Ensembl ID ENSG00000124570 Gene ID 5269 Accession 8950
Gene Symbol SERPINB6 Alias CAP;PI6;PTI;PI-6;SPI3;DFNB91;MSTP057 Full Name serpin family B member 6
Position 6 : 2948159 - 2972165 Length 24007 bases Strand Minus strand
Status Confidence Main interacting RNAsN.A.RBP type Non-canonical_RBPs
Summary The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

ENSG00000124570 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000124570 SERPINB6 0.53 4.20e-24 KIRC
ENSG00000124570 SERPINB6 -1.2 1.21e-28 LUSC
ENSG00000124570 SERPINB6 -0.5 1.23e-12 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000124570 SERPINB6 cancer 10216950
ENSG00000124570 SERPINB6 prostate cancer 10463585
ENSG00000124570 SERPINB6 pancreatic cancer 10554036
ENSG00000124570 SERPINB6 tumour 10674022
ENSG00000124570 SERPINB6 prostate cancer 11745444
ENSG00000124570 SERPINB6 prostate tumor 12736433
ENSG00000124570 SERPINB6 cancer 14652284
ENSG00000124570 SERPINB6 prostate tumor 15716006
ENSG00000124570 SERPINB6 colon cancer 16684083
ENSG00000124570 SERPINB6 prostate cancer 16707856
ENSG00000124570 SERPINB6 cancer 16717037
ENSG00000124570 SERPINB6 cancer 16969121
ENSG00000124570 SERPINB6 prostate tumor 18853312
ENSG00000124570 SERPINB6 colon cancer 19425502
ENSG00000124570 SERPINB6 squamous cell cancer 1997617
ENSG00000124570 SERPINB6 tumour 20838377
ENSG00000124570 SERPINB6 prostate cancer 22355332
ENSG00000124570 SERPINB6 lung cancer 23338686
ENSG00000124570 SERPINB6 cancer 24195657
ENSG00000124570 SERPINB6 pancreatic cancer 24405276
ENSG00000124570 SERPINB6 tumors 24571548
ENSG00000124570 SERPINB6 cancer 25621294
ENSG00000124570 SERPINB6 prostate cancer 26110379
ENSG00000124570 SERPINB6 cancer 26337905
ENSG00000124570 SERPINB6 Pancreatic cancer 27429841
ENSG00000124570 SERPINB6 cancer 28874822
ENSG00000124570 SERPINB6 tumor 29137411
ENSG00000124570 SERPINB6 tumor 29517999
ENSG00000124570 SERPINB6 cervical cancer 31271297
ENSG00000124570 SERPINB6 tumor 31602163
ENSG00000124570 SERPINB6 cancer 31976125
ENSG00000124570 SERPINB6 tumor 7542776
ENSG00000124570 SERPINB6 tumor 8988032
ENSG00000124570 SERPINB6 cancer 9465091
ENSG00000124570 SERPINB6 colon cancer 9713282
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000124570 SERPINB6 MESO 0.025 high
ENSG00000124570 SERPINB6 UVM 0.00027 low
ENSG00000124570 SERPINB6 UCEC 0.0016 low
ENSG00000124570 SERPINB6 ACC 0.012 high
ENSG00000124570 SERPINB6 LUSC 0.044 high
ENSG00000124570 SERPINB6 HNSC 0.012 high
ENSG00000124570 SERPINB6 READ 0.0038 low
ENSG00000124570 SERPINB6 KICH 0.011 high
ENSG00000124570 SERPINB6 LUAD 0.0072 low
ENSG00000124570 SERPINB6 PCPG 0.007 low
ENSG00000124570 SERPINB6 COAD 0.026 high
ENSG00000124570 SERPINB6 UCS 0.0011 high
ENSG00000124570 SERPINB6 OV 0.00019 low
ENSG00000124570 SERPINB6 TGCT 0.017 high
ENSG00000124570 SERPINB6 BLCA 0.0021 low
ENSG00000124570 SERPINB6 LAML 0.00032 high
ENSG00000124570 SERPINB6 GBM 0.022 high
ENSG00000124570 SERPINB6 LIHC 0.0021 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000124570 SERPINB6 LUSC Del 2.404490 0.087736 0.360538 0.261477
ENSG00000124570 SERPINB6 THYM Del 2.873248 0.080979 0.405209 0.211382
ENSG00000124570 SERPINB6 SARC Del 1.218740 0.136911 0.515255 0.319066
ENSG00000124570 SERPINB6 PAAD Del 2.624918 0.080610 0.355778 0.402174
ENSG00000124570 SERPINB6 ESCA Del 7.106273 0.235359 0.447055 0.353261
ENSG00000124570 SERPINB6 SKCM Amp 5.836903 0.262728 0.752125 0.572207
ENSG00000124570 SERPINB6 HNSC Del 0.664668 0.053510 0.361886 0.178161
ENSG00000124570 SERPINB6 LIHC Amp 4.660479 0.200652 0.760905 0.429730
ENSG00000124570 SERPINB6 BLCA Amp 1.257285 0.185074 0.448673 0.289216
ENSG00000124570 SERPINB6 BLCA Del 2.373866 0.103489 0.392569 0.220588
ENSG00000124570 SERPINB6 BRCA Del 3.975190 0.087113 0.428485 0.182407
ENSG00000124570 SERPINB6 STAD Del 4.555516 0.104583 0.395599 0.185941
ENSG00000124570 SERPINB6 UVM Amp 3.966451 0.349455 1.179661 0.562500
ENSG00000124570 SERPINB6 OV Amp 5.591620 0.463439 0.737896 0.480138