Ensembl ID ENSG00000137802 Gene ID 23005 Accession 29536
Gene Symbol MAPKBP1 Alias JNKBP1;NPHP20;JNKBP-1 Full Name mitogen-activated protein kinase binding protein 1
Position 15 : 41774434 - 41827855 Length 53422 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Canonical_RBPs
Summary This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

ENSG00000137802 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137802 MAPKBP1 -1.0 1.64e-11 BLCA
ENSG00000137802 MAPKBP1 -0.7 2.51e-47 BRCA
ENSG00000137802 MAPKBP1 0.80 4.31e-15 KICH
ENSG00000137802 MAPKBP1 0.74 6.20e-11 LUSC
ENSG00000137802 MAPKBP1 -0.5 7.75e-15 PRAD
ENSG00000137802 MAPKBP1 0.58 2.53e-14 LIHC
ENSG00000137802 MAPKBP1 -0.9 3.65e-18 STAD
ENSG00000137802 MAPKBP1 -0.9 7.32e-21 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137802 MAPKBP1 AML 26506237
ENSG00000137802 MAPKBP1 AML 27686215
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137802 MAPKBP1 SARC 0.016 low
ENSG00000137802 MAPKBP1 PAAD 0.0014 low
ENSG00000137802 MAPKBP1 UCEC 0.00011 low
ENSG00000137802 MAPKBP1 HNSC 0.018 low
ENSG00000137802 MAPKBP1 KICH 0.0072 high
ENSG00000137802 MAPKBP1 PCPG 0.021 low
ENSG00000137802 MAPKBP1 ESCA 0.017 low
ENSG00000137802 MAPKBP1 OV 0.00037 high
ENSG00000137802 MAPKBP1 PRAD 0.012 low
ENSG00000137802 MAPKBP1 BLCA 0.021 high
ENSG00000137802 MAPKBP1 LAML 0.0088 high
ENSG00000137802 MAPKBP1 SKCM 0.013 high
ENSG00000137802 MAPKBP1 CESC 0.013 low
ENSG00000137802 MAPKBP1 LIHC 0.0032 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137802 MAPKBP1 LUSC Del 3.649341 0.100702 0.343466 0.355289
ENSG00000137802 MAPKBP1 LUAD Del 6.178006 0.101551 0.328073 0.532946
ENSG00000137802 MAPKBP1 CESC Del 2.949403 0.104962 0.460681 0.240678
ENSG00000137802 MAPKBP1 ACC Del 1.065576 0.113077 0.505062 0.277778
ENSG00000137802 MAPKBP1 READ Del 0.637830 0.068896 0.468578 0.478788
ENSG00000137802 MAPKBP1 COAD Del 4.646483 0.078018 0.477832 0.379157
ENSG00000137802 MAPKBP1 UCS Del 6.831075 0.560658 0.563998 0.767857
ENSG00000137802 MAPKBP1 GBM Del 9.357743 0.121399 0.520389 0.258232
ENSG00000137802 MAPKBP1 PAAD Del 0.865388 0.048837 0.327096 0.195652
ENSG00000137802 MAPKBP1 SKCM Del 10.095250 0.169625 0.519748 0.253406
ENSG00000137802 MAPKBP1 DLBC Del 2.018645 0.205252 0.619852 0.250000
ENSG00000137802 MAPKBP1 BRCA Del 9.538555 0.112977 0.410999 0.364815
ENSG00000137802 MAPKBP1 STAD Del 2.454984 0.083961 0.339541 0.274376
ENSG00000137802 MAPKBP1 UCEC Del 4.655828 0.085969 0.534266 0.252319
ENSG00000137802 MAPKBP1 MESO Del 8.567246 0.360883 0.597609 0.321839
ENSG00000137802 MAPKBP1 OV Del 20.080581 0.382761 0.605426 0.621762