSG00000146731homo_sapiensENSP0000027560364.971761.0169heterocephalus_glaber_femaleENSHGLP0000003728389.378283.9378
ENSG00000146731homo_sapiensENSP0000027560389.830586.2524heterocephalus_glaber_femaleENSHGLP0000002188694.455490.6931
ENSG00000146731homo_sapiensENSP0000027560398.870196.4218heterocephalus_glaber_femaleENSHGLP0000001348998.870196.4218
ENSG00000146731homo_sapiensENSP0000027560399.623498.8701rhinopithecus_bietiENSRBIP0000002796790.119289.4378
ENSG00000146731homo_sapiensENSP0000027560399.811797.9284canis_lupus_dingoENSCAFP0002000631999.811797.9284
ENSG00000146731homo_sapiensENSP0000027560390.960488.3239sciurus_vulgarisENSSVLP0000501006997.773394.9393
ENSG00000146731homo_sapiensENSP0000027560399.811797.3635sciurus_vulgarisENSSVLP0000501383299.811797.3635
ENSG00000146731homo_sapiensENSP0000027560397.740192.2787phascolarctos_cinereusENSPCIP0000004088497.740192.2787
ENSG00000146731homo_sapiensENSP0000027560391.337188.5122procavia_capensisENSPCAP0000001453591.682488.8469
ENSG00000146731homo_sapiensENSP0000027560376.647870.6215nannospalax_galiliENSNGAP0000000260487.339180.4721
ENSG00000146731homo_sapiensENSP0000027560371.563165.9134nannospalax_galiliENSNGAP0000000589487.759880.8314
ENSG00000146731homo_sapiensENSP0000027560310097.1751nannospalax_galiliENSNGAP0000002290010097.1751
ENSG00000146731homo_sapiensENSP0000027560399.623497.1751bos_grunniensENSBGRP0000002695299.623497.1751
ENSG00000146731homo_sapiensENSP0000027560364.783460.8286bos_grunniensENSBGRP0000000430892.97387.2973
ENSG00000146731homo_sapiensENSP0000027560398.681795.2919chinchilla_lanigeraENSCLAP0000000627298.681795.2919
ENSG00000146731homo_sapiensENSP0000027560370.809867.42cervus_hanglu_yarkandensisENSCHYP0000003893792.839588.3951
ENSG00000146731homo_sapiensENSP0000027560399.623497.1751catagonus_wagneriENSCWAP0000000790599.623497.1751
ENSG00000146731homo_sapiensENSP0000027560399.811796.7985ictidomys_tridecemlineatusENSSTOP0000000941099.811796.7985
ENSG00000146731homo_sapiensENSP0000027560391.525488.7006otolemur_garnettiiENSOGAP0000000715099.183796.1225
ENSG00000146731homo_sapiensENSP0000027560384.557479.096otolemur_garnettiiENSOGAP0000002050393.541787.5
ENSG00000146731homo_sapiensENSP0000027560399.246796.2335otolemur_garnettiiENSOGAP0000001799999.246796.2335
ENSG00000146731homo_sapiensENSP0000027560376.647875.7062cebus_imitatorENSCCAP0000001073810098.7715
ENSG00000146731homo_sapiensENSP0000027560399.811796.9868urocitellus_parryiiENSUPAP0001002429899.811796.9868
ENSG00000146731homo_sapiensENSP0000027560398.493495.2919moschus_moschiferusENSMMSP0000002828698.493495.2919
ENSG00000146731homo_sapiensENSP0000027560360.45256.8738moschus_moschiferusENSMMSP0000001008090.168584.8315
ENSG00000146731homo_sapiensENSP0000027560396.986894.162moschus_moschiferusENSMMSP0000000385899.613296.7118
ENSG00000146731homo_sapiensENSP0000027560389.830586.4407rhinopithecus_roxellanaENSRROP0000001964991.907588.4393
ENSG00000146731homo_sapiensENSP0000027560310099.2467rhinopithecus_roxellanaENSRROP0000002759010099.2467
ENSG00000146731homo_sapiensENSP0000027560392.090489.2655propithecus_coquereliENSPCOP0000002192289.07186.3388
ENSG00000146731homo_sapiensENSP0000027560393.59790.9604propithecus_coquereliENSPCOP0000000677089.711287.1841
ENSG00000146731homo_sapiensENSP0000027560379.09675.8945propithecus_coquereliENSPCOP0000002361395.67291.7995
ENSG00000146731homo_sapiensENSP0000027560399.623498.1168propithecus_coquereliENSPCOP0000000564195.315393.8739

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005737located_in cytoplasm1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005832part_of chaperonin-containing T-complex4IBA,IDA,IPI,TASHomo_sapiens(9606)Component
GO:0005874located_in microtubule1IDAHomo_sapiens(9606)Component
GO:0006457involved_in protein folding2IBA,IDAHomo_sapiens(9606)Process
GO:0016887enables ATP hydrolysis activity1IEAHomo_sapiens(9606)Function
GO:0032212involved_in positive regulation of telomere maintenance via telomerase1IMPHomo_sapiens(9606)Process
GO:0044183enables protein folding chaperone1IDAHomo_sapiens(9606)Function
GO:0050821involved_in protein stabilization1IMPHomo_sapiens(9606)Process
GO:0051082enables unfolded protein binding1IBAHomo_sapiens(9606)Function
GO:0061077involved_in chaperone-mediated protein folding1IDAHomo_sapiens(9606)Process
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0071987enables WD40-repeat domain binding1IPIHomo_sapiens(9606)Function
GO:0140662enables ATP-dependent protein folding chaperone1IEAHomo_sapiens(9606)Function
GO:1904851involved_in positive regulation of establishment of protein localization to telomere1IMPHomo_sapiens(9606)Process
GO:1904871involved_in positive regulation of protein localization to Cajal body1HMPHomo_sapiens(9606)Process
GO:1904874involved_in positive regulation of telomerase RNA localization to Cajal body1HMPHomo_sapiens(9606)Process

Expression