RBP Type
Canonical_RBPs
Diseases
Flaviviruses SARS-COV-2 Dengue Zika
Drug
N.A.
Main interacting RNAs
snRNA
Moonlighting functions
N.A.
Localizations
N.A.
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000128739 Gene ID
6638 Accession
11164
Symbol
SNRPN
Alias
SMN;PWCR;SM-D;sm-N;RT-LI;HCERN3;SNRNP-N;SNURF-SNRPN
Full Name
small nuclear ribonucleoprotein polypeptide N
Status
Confidence
Length
155077 bases
Strand
Plus strand
Position
15 : 24823647 - 24978723
RNA binding domain
LSM
Summary
This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000463510
LSM
PF01423 1.4e-19
1
ENSP00000306223
LSM
PF01423 3e-19
1
ENSP00000375105
LSM
PF01423 3e-19
1
ENSP00000382969
LSM
PF01423 3e-19
1
ENSP00000382972
LSM
PF01423 3e-19
1
ENSP00000463458
LSM
PF01423 3e-19
1
ENSP00000494831
LSM
PF01423 3e-19
1
ENSP00000495345
LSM
PF01423 3e-19
1
ENSP00000452342
LSM
PF01423 3.1e-19
1
ENSP00000462211
LSM
PF01423 6.1e-14
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
27146458 RBFOX1 and RBFOX2 are dispensable in iPSCs and iPSC-derived neurons and do not contribute to neural-specific paternal UBE3A silencing.
Pin-Fang Chen
2016-05-05
Scientific reports
29507115 Neurochondrin interacts with the SMN protein suggesting a novel mechanism for spinal muscular atrophy pathology.
W Luke Thompson
2018-04-17
Journal of cell science
27288824 Single Gene and Syndromic Causes of Obesity: Illustrative Examples.
G Merlin Butler
2016-01-01
Progress in molecular biology and translational science
Name
Transcript ID
bp
Protein
Translation ID
SNRPN-204
ENST00000400098
525
No protein
-
SNRPN-205
ENST00000400100
1751
240aa
ENSP00000382972
SNRPN-212
ENST00000645002
1940
240aa
ENSP00000494831
SNRPN-211
ENST00000642807
1835
240aa
ENSP00000495345
SNRPN-203
ENST00000400097
1605
240aa
ENSP00000382969
SNRPN-206
ENST00000553597
849
No protein
-
SNRPN-202
ENST00000390687
1468
240aa
ENSP00000375105
SNRPN-210
ENST00000584968
908
59aa
ENSP00000462211
SNRPN-201
ENST00000346403
1304
240aa
ENSP00000306223
SNRPN-207
ENST00000554227
1763
244aa
ENSP00000452342
SNRPN-209
ENST00000579070
871
169aa
ENSP00000463510
SNRPN-208
ENST00000577565
1298
240aa
ENSP00000463458
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
360 Respiratory Function Tests 1.36266882142553E-6 17903307 15854 Stroke 1.0883615E-004 - 33847 Glomerular Filtration Rate 5.9744733E-005 - 65671 Periodontitis 4E-8 26962152 65672 Tooth 4E-8 26962152 70584 Plaque, Atherosclerotic 5E-6 28282560 86021 Hormones 2E-6 23251661 102065 Respiratory Function Tests 1E-6 17903307
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000128739 homo_sapiens ENSP00000370746 96.1039 91.7749 homo_sapiens ENSP00000375105 92.5 88.3333
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000128739 homo_sapiens ENSP00000375105 83.75 83.75 nomascus_leucogenys ENSNLEP00000001621 84.4538 84.4538 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 pan_paniscus ENSPPAP00000008842 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 pongo_abelii ENSPPYP00000027556 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 pan_troglodytes ENSPTRP00000067893 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 gorilla_gorilla ENSGGOP00000003913 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 97.9167 95 sarcophilus_harrisii ENSSHAP00000011953 97.9167 95 ENSG00000128739 homo_sapiens ENSP00000375105 96.6667 96.25 choloepus_hoffmanni ENSCHOP00000001628 87.218 86.8421 ENSG00000128739 homo_sapiens ENSP00000375105 99.1667 98.75 dasypus_novemcinctus ENSDNOP00000025369 97.541 97.1311 ENSG00000128739 homo_sapiens ENSP00000375105 99.1667 98.3333 erinaceus_europaeus ENSEEUP00000006755 99.5816 98.7448 ENSG00000128739 homo_sapiens ENSP00000375105 77.9167 77.5 erinaceus_europaeus ENSEEUP00000007143 99.4681 98.9362 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 callithrix_jacchus ENSCJAP00000039038 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 cercocebus_atys ENSCATP00000017219 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 macaca_fascicularis ENSMFAP00000030186 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 macaca_mulatta ENSMMUP00000066890 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 macaca_nemestrina ENSMNEP00000014334 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 papio_anubis ENSPANP00000016140 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 mandrillus_leucophaeus ENSMLEP00000029270 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 tursiops_truncatus ENSTTRP00000010395 87.4539 87.4539 ENSG00000128739 homo_sapiens ENSP00000375105 94.5833 94.5833 vulpes_vulpes ENSVVUP00000024527 93.0328 93.0328 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 mus_spretus MGP_SPRETEiJ_P0083252 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 equus_asinus ENSEASP00005026212 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 capra_hircus ENSCHIP00000017774 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 99.1667 99.1667 loxodonta_africana ENSLAFP00000007931 99.1667 99.1667 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 panthera_leo ENSPLOP00000004768 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 58.3333 51.6667 panthera_leo ENSPLOP00000027146 53.2319 47.1483 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 ailuropoda_melanoleuca ENSAMEP00000007414 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 bos_indicus_hybrid ENSBIXP00005022818 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 oryctolagus_cuniculus ENSOCUP00000003059 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 equus_caballus ENSECAP00000015877 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 95.8333 95 canis_lupus_familiaris ENSCAFP00845027141 89.1473 88.3721 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 panthera_pardus ENSPPRP00000027974 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 marmota_marmota_marmota ENSMMMP00000021783 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 98.3333 98.3333 balaenoptera_musculus ENSBMSP00010011621 96.7213 96.7213 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 cavia_porcellus ENSCPOP00000015056 98.7654 98.7654 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 felis_catus ENSFCAP00000018366 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 75.4167 71.25 felis_catus ENSFCAP00000032616 72.1116 68.1275 ENSG00000128739 homo_sapiens ENSP00000375105 94.1667 92.9167 ursus_americanus ENSUAMP00000020677 78.7456 77.7003 ENSG00000128739 homo_sapiens ENSP00000375105 93.3333 90.4167 monodelphis_domestica ENSMODP00000049062 82.0513 79.4872 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 bison_bison_bison ENSBBBP00000011667 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 98.3333 98.3333 monodon_monoceros ENSMMNP00015015799 96.7213 96.7213 ENSG00000128739 homo_sapiens ENSP00000375105 90.8333 90.8333 sus_scrofa ENSSSCP00000021510 87.2 87.2 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 microcebus_murinus ENSMICP00000037669 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 86.25 84.5833 octodon_degus ENSODEP00000021848 93.2432 91.4414 ENSG00000128739 homo_sapiens ENSP00000375105 96.6667 95.8333 octodon_degus ENSODEP00000026307 97.479 96.6387 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 ovis_aries_rambouillet ENSOARP00020010229 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 ursus_maritimus ENSUMAP00000035591 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 95.4167 95.4167 delphinapterus_leucas ENSDLEP00000019504 98.7069 98.7069 ENSG00000128739 homo_sapiens ENSP00000375105 87.0833 85 physeter_catodon ENSPCTP00005012229 93.3036 91.0714 ENSG00000128739 homo_sapiens ENSP00000375105 98.3333 98.3333 physeter_catodon ENSPCTP00005012468 96.7213 96.7213 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 mus_caroli MGP_CAROLIEiJ_P0079906 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 mus_musculus ENSMUSP00000096003 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 dipodomys_ordii ENSDORP00000004237 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 mustela_putorius_furo ENSMPUP00000014529 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 aotus_nancymaae ENSANAP00000033135 89.1791 89.1791 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 saimiri_boliviensis_boliviensis ENSSBOP00000000093 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 56.25 55.4167 vicugna_pacos ENSVPAP00000007864 50 49.2593 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 chlorocebus_sabaeus ENSCSAP00000002699 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 mesocricetus_auratus ENSMAUP00000000029 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 98.3333 98.3333 phocoena_sinus ENSPSNP00000011592 96.7213 96.7213 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.1667 camelus_dromedarius ENSCDRP00005005252 79.9331 79.5987 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 carlito_syrichta ENSTSYP00000004788 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 94.1667 94.1667 panthera_tigris_altaica ENSPTIP00000001775 90.4 90.4 ENSG00000128739 homo_sapiens ENSP00000375105 97.9167 97.5 rattus_norvegicus ENSRNOP00000077384 97.9167 97.5 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 microtus_ochrogaster ENSMOCP00000016459 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 77.5 77.5 sorex_araneus ENSSARP00000000067 77.8243 77.8243 ENSG00000128739 homo_sapiens ENSP00000375105 97.0833 95.8333 peromyscus_maniculatus_bairdii ENSPEMP00000024152 97.0833 95.8333 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 peromyscus_maniculatus_bairdii ENSPEMP00000012633 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 bos_mutus ENSBMUP00000036142 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 mus_spicilegus ENSMSIP00000018041 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 99.1667 99.1667 cricetulus_griseus_chok1gshd ENSCGRP00001003434 96.748 96.748 ENSG00000128739 homo_sapiens ENSP00000375105 59.1667 59.1667 pteropus_vampyrus ENSPVAP00000003844 52.7881 52.7881 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 myotis_lucifugus ENSMLUP00000020284 97.1311 97.1311 ENSG00000128739 homo_sapiens ENSP00000375105 80.4167 78.75 rhinolophus_ferrumequinum ENSRFEP00010028082 62.6623 61.3636 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 neovison_vison ENSNVIP00000019775 99.5833 99.5833 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 bos_taurus ENSBTAP00000010856 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 heterocephalus_glaber_female ENSHGLP00000016666 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 rhinopithecus_bieti ENSRBIP00000036293 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 82.0833 78.3333 canis_lupus_dingo ENSCAFP00020030865 73.5075 70.1493 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 sciurus_vulgaris ENSSVLP00005014671 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 97.5 94.5833 phascolarctos_cinereus ENSPCIP00000005632 74.7604 72.524 ENSG00000128739 homo_sapiens ENSP00000375105 61.6667 55.4167 procavia_capensis ENSPCAP00000005659 60.4082 54.2857 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 nannospalax_galili ENSNGAP00000000222 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 bos_grunniens ENSBGRP00000038045 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 chinchilla_lanigera ENSCLAP00000016545 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 cervus_hanglu_yarkandensis ENSCHYP00000008219 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 catagonus_wagneri ENSCWAP00000008898 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 ictidomys_tridecemlineatus ENSSTOP00000001197 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 otolemur_garnettii ENSOGAP00000006612 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 cebus_imitator ENSCCAP00000012919 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 70.4167 70.4167 urocitellus_parryii ENSUPAP00010008727 72.2222 72.2222 ENSG00000128739 homo_sapiens ENSP00000375105 98.75 98.75 moschus_moschiferus ENSMMSP00000016070 98.75 98.75 ENSG00000128739 homo_sapiens ENSP00000375105 99.5833 99.5833 rhinopithecus_roxellana ENSRROP00000022598 97.9508 97.9508 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 mus_pahari MGP_PahariEiJ_P0016764 100 100 ENSG00000128739 homo_sapiens ENSP00000375105 100 100 propithecus_coquereli ENSPCOP00000006223 88.5609 88.5609 ENSG00000128739 homo_sapiens ENSP00000375105 48.3333 37.5 caenorhabditis_elegans W08E3.1.1 72.5 56.25 ENSG00000128739 homo_sapiens ENSP00000375105 50.8333 45.8333 ciona_intestinalis ENSCINP00000028023 73.0539 65.8683 ENSG00000128739 homo_sapiens ENSP00000375105 95 91.25 gadus_morhua ENSGMOP00000045234 85.7143 82.3308 ENSG00000128739 homo_sapiens ENSP00000375105 58.3333 55 fundulus_heteroclitus ENSFHEP00000032693 77.3481 72.9282 ENSG00000128739 homo_sapiens ENSP00000375105 94.5833 91.25 oryzias_javanicus ENSOJAP00000047727 94.5833 91.25 ENSG00000128739 homo_sapiens ENSP00000375105 47.0833 41.6667 ciona_savignyi ENSCSAVP00000002805 75.8389 67.1141 ENSG00000128739 homo_sapiens ENSP00000375105 38.3333 26.25 saccharomyces_cerevisiae YER029C 46.9388 32.1429 ENSG00000128739 homo_sapiens ENSP00000375105 94.5833 90.8333 cyprinodon_variegatus ENSCVAP00000011861 94.1909 90.4564 ENSG00000128739 homo_sapiens ENSP00000375105 94.5833 91.25 oryzias_melastigma ENSOMEP00000022489 94.5833 91.25
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000398 involved_in mRNA splicing, via spliceosome 1 IBA Homo_sapiens(9606) Process GO:0003723 enables RNA binding 1 IEA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005654 located_in nucleoplasm 2 IDA,TAS Homo_sapiens(9606) Component GO:0005681 part_of spliceosomal complex 1 TAS Homo_sapiens(9606) Component GO:0005682 part_of U5 snRNP 1 IBA Homo_sapiens(9606) Component GO:0005685 part_of U1 snRNP 1 IBA Homo_sapiens(9606) Component GO:0005686 part_of U2 snRNP 1 IBA Homo_sapiens(9606) Component GO:0005687 part_of U4 snRNP 1 IBA Homo_sapiens(9606) Component GO:0005737 is_active_in cytoplasm 1 IBA Homo_sapiens(9606) Component GO:0008380 involved_in RNA splicing 1 TAS Homo_sapiens(9606) Process GO:0030532 part_of small nuclear ribonucleoprotein complex 1 TAS Homo_sapiens(9606) Component GO:0046540 part_of U4/U6 x U5 tri-snRNP complex 1 IBA Homo_sapiens(9606) Component GO:0071004 part_of U2-type prespliceosome 1 IBA Homo_sapiens(9606) Component GO:0071013 part_of catalytic step 2 spliceosome 1 IBA Homo_sapiens(9606) Component
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