Ensembl ID ENSG00000128739 Gene ID 6638 Accession 11164
Gene Symbol SNRPN Alias SMN;PWCR;SM-D;sm-N;RT-LI;HCERN3;SNRNP-N;SNURF-SNRPN Full Name small nuclear ribonucleoprotein polypeptide N
Position 15 : 24823647 - 24978723 Length 155077 bases Strand Plus strand
Status Confidence Main interacting RNAssnRNARBP type Canonical_RBPs
Summary This gene is located within the Prader-Willi Syndrome critical region on chromosome 15 and is imprinted and expressed from the paternal allele. It encodes a component of the small nuclear ribonucleoprotein complex, which functions in pre-mRNA processing and may contribute to tissue-specific alternative splicing. Alternative promoter use and alternative splicing result in a multitude of transcript variants encoding the same protein. Transcript variants that initiate at the CpG island-associated imprinting center may be bicistronic and also encode the SNRPN upstream reading frame protein (SNURF) from an upstream open reading frame. In addition, long spliced transcripts for small nucleolar RNA host gene 14 (SNHG14) may originate from the promoters at this locus and share exons with this gene. Alterations in this region are associated with parental imprint switch failure, which may cause Angelman syndrome or Prader-Willi syndrome. [provided by RefSeq, Mar 2017]

ENSG00000128739 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000128739 SNRPN -1.2 3.46e-62 KIRC
ENSG00000128739 SNRPN -1.3 1.72e-14 HNSC
ENSG00000128739 SNRPN -0.9 1.13e-12 LUSC
ENSG00000128739 SNRPN -1.0 1.75e-13 KIRP
ENSG00000128739 SNRPN -1.6 1.40e-14 STAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000128739 SNRPN tumor 10454587
ENSG00000128739 SNRPN tumors 10521301
ENSG00000128739 SNRPN cancers 10891541
ENSG00000128739 SNRPN germ cell tumors 11585765
ENSG00000128739 SNRPN germ cell tumors 11746975
ENSG00000128739 SNRPN germ cell tumors 16001432
ENSG00000128739 SNRPN tumors 17227125
ENSG00000128739 SNRPN breast cancer 17998253
ENSG00000128739 SNRPN tumours 18629284
ENSG00000128739 SNRPN colon cancer 18636156
ENSG00000128739 SNRPN cancer 19109880
ENSG00000128739 SNRPN tumor 19245437
ENSG00000128739 SNRPN tumor 20007506
ENSG00000128739 SNRPN tumor 20194112
ENSG00000128739 SNRPN germ cell tumours 20582452
ENSG00000128739 SNRPN cancer 21042416
ENSG00000128739 SNRPN colorectal cancer 21750708
ENSG00000128739 SNRPN tumor 23225212
ENSG00000128739 SNRPN breast cancer 23409079
ENSG00000128739 SNRPN cancer 25560175
ENSG00000128739 SNRPN tumors 25571951
ENSG00000128739 SNRPN tumor 25572872
ENSG00000128739 SNRPN pancreatic cancer 26261020
ENSG00000128739 SNRPN in situ breast cancer 26347357
ENSG00000128739 SNRPN tumour 26628061
ENSG00000128739 SNRPN gastric cancer 26769141
ENSG00000128739 SNRPN tumor 28288660
ENSG00000128739 SNRPN tumors 29371935
ENSG00000128739 SNRPN tumor of the uterus 9224757
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000128739 SNRPN MESO 0.005 low
ENSG00000128739 SNRPN STAD 0.044 high
ENSG00000128739 SNRPN PAAD 0.014 low
ENSG00000128739 SNRPN THCA 0.022 low
ENSG00000128739 SNRPN HNSC 0.017 low
ENSG00000128739 SNRPN READ 0.013 high
ENSG00000128739 SNRPN KIRP 0.00017 low
ENSG00000128739 SNRPN LUAD 0.005 low
ENSG00000128739 SNRPN UCS 0.043 low
ENSG00000128739 SNRPN ESCA 0.025 high
ENSG00000128739 SNRPN KIRC 0.00079 low
ENSG00000128739 SNRPN PRAD 0.027 low
ENSG00000128739 SNRPN BLCA 0.044 low
ENSG00000128739 SNRPN LAML 0.043 high
ENSG00000128739 SNRPN GBM 0.019 low
ENSG00000128739 SNRPN SKCM 0.0014 low
ENSG00000128739 SNRPN LIHC 0.02 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000128739 SNRPN LUSC Del 3.510444 0.099405 0.337229 0.339321
ENSG00000128739 SNRPN LUAD Del 8.430395 0.116448 0.331752 0.511628
ENSG00000128739 SNRPN READ Del 0.637830 0.068896 0.473342 0.454545
ENSG00000128739 SNRPN COAD Del 5.947714 0.087140 0.475082 0.392461
ENSG00000128739 SNRPN UCS Del 6.788839 0.556791 0.576362 0.732143
ENSG00000128739 SNRPN GBM Del 0.930369 0.054977 0.482751 0.211438
ENSG00000128739 SNRPN ESCA Del 1.014078 0.105911 0.327141 0.336957
ENSG00000128739 SNRPN SKCM Del 3.483486 0.105610 0.467071 0.193460
ENSG00000128739 SNRPN BLCA Del 1.444065 0.089955 0.344984 0.372549
ENSG00000128739 SNRPN BRCA Del 11.022514 0.118691 0.413681 0.338889
ENSG00000128739 SNRPN STAD Del 4.056815 0.100164 0.348785 0.272109
ENSG00000128739 SNRPN PRAD Amp 1.437721 0.056607 0.824996 0.030488
ENSG00000128739 SNRPN UCEC Del 2.247523 0.065682 0.507795 0.228200
ENSG00000128739 SNRPN MESO Del 3.109288 0.214041 0.512932 0.241379
ENSG00000128739 SNRPN OV Del 11.544777 0.314324 0.585980 0.521589