Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions E3 ligase
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000132109 Gene ID 6737 Accession 11312
Symbol TRIM21 Alias SSA;RO52;SSA1;RNF81;Ro/SSA Full Name tripartite motif containing 21
Status Confidence Length 8806 bases Strand Minus strand
Position 11 : 4384897 - 4393702 RNA binding domain SPRY
Summary This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000254436 SPRY PF00622 6.7e-19 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37327222 Regulation of PKR-dependent RNA translation inhibition by TRIM21 upon virus infection or other stress. Huiyi Li 2023-06-01 PLoS pathogens
32678213 Negative feedback regulation by HuR controls TRIM21 expression and function in response to UV radiation. Abhishek Guha 2020-07-16 Scientific reports
29949725 TRIM Proteins and Their Roles in Antiviral Host Defenses. Michiel M van 2018-09-29 Annual review of virology
35024595 Autoantibodies in Sjögren's syndrome and its classification criteria. Sharon Veenbergen 2022-01-01 Journal of translational autoimmunity
31103853 Integrated Regulation of HuR by Translation Repression and Protein Degradation Determines Pulsatile Expression of p53 Under DNA Damage. Abhishek Guha 2019-05-31 iScience

Transcripts

Name Transcript ID bp Protein Translation ID
TRIM21-202 ENST00000533692 706 90aa ENSP00000434053
TRIM21-201 ENST00000254436 1935 475aa ENSP00000254436

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
18488Hemoglobin A23.749e-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000132109homo_sapiensENSP0000036640451.46232.7485homo_sapiensENSP0000025443655.578935.3684
ENSG00000132109homo_sapiensENSP000002566492514.1379homo_sapiensENSP0000025443630.526317.2632
ENSG00000132109homo_sapiensENSP0000025481629.310318.9655homo_sapiensENSP0000025443639.368425.4737
ENSG00000132109homo_sapiensENSP0000049630126.860315.608homo_sapiensENSP0000025443631.157918.1053
ENSG00000132109homo_sapiensENSP0000051816437.579626.5393homo_sapiensENSP0000025443637.263226.3158
ENSG00000132109homo_sapiensENSP0000042114239.915127.6008homo_sapiensENSP0000025443639.578927.3684
ENSG00000132109homo_sapiensENSP0000042393424.58113.8268homo_sapiensENSP0000025443637.052620.8421
ENSG00000132109homo_sapiensENSP0000036588438.279625.1613homo_sapiensENSP0000025443637.473724.6316
ENSG00000132109homo_sapiensENSP0000035125015.26188.87311homo_sapiensENSP0000025443636.210521.0526
ENSG00000132109homo_sapiensENSP0000026229419.087110.8921homo_sapiensENSP0000025443638.736822.1053
ENSG00000132109homo_sapiensENSP0000032799435.523622.3819homo_sapiensENSP0000025443636.421122.9474
ENSG00000132109homo_sapiensENSP0000034312927.040815.4762homo_sapiensENSP0000025443633.473719.1579
ENSG00000132109homo_sapiensENSP0000050713116.85539.68553homo_sapiensENSP0000025443628.210516.2105
ENSG00000132109homo_sapiensENSP0000035561316.219710.2171homo_sapiensENSP0000025443626.736816.8421
ENSG00000132109homo_sapiensENSP0000047467835.840724.5575homo_sapiensENSP0000025443634.105323.3684
ENSG00000132109homo_sapiensENSP0000048509735.840724.5575homo_sapiensENSP0000025443634.105323.3684
ENSG00000132109homo_sapiensENSP0000040241436.607124.1071homo_sapiensENSP0000025443617.263211.3684
ENSG00000132109homo_sapiensENSP0000029141645.473728homo_sapiensENSP0000025443645.473728
ENSG00000132109homo_sapiensENSP0000036937342.596329.0061homo_sapiensENSP0000025443644.210530.1053
ENSG00000132109homo_sapiensENSP0000026805819.274410.5442homo_sapiensENSP0000025443635.789519.5789
ENSG00000132109homo_sapiensENSP0000031861532.418.4homo_sapiensENSP0000025443617.05269.68421
ENSG00000132109homo_sapiensENSP0000028580532.418.4homo_sapiensENSP0000025443617.05269.68421
ENSG00000132109homo_sapiensENSP0000047400334.222222.4444homo_sapiensENSP0000025443632.421121.2632
ENSG00000132109homo_sapiensENSP0000030516118.145710.596homo_sapiensENSP0000025443628.842116.8421
ENSG00000132109homo_sapiensENSP0000031267533.333321.3836homo_sapiensENSP0000025443633.473721.4737
ENSG00000132109homo_sapiensENSP0000029941317.441911.9186homo_sapiensENSP0000025443612.63168.63158
ENSG00000132109homo_sapiensENSP0000034959652.258138.7097homo_sapiensENSP0000025443651.157937.8947
ENSG00000132109homo_sapiensENSP0000028455153.846238.2479homo_sapiensENSP0000025443653.052637.6842
ENSG00000132109homo_sapiensENSP0000036742434.889420.3931homo_sapiensENSP0000025443629.894717.4737
ENSG00000132109homo_sapiensENSP0000040259540.368926.6393homo_sapiensENSP0000025443641.473727.3684
ENSG00000132109homo_sapiensENSP0000049541310.63225.67529homo_sapiensENSP0000025443631.157916.6316
ENSG00000132109homo_sapiensENSP0000034079723.790313.3065homo_sapiensENSP0000025443637.263220.8421
ENSG00000132109homo_sapiensENSP0000032388927.777816.8254homo_sapiensENSP0000025443636.842122.3158
ENSG00000132109homo_sapiensENSP0000049271937.219724.6637homo_sapiensENSP0000025443634.947423.1579
ENSG00000132109homo_sapiensENSP0000027239537.443924.6637homo_sapiensENSP0000025443635.157923.1579
ENSG00000132109homo_sapiensENSP00000340507168.7619homo_sapiensENSP0000025443635.368419.3684
ENSG00000132109homo_sapiensENSP0000037980050.614835.4508homo_sapiensENSP000002544365236.4211
ENSG00000132109homo_sapiensENSP0000048181536.666723.7778homo_sapiensENSP0000025443634.736822.5263
ENSG00000132109homo_sapiensENSP0000033296937.416524.7216homo_sapiensENSP0000025443635.368423.3684
ENSG00000132109homo_sapiensENSP0000048376437.639224.9443homo_sapiensENSP0000025443635.578923.5789
ENSG00000132109homo_sapiensENSP0000033228445.828.4homo_sapiensENSP0000025443648.210529.8947
ENSG00000132109homo_sapiensENSP0000024436039.488627.2727homo_sapiensENSP0000025443629.263220.2105
ENSG00000132109homo_sapiensENSP0000049132043.162426.4957homo_sapiensENSP0000025443642.526326.1053
ENSG00000132109homo_sapiensENSP0000032391325.36513.8686homo_sapiensENSP0000025443629.263216
ENSG00000132109homo_sapiensENSP0000036941533.519616.7598homo_sapiensENSP0000025443625.263212.6316
ENSG00000132109homo_sapiensENSP0000036329833.333320.398homo_sapiensENSP0000025443628.210517.2632
ENSG00000132109homo_sapiensENSP0000037982640.310124.4186homo_sapiensENSP0000025443621.894713.2632
ENSG00000132109homo_sapiensENSP0000032086931.428622.0635homo_sapiensENSP0000025443641.684229.2632
ENSG00000132109homo_sapiensENSP0000050855325.78419.8606homo_sapiensENSP0000025443615.578912
ENSG00000132109homo_sapiensENSP0000040829227.871416.2328homo_sapiensENSP0000025443638.315822.3158
ENSG00000132109homo_sapiensENSP0000026284321.360511.8367homo_sapiensENSP0000025443633.052618.3158
ENSG00000132109homo_sapiensENSP0000034420833.710421.267homo_sapiensENSP0000025443631.368419.7895
ENSG00000132109homo_sapiensENSP0000037327218.77889.21659homo_sapiensENSP0000025443634.315816.8421
ENSG00000132109homo_sapiensENSP0000039707345.945930.1455homo_sapiensENSP0000025443646.526330.5263
ENSG00000132109homo_sapiensENSP0000049718529.609917.0213homo_sapiensENSP0000025443635.157920.2105
ENSG00000132109homo_sapiensENSP0000028634921.300113.0014homo_sapiensENSP0000025443632.421119.7895
ENSG00000132109homo_sapiensENSP0000033965923.735413.0999homo_sapiensENSP0000025443638.526321.2632
ENSG00000132109homo_sapiensENSP0000035565948.84733.9623homo_sapiensENSP0000025443649.052634.1053
ENSG00000132109homo_sapiensENSP0000025302416.16779.22156homo_sapiensENSP0000025443628.421116.2105
ENSG00000132109homo_sapiensENSP0000027477334.246624.0704homo_sapiensENSP0000025443636.842125.8947
ENSG00000132109homo_sapiensENSP0000050741343.935930.8924homo_sapiensENSP0000025443640.421128.4211
ENSG00000132109homo_sapiensENSP0000041044634.508425.603homo_sapiensENSP0000025443639.157929.0526
ENSG00000132109homo_sapiensENSP0000030192442.190726.572homo_sapiensENSP0000025443643.789527.5789
ENSG00000132109homo_sapiensENSP0000036339036.260619.2635homo_sapiensENSP0000025443626.947414.3158
ENSG00000132109homo_sapiensENSP0000036929941.566327.7108homo_sapiensENSP0000025443643.578929.0526
ENSG00000132109homo_sapiensENSP0000031267823.98814.093homo_sapiensENSP0000025443633.684219.7895
ENSG00000132109homo_sapiensENSP0000032773851.282135.6838homo_sapiensENSP0000025443650.526335.1579
ENSG00000132109homo_sapiensENSP0000033021636.061924.5575homo_sapiensENSP0000025443634.315823.3684
ENSG00000132109homo_sapiensENSP0000038829935.840723.6726homo_sapiensENSP0000025443634.105322.5263
ENSG00000132109homo_sapiensENSP0000032760435.840723.6726homo_sapiensENSP0000025443634.105322.5263
ENSG00000132109homo_sapiensENSP0000026938325.531915.6673homo_sapiensENSP0000025443627.789517.0526
ENSG00000132109homo_sapiensENSP0000030074742.886631.7526homo_sapiensENSP0000025443643.789532.4211
ENSG00000132109homo_sapiensENSP0000039508637.389423.8938homo_sapiensENSP0000025443635.578922.7368
ENSG00000132109homo_sapiensENSP0000049705035.17722.7876homo_sapiensENSP0000025443633.473721.6842
ENSG00000132109homo_sapiensENSP0000027573635.44324.8945homo_sapiensENSP0000025443635.368424.8421
ENSG00000132109homo_sapiensENSP0000033465723.847214.2292homo_sapiensENSP0000025443638.105322.7368
ENSG00000132109homo_sapiensENSP0000035543752.469139.3004homo_sapiensENSP0000025443653.684240.2105
ENSG00000132109homo_sapiensENSP0000036592433.411822.1176homo_sapiensENSP0000025443629.894719.7895
ENSG00000132109homo_sapiensENSP0000021959617.797710.3713homo_sapiensENSP0000025443629.263217.0526
ENSG00000132109homo_sapiensENSP0000036944041.666729.845homo_sapiensENSP0000025443645.263232.4211

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000132109homo_sapiensENSP0000025443698.736897.4737nomascus_leucogenysENSNLEP0000002104498.736897.4737
ENSG00000132109homo_sapiensENSP0000025443699.578999.5789pan_paniscusENSPPAP0000004150499.578999.5789
ENSG00000132109homo_sapiensENSP0000025443699.578997.8947pongo_abeliiENSPPYP0000000414399.578997.8947
ENSG00000132109homo_sapiensENSP00000254436100100pan_troglodytesENSPTRP00000005673100100
ENSG00000132109homo_sapiensENSP0000025443699.578998.9474gorilla_gorillaENSGGOP0000000637599.578998.9474
ENSG00000132109homo_sapiensENSP0000025443653.684238.1053ornithorhynchus_anatinusENSOANP0000000028858.620741.6092
ENSG00000132109homo_sapiensENSP0000025443650.526339.7895choloepus_hoffmanniENSCHOP0000000913784.50766.5493
ENSG00000132109homo_sapiensENSP0000025443686.526375.5789dasypus_novemcinctusENSDNOP0000002979873.131763.879
ENSG00000132109homo_sapiensENSP0000025443668.421157.0526erinaceus_europaeusENSEEUP0000000583368.134256.8134
ENSG00000132109homo_sapiensENSP0000025443662.526351.3684echinops_telfairiENSETEP0000001083173.697360.5459
ENSG00000132109homo_sapiensENSP0000025443669.473759.5789echinops_telfairiENSETEP0000001457081.481569.8765
ENSG00000132109homo_sapiensENSP0000025443696.842192.4211callithrix_jacchusENSCJAP0000002873296.842192.4211
ENSG00000132109homo_sapiensENSP0000025443698.105396.2105cercocebus_atysENSCATP0000001358298.105396.2105
ENSG00000132109homo_sapiensENSP0000025443697.684295.7895macaca_fascicularisENSMFAP0000003481997.47995.5882
ENSG00000132109homo_sapiensENSP0000025443697.684295.7895macaca_mulattaENSMMUP0000007627097.684295.7895
ENSG00000132109homo_sapiensENSP0000025443697.894796macaca_nemestrinaENSMNEP0000000604597.894796
ENSG00000132109homo_sapiensENSP0000025443696.842194.7368papio_anubisENSPANP0000004819697.046494.9367
ENSG00000132109homo_sapiensENSP0000025443698.105396.2105mandrillus_leucophaeusENSMLEP0000001254498.105396.2105
ENSG00000132109homo_sapiensENSP0000025443683.578975.7895tursiops_truncatusENSTTRP0000000889687.444979.2952
ENSG00000132109homo_sapiensENSP0000025443682.736874.5263vulpes_vulpesENSVVUP0000003612383.795375.4797
ENSG00000132109homo_sapiensENSP0000025443680.631667.3684mus_spretusMGP_SPRETEiJ_P008449682.900469.2641
ENSG00000132109homo_sapiensENSP0000025443688.421180equus_asinusENSEASP0000500095289.552281.0235
ENSG00000132109homo_sapiensENSP0000025443686.526375.1579capra_hircusENSCHIP0000002941188.387176.7742
ENSG00000132109homo_sapiensENSP0000025443642.526335.3684loxodonta_africanaENSLAFP0000002901584.166770
ENSG00000132109homo_sapiensENSP0000025443659.157949.0526loxodonta_africanaENSLAFP0000002497381.213967.341
ENSG00000132109homo_sapiensENSP0000025443678.315867.3684loxodonta_africanaENSLAFP0000002418382.119270.6402
ENSG00000132109homo_sapiensENSP000002544368070.7368loxodonta_africanaENSLAFP0000001183885.201875.3363
ENSG00000132109homo_sapiensENSP0000025443662.526350.9474loxodonta_africanaENSLAFP0000002423470.714357.619
ENSG00000132109homo_sapiensENSP0000025443685.473776.8421panthera_leoENSPLOP0000000682286.567277.8252
ENSG00000132109homo_sapiensENSP0000025443686.105377.4737ailuropoda_melanoleucaENSAMEP0000001590486.105377.4737
ENSG00000132109homo_sapiensENSP0000025443686.315876.2105bos_indicus_hybridENSBIXP0000502088180.234870.8415
ENSG00000132109homo_sapiensENSP0000025443640.631635.7895oryctolagus_cuniculusENSOCUP0000002193678.137668.8259
ENSG00000132109homo_sapiensENSP0000025443679.789569.8947equus_caballusENSECAP0000000471279.288769.4561
ENSG00000132109homo_sapiensENSP0000025443682.736874.5263canis_lupus_familiarisENSCAFP0084501643283.795375.4797
ENSG00000132109homo_sapiensENSP0000025443684.421175.7895panthera_pardusENSPPRP0000000890685.683876.9231
ENSG00000132109homo_sapiensENSP0000025443688.210577.2632marmota_marmota_marmotaENSMMMP0000001417990.301779.0948
ENSG00000132109homo_sapiensENSP0000025443687.578978.5263balaenoptera_musculusENSBMSP0001002915888.135679.0254
ENSG00000132109homo_sapiensENSP0000025443682.105370.7368cavia_porcellusENSCPOP0000001096283.511871.9486
ENSG00000132109homo_sapiensENSP0000025443685.263276.8421felis_catusENSFCAP0000003918486.353977.8252
ENSG00000132109homo_sapiensENSP0000025443684.842175.7895ursus_americanusENSUAMP0000000023285.927576.7591
ENSG00000132109homo_sapiensENSP000002544368879.1579monodon_monocerosENSMMNP0001502721389.125880.1706
ENSG00000132109homo_sapiensENSP0000025443685.473775.5789sus_scrofaENSSSCP0000001569985.65475.7384
ENSG00000132109homo_sapiensENSP0000025443687.789577.6842microcebus_murinusENSMICP0000001949987.60577.521
ENSG00000132109homo_sapiensENSP0000025443681.473768octodon_degusENSODEP0000001074085.430571.3024
ENSG00000132109homo_sapiensENSP0000025443682.947472.2105jaculus_jaculusENSJJAP0000001423585.097274.0821
ENSG00000132109homo_sapiensENSP0000025443686.736875.5789ovis_aries_rambouilletENSOARP0002001412687.288176.0593
ENSG00000132109homo_sapiensENSP0000025443684.842175.5789ursus_maritimusENSUMAP0000000724085.927576.5458
ENSG00000132109homo_sapiensENSP0000025443676.631663.7895ochotona_princepsENSOPRP0000001321676.793363.924
ENSG00000132109homo_sapiensENSP0000025443688.210579.3684delphinapterus_leucasENSDLEP0000001060489.33980.3838
ENSG00000132109homo_sapiensENSP0000025443687.578977.6842physeter_catodonENSPCTP0000502863488.888978.8462
ENSG00000132109homo_sapiensENSP0000025443681.052668.4211mus_caroliMGP_CAROLIEiJ_P008113283.333370.3463
ENSG00000132109homo_sapiensENSP0000025443680.631668.2105mus_musculusENSMUSP0000003326482.900470.1299
ENSG00000132109homo_sapiensENSP0000025443683.368473.2632dipodomys_ordiiENSDORP0000000685185.161374.8387
ENSG00000132109homo_sapiensENSP0000025443685.263275.1579mustela_putorius_furoENSMPUP0000001042786.538576.2821
ENSG00000132109homo_sapiensENSP0000025443695.789590.9474aotus_nancymaaeENSANAP0000003006195.789590.9474
ENSG00000132109homo_sapiensENSP0000025443695.789591.3684saimiri_boliviensis_boliviensisENSSBOP0000004013395.789591.3684
ENSG00000132109homo_sapiensENSP0000025443682.526373.4737vicugna_pacosENSVPAP0000001124285.032575.705
ENSG00000132109homo_sapiensENSP0000025443698.315896.2105chlorocebus_sabaeusENSCSAP0000000060998.315896.2105
ENSG00000132109homo_sapiensENSP0000025443651.157943.5789tupaia_belangeriENSTBEP0000000796073.192862.3494
ENSG00000132109homo_sapiensENSP0000025443681.894767.3684mesocricetus_auratusENSMAUP0000002505183.297668.5225
ENSG00000132109homo_sapiensENSP000002544368878.7368phocoena_sinusENSPSNP0000001069289.125879.7441
ENSG00000132109homo_sapiensENSP0000025443685.894777.2632camelus_dromedariusENSCDRP0000500191087.93179.0948
ENSG00000132109homo_sapiensENSP0000025443688.631679.7895carlito_syrichtaENSTSYP0000001082689.765580.8102
ENSG00000132109homo_sapiensENSP0000025443685.263276.6316panthera_tigris_altaicaENSPTIP0000001746486.353977.6119
ENSG00000132109homo_sapiensENSP0000025443681.052669.2632rattus_norvegicusENSRNOP0000002499280.208368.5417
ENSG00000132109homo_sapiensENSP0000025443686.736876.6316prolemur_simusENSPSMP0000001983387.103676.9556
ENSG00000132109homo_sapiensENSP0000025443683.157970.1053microtus_ochrogasterENSMOCP0000000173984.401771.1538
ENSG00000132109homo_sapiensENSP0000025443683.789573.0526sorex_araneusENSSARP0000001303983.613472.8992
ENSG00000132109homo_sapiensENSP0000025443681.684269.0526peromyscus_maniculatus_bairdiiENSPEMP0000001257483.801370.8423
ENSG00000132109homo_sapiensENSP0000025443686.315876.4211bos_mutusENSBMUP0000003587987.4277.3987
ENSG00000132109homo_sapiensENSP0000025443629.473723.5789mus_spicilegusENSMSIP0000002244077.348161.8785
ENSG00000132109homo_sapiensENSP0000025443681.263267.7895cricetulus_griseus_chok1gshdENSCGRP0000102650983.369369.5464
ENSG00000132109homo_sapiensENSP0000025443686.947477.2632pteropus_vampyrusENSPVAP0000000511687.130877.4262
ENSG00000132109homo_sapiensENSP0000025443686.736877.8947myotis_lucifugusENSMLUP0000000337187.473578.5563
ENSG00000132109homo_sapiensENSP0000025443687.157977.6842rhinolophus_ferrumequinumENSRFEP0001002108388.272978.678
ENSG00000132109homo_sapiensENSP0000025443685.684276neovison_visonENSNVIP0000002446986.965877.1367
ENSG00000132109homo_sapiensENSP0000025443686.315876.2105bos_taurusENSBTAP0000001845987.4277.1855
ENSG00000132109homo_sapiensENSP0000025443685.684273.0526heterocephalus_glaber_femaleENSHGLP0000006059278.723467.118
ENSG00000132109homo_sapiensENSP0000025443698.315896rhinopithecus_bietiENSRBIP0000000591898.315896
ENSG00000132109homo_sapiensENSP0000025443682.736874.5263canis_lupus_dingoENSCAFP0002001085083.795375.4797
ENSG00000132109homo_sapiensENSP0000025443630.736825.8947sciurus_vulgarisENSSVLP0000500765579.781467.2131
ENSG00000132109homo_sapiensENSP0000025443689.894779.1579sciurus_vulgarisENSSVLP0000500866489.894779.1579
ENSG00000132109homo_sapiensENSP0000025443675.368463.7895procavia_capensisENSPCAP0000000417576.008564.3312
ENSG00000132109homo_sapiensENSP0000025443682.947471.3684nannospalax_galiliENSNGAP0000000165484.368372.591
ENSG00000132109homo_sapiensENSP0000025443686.315876.4211bos_grunniensENSBGRP0000002039380.234871.0372
ENSG00000132109homo_sapiensENSP0000025443683.157971.1579chinchilla_lanigeraENSCLAP0000002251884.401772.2222
ENSG00000132109homo_sapiensENSP0000025443686.736876.8421cervus_hanglu_yarkandensisENSCHYP0000001141377.882868.9981
ENSG00000132109homo_sapiensENSP0000025443685.473774.9474catagonus_wagneriENSCWAP0000000081385.473774.9474
ENSG00000132109homo_sapiensENSP0000025443688.631678.3158ictidomys_tridecemlineatusENSSTOP0000000444888.2677.9874
ENSG00000132109homo_sapiensENSP0000025443645.473737.4737otolemur_garnettiiENSOGAP0000000827784.046769.2607
ENSG00000132109homo_sapiensENSP0000025443696.631692.4211cebus_imitatorENSCCAP0000003906496.631692.4211
ENSG00000132109homo_sapiensENSP000002544368877.8947urocitellus_parryiiENSUPAP0001002415487.63177.5681
ENSG00000132109homo_sapiensENSP0000025443686.526376.2105moschus_moschiferusENSMMSP0000002288486.892276.5328
ENSG00000132109homo_sapiensENSP0000025443698.315895.7895rhinopithecus_roxellanaENSRROP0000002350398.315895.7895
ENSG00000132109homo_sapiensENSP0000025443681.894769.8947mus_pahariMGP_PahariEiJ_P001796384.017371.7063
ENSG00000132109homo_sapiensENSP000002544368879.7895propithecus_coquereliENSPCOP000000213518879.7895

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000209involved_in protein polyubiquitination2IBA,IDAHomo_sapiens(9606)Process
GO:0000932located_in P-body1IEAHomo_sapiens(9606)Component
GO:0003677enables DNA binding1IEAHomo_sapiens(9606)Function
GO:0003713enables transcription coactivator activity1IDAHomo_sapiens(9606)Function
GO:0003723enables RNA binding1IEAHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity2IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005654is_active_in nucleoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IC,IDAHomo_sapiens(9606)Component
GO:0005776located_in autophagosome1IEAHomo_sapiens(9606)Component
GO:0005829is_active_in cytosol2IBA,TASHomo_sapiens(9606)Component
GO:0006513involved_in protein monoubiquitination1IDAHomo_sapiens(9606)Process
GO:0007049involved_in cell cycle1IEAHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0010498involved_in proteasomal protein catabolic process1IDAHomo_sapiens(9606)Process
GO:0010508involved_in positive regulation of autophagy2IBA,IMPHomo_sapiens(9606)Process
GO:0016567involved_in protein ubiquitination1IDAHomo_sapiens(9606)Process
GO:0019901enables protein kinase binding1IBAHomo_sapiens(9606)Function
GO:0031410located_in cytoplasmic vesicle1IEAHomo_sapiens(9606)Component
GO:0031648involved_in protein destabilization1IMPHomo_sapiens(9606)Process
GO:0032088involved_in negative regulation of NF-kappaB transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0032092involved_in positive regulation of protein binding1IMPHomo_sapiens(9606)Process
GO:0032479involved_in regulation of type I interferon production1TASHomo_sapiens(9606)Process
GO:0032880involved_in regulation of protein localization1IBAHomo_sapiens(9606)Process
GO:0032897involved_in negative regulation of viral transcription1IDAHomo_sapiens(9606)Process
GO:0034341involved_in response to type II interferon1IDAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0042803enables protein homodimerization activity1IBAHomo_sapiens(9606)Function
GO:0043123involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling1IBAHomo_sapiens(9606)Process
GO:0044314involved_in protein K27-linked ubiquitination1IDAHomo_sapiens(9606)Process
GO:0044790involved_in suppression of viral release by host1IDAHomo_sapiens(9606)Process
GO:0045087involved_in innate immune response2IBA,IDAHomo_sapiens(9606)Process
GO:0045787involved_in positive regulation of cell cycle1IMPHomo_sapiens(9606)Process
GO:0045824involved_in negative regulation of innate immune response1IDAHomo_sapiens(9606)Process
GO:0045893involved_in positive regulation of DNA-templated transcription1IEAHomo_sapiens(9606)Process
GO:0046596involved_in regulation of viral entry into host cell1IBAHomo_sapiens(9606)Process
GO:0046598involved_in positive regulation of viral entry into host cell1IEAHomo_sapiens(9606)Process
GO:0051091involved_in positive regulation of DNA-binding transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IBAHomo_sapiens(9606)Process
GO:0051865involved_in protein autoubiquitination1IDAHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0062197involved_in cellular response to chemical stress1TASHomo_sapiens(9606)Process
GO:0070269involved_in pyroptosis1IDAHomo_sapiens(9606)Process
GO:0070534involved_in protein K63-linked ubiquitination1IMPHomo_sapiens(9606)Process
GO:0070936involved_in protein K48-linked ubiquitination1IDAHomo_sapiens(9606)Process
GO:0085020involved_in protein K6-linked ubiquitination1IDAHomo_sapiens(9606)Process
GO:0090086involved_in negative regulation of protein deubiquitination1IMPHomo_sapiens(9606)Process
GO:1990904part_of ribonucleoprotein complex1IEAHomo_sapiens(9606)Component

Expression