Ensembl ID
ENSG00000124570
Gene ID
5269
Accession
8950
Gene Symbol
SERPINB6
Alias
CAP;PI6;PTI;PI-6;SPI3;DFNB91;MSTP057
Full Name
serpin family B member 6
Position
6 : 2948159 - 2972165
Length
24007 bases
Strand
Minus strand
Status
Confidence
Main interacting RNAs N.A. RBP type
Non-canonical_RBPs
Summary
The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
ENSG00000124570 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000124570
SERPINB6
0.53
4.20e-24
KIRC
ENSG00000124570
SERPINB6
-1.2
1.21e-28
LUSC
ENSG00000124570
SERPINB6
-0.5
1.23e-12
LUAD
Ensembl ID
Gene symbol
Cancer types
Pubmed ID
ENSG00000124570
SERPINB6
cancer
10216950
ENSG00000124570
SERPINB6
prostate cancer
10463585
ENSG00000124570
SERPINB6
pancreatic cancer
10554036
ENSG00000124570
SERPINB6
tumour
10674022
ENSG00000124570
SERPINB6
prostate cancer
11745444
ENSG00000124570
SERPINB6
prostate tumor
12736433
ENSG00000124570
SERPINB6
cancer
14652284
ENSG00000124570
SERPINB6
prostate tumor
15716006
ENSG00000124570
SERPINB6
colon cancer
16684083
ENSG00000124570
SERPINB6
prostate cancer
16707856
ENSG00000124570
SERPINB6
cancer
16717037
ENSG00000124570
SERPINB6
cancer
16969121
ENSG00000124570
SERPINB6
prostate tumor
18853312
ENSG00000124570
SERPINB6
colon cancer
19425502
ENSG00000124570
SERPINB6
squamous cell cancer
1997617
ENSG00000124570
SERPINB6
tumour
20838377
ENSG00000124570
SERPINB6
prostate cancer
22355332
ENSG00000124570
SERPINB6
lung cancer
23338686
ENSG00000124570
SERPINB6
cancer
24195657
ENSG00000124570
SERPINB6
pancreatic cancer
24405276
ENSG00000124570
SERPINB6
tumors
24571548
ENSG00000124570
SERPINB6
cancer
25621294
ENSG00000124570
SERPINB6
prostate cancer
26110379
ENSG00000124570
SERPINB6
cancer
26337905
ENSG00000124570
SERPINB6
Pancreatic cancer
27429841
ENSG00000124570
SERPINB6
cancer
28874822
ENSG00000124570
SERPINB6
tumor
29137411
ENSG00000124570
SERPINB6
tumor
29517999
ENSG00000124570
SERPINB6
cervical cancer
31271297
ENSG00000124570
SERPINB6
tumor
31602163
ENSG00000124570
SERPINB6
cancer
31976125
ENSG00000124570
SERPINB6
tumor
7542776
ENSG00000124570
SERPINB6
tumor
8988032
ENSG00000124570
SERPINB6
cancer
9465091
ENSG00000124570
SERPINB6
colon cancer
9713282
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000124570
SERPINB6
MESO
0.025
high
show
ENSG00000124570
SERPINB6
UVM
0.00027
low
show
ENSG00000124570
SERPINB6
UCEC
0.0016
low
show
ENSG00000124570
SERPINB6
ACC
0.012
high
show
ENSG00000124570
SERPINB6
LUSC
0.044
high
show
ENSG00000124570
SERPINB6
HNSC
0.012
high
show
ENSG00000124570
SERPINB6
READ
0.0038
low
show
ENSG00000124570
SERPINB6
KICH
0.011
high
show
ENSG00000124570
SERPINB6
LUAD
0.0072
low
show
ENSG00000124570
SERPINB6
PCPG
0.007
low
show
ENSG00000124570
SERPINB6
COAD
0.026
high
show
ENSG00000124570
SERPINB6
UCS
0.0011
high
show
ENSG00000124570
SERPINB6
OV
0.00019
low
show
ENSG00000124570
SERPINB6
TGCT
0.017
high
show
ENSG00000124570
SERPINB6
BLCA
0.0021
low
show
ENSG00000124570
SERPINB6
LAML
0.00032
high
show
ENSG00000124570
SERPINB6
GBM
0.022
high
show
ENSG00000124570
SERPINB6
LIHC
0.0021
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000124570
SERPINB6
LUSC
Del
2.404490
0.087736
0.360538
0.261477
ENSG00000124570
SERPINB6
THYM
Del
2.873248
0.080979
0.405209
0.211382
ENSG00000124570
SERPINB6
SARC
Del
1.218740
0.136911
0.515255
0.319066
ENSG00000124570
SERPINB6
PAAD
Del
2.624918
0.080610
0.355778
0.402174
ENSG00000124570
SERPINB6
ESCA
Del
7.106273
0.235359
0.447055
0.353261
ENSG00000124570
SERPINB6
SKCM
Amp
5.836903
0.262728
0.752125
0.572207
ENSG00000124570
SERPINB6
HNSC
Del
0.664668
0.053510
0.361886
0.178161
ENSG00000124570
SERPINB6
LIHC
Amp
4.660479
0.200652
0.760905
0.429730
ENSG00000124570
SERPINB6
BLCA
Amp
1.257285
0.185074
0.448673
0.289216
ENSG00000124570
SERPINB6
BLCA
Del
2.373866
0.103489
0.392569
0.220588
ENSG00000124570
SERPINB6
BRCA
Del
3.975190
0.087113
0.428485
0.182407
ENSG00000124570
SERPINB6
STAD
Del
4.555516
0.104583
0.395599
0.185941
ENSG00000124570
SERPINB6
UVM
Amp
3.966451
0.349455
1.179661
0.562500
ENSG00000124570
SERPINB6
OV
Amp
5.591620
0.463439
0.737896
0.480138
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