Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations NucleoliNucleoli rim
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000137802 Gene ID 23005 Accession 29536
Symbol MAPKBP1 Alias JNKBP1;NPHP20;JNKBP-1 Full Name mitogen-activated protein kinase binding protein 1
Status Confidence Length 53422 bases Strand Plus strand
Position 15 : 41774434 - 41827855 RNA binding domain eIF2A
Summary This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000427582 eIF2A PF08662 1.9e-05 1
ENSP00000422132 eIF2A PF08662 0.00039 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
MAPKBP1-214 ENST00000512970 4804 331aa ENSP00000427582
MAPKBP1-202 ENST00000457542 7182 1508aa ENSP00000397570
MAPKBP1-207 ENST00000505373 4695 69aa ENSP00000421891
MAPKBP1-201 ENST00000456763 7158 1514aa ENSP00000393099
MAPKBP1-215 ENST00000514566 5394 1231aa ENSP00000426154
MAPKBP1-203 ENST00000502292 2509 No protein -
MAPKBP1-212 ENST00000510535 908 156aa ENSP00000422132
MAPKBP1-217 ENST00000627631 210 69aa ENSP00000487189
MAPKBP1-206 ENST00000505061 5931 No protein -
MAPKBP1-210 ENST00000507762 544 No protein -
MAPKBP1-216 ENST00000515164 677 No protein -
MAPKBP1-209 ENST00000507147 334 No protein -
MAPKBP1-205 ENST00000503526 460 No protein -
MAPKBP1-211 ENST00000508050 605 No protein -
MAPKBP1-208 ENST00000506301 563 No protein -
MAPKBP1-204 ENST00000502695 577 No protein -
MAPKBP1-213 ENST00000512433 603 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
38798Platelet Function Tests1.9918300E-005-
96231Education7E-625201988

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000137802homo_sapiensENSP0000042276316.36798.72954homo_sapiensENSP0000039757013.92577.42706
ENSG00000137802homo_sapiensENSP0000026369440.05623.2493homo_sapiensENSP000003975709.482765.50398
ENSG00000137802homo_sapiensENSP0000032779629.040414.6465homo_sapiensENSP000003975707.625993.84615
ENSG00000137802homo_sapiensENSP0000042857912.36036.63408homo_sapiensENSP0000039757011.73746.29973
ENSG00000137802homo_sapiensENSP0000026560225.919712.9599homo_sapiensENSP0000039757020.55710.2785
ENSG00000137802homo_sapiensENSP0000038660912.05565.9763homo_sapiensENSP0000039757015.51727.69231
ENSG00000137802homo_sapiensENSP0000036888734.693919.6429homo_sapiensENSP000003975709.018575.1061
ENSG00000137802homo_sapiensENSP0000036267736.624221.0191homo_sapiensENSP000003975707.625994.37666
ENSG00000137802homo_sapiensENSP0000038037838.292720.2439homo_sapiensENSP0000039757010.41115.50398
ENSG00000137802homo_sapiensENSP000002627159.630765.06281homo_sapiensENSP0000039757016.77728.81963
ENSG00000137802homo_sapiensENSP0000029648439.31224.8157homo_sapiensENSP0000039757010.61016.69761
ENSG00000137802homo_sapiensENSP0000035144637.125718.8623homo_sapiensENSP000003975708.222814.17772
ENSG00000137802homo_sapiensENSP0000033038137.575818.4848homo_sapiensENSP000003975708.222814.04509
ENSG00000137802homo_sapiensENSP0000031189936.385519.0361homo_sapiensENSP0000039757010.01335.23873
ENSG00000137802homo_sapiensENSP0000035114730.505116.5657homo_sapiensENSP0000039757010.01335.43767
ENSG00000137802homo_sapiensENSP0000031649629.620314.4304homo_sapiensENSP000003975707.758623.77984
ENSG00000137802homo_sapiensENSP0000031419324.578313.253homo_sapiensENSP0000039757013.52797.29443
ENSG00000137802homo_sapiensENSP0000034812933.262717.7966homo_sapiensENSP0000039757010.41115.57029
ENSG00000137802homo_sapiensENSP0000032330237.447720.7113homo_sapiensENSP0000039757011.876.56499
ENSG00000137802homo_sapiensENSP0000041628918.65929.05028homo_sapiensENSP0000039757011.07435.37135
ENSG00000137802homo_sapiensENSP0000026674222.121210.7576homo_sapiensENSP000003975709.68174.70822
ENSG00000137802homo_sapiensENSP0000025444218.79199.93289homo_sapiensENSP0000039757018.56769.81432
ENSG00000137802homo_sapiensENSP0000038430225.849315.2142homo_sapiensENSP0000039757011.60486.83024
ENSG00000137802homo_sapiensENSP0000035664117.92077.52394homo_sapiensENSP000003975708.6873.64721
ENSG00000137802homo_sapiensENSP0000030726034.899316.5548homo_sapiensENSP0000039757010.34484.90716
ENSG00000137802homo_sapiensENSP0000038479253.381538.9363homo_sapiensENSP0000039757053.912539.3236

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000137802homo_sapiensENSP0000039757098.806498.1432nomascus_leucogenysENSNLEP0000004287998.414897.7543
ENSG00000137802homo_sapiensENSP0000039757099.005398.4748pongo_abeliiENSPPYP0000004114198.678198.1494
ENSG00000137802homo_sapiensENSP0000039757099.668499.4695pan_troglodytesENSPTRP0000007033899.273499.0753
ENSG00000137802homo_sapiensENSP0000039757088.594287.2016gorilla_gorillaENSGGOP0000004026595.496893.9957
ENSG00000137802homo_sapiensENSP0000039757098.673797.8117gorilla_gorillaENSGGOP0000001144098.088397.2314
ENSG00000137802homo_sapiensENSP0000039757039.257337.5332ornithorhynchus_anatinusENSOANP0000004578692.355788.2995
ENSG00000137802homo_sapiensENSP0000039757086.339580.1061sarcophilus_harrisiiENSSHAP0000000686385.714379.526
ENSG00000137802homo_sapiensENSP0000039757083.090277.122notamacropus_eugeniiENSMEUP0000000574184.490978.4221
ENSG00000137802homo_sapiensENSP0000039757091.909889.0584dasypus_novemcinctusENSDNOP0000000592492.647189.7727
ENSG00000137802homo_sapiensENSP0000039757083.023978.183erinaceus_europaeusENSEEUP0000000458884.083379.1807
ENSG00000137802homo_sapiensENSP0000039757075.994772.4801echinops_telfairiENSETEP0000000864982.091778.2951
ENSG00000137802homo_sapiensENSP0000039757097.082294.496callithrix_jacchusENSCJAP0000008171496.697594.1215
ENSG00000137802homo_sapiensENSP0000039757098.076997.0159cercocebus_atysENSCATP0000000828797.688296.6314
ENSG00000137802homo_sapiensENSP0000039757098.342297.2812macaca_fascicularisENSMFAP0000003028794.699993.6782
ENSG00000137802homo_sapiensENSP0000039757098.408597.2812macaca_mulattaENSMMUP0000000511898.018596.8956
ENSG00000137802homo_sapiensENSP0000039757098.408597.2149macaca_nemestrinaENSMNEP0000000852498.018596.8296
ENSG00000137802homo_sapiensENSP0000039757098.408597.2812papio_anubisENSPANP0000003954798.018596.8956
ENSG00000137802homo_sapiensENSP0000039757098.209597.0822mandrillus_leucophaeusENSMLEP0000000724897.820396.6975
ENSG00000137802homo_sapiensENSP0000039757086.405883.2228tursiops_truncatusENSTTRP0000000237186.348683.1677
ENSG00000137802homo_sapiensENSP0000039757092.241489.2573vulpes_vulpesENSVVUP0000003761592.548289.5542
ENSG00000137802homo_sapiensENSP0000039757091.511986.8037mus_spretusMGP_SPRETEiJ_P005601391.816487.0925
ENSG00000137802homo_sapiensENSP0000039757094.429791.9098equus_asinusENSEASP0000504065292.22889.7668
ENSG00000137802homo_sapiensENSP0000039757092.838289.2573capra_hircusENSCHIP0000000672593.520489.9132
ENSG00000137802homo_sapiensENSP0000039757091.843588.8594loxodonta_africanaENSLAFP0000002618691.600588.6243
ENSG00000137802homo_sapiensENSP0000039757094.297191.9761panthera_leoENSPLOP0000003010794.172291.8543
ENSG00000137802homo_sapiensENSP0000039757094.230891.7109ailuropoda_melanoleucaENSAMEP0000002799194.168391.6501
ENSG00000137802homo_sapiensENSP0000039757093.633990.3183bos_indicus_hybridENSBIXP0000504391793.509990.1987
ENSG00000137802homo_sapiensENSP0000039757078.116776.7905oryctolagus_cuniculusENSOCUP0000001030095.694694.0699
ENSG00000137802homo_sapiensENSP0000039757094.562392.1088equus_caballusENSECAP000000501839289.6129
ENSG00000137802homo_sapiensENSP0000039757079.111477.1883canis_lupus_familiarisENSCAFP0084504206596.834494.4805
ENSG00000137802homo_sapiensENSP0000039757094.297191.9098panthera_pardusENSPPRP0000002169194.172291.7881
ENSG00000137802homo_sapiensENSP0000039757092.771990.053marmota_marmota_marmotaENSMMMP0000002284292.833490.1128
ENSG00000137802homo_sapiensENSP0000039757094.562391.6446balaenoptera_musculusENSBMSP0001000673194.499791.5838
ENSG00000137802homo_sapiensENSP0000039757091.843587.5995cavia_porcellusENSCPOP0000001987192.271888.008
ENSG00000137802homo_sapiensENSP0000039757094.297191.9098felis_catusENSFCAP0000004114794.109991.7273
ENSG00000137802homo_sapiensENSP0000039757093.501390.9814ursus_americanusENSUAMP0000002880494.188491.65
ENSG00000137802homo_sapiensENSP0000039757084.084976.3263monodelphis_domesticaENSMODP0000000003082.9375.278
ENSG00000137802homo_sapiensENSP0000039757071.087563.4615monodelphis_domesticaENSMODP0000002079277.850469.4989
ENSG00000137802homo_sapiensENSP0000039757093.700390.3846bison_bison_bisonENSBBBP0000000551293.638290.3247
ENSG00000137802homo_sapiensENSP0000039757094.297191.2467monodon_monocerosENSMMNP0001501806694.234691.1862
ENSG00000137802homo_sapiensENSP0000039757093.633990.1857sus_scrofaENSSSCP0000000511593.571990.1259
ENSG00000137802homo_sapiensENSP0000039757095.424492.7056microcebus_murinusENSMICP0000001769895.361292.6441
ENSG00000137802homo_sapiensENSP0000039757021.551721.5517octodon_degusENSODEP0000002313399.388499.3884
ENSG00000137802homo_sapiensENSP0000039757021.352821.0212jaculus_jaculusENSJJAP0000001361098.470996.9419
ENSG00000137802homo_sapiensENSP0000039757092.572989.1247ovis_aries_rambouilletENSOARP0002001673592.942789.4807
ENSG00000137802homo_sapiensENSP0000039757084.217581.6976ursus_maritimusENSUMAP0000001552494.353691.5305
ENSG00000137802homo_sapiensENSP0000039757087.864785.0133ochotona_princepsENSOPRP0000000316992.463489.4627
ENSG00000137802homo_sapiensENSP0000039757093.302490.1194delphinapterus_leucasENSDLEP0000000333293.117189.9404
ENSG00000137802homo_sapiensENSP0000039757094.230891.5119physeter_catodonENSPCTP0000502508594.168391.4513
ENSG00000137802homo_sapiensENSP0000039757091.379386.9363mus_caroliMGP_CAROLIEiJ_P005391491.805587.3418
ENSG00000137802homo_sapiensENSP0000039757091.246786.4058mus_musculusENSMUSP0000015516391.186286.3486
ENSG00000137802homo_sapiensENSP0000039757021.551721.4191dipodomys_ordiiENSDORP0000001232199.388498.7768
ENSG00000137802homo_sapiensENSP0000039757093.43590.5836mustela_putorius_furoENSMPUP0000000891793.311390.4636
ENSG00000137802homo_sapiensENSP0000039757096.419194.496aotus_nancymaaeENSANAP0000003810396.03794.1215
ENSG00000137802homo_sapiensENSP0000039757097.148594.695saimiri_boliviensis_boliviensisENSSBOP0000002207196.763594.3197
ENSG00000137802homo_sapiensENSP0000039757098.143297.0822chlorocebus_sabaeusENSCSAP0000000410997.754396.6975
ENSG00000137802homo_sapiensENSP0000039757078.647277.0557tupaia_belangeriENSTBEP0000000263982.705781.0321
ENSG00000137802homo_sapiensENSP0000039757021.352821.0875mesocricetus_auratusENSMAUP0000002100198.470997.2477
ENSG00000137802homo_sapiensENSP0000039757094.297191.0477phocoena_sinusENSPSNP0000000239394.234690.9874
ENSG00000137802homo_sapiensENSP0000039757093.965591.1141camelus_dromedariusENSCDRP0000502877694.027991.1745
ENSG00000137802homo_sapiensENSP0000039757095.159193.0371carlito_syrichtaENSTSYP0000002864394.719592.6073
ENSG00000137802homo_sapiensENSP0000039757094.230891.7109panthera_tigris_altaicaENSPTIP0000000354494.10691.5894
ENSG00000137802homo_sapiensENSP0000039757091.180486.7374rattus_norvegicusENSRNOP0000009228291.240986.795
ENSG00000137802homo_sapiensENSP0000039757095.954993.435prolemur_simusENSPSMP0000000907295.891393.3731
ENSG00000137802homo_sapiensENSP0000039757021.419121.2202microtus_ochrogasterENSMOCP0000002224298.776897.8593
ENSG00000137802homo_sapiensENSP0000039757090.848887.1353peromyscus_maniculatus_bairdiiENSPEMP0000003325391.272587.5416
ENSG00000137802homo_sapiensENSP0000039757093.700390.3846bos_mutusENSBMUP0000002577393.576290.2649
ENSG00000137802homo_sapiensENSP0000039757091.511986.7374mus_spicilegusENSMSIP0000003280091.451386.6799
ENSG00000137802homo_sapiensENSP0000039757091.511987.7984cricetulus_griseus_chok1gshdENSCGRP0000100603391.938788.2079
ENSG00000137802homo_sapiensENSP0000039757089.721586.8037pteropus_vampyrusENSPVAP0000001296089.66286.7462
ENSG00000137802homo_sapiensENSP0000039757090.185787.4005myotis_lucifugusENSMLUP0000001816292.140989.2954
ENSG00000137802homo_sapiensENSP0000039757087.201681.1671vombatus_ursinusENSVURP0001000969186.913480.8989
ENSG00000137802homo_sapiensENSP0000039757093.633990.5172rhinolophus_ferrumequinumENSRFEP0001000253993.571990.4573
ENSG00000137802homo_sapiensENSP0000039757093.567690.9151neovison_visonENSNVIP0000002337193.505690.8549
ENSG00000137802homo_sapiensENSP0000039757093.700390.3846bos_taurusENSBTAP0000003203293.762490.4446
ENSG00000137802homo_sapiensENSP0000039757092.175188.2626heterocephalus_glaber_femaleENSHGLP0000004253092.420288.4973
ENSG00000137802homo_sapiensENSP0000039757098.076996.7507rhinopithecus_bietiENSRBIP0000001843397.688296.3672
ENSG00000137802homo_sapiensENSP0000039757094.230891.5119canis_lupus_dingoENSCAFP0002000625394.230891.5119
ENSG00000137802homo_sapiensENSP0000039757092.705689.8541sciurus_vulgarisENSSVLP0000500236792.644189.7946
ENSG00000137802homo_sapiensENSP0000039757055.702952.8515phascolarctos_cinereusENSPCIP0000003766892.105387.3904
ENSG00000137802homo_sapiensENSP0000039757082.029278.1167procavia_capensisENSPCAP0000001251882.964579.0074
ENSG00000137802homo_sapiensENSP0000039757021.750721.4191nannospalax_galiliENSNGAP0000000276098.498596.997
ENSG00000137802homo_sapiensENSP0000039757092.506688.4615chinchilla_lanigeraENSCLAP000000141159388.9333
ENSG00000137802homo_sapiensENSP0000039757092.904589.6552cervus_hanglu_yarkandensisENSCHYP0000001825792.966289.7147
ENSG00000137802homo_sapiensENSP0000039757093.501390.1194catagonus_wagneriENSCWAP0000000091893.439490.0596
ENSG00000137802homo_sapiensENSP0000039757092.970890.3183ictidomys_tridecemlineatusENSSTOP0000000060793.404490.7395
ENSG00000137802homo_sapiensENSP0000039757094.230890.7825otolemur_garnettiiENSOGAP0000001436693.486890.0658
ENSG00000137802homo_sapiensENSP0000039757097.480195.2255cebus_imitatorENSCCAP0000003138997.093894.8481
ENSG00000137802homo_sapiensENSP0000039757092.572989.7215urocitellus_parryiiENSUPAP0001001793993.190990.3204
ENSG00000137802homo_sapiensENSP0000039757093.169889.6552moschus_moschiferusENSMMSP0000001026793.10889.5958
ENSG00000137802homo_sapiensENSP0000039757098.143296.6843rhinopithecus_roxellanaENSRROP0000002994197.754396.3012
ENSG00000137802homo_sapiensENSP0000039757091.180486.7374mus_pahariMGP_PahariEiJ_P006489491.483787.0259
ENSG00000137802homo_sapiensENSP0000039757095.291892.6393propithecus_coquereliENSPCOP0000001045695.228692.5779
ENSG00000137802homo_sapiensENSP0000039757064.588951.4589latimeria_chalumnaeENSLACP0000000898366.803853.2236
ENSG00000137802homo_sapiensENSP0000039757072.082259.5491xenopus_tropicalisENSXETP0000011627666.646255.0582
ENSG00000137802homo_sapiensENSP0000039757077.851566.5782chrysemys_picta_belliiENSCPBP0000001836971.892261.4819
ENSG00000137802homo_sapiensENSP0000039757022.281220.4907sphenodon_punctatusENSSPUP0000002415491.803384.4262
ENSG00000137802homo_sapiensENSP0000039757075.198963.992crocodylus_porosusENSCPRP0000502673572.785661.9384
ENSG00000137802homo_sapiensENSP0000039757057.891250.3979laticauda_laticaudataENSLLTP0000002144182.126171.4958
ENSG00000137802homo_sapiensENSP0000039757021.087519.4297notechis_scutatusENSNSUP0000001147397.247789.6024
ENSG00000137802homo_sapiensENSP0000039757073.872762.1353pseudonaja_textilisENSPTXP0000000427972.478960.9629
ENSG00000137802homo_sapiensENSP0000039757077.652565.9151anas_platyrhynchos_platyrhynchosENSAPLP0000002975871.752460.9069
ENSG00000137802homo_sapiensENSP0000039757077.718865.8488gallus_gallusENSGALP0001002884571.550760.6227
ENSG00000137802homo_sapiensENSP0000039757077.718865.7162meleagris_gallopavoENSMGAP0000002005971.550760.5006
ENSG00000137802homo_sapiensENSP0000039757077.851565.8488serinus_canariaENSSCAP0000000164871.936360.8456
ENSG00000137802homo_sapiensENSP0000039757077.387365.7162parus_majorENSPMJP0000001970071.245460.5006
ENSG00000137802homo_sapiensENSP0000039757076.591565.1857anolis_carolinensisENSACAP0000002824370.772160.2328
ENSG00000137802homo_sapiensENSP0000039757072.413860.9416naja_najaENSNNAP0000000110772.365860.9013
ENSG00000137802homo_sapiensENSP0000039757074.535863.3289podarcis_muralisENSPMRP0000000341771.729460.9445
ENSG00000137802homo_sapiensENSP0000039757077.453665.5836taeniopygia_guttataENSTGUP0000003571171.306560.3785
ENSG00000137802homo_sapiensENSP0000039757076.856864.9867salvator_merianaeENSSMRP0000001312371.235460.2336
ENSG00000137802homo_sapiensENSP0000039757064.721557.3607pelodiscus_sinensisENSPSIP0000001588884.722275.0868
ENSG00000137802homo_sapiensENSP0000039757021.750720.0928gopherus_evgoodeiENSGEVP0000501289094.797787.5723
ENSG00000137802homo_sapiensENSP0000039757021.81720.2918chelonoidis_abingdoniiENSCABP0000000766095.086788.4393
ENSG00000137802homo_sapiensENSP0000039757077.984166.0477struthio_camelus_australisENSSCUP0000002406371.751160.7688
ENSG00000137802homo_sapiensENSP0000039757073.93964.191anser_brachyrhynchusENSABRP0000000270677.808867.5506
ENSG00000137802homo_sapiensENSP0000039757078.116766.4456strigops_habroptilaENSSHBP0000500316972.137261.3595
ENSG00000137802homo_sapiensENSP0000039757074.734764.9204terrapene_carolina_triunguisENSTMTP0000001906478.756168.4137
ENSG00000137802homo_sapiensENSP0000039757078.18366.5782aquila_chrysaetos_chrysaetosENSACCP0002000977871.066960.5184
ENSG00000137802homo_sapiensENSP0000039757077.917866.0477ficedula_albicollisENSFALP0000000627271.997661.0294
ENSG00000137802homo_sapiensENSP0000039757074.204263.3952coturnix_japonicaENSCJPP0000501776378.306566.8999
ENSG00000137802homo_sapiensENSP0000039757022.347518.435tetraodon_nigroviridisENSTNIP0000000095982.59868.1373

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005654located_in nucleoplasm1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0032717involved_in negative regulation of interleukin-8 production1IMPHomo_sapiens(9606)Process
GO:0043124involved_in negative regulation of I-kappaB kinase/NF-kappaB signaling2IBA,IMPHomo_sapiens(9606)Process
GO:0046330involved_in positive regulation of JNK cascade1IBAHomo_sapiens(9606)Process
GO:0097431located_in mitotic spindle pole1IDAHomo_sapiens(9606)Component
GO:1900425involved_in negative regulation of defense response to bacterium1IMPHomo_sapiens(9606)Process

Expression