Ensembl ID ENSG00000137309 Gene ID 3159 Accession 5010
Gene Symbol HMGA1 Alias HMG-R;HMGIY;HMGA1A Full Name high mobility group AT-hook 1
Position 6 : 34236873 - 34246231 Length 9359 bases Strand Plus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]

ENSG00000137309 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000137309 HMGA1 1.57 1.36e-58 BRCA
ENSG00000137309 HMGA1 1.39 4.05e-32 COAD
ENSG00000137309 HMGA1 2.80 6.05e-157 LUSC
ENSG00000137309 HMGA1 2.90 3.69e-17 PCPG
ENSG00000137309 HMGA1 1.70 3.49e-26 LIHC
ENSG00000137309 HMGA1 2.13 1.83e-29 UCEC
ENSG00000137309 HMGA1 2.81 1.62e-14 CHOL
ENSG00000137309 HMGA1 3.14 7.90e-12 CESC
ENSG00000137309 HMGA1 2.27 2.04e-51 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000137309 HMGA1 colorectal cancer 10096541
ENSG00000137309 HMGA1 tumors 10344762
ENSG00000137309 HMGA1 tumors 10347218
ENSG00000137309 HMGA1 tumor 10347561
ENSG00000137309 HMGA1 colorectal cancer 10404089
ENSG00000137309 HMGA1 mesenchymal tumors 10448117
ENSG00000137309 HMGA1 mesenchymal tumors 10451711
ENSG00000137309 HMGA1 tumors 10469450
ENSG00000137309 HMGA1 tumors 10472377
ENSG00000137309 HMGA1 mesenchymal tumors 10526529
ENSG00000137309 HMGA1 tumors 10550310
ENSG00000137309 HMGA1 breast cancer 10582687
ENSG00000137309 HMGA1 benign tumor 10714095
ENSG00000137309 HMGA1 mesenchymal tumors 10744071
ENSG00000137309 HMGA1 tumors 10862029
ENSG00000137309 HMGA1 Cancer 10866296
ENSG00000137309 HMGA1 tumors 10889043
ENSG00000137309 HMGA1 mesenchymal tumors 11035986
ENSG00000137309 HMGA1 tumors 11063803
ENSG00000137309 HMGA1 tumours 11076660
ENSG00000137309 HMGA1 tumor 11134344
ENSG00000137309 HMGA1 tumours 11212080
ENSG00000137309 HMGA1 tumors 11410365
ENSG00000137309 HMGA1 mesenchymal tumors 11494149
ENSG00000137309 HMGA1 metastatic tumor 11578814
ENSG00000137309 HMGA1 tumors 11672774
ENSG00000137309 HMGA1 tumor 11685128
ENSG00000137309 HMGA1 prostate cancer 11830513
ENSG00000137309 HMGA1 tumors 12082527
ENSG00000137309 HMGA1 tumors 12142746
ENSG00000137309 HMGA1 cancer 12188916
ENSG00000137309 HMGA1 prostate cancer 12532335
ENSG00000137309 HMGA1 gastric cancer 12713623
ENSG00000137309 HMGA1 tumours 12778070
ENSG00000137309 HMGA1 malignant tumors 12807722
ENSG00000137309 HMGA1 tumours 12970064
ENSG00000137309 HMGA1 tumour 12973668
ENSG00000137309 HMGA1 cancer 13680222
ENSG00000137309 HMGA1 colorectal cancer 14666966
ENSG00000137309 HMGA1 tumors 14714251
ENSG00000137309 HMGA1 tumor 15064752
ENSG00000137309 HMGA1 cancer 15087128
ENSG00000137309 HMGA1 thyroid tumors 15107999
ENSG00000137309 HMGA1 prostate cancer 15162382
ENSG00000137309 HMGA1 mesenchymal tumors 15249855
ENSG00000137309 HMGA1 pancreatic cancer 15272314
ENSG00000137309 HMGA1 ovarian cancer 15378028
ENSG00000137309 HMGA1 breast cancer 15569996
ENSG00000137309 HMGA1 cancers 15591590
ENSG00000137309 HMGA1 tumors 15650238
ENSG00000137309 HMGA1 malignant tumours 15713121
ENSG00000137309 HMGA1 prostate cancer 15835918
ENSG00000137309 HMGA1 breast cancer 15893306
ENSG00000137309 HMGA1 cancer 15923078
ENSG00000137309 HMGA1 cancer 15958792
ENSG00000137309 HMGA1 cancers 16007157
ENSG00000137309 HMGA1 ovarian cancer 16030107
ENSG00000137309 HMGA1 tumor 16033759
ENSG00000137309 HMGA1 malignant peripheral nerve sheath tumors 16056249
ENSG00000137309 HMGA1 tumors 16166307
ENSG00000137309 HMGA1 cancer 16306787
ENSG00000137309 HMGA1 lung cancer 16521118
ENSG00000137309 HMGA1 thyroid cancer 16540646
ENSG00000137309 HMGA1 breast cancer 16707431
ENSG00000137309 HMGA1 cancer 16752910
ENSG00000137309 HMGA1 tumor 17045586
ENSG00000137309 HMGA1 pancreatic cancers 17114012
ENSG00000137309 HMGA1 tumor 17178855
ENSG00000137309 HMGA1 tumors 17290307
ENSG00000137309 HMGA1 pancreatic cancer 17342093
ENSG00000137309 HMGA1 tumor 17364334
ENSG00000137309 HMGA1 cancer 17455969
ENSG00000137309 HMGA1 cancer 17510387
ENSG00000137309 HMGA1 pancreatic cancer 17510394
ENSG00000137309 HMGA1 tumor 17550233
ENSG00000137309 HMGA1 tumor 17616660
ENSG00000137309 HMGA1 mesenchymal tumors 17654722
ENSG00000137309 HMGA1 cancer 17877762
ENSG00000137309 HMGA1 germ cell tumours 17935122
ENSG00000137309 HMGA1 tumour 18155899
ENSG00000137309 HMGA1 malignant epithelial tumors 18202751
ENSG00000137309 HMGA1 pancreatic cancer 18316571
ENSG00000137309 HMGA1 tumor 18473350
ENSG00000137309 HMGA1 mesenchymal tumors 18505920
ENSG00000137309 HMGA1 tumours 18651940
ENSG00000137309 HMGA1 tumors 18670638
ENSG00000137309 HMGA1 malignant tumours 18783938
ENSG00000137309 HMGA1 thyroid tumor 19060921
ENSG00000137309 HMGA1 cancers 19074878
ENSG00000137309 HMGA1 tumours 19156147
ENSG00000137309 HMGA1 tumor 19602464
ENSG00000137309 HMGA1 colorectal cancer 19609535
ENSG00000137309 HMGA1 cancer 19687300
ENSG00000137309 HMGA1 gastric cancer 19729480
ENSG00000137309 HMGA1 tumor 19820691
ENSG00000137309 HMGA1 pancreatic cancer 19848064
ENSG00000137309 HMGA1 large-cell lung cancer 19903768
ENSG00000137309 HMGA1 cancers 19916743
ENSG00000137309 HMGA1 tumor 20004941
ENSG00000137309 HMGA1 cancers 20068164
ENSG00000137309 HMGA1 ovarian cancer 20228781
ENSG00000137309 HMGA1 cancer 20335021
ENSG00000137309 HMGA1 tumour 20459557
ENSG00000137309 HMGA1 head and neck tumors 20530413
ENSG00000137309 HMGA1 tumor 20535291
ENSG00000137309 HMGA1 tumours 20701767
ENSG00000137309 HMGA1 cancer 20724141
ENSG00000137309 HMGA1 tumor 20961861
ENSG00000137309 HMGA1 cancer 21087998
ENSG00000137309 HMGA1 prostate cancer 21138859
ENSG00000137309 HMGA1 tumors 21156240
ENSG00000137309 HMGA1 cancer 21282977
ENSG00000137309 HMGA1 tumor 21300033
ENSG00000137309 HMGA1 tumor 21336378
ENSG00000137309 HMGA1 cancer 21530505
ENSG00000137309 HMGA1 lung cancer 21542969
ENSG00000137309 HMGA1 tumor 21573994
ENSG00000137309 HMGA1 tumors 21656127
ENSG00000137309 HMGA1 Tumor 21779448
ENSG00000137309 HMGA1 tumor 21835047
ENSG00000137309 HMGA1 metastatic cancers 21854010
ENSG00000137309 HMGA1 tumor 21984063
ENSG00000137309 HMGA1 tumors 22053823
ENSG00000137309 HMGA1 prostate cancer 22213442
ENSG00000137309 HMGA1 tumor 22249617
ENSG00000137309 HMGA1 Colon Cancer 22276142
ENSG00000137309 HMGA1 tumour 22276603
ENSG00000137309 HMGA1 tumor 22332738
ENSG00000137309 HMGA1 tumours 22363436
ENSG00000137309 HMGA1 cancer 22389255
ENSG00000137309 HMGA1 cancers 22419021
ENSG00000137309 HMGA1 gastric cancer 22448338
ENSG00000137309 HMGA1 tumor 22503056
ENSG00000137309 HMGA1 cancer 22654833
ENSG00000137309 HMGA1 colorectal cancers 22706202
ENSG00000137309 HMGA1 pancreatic cancers 22898640
ENSG00000137309 HMGA1 prostate cancer 22912571
ENSG00000137309 HMGA1 cancer 22932725
ENSG00000137309 HMGA1 tumours 22961697
ENSG00000137309 HMGA1 tumor 22965931
ENSG00000137309 HMGA1 cancers 23166588
ENSG00000137309 HMGA1 colorectal cancer 23201162
ENSG00000137309 HMGA1 cancers 23311322
ENSG00000137309 HMGA1 prostate cancer 23325049
ENSG00000137309 HMGA1 breast cancer 23545254
ENSG00000137309 HMGA1 Tumor 23658826
ENSG00000137309 HMGA1 bladder cancer 23796420
ENSG00000137309 HMGA1 prostate cancer 23798998
ENSG00000137309 HMGA1 tumors 23926501
ENSG00000137309 HMGA1 tumor 23935884
ENSG00000137309 HMGA1 cancer 23936116
ENSG00000137309 HMGA1 breast cancer 23945276
ENSG00000137309 HMGA1 cancer 24062859
ENSG00000137309 HMGA1 tumours 24336083
ENSG00000137309 HMGA1 cancer 24367622
ENSG00000137309 HMGA1 cancer 24410339
ENSG00000137309 HMGA1 lung cancer 24564251
ENSG00000137309 HMGA1 cancer 24684280
ENSG00000137309 HMGA1 colorectal cancer 24696416
ENSG00000137309 HMGA1 tumor 24803022
ENSG00000137309 HMGA1 colon cancer 24833610
ENSG00000137309 HMGA1 prostate cancer 24837491
ENSG00000137309 HMGA1 tumor 24870930
ENSG00000137309 HMGA1 tumour 25245141
ENSG00000137309 HMGA1 cancer 25268743
ENSG00000137309 HMGA1 breast cancer 25276782
ENSG00000137309 HMGA1 cancer 25313540
ENSG00000137309 HMGA1 non-small cell lung cancer 25344216
ENSG00000137309 HMGA1 cancer 25409711
ENSG00000137309 HMGA1 tumor 25455159
ENSG00000137309 HMGA1 cancer 25483074
ENSG00000137309 HMGA1 breast cancer 25572132
ENSG00000137309 HMGA1 epithelial ovarian cancer 25586095
ENSG00000137309 HMGA1 tumor 25621995
ENSG00000137309 HMGA1 tumor 25755724
ENSG00000137309 HMGA1 breast cancer 25772486
ENSG00000137309 HMGA1 tumors 25823555
ENSG00000137309 HMGA1 breast cancer 25846193
ENSG00000137309 HMGA1 cancer 25859543
ENSG00000137309 HMGA1 pituitary tumors 25894544
ENSG00000137309 HMGA1 tumors 26009886
ENSG00000137309 HMGA1 cancer 26009897
ENSG00000137309 HMGA1 cervical cancer 26084422
ENSG00000137309 HMGA1 GBM 26092597
ENSG00000137309 HMGA1 tumor 26117853
ENSG00000137309 HMGA1 pituitary tumors 26137461
ENSG00000137309 HMGA1 tumor 26244988
ENSG00000137309 HMGA1 malignant tumours 26251519
ENSG00000137309 HMGA1 breast cancer 26265440
ENSG00000137309 HMGA1 tumours 26411793
ENSG00000137309 HMGA1 Breast Cancer 26527623
ENSG00000137309 HMGA1 gastric cancer 26537313
ENSG00000137309 HMGA1 breast cancer 26627005
ENSG00000137309 HMGA1 malignant tumors 26657872
ENSG00000137309 HMGA1 Breast Cancer 26680797
ENSG00000137309 HMGA1 tumor 26708416
ENSG00000137309 HMGA1 breast cancer 26806308
ENSG00000137309 HMGA1 tumour 26806704
ENSG00000137309 HMGA1 non-small cell lung cancer 26834854
ENSG00000137309 HMGA1 cancer 26889953
ENSG00000137309 HMGA1 cancer 26895108
ENSG00000137309 HMGA1 tumor 26898758
ENSG00000137309 HMGA1 tumor 26923360
ENSG00000137309 HMGA1 Cancer 26980699
ENSG00000137309 HMGA1 tumors 27001612
ENSG00000137309 HMGA1 thyroid cancer 27008379
ENSG00000137309 HMGA1 cancers 27025651
ENSG00000137309 HMGA1 esophageal tumors 27027341
ENSG00000137309 HMGA1 cancer 27045138
ENSG00000137309 HMGA1 tumors 27081085
ENSG00000137309 HMGA1 prostate cancer 27175617
ENSG00000137309 HMGA1 tumors 27264189
ENSG00000137309 HMGA1 tumor 27292155
ENSG00000137309 HMGA1 tumor 27470368
ENSG00000137309 HMGA1 tumor 27486901
ENSG00000137309 HMGA1 colorectal cancer 27537384
ENSG00000137309 HMGA1 ovarian cancer 27561949
ENSG00000137309 HMGA1 tumor 27602961
ENSG00000137309 HMGA1 breast cancer 27723831
ENSG00000137309 HMGA1 Tumor 27855356
ENSG00000137309 HMGA1 cancer 27874091
ENSG00000137309 HMGA1 cancer 28000891
ENSG00000137309 HMGA1 tumor 28032857
ENSG00000137309 HMGA1 tumors 28255749
ENSG00000137309 HMGA1 Non-Small Cell Lung Cancer 28290473
ENSG00000137309 HMGA1 colon cancer 28358427
ENSG00000137309 HMGA1 cancers 28367244
ENSG00000137309 HMGA1 thyroid cancer 28393241
ENSG00000137309 HMGA1 colorectal cancer 28452345
ENSG00000137309 HMGA1 tumor 28467612
ENSG00000137309 HMGA1 cancers 28697176
ENSG00000137309 HMGA1 pancreatic cancer 28703779
ENSG00000137309 HMGA1 tumor 28731203
ENSG00000137309 HMGA1 tumor 28753127
ENSG00000137309 HMGA1 cancer 28777374
ENSG00000137309 HMGA1 breast cancer 28912895
ENSG00000137309 HMGA1 cancer 28924209
ENSG00000137309 HMGA1 cancer 29023799
ENSG00000137309 HMGA1 lung cancer 29038488
ENSG00000137309 HMGA1 tumor 29113200
ENSG00000137309 HMGA1 cancer 29149041
ENSG00000137309 HMGA1 cancer 29152644
ENSG00000137309 HMGA1 malignant tumors 29245994
ENSG00000137309 HMGA1 cancer 29262452
ENSG00000137309 HMGA1 cancers 29266325
ENSG00000137309 HMGA1 Breast Cancer 29316384
ENSG00000137309 HMGA1 cancer 29328367
ENSG00000137309 HMGA1 Non-melanoma Skin Cancer 29374701
ENSG00000137309 HMGA1 cancers 29416690
ENSG00000137309 HMGA1 cancer 29462157
ENSG00000137309 HMGA1 cancers 29511732
ENSG00000137309 HMGA1 tumor 29581847
ENSG00000137309 HMGA1 Tumor 29618461
ENSG00000137309 HMGA1 cancer 29697014
ENSG00000137309 HMGA1 tumour 29743479
ENSG00000137309 HMGA1 tumor 29789601
ENSG00000137309 HMGA1 cancer 29853899
ENSG00000137309 HMGA1 tumors 29880060
ENSG00000137309 HMGA1 breast cancer 29928320
ENSG00000137309 HMGA1 Breast Cancer 29945308
ENSG00000137309 HMGA1 tumors 29980789
ENSG00000137309 HMGA1 tumor 30008826
ENSG00000137309 HMGA1 gastric cancer 30098426
ENSG00000137309 HMGA1 Triple-Negative Breast Cancer 30135148
ENSG00000137309 HMGA1 bladder tumor 30216500
ENSG00000137309 HMGA1 DLBCL 30216798
ENSG00000137309 HMGA1 tumour 30228296
ENSG00000137309 HMGA1 tumor 30353687
ENSG00000137309 HMGA1 breast cancer 30365085
ENSG00000137309 HMGA1 tumour 30414623
ENSG00000137309 HMGA1 Cancer 30614613
ENSG00000137309 HMGA1 non-small-cell lung cancer 30666160
ENSG00000137309 HMGA1 colorectal cancer 30776481
ENSG00000137309 HMGA1 tumor 30778219
ENSG00000137309 HMGA1 ovarian cancer 30816441
ENSG00000137309 HMGA1 neuroendocrine tumors 30999005
ENSG00000137309 HMGA1 Cancer 30999858
ENSG00000137309 HMGA1 cervical cancer 31043793
ENSG00000137309 HMGA1 cancer 31067275
ENSG00000137309 HMGA1 tumors 31096664
ENSG00000137309 HMGA1 gastric cancer 31104318
ENSG00000137309 HMGA1 gastric cancer 31115003
ENSG00000137309 HMGA1 cancer 31116627
ENSG00000137309 HMGA1 cancer 31151404
ENSG00000137309 HMGA1 Breast Cancer 31167352
ENSG00000137309 HMGA1 tumor 31188873
ENSG00000137309 HMGA1 bladder cancer 31196036
ENSG00000137309 HMGA1 tumours 31217897
ENSG00000137309 HMGA1 gastric cancer 31229266
ENSG00000137309 HMGA1 Triple-Negative Breast Cancers 31300541
ENSG00000137309 HMGA1 tumor 31311575
ENSG00000137309 HMGA1 tumor 31340839
ENSG00000137309 HMGA1 Triple-Negative Breast Cancer 31382504
ENSG00000137309 HMGA1 tumor 31394192
ENSG00000137309 HMGA1 pituitary tumors 31487906
ENSG00000137309 HMGA1 breast cancer 31531802
ENSG00000137309 HMGA1 GI tumors 31737655
ENSG00000137309 HMGA1 Breast Cancer 31779212
ENSG00000137309 HMGA1 non-small cell lung cancer 31814893
ENSG00000137309 HMGA1 Gastric Cancer 31908497
ENSG00000137309 HMGA1 prostate cancer 8221692
ENSG00000137309 HMGA1 tumor 8495429
ENSG00000137309 HMGA1 tumour 8761372
ENSG00000137309 HMGA1 tumors 8946199
ENSG00000137309 HMGA1 atypical lipomatous tumors 9212729
ENSG00000137309 HMGA1 mesenchymal tumors 9290959
ENSG00000137309 HMGA1 breast cancer 9622058
ENSG00000137309 HMGA1 tumor 9692546
ENSG00000137309 HMGA1 thyroid tumors 9751634
ENSG00000137309 HMGA1 mesenchymal tumors 9824199
ENSG00000137309 HMGA1 tumor 9973936
ENSG00000137309 HMGA1 tumors 9989879
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
ENSG00000137309 HMGA1 colorectal adenocarcinoma sequence_alteration 0.4394% (5/1138) 1 entry
ENSG00000137309 HMGA1 brain glioblastoma sequence_alteration 0.7559% (7/926) 2 entries
ENSG00000137309 HMGA1 esophageal squamous cell carcinoma sequence_alteration 0.1481% (1/675) 1 entry
ENSG00000137309 HMGA1 prostate adenocarcinoma sequence_alteration 0.06878% (1/1454) 1 entry
ENSG00000137309 HMGA1 melanoma missense_variant 0.9901% (1/101) 1 entry
ENSG00000137309 HMGA1 Merkel cell skin cancer sequence_alteration 3.333% (1/30) 1 entry
ENSG00000137309 HMGA1 bile duct adenocarcinoma sequence_alteration 0.5291% (1/189) 1 entry
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000137309 HMGA1 MESO 0.0024 high
ENSG00000137309 HMGA1 STAD 0.0061 low
ENSG00000137309 HMGA1 UVM 0.023 low
ENSG00000137309 HMGA1 PAAD 0.00016 high
ENSG00000137309 HMGA1 UCEC 0.00049 high
ENSG00000137309 HMGA1 ACC 0.011 high
ENSG00000137309 HMGA1 LUSC 0.048 low
ENSG00000137309 HMGA1 HNSC 0.0011 high
ENSG00000137309 HMGA1 PCPG 0.0035 low
ENSG00000137309 HMGA1 THYM 0.00015 low
ENSG00000137309 HMGA1 COAD 0.018 low
ENSG00000137309 HMGA1 UCS 0.044 low
ENSG00000137309 HMGA1 OV 0.039 low
ENSG00000137309 HMGA1 BLCA 0.013 high
ENSG00000137309 HMGA1 LAML 7e-04 high
ENSG00000137309 HMGA1 SKCM 0.019 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000137309 HMGA1 PAAD Amp 1.006594 0.092217 0.745945 0.065217
ENSG00000137309 HMGA1 SKCM Amp 1.601755 0.149831 0.741895 0.509537
ENSG00000137309 HMGA1 UVM Amp 1.872709 0.238074 1.140112 0.537500