Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions TF
Localizations Stress granucleNucleoli
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000137309 Gene ID 3159 Accession 5010
Symbol HMGA1 Alias HMG-R;HMGIY;HMGA1A Full Name high mobility group AT-hook 1
Status Confidence Length 9359 bases Strand Plus strand
Position 6 : 34236873 - 34246231 RNA binding domain N.A.
Summary This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
21087998 7SK small nuclear RNA directly affects HMGA1 function in transcription regulation. Sebastian Eilebrecht 2011-03-01 Nucleic acids research
26895108 HMGA1-pseudogenes and cancer. Marco M De 2016-05-10 Oncotarget
35117745 High-mobility group A1 proteins may be involved in estrogen receptor status of breast cancer. Yoshihiro Harada 2020-06-01 Translational cancer research
29678492 HMGA1a induces alternative splicing of estrogen receptor alpha in MCF-7 human breast cancer cells. Kenji Ohe 2018-09-01 The Journal of steroid biochemistry and molecular biology
23392246 HMGA1 directly interacts with TAR to modulate basal and Tat-dependent HIV transcription. Sebastian Eilebrecht 2013-03-01 RNA biology
26156556 The extended AT-hook is a novel RNA binding motif. Michael Filarsky 2015-01-01 RNA biology
26117853 RNA-Mediated Regulation of HMGA1 Function. G Arndt Benecke 2015-01-01 Biomolecules
26509637 Anti-Transcription Factor RNA Aptamers as Potential Therapeutics. Estefanía Mondragón 2016-02-01 Nucleic acid therapeutics
31645542 The TWIST1-centered competing endogenous RNA network promotes proliferation, invasion, and migration of lung adenocarcinoma. Wenjie Xia 2019-10-23 Oncogenesis
29037489 Latent HIV-1 TAR Regulates 7SK-responsive P-TEFb Target Genes and Targets Cellular Immune Responses in the Absence of Tat. Sebastian Eilebrecht 2017-10-01 Genomics, proteomics & bioinformatics
28430823 Modulation the alternative splicing of GLA (IVS4+919G>A) in Fabry disease. Wen-Hsin Chang 2017-01-01 PloS one
35058711 High-Mobility Group AT-Hook 1 Served as a Prognosis Biomarker and Associated with Immune Infiltrate in Hepatocellular Carcinoma. Yong-Guang Wei 2022-01-01 International journal of general medicine
31300541 AP-1 Signaling by Fra-1 Directly Regulates HMGA1 Oncogene Transcription in Triple-Negative Breast Cancers. Claire Tolza 2019-10-01 Molecular cancer research : MCR
30614613 HMGA1 in cancer: Cancer classification by location. Yuhong Wang 2019-04-01 Journal of cellular and molecular medicine

Transcripts

Name Transcript ID bp Protein Translation ID

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
97507Body Height2E-821998595

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000137309

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000137309homo_sapiensENSP0000030822782.24380.3738nomascus_leucogenysENSNLEP0000001009797.777895.5556
ENSG00000137309homo_sapiensENSP0000030822786.915985.9813pan_paniscusENSPPAP0000003686049.206348.6772
ENSG00000137309homo_sapiensENSP0000030822793.457991.5888pan_paniscusENSPPAP0000000891460.975659.7561
ENSG00000137309homo_sapiensENSP0000030822792.523490.6542pongo_abeliiENSPPYP0000004172886.08784.3478
ENSG00000137309homo_sapiensENSP0000030822787.850584.1122pongo_abeliiENSPPYP0000002991887.850584.1122
ENSG00000137309homo_sapiensENSP0000030822792.523490.6542pan_troglodytesENSPTRP0000006440360.365959.1463
ENSG00000137309homo_sapiensENSP0000030822785.981385.0467pan_troglodytesENSPTRP0000006958848.677248.1481
ENSG00000137309homo_sapiensENSP0000030822780.373879.4393pan_troglodytesENSPTRP0000006707989.583388.5417
ENSG00000137309homo_sapiensENSP0000030822787.850586.9159gorilla_gorillaENSGGOP0000003398549.735549.2063
ENSG00000137309homo_sapiensENSP0000030822778.504776.6355ornithorhynchus_anatinusENSOANP0000004345084.848582.8283
ENSG00000137309homo_sapiensENSP0000030822773.831869.1589sarcophilus_harrisiiENSSHAP0000004241644.134141.3408
ENSG00000137309homo_sapiensENSP0000030822796.261792.5234dasypus_novemcinctusENSDNOP0000003174863.580261.1111
ENSG00000137309homo_sapiensENSP0000030822761.682261.6822echinops_telfairiENSETEP0000001403837.288137.2881
ENSG00000137309homo_sapiensENSP0000030822787.850587.8505callithrix_jacchusENSCJAP0000006256797.916797.9167
ENSG00000137309homo_sapiensENSP0000030822780.373877.5701cercocebus_atysENSCATP0000001723948.044746.3687
ENSG00000137309homo_sapiensENSP0000030822778.504775.7009cercocebus_atysENSCATP0000002566889.361786.1702
ENSG00000137309homo_sapiensENSP0000030822777.570171.028macaca_fascicularisENSMFAP0000005027216.435615.0495
ENSG00000137309homo_sapiensENSP0000030822765.420660.7477macaca_mulattaENSMMUP0000002565815.555614.4444
ENSG00000137309homo_sapiensENSP0000030822781.308478.5047macaca_nemestrinaENSMNEP0000003366248.603446.9274
ENSG00000137309homo_sapiensENSP00000308227100100papio_anubisENSPANP00000057553100100
ENSG00000137309homo_sapiensENSP0000030822778.504774.7664mandrillus_leucophaeusENSMLEP0000000251846.927444.6927
ENSG00000137309homo_sapiensENSP0000030822780.373873.8318mandrillus_leucophaeusENSMLEP0000002181658.904154.1096
ENSG00000137309homo_sapiensENSP0000030822771.962666.3551tursiops_truncatusENSTTRP0000001427647.826144.0994
ENSG00000137309homo_sapiensENSP0000030822788.78588.785vulpes_vulpesENSVVUP0000003642728.273828.2738
ENSG00000137309homo_sapiensENSP0000030822796.261796.2617mus_spretusMGP_SPRETEiJ_P004544596.261796.2617
ENSG00000137309homo_sapiensENSP0000030822796.261796.2617mus_spretusMGP_SPRETEiJ_P004544892.792892.7928
ENSG00000137309homo_sapiensENSP00000308227100100equus_asinusENSEASP0000505215760.112460.1124
ENSG00000137309homo_sapiensENSP0000030822779.439378.5047capra_hircusENSCHIP0000000748380.952480
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654loxodonta_africanaENSLAFP0000002078899.065499.0654
ENSG00000137309homo_sapiensENSP00000308227100100panthera_leoENSPLOP00000016380100100
ENSG00000137309homo_sapiensENSP00000308227100100ailuropoda_melanoleucaENSAMEP00000001101100100
ENSG00000137309homo_sapiensENSP0000030822776.635573.8318bos_indicus_hybridENSBIXP0000503239143.386241.7989
ENSG00000137309homo_sapiensENSP0000030822770.093564.486oryctolagus_cuniculusENSOCUP0000003082734.090931.3636
ENSG00000137309homo_sapiensENSP0000030822788.78588.785equus_caballusENSECAP0000008523636.538536.5385
ENSG00000137309homo_sapiensENSP0000030822788.78588.785canis_lupus_familiarisENSCAFP0084503682498.958398.9583
ENSG00000137309homo_sapiensENSP00000308227100100panthera_pardusENSPPRP00000021160100100
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654marmota_marmota_marmotaENSMMMP0000002785599.065499.0654
ENSG00000137309homo_sapiensENSP00000308227100100balaenoptera_musculusENSBMSP00010013147100100
ENSG00000137309homo_sapiensENSP0000030822797.196397.1963cavia_porcellusENSCPOP0000003158496.296396.2963
ENSG00000137309homo_sapiensENSP00000308227100100felis_catusENSFCAP00000050053100100
ENSG00000137309homo_sapiensENSP00000308227100100ursus_americanusENSUAMP00000019887100100
ENSG00000137309homo_sapiensENSP0000030822783.177681.3084bison_bison_bisonENSBBBP0000002041183.177681.3084
ENSG00000137309homo_sapiensENSP0000030822785.046783.1776sus_scrofaENSSSCP0000003241160.264958.9404
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654microcebus_murinusENSMICP0000003974399.065499.0654
ENSG00000137309homo_sapiensENSP0000030822786.915986.9159octodon_degusENSODEP0000002326696.87596.875
ENSG00000137309homo_sapiensENSP0000030822790.654289.7196jaculus_jaculusENSJJAP0000001840594.174893.2039
ENSG00000137309homo_sapiensENSP0000030822787.850587.8505ovis_aries_rambouilletENSOARP0002002432997.916797.9167
ENSG00000137309homo_sapiensENSP00000308227100100ursus_maritimusENSUMAP00000014817100100
ENSG00000137309homo_sapiensENSP0000030822784.112283.1776delphinapterus_leucasENSDLEP0000002790784.112283.1776
ENSG00000137309homo_sapiensENSP00000308227100100physeter_catodonENSPCTP00005021740100100
ENSG00000137309homo_sapiensENSP0000030822797.196397.1963mus_caroliMGP_CAROLIEiJ_P004353697.196397.1963
ENSG00000137309homo_sapiensENSP0000030822797.196397.1963mus_caroliMGP_CAROLIEiJ_P004353997.196397.1963
ENSG00000137309homo_sapiensENSP0000030822775.700972.8972mus_musculusENSMUSP0000015596668.644166.1017
ENSG00000137309homo_sapiensENSP0000030822798.130898.1308dipodomys_ordiiENSDORP0000002046298.130898.1308
ENSG00000137309homo_sapiensENSP0000030822796.261794.3925aotus_nancymaaeENSANAP0000002963297.169895.283
ENSG00000137309homo_sapiensENSP0000030822787.850585.0467aotus_nancymaaeENSANAP0000000155897.916794.7917
ENSG00000137309homo_sapiensENSP0000030822796.261794.3925aotus_nancymaaeENSANAP0000001886362.424261.2121
ENSG00000137309homo_sapiensENSP0000030822788.78588.785saimiri_boliviensis_boliviensisENSSBOP0000000016798.958398.9583
ENSG00000137309homo_sapiensENSP00000308227100100chlorocebus_sabaeusENSCSAP00000006023100100
ENSG00000137309homo_sapiensENSP0000030822749.532742.0561tupaia_belangeriENSTBEP0000000551835.099329.8013
ENSG00000137309homo_sapiensENSP0000030822785.981384.1122mesocricetus_auratusENSMAUP0000001226395.833393.75
ENSG00000137309homo_sapiensENSP0000030822773.831869.1589camelus_dromedariusENSCDRP0000500546744.134141.3408
ENSG00000137309homo_sapiensENSP0000030822797.196397.1963carlito_syrichtaENSTSYP0000001714497.196397.1963
ENSG00000137309homo_sapiensENSP00000308227100100panthera_tigris_altaicaENSPTIP00000008206100100
ENSG00000137309homo_sapiensENSP0000030822762.616861.6822rattus_norvegicusENSRNOP0000008241337.853137.2881
ENSG00000137309homo_sapiensENSP0000030822788.78588.785prolemur_simusENSPSMP0000001203647.029747.0297
ENSG00000137309homo_sapiensENSP0000030822797.196397.1963microtus_ochrogasterENSMOCP0000002496497.196397.1963
ENSG00000137309homo_sapiensENSP0000030822798.130898.1308peromyscus_maniculatus_bairdiiENSPEMP0000003178398.130898.1308
ENSG00000137309homo_sapiensENSP0000030822777.570173.8318bos_mutusENSBMUP0000001525843.915341.7989
ENSG00000137309homo_sapiensENSP0000030822785.981383.1776cricetulus_griseus_chok1gshdENSCGRP0000101188695.833392.7083
ENSG00000137309homo_sapiensENSP0000030822798.130898.1308cricetulus_griseus_chok1gshdENSCGRP0000100223098.130898.1308
ENSG00000137309homo_sapiensENSP0000030822772.897265.4206pteropus_vampyrusENSPVAP0000001346046.428641.6667
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654myotis_lucifugusENSMLUP0000000919699.065499.0654
ENSG00000137309homo_sapiensENSP0000030822785.981385.9813rhinolophus_ferrumequinumENSRFEP0001002653985.185285.1852
ENSG00000137309homo_sapiensENSP0000030822769.158966.3551rhinolophus_ferrumequinumENSRFEP0001000324963.793161.2069
ENSG00000137309homo_sapiensENSP00000308227100100neovison_visonENSNVIP00000015763100100
ENSG00000137309homo_sapiensENSP0000030822776.635573.8318bos_taurusENSBTAP0000007433343.386241.7989
ENSG00000137309homo_sapiensENSP0000030822786.915984.1122heterocephalus_glaber_femaleENSHGLP0000003612537.536.2903
ENSG00000137309homo_sapiensENSP0000030822783.177683.1776rhinopithecus_bietiENSRBIP0000001330364.492864.4928
ENSG00000137309homo_sapiensENSP0000030822786.915985.0467rhinopithecus_bietiENSRBIP0000001225846.268745.2736
ENSG00000137309homo_sapiensENSP00000308227100100canis_lupus_dingoENSCAFP00020007700100100
ENSG00000137309homo_sapiensENSP0000030822787.850587.8505sciurus_vulgarisENSSVLP0000501254497.916797.9167
ENSG00000137309homo_sapiensENSP0000030822785.981385.0467phascolarctos_cinereusENSPCIP0000003280793.877592.8571
ENSG00000137309homo_sapiensENSP0000030822772.897264.486procavia_capensisENSPCAP000000150206557.5
ENSG00000137309homo_sapiensENSP0000030822797.196397.1963nannospalax_galiliENSNGAP0000000622397.196397.1963
ENSG00000137309homo_sapiensENSP0000030822777.570173.8318bos_grunniensENSBGRP0000003334143.915341.7989
ENSG00000137309homo_sapiensENSP0000030822798.130898.1308chinchilla_lanigeraENSCLAP0000001520195.454595.4545
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654cervus_hanglu_yarkandensisENSCHYP0000002693899.065499.0654
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654catagonus_wagneriENSCWAP0000001654599.065499.0654
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654ictidomys_tridecemlineatusENSSTOP0000001482299.065499.0654
ENSG00000137309homo_sapiensENSP0000030822777.570171.028cebus_imitatorENSCCAP0000000537085.56778.3505
ENSG00000137309homo_sapiensENSP00000308227100100cebus_imitatorENSCCAP00000013031100100
ENSG00000137309homo_sapiensENSP0000030822799.065499.0654urocitellus_parryiiENSUPAP0001001783199.065499.0654
ENSG00000137309homo_sapiensENSP0000030822788.78588.785moschus_moschiferusENSMMSP0000003166798.958398.9583
ENSG00000137309homo_sapiensENSP0000030822788.78588.785rhinopithecus_roxellanaENSRROP0000002835198.958398.9583
ENSG00000137309homo_sapiensENSP0000030822796.261796.2617mus_pahariMGP_PahariEiJ_P005584296.261796.2617
ENSG00000137309homo_sapiensENSP0000030822796.261796.2617mus_pahariMGP_PahariEiJ_P005584496.261796.2617
ENSG00000137309homo_sapiensENSP0000030822710099.0654propithecus_coquereliENSPCOP0000002077210099.0654
ENSG00000137309homo_sapiensENSP0000030822748.598135.514danio_rerioENSDARP0000012885046.846834.2342
ENSG00000137309homo_sapiensENSP0000030822745.794433.6449astyanax_mexicanusENSAMXP0000002990642.982531.5789
ENSG00000137309homo_sapiensENSP0000030822741.121530.8411xenopus_tropicalisENSXETP0000010339115.438611.5789
ENSG00000137309homo_sapiensENSP0000030822763.551460.7477sphenodon_punctatusENSSPUP000000033818076.4706
ENSG00000137309homo_sapiensENSP0000030822770.093561.6822crocodylus_porosusENSCPRP0000502030249.019643.1373
ENSG00000137309homo_sapiensENSP0000030822752.336445.7944notechis_scutatusENSNSUP0000001610381.159471.0145
ENSG00000137309homo_sapiensENSP0000030822777.570171.028pseudonaja_textilisENSPTXP0000002517784.693977.551
ENSG00000137309homo_sapiensENSP0000030822762.616852.3364gallus_gallusENSGALP0001003941523.024119.244
ENSG00000137309homo_sapiensENSP0000030822762.616858.8785serinus_canariaENSSCAP0000002223533.168331.1881
ENSG00000137309homo_sapiensENSP0000030822769.158963.5514parus_majorENSPMJP0000001656141.57338.2022
ENSG00000137309homo_sapiensENSP0000030822775.700966.3551anolis_carolinensisENSACAP0000002066657.857150.7143
ENSG00000137309homo_sapiensENSP0000030822777.570171.028naja_najaENSNNAP0000000832984.693977.551
ENSG00000137309homo_sapiensENSP0000030822760.747751.4019podarcis_muralisENSPMRP000000188486555
ENSG00000137309homo_sapiensENSP0000030822784.112272.8972pelodiscus_sinensisENSPSIP0000000501683.333372.2222
ENSG00000137309homo_sapiensENSP0000030822779.439371.9626gopherus_evgoodeiENSGEVP0000500424887.628979.3814
ENSG00000137309homo_sapiensENSP0000030822767.289760.7477chelonoidis_abingdoniiENSCABP000000082938072.2222
ENSG00000137309homo_sapiensENSP0000030822765.420659.8131terrapene_carolina_triunguisENSTMTP0000000843481.395374.4186
ENSG00000137309homo_sapiensENSP0000030822748.598137.3832pygocentrus_nattereriENSPNAP0000002683644.444434.188
ENSG00000137309homo_sapiensENSP0000030822776.635571.028aquila_chrysaetos_chrysaetosENSACCP0002001970984.536178.3505
ENSG00000137309homo_sapiensENSP0000030822763.551458.8785ficedula_albicollisENSFALP0000000395566.666761.7647

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1ISSHomo_sapiens(9606)Function
GO:0000987enables cis-regulatory region sequence-specific DNA binding1IDAHomo_sapiens(9606)Function
GO:0001221enables transcription coregulator binding1IDAHomo_sapiens(9606)Function
GO:0003677enables DNA binding2EXP,IDAHomo_sapiens(9606)Function
GO:0003680enables minor groove of adenine-thymine-rich DNA binding3IDA,ISS,TASHomo_sapiens(9606)Function
GO:0003682enables chromatin binding1ISSHomo_sapiens(9606)Function
GO:0003712enables transcription coregulator activity1IBAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity3EXP,IMP,ISSHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IPIHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus3HDA,IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005667part_of transcription regulator complex1TASHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005925located_in focal adhesion1HDAHomo_sapiens(9606)Component
GO:0006268involved_in DNA unwinding involved in DNA replication1NASHomo_sapiens(9606)Process
GO:0006337involved_in nucleosome disassembly1TASHomo_sapiens(9606)Process
GO:0006351involved_in DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0006355involved_in regulation of DNA-templated transcription1IBAHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0008301enables DNA binding, bending1EXPHomo_sapiens(9606)Function
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0030374enables nuclear receptor coactivator activity1IMPHomo_sapiens(9606)Function
GO:0030527enables structural constituent of chromatin1TASHomo_sapiens(9606)Function
GO:0035985part_of senescence-associated heterochromatin focus1IDAHomo_sapiens(9606)Component
GO:0042974enables nuclear retinoic acid receptor binding1IDAHomo_sapiens(9606)Function
GO:0042975enables peroxisome proliferator activated receptor binding1IDAHomo_sapiens(9606)Function
GO:0045892involved_in negative regulation of DNA-templated transcription1IMPHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IMPHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0046965enables nuclear retinoid X receptor binding1IDAHomo_sapiens(9606)Function
GO:0060090enables molecular adaptor activity1IDAHomo_sapiens(9606)Function
GO:0090402involved_in oncogene-induced cell senescence1IDAHomo_sapiens(9606)Process
GO:0090575part_of RNA polymerase II transcription regulator complex1ISSHomo_sapiens(9606)Component
GO:0140677enables molecular function activator activity1IMPHomo_sapiens(9606)Function

Expression