Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions Transmemebrane
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000124570 Gene ID 5269 Accession 8950
Symbol SERPINB6 Alias CAP;PI6;PTI;PI-6;SPI3;DFNB91;MSTP057 Full Name serpin family B member 6
Status Confidence Length 24007 bases Strand Minus strand
Position 6 : 2948159 - 2972165 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
SERPINB6-211 ENST00000643314 3265 No protein -
SERPINB6-202 ENST00000380524 1495 376aa ENSP00000369896
SERPINB6-203 ENST00000380529 1370 376aa ENSP00000369901
SERPINB6-204 ENST00000380539 1315 376aa ENSP00000369912
SERPINB6-205 ENST00000380546 1375 376aa ENSP00000369919
SERPINB6-209 ENST00000643098 1638 376aa ENSP00000493936
SERPINB6-222 ENST00000646722 2188 No protein -
SERPINB6-225 ENST00000649845 3489 57aa ENSP00000497149
SERPINB6-212 ENST00000644178 5620 376aa ENSP00000496073
SERPINB6-224 ENST00000647157 3599 No protein -
SERPINB6-206 ENST00000612421 1566 395aa ENSP00000484343
SERPINB6-215 ENST00000644697 2120 No protein -
SERPINB6-207 ENST00000616722 2036 380aa ENSP00000481398
SERPINB6-208 ENST00000642543 1384 332aa ENSP00000494161
SERPINB6-213 ENST00000644388 1494 376aa ENSP00000494650
SERPINB6-201 ENST00000380520 1313 376aa ENSP00000369891
SERPINB6-220 ENST00000645580 1565 380aa ENSP00000495362
SERPINB6-214 ENST00000644693 1467 81aa ENSP00000495361
SERPINB6-217 ENST00000644828 1123 171aa ENSP00000495086
SERPINB6-223 ENST00000646775 514 17aa ENSP00000496225
SERPINB6-210 ENST00000643227 452 77aa ENSP00000494217
SERPINB6-219 ENST00000645421 477 77aa ENSP00000496341
SERPINB6-221 ENST00000646688 489 61aa ENSP00000494453
SERPINB6-216 ENST00000644777 925 60aa ENSP00000494783
SERPINB6-218 ENST00000644875 536 11aa ENSP00000494930

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
61958Leukemia, Lymphocytic, Chronic, B-Cell2E-826956414

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000124570homo_sapiensENSP0000035562730.462214.916homo_sapiensENSP0000036991238.563818.883
ENSG00000124570homo_sapiensENSP0000050151748.920929.7362homo_sapiensENSP0000036991254.255332.9787
ENSG00000124570homo_sapiensENSP0000044149760.969441.5816homo_sapiensENSP0000036991263.563843.3511
ENSG00000124570homo_sapiensENSP0000035667147.629330.3879homo_sapiensENSP0000036991258.776637.5
ENSG00000124570homo_sapiensENSP0000026467754.074134.0741homo_sapiensENSP0000036991258.244736.7021
ENSG00000124570homo_sapiensENSP0000027840731.218homo_sapiensENSP0000036991241.489423.9362
ENSG00000124570homo_sapiensENSP0000038110156.578937.3684homo_sapiensENSP0000036991257.180937.766
ENSG00000124570homo_sapiensENSP0000034158461.125342.1995homo_sapiensENSP0000036991263.563843.883
ENSG00000124570homo_sapiensENSP0000029950260.963945.3012homo_sapiensENSP0000036991267.287250
ENSG00000124570homo_sapiensENSP0000026199440.99123.4234homo_sapiensENSP0000036991248.404327.6596
ENSG00000124570homo_sapiensENSP0000025472240.191422.0096homo_sapiensENSP0000036991244.680924.4681
ENSG00000124570homo_sapiensENSP0000035089442.583724.8804homo_sapiensENSP0000036991247.340427.6596
ENSG00000124570homo_sapiensENSP0000037221858.117638.8235homo_sapiensENSP0000036991265.691543.883
ENSG00000124570homo_sapiensENSP0000048688840.129422.9773homo_sapiensENSP0000036991232.978718.883
ENSG00000124570homo_sapiensENSP0000037680247.129228.9474homo_sapiensENSP0000036991252.393632.1809
ENSG00000124570homo_sapiensENSP0000040228636.048921.1813homo_sapiensENSP0000036991247.074527.6596
ENSG00000124570homo_sapiensENSP0000021572736.272522.4449homo_sapiensENSP0000036991248.138329.7872
ENSG00000124570homo_sapiensENSP0000022309547.014930.3483homo_sapiensENSP0000036991250.26632.4468
ENSG00000124570homo_sapiensENSP0000034344565.64146.9231homo_sapiensENSP0000036991268.085148.6702
ENSG00000124570homo_sapiensENSP0000028375265.128245.8974homo_sapiensENSP0000036991267.553247.6064
ENSG00000124570homo_sapiensENSP0000037007478.989462.766homo_sapiensENSP0000036991278.989462.766
ENSG00000124570homo_sapiensENSP0000050641145.049525homo_sapiensENSP0000036991248.404326.8617
ENSG00000124570homo_sapiensENSP0000023850863.72845.0882homo_sapiensENSP0000036991267.287247.6064
ENSG00000124570homo_sapiensENSP0000050393545.652226.57homo_sapiensENSP0000036991250.26629.2553
ENSG00000124570homo_sapiensENSP0000045083844.028127.1663homo_sapiensENSP000003699125030.8511
ENSG00000124570homo_sapiensENSP0000039737350.731731.4634homo_sapiensENSP0000036991255.319134.3085
ENSG00000124570homo_sapiensENSP0000038641251.385429.2191homo_sapiensENSP0000036991254.255330.8511
ENSG00000124570homo_sapiensENSP0000038107281.01667.6471homo_sapiensENSP0000036991280.585167.2872
ENSG00000124570homo_sapiensENSP0000037222159.733336.8homo_sapiensENSP0000036991259.574536.7021
ENSG00000124570homo_sapiensENSP0000037679346.572129.7872homo_sapiensENSP0000036991252.393633.5106
ENSG00000124570homo_sapiensENSP0000033502445.734627.0142homo_sapiensENSP0000036991251.329830.3191
ENSG00000124570homo_sapiensENSP0000036164444.819326.988homo_sapiensENSP0000036991249.468129.7872
ENSG00000124570homo_sapiensENSP0000037011569.129350.6596homo_sapiensENSP0000036991269.680951.0638
ENSG00000124570homo_sapiensENSP0000034285047.654331.358homo_sapiensENSP0000036991251.329833.7766
ENSG00000124570homo_sapiensENSP000003332035029.5567homo_sapiensENSP0000036991253.989431.9149
ENSG00000124570homo_sapiensENSP0000038620772.661955.3957homo_sapiensENSP0000036991226.861720.4787

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000124570homo_sapiensENSP0000036991299.202198.1383nomascus_leucogenysENSNLEP0000004884692.555891.5633
ENSG00000124570homo_sapiensENSP0000036991210099.734pan_paniscusENSPPAP0000004288291.262191.0194
ENSG00000124570homo_sapiensENSP0000036991299.73499.4681pongo_abeliiENSPPYP0000002380294.936794.6835
ENSG00000124570homo_sapiensENSP0000036991210099.734pan_troglodytesENSPTRP0000008804795.189994.9367
ENSG00000124570homo_sapiensENSP00000369912100100gorilla_gorillaENSGGOP0000003088895.189995.1899
ENSG00000124570homo_sapiensENSP0000036991227.925524.734choloepus_hoffmanniENSCHOP0000000291792.105381.5789
ENSG00000124570homo_sapiensENSP0000036991280.585171.0106choloepus_hoffmanniENSCHOP0000000685180.871.2
ENSG00000124570homo_sapiensENSP0000036991260.372353.1915dasypus_novemcinctusENSDNOP0000003312887.307776.9231
ENSG00000124570homo_sapiensENSP0000036991265.691559.0426echinops_telfairiENSETEP0000000278164.829458.2677
ENSG00000124570homo_sapiensENSP0000036991296.542690.9574callithrix_jacchusENSCJAP0000006727193.076987.6923
ENSG00000124570homo_sapiensENSP0000036991296.542691.2234callithrix_jacchusENSCJAP0000002055091.20686.1809
ENSG00000124570homo_sapiensENSP0000036991298.404396.5426cercocebus_atysENSCATP0000001268097.368495.5263
ENSG00000124570homo_sapiensENSP0000036991298.404396.5426macaca_fascicularisENSMFAP0000006384977.405975.9414
ENSG00000124570homo_sapiensENSP0000036991298.404396.5426macaca_mulattaENSMMUP0000001121593.670991.8987
ENSG00000124570homo_sapiensENSP0000036991285.638383.7766macaca_nemestrinaENSMNEP0000002922993.063691.0405
ENSG00000124570homo_sapiensENSP0000036991298.404396.5426mandrillus_leucophaeusENSMLEP0000000326093.670991.8987
ENSG00000124570homo_sapiensENSP0000036991284.574572.0745mus_spretusMGP_SPRETEiJ_P003563584.350171.8833
ENSG00000124570homo_sapiensENSP0000036991271.542657.4468mus_spretusMGP_SPRETEiJ_P003564871.733357.6
ENSG00000124570homo_sapiensENSP0000036991280.053268.0851mus_spretusMGP_SPRETEiJ_P003565279.419567.5462
ENSG00000124570homo_sapiensENSP0000036991287.576.5957mus_spretusMGP_SPRETEiJ_P003565682.456172.1805
ENSG00000124570homo_sapiensENSP0000036991289.627780.3191loxodonta_africanaENSLAFP0000000998289.153479.8942
ENSG00000124570homo_sapiensENSP0000036991274.73460.1064loxodonta_africanaENSLAFP0000001655975.945961.0811
ENSG00000124570homo_sapiensENSP0000036991282.712869.6809oryctolagus_cuniculusENSOCUP0000004484751.320143.2343
ENSG00000124570homo_sapiensENSP0000036991285.372376.0638marmota_marmota_marmotaENSMMMP0000000262879.652670.9677
ENSG00000124570homo_sapiensENSP0000036991290.159680.5851marmota_marmota_marmotaENSMMMP0000000109988.743579.3194
ENSG00000124570homo_sapiensENSP0000036991285.638375.266cavia_porcellusENSCPOP0000000742085.185274.8677
ENSG00000124570homo_sapiensENSP0000036991292.021384.8404microcebus_murinusENSMICP0000000180591.292984.1689
ENSG00000124570homo_sapiensENSP0000036991284.308573.6702octodon_degusENSODEP0000001114583.862473.2804
ENSG00000124570homo_sapiensENSP0000036991282.978771.0106jaculus_jaculusENSJJAP0000001282781.675469.8953
ENSG00000124570homo_sapiensENSP0000036991287.575.5319ochotona_princepsENSOPRP0000001418185.677173.9583
ENSG00000124570homo_sapiensENSP0000036991285.904372.6064mus_caroliMGP_CAROLIEiJ_P003404285.676472.4138
ENSG00000124570homo_sapiensENSP0000036991281.914970.2128mus_caroliMGP_CAROLIEiJ_P003405381.266569.657
ENSG00000124570homo_sapiensENSP0000036991288.031977.6596mus_caroliMGP_CAROLIEiJ_P003405782.957473.183
ENSG00000124570homo_sapiensENSP0000036991272.340458.5106mus_musculusENSMUSP0000006302572.533358.6667
ENSG00000124570homo_sapiensENSP0000036991287.23476.5957mus_musculusENSMUSP0000001718882.205572.1805
ENSG00000124570homo_sapiensENSP0000036991285.106472.3404mus_musculusENSMUSP0000010592284.880672.1485
ENSG00000124570homo_sapiensENSP0000036991273.404358.2447mus_musculusENSMUSP0000010590464.335751.049
ENSG00000124570homo_sapiensENSP0000036991280.053268.0851mus_musculusENSMUSP0000012761979.419567.5462
ENSG00000124570homo_sapiensENSP0000036991296.010690.9574aotus_nancymaaeENSANAP0000003255190.703585.9296
ENSG00000124570homo_sapiensENSP0000036991296.276690.6915saimiri_boliviensis_boliviensisENSSBOP0000000508290.954885.6784
ENSG00000124570homo_sapiensENSP0000036991298.138396.0106chlorocebus_sabaeusENSCSAP0000000347898.138396.0106
ENSG00000124570homo_sapiensENSP0000036991284.308571.0106tupaia_belangeriENSTBEP0000000389083.421170.2632
ENSG00000124570homo_sapiensENSP0000036991263.829855.8511mesocricetus_auratusENSMAUP0000000146484.50773.9437
ENSG00000124570homo_sapiensENSP0000036991284.042673.1383mesocricetus_auratusENSMAUP0000000741984.266773.3333
ENSG00000124570homo_sapiensENSP0000036991284.308575camelus_dromedariusENSCDRP0000502193257.952551.5539
ENSG00000124570homo_sapiensENSP0000036991292.021382.1809carlito_syrichtaENSTSYP0000002900689.637380.0518
ENSG00000124570homo_sapiensENSP0000036991285.106473.9362rattus_norvegicusENSRNOP000000891048069.5
ENSG00000124570homo_sapiensENSP0000036991272.872357.7128rattus_norvegicusENSRNOP0000007789972.295557.2559
ENSG00000124570homo_sapiensENSP0000036991284.574572.3404rattus_norvegicusENSRNOP0000008026281.958870.1031
ENSG00000124570homo_sapiensENSP0000036991277.127759.3085rattus_norvegicusENSRNOP0000008800368.396252.5943
ENSG00000124570homo_sapiensENSP0000036991291.223484.8404prolemur_simusENSPSMP0000003616586.180980.1508
ENSG00000124570homo_sapiensENSP0000036991244.946838.2979microtus_ochrogasterENSMOCP0000001835185.353572.7273
ENSG00000124570homo_sapiensENSP0000036991285.638374.4681microtus_ochrogasterENSMOCP0000001779685.866774.6667
ENSG00000124570homo_sapiensENSP000003699122521.2766microtus_ochrogasterENSMOCP0000000060988.679275.4717
ENSG00000124570homo_sapiensENSP0000036991284.840473.1383microtus_ochrogasterENSMOCP0000001093384.391572.7513
ENSG00000124570homo_sapiensENSP0000036991282.978772.0745peromyscus_maniculatus_bairdiiENSPEMP0000000451179.389368.9567
ENSG00000124570homo_sapiensENSP0000036991277.925567.0213peromyscus_maniculatus_bairdiiENSPEMP0000000755982.303470.7865
ENSG00000124570homo_sapiensENSP0000036991279.521369.9468peromyscus_maniculatus_bairdiiENSPEMP0000001199881.029871.2737
ENSG00000124570homo_sapiensENSP0000036991216.223413.8298peromyscus_maniculatus_bairdiiENSPEMP0000002958978.205166.6667
ENSG00000124570homo_sapiensENSP0000036991284.308572.3404peromyscus_maniculatus_bairdiiENSPEMP0000000483184.308572.3404
ENSG00000124570homo_sapiensENSP0000036991285.106472.0745mus_spicilegusENSMSIP0000001511984.880671.8833
ENSG00000124570homo_sapiensENSP0000036991287.23476.8617mus_spicilegusENSMSIP0000000376186.772576.455
ENSG00000124570homo_sapiensENSP0000036991280.319168.3511mus_spicilegusENSMSIP0000000381879.683467.81
ENSG00000124570homo_sapiensENSP0000036991272.340458.5106mus_spicilegusENSMSIP0000001033872.533358.6667
ENSG00000124570homo_sapiensENSP0000036991272.074558.2447mus_spicilegusENSMSIP0000000393172.266758.4
ENSG00000124570homo_sapiensENSP0000036991273.404358.2447mus_spicilegusENSMSIP0000000386964.63751.2881
ENSG00000124570homo_sapiensENSP0000036991288.031978.7234cricetulus_griseus_chok1gshdENSCGRP0000101460382.957474.1855
ENSG00000124570homo_sapiensENSP0000036991284.840473.9362cricetulus_griseus_chok1gshdENSCGRP0000102198384.168973.3509
ENSG00000124570homo_sapiensENSP0000036991285.638373.9362heterocephalus_glaber_femaleENSHGLP0000002137584.514472.9659
ENSG00000124570homo_sapiensENSP0000036991298.404396.0106rhinopithecus_bietiENSRBIP0000002227994.147691.8575
ENSG00000124570homo_sapiensENSP0000036991290.159681.6489sciurus_vulgarisENSSVLP0000500925088.511780.1567
ENSG00000124570homo_sapiensENSP0000036991276.329862.234phascolarctos_cinereusENSPCIP0000000091061.063849.7872
ENSG00000124570homo_sapiensENSP0000036991284.042673.6702procavia_capensisENSPCAP0000001519083.377373.0871
ENSG00000124570homo_sapiensENSP0000036991223.404318.617procavia_capensisENSPCAP0000001611478.571462.5
ENSG00000124570homo_sapiensENSP0000036991264.627758.2447procavia_capensisENSPCAP0000001526789.01180.2198
ENSG00000124570homo_sapiensENSP0000036991276.063867.0213nannospalax_galiliENSNGAP0000001900587.195176.8293
ENSG00000124570homo_sapiensENSP0000036991284.308575.7979chinchilla_lanigeraENSCLAP0000000346683.862475.3968
ENSG00000124570homo_sapiensENSP0000036991285.106474.734ictidomys_tridecemlineatusENSSTOP0000001843184.880674.5358
ENSG00000124570homo_sapiensENSP0000036991246.808540.9574ictidomys_tridecemlineatusENSSTOP0000001756389.340178.1726
ENSG00000124570homo_sapiensENSP0000036991288.031976.5957otolemur_garnettiiENSOGAP0000001828387.335175.9894
ENSG00000124570homo_sapiensENSP0000036991295.478789.8936cebus_imitatorENSCCAP0000003217890.20184.9246
ENSG00000124570homo_sapiensENSP0000036991278.989465.6915urocitellus_parryiiENSUPAP0001000637173.880661.4428
ENSG00000124570homo_sapiensENSP0000036991260.372353.7234urocitellus_parryiiENSUPAP0001003016888.326978.5992
ENSG00000124570homo_sapiensENSP0000036991245.212839.6277urocitellus_parryiiENSUPAP0001000020884.158473.7624
ENSG00000124570homo_sapiensENSP0000036991298.404396.0106rhinopithecus_roxellanaENSRROP0000003853397.368495
ENSG00000124570homo_sapiensENSP0000036991286.170273.6702mus_pahariMGP_PahariEiJ_P004064685.941673.4748
ENSG00000124570homo_sapiensENSP0000036991271.542656.9149mus_pahariMGP_PahariEiJ_P004065771.733357.0667
ENSG00000124570homo_sapiensENSP0000036991273.404356.9149mus_pahariMGP_PahariEiJ_P004065864.335749.8834
ENSG00000124570homo_sapiensENSP0000036991283.510671.5426mus_pahariMGP_PahariEiJ_P004066183.068871.164
ENSG00000124570homo_sapiensENSP0000036991287.575.7979mus_pahariMGP_PahariEiJ_P004066582.456171.4286
ENSG00000124570homo_sapiensENSP0000036991289.893681.383propithecus_coquereliENSPCOP0000001465988.713980.315

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0002020enables protease binding1IPIHomo_sapiens(9606)Function
GO:0004867enables serine-type endopeptidase inhibitor activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1HDAHomo_sapiens(9606)Component
GO:0005615is_active_in extracellular space1IBAHomo_sapiens(9606)Component
GO:0005634NOT located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1TASHomo_sapiens(9606)Component
GO:0007605involved_in sensory perception of sound1IMPHomo_sapiens(9606)Process
GO:0010951involved_in negative regulation of endopeptidase activity2IBA,IDAHomo_sapiens(9606)Process
GO:0030667located_in secretory granule membrane1TASHomo_sapiens(9606)Component
GO:0062023located_in collagen-containing extracellular matrix1HDAHomo_sapiens(9606)Component
GO:0070062located_in extracellular exosome1HDAHomo_sapiens(9606)Component
GO:0070821located_in tertiary granule membrane1TASHomo_sapiens(9606)Component
GO:0071470involved_in cellular response to osmotic stress1IMPHomo_sapiens(9606)Process
GO:0097180part_of serine protease inhibitor complex1IDAHomo_sapiens(9606)Component
GO:0101003located_in ficolin-1-rich granule membrane1TASHomo_sapiens(9606)Component

Expression