Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions E3 ligase
Localizations Stress granucle
BulkPerturb-seq DataSet_02_135

Description

Ensembl ID ENSG00000122257 Gene ID 5930 Accession 9889
Symbol RBBP6 Alias PACT;MY038;P2P-R;RBQ-1;SNAMA Full Name RB binding protein 6, ubiquitin ligase
Status Confidence Length 35171 bases Strand Plus strand
Position 16 : 24537693 - 24572863 RNA binding domain zf-CCHC_2 , zf-CCHC
Summary The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000481477 zf-CCHC PF00098 2.9e-05 1
ENSP00000481477 zf-CCHC_2 PF13696 3.1e-09 2
ENSP00000457716 zf-CCHC PF00098 7.9e-05 1
ENSP00000457716 zf-CCHC_2 PF13696 8.9e-09 2
ENSP00000370427 zf-CCHC PF00098 0.00013 1
ENSP00000370427 zf-CCHC_2 PF13696 3.4e-08 2
ENSP00000456750 zf-CCHC PF00098 0.00014 1
ENSP00000456750 zf-CCHC_2 PF13696 3.7e-08 2
ENSP00000496720 zf-CCHC PF00098 0.00025 1
ENSP00000496720 zf-CCHC_2 PF13696 2.8e-08 2
ENSP00000316291 zf-CCHC PF00098 0.00027 1
ENSP00000316291 zf-CCHC_2 PF13696 2.8e-08 2
ENSP00000317872 zf-CCHC PF00098 0.00027 1
ENSP00000317872 zf-CCHC_2 PF13696 2.9e-08 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
16396680 DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways. R J David Pugh 2006-01-05 BMC structural biology
27677860 Alternative polyadenylation of mRNA precursors. Bin Tian 2017-01-01 Nature reviews. Molecular cell biology
25319826 RBBP6 isoforms regulate the human polyadenylation machinery and modulate expression of mRNAs with AU-rich 3' UTRs. Campigli Dafne DC Di 2014-10-15 Genes & development
36634677 Knowing when to stop: Transcription termination on protein-coding genes by eukaryotic RNAPII. B Juan Rodríguez-Molina 2023-02-02 Molecular cell
35177537 Reconstitution of 3' end processing of mammalian pre-mRNA reveals a central role of RBBP6. Moritz Schmidt 2022-02-01 Genes & development
31940815 The Ebola Virus Nucleoprotein Recruits the Nuclear RNA Export Factor NXF1 into Inclusion Bodies to Facilitate Viral Protein Expression. Lisa Wendt 2020-01-11 Cells
36232288 Molecular Insights into mRNA Polyadenylation and Deadenylation. Junjie Liu 2022-09-20 International journal of molecular sciences
35177536 RBBP6 activates the pre-mRNA 3' end processing machinery in humans. Vytaute Boreikaite 2022-02-01 Genes & development
36416579 Birth of a poly(A) tail: mechanisms and control of mRNA polyadenylation. B Juan Rodríguez-Molina 2023-07-01 FEBS open bio
30550789 Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication. Jyoti Batra 2018-12-13 Cell

Transcripts

Name Transcript ID bp Protein Translation ID
RBBP6-207 ENST00000564314 3361 1008aa ENSP00000456750
RBBP6-209 ENST00000567686 1138 300aa ENSP00000457716
RBBP6-210 ENST00000568015 695 158aa ENSP00000460821
RBBP6-201 ENST00000319715 6858 1792aa ENSP00000317872
RBBP6-211 ENST00000568316 556 No protein -
RBBP6-204 ENST00000452655 854 118aa ENSP00000390537
RBBP6-203 ENST00000381039 3384 952aa ENSP00000370427
RBBP6-214 ENST00000646282 5332 1759aa ENSP00000496720
RBBP6-202 ENST00000348022 5739 1758aa ENSP00000316291
RBBP6-213 ENST00000613729 1946 No protein -
RBBP6-208 ENST00000564726 514 No protein -
RBBP6-205 ENST00000562430 6482 No protein -
RBBP6-206 ENST00000562683 529 138aa ENSP00000481477
RBBP6-212 ENST00000570185 505 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
6766von Willebrand Factor5.46929428156633E-617903294
6780von Willebrand Factor4.2474517914842E-717903294
16071Stroke5.2457805E-00419369658
74944Galvanic Skin Response7E-625387706
75475Galvanic Skin Response3E-625387706
97911Motor Activity9E-623251661

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000122257homo_sapiensENSP0000036141143.568529.0456homo_sapiensENSP000003178725.859383.90625

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000122257homo_sapiensENSP0000031787293.359492.7455nomascus_leucogenysENSNLEP0000001445499.583398.9286
ENSG00000122257homo_sapiensENSP0000031787298.102797.8795pan_paniscusENSPPAP0000000581699.54799.3205
ENSG00000122257homo_sapiensENSP0000031787299.609498.9955pongo_abeliiENSPPYP0000004219999.609498.9955
ENSG00000122257homo_sapiensENSP0000031787299.832699.6652pan_troglodytesENSPTRP0000001348299.832699.6652
ENSG00000122257homo_sapiensENSP0000031787299.832699.442gorilla_gorillaENSGGOP0000000698499.832699.442
ENSG00000122257homo_sapiensENSP0000031787288.05882.5893ornithorhynchus_anatinusENSOANP0000001222186.418481.0515
ENSG00000122257homo_sapiensENSP0000031787290.122884.933sarcophilus_harrisiiENSSHAP0000002919589.226584.0884
ENSG00000122257homo_sapiensENSP0000031787277.232172.6562notamacropus_eugeniiENSMEUP0000001324078.147973.5178
ENSG00000122257homo_sapiensENSP0000031787269.196467.1875choloepus_hoffmanniENSCHOP0000000024572.176970.0815
ENSG00000122257homo_sapiensENSP0000031787296.87594.0848dasypus_novemcinctusENSDNOP0000003061194.967292.2319
ENSG00000122257homo_sapiensENSP0000031787287.165282.6451erinaceus_europaeusENSEEUP0000000153990.445985.7556
ENSG00000122257homo_sapiensENSP0000031787290.457686.7746echinops_telfairiENSETEP0000000223290.812387.1148
ENSG00000122257homo_sapiensENSP0000031787299.162998.3259callithrix_jacchusENSCJAP0000003843199.107698.2711
ENSG00000122257homo_sapiensENSP0000031787299.330498.8281cercocebus_atysENSCATP0000001977899.330498.8281
ENSG00000122257homo_sapiensENSP0000031787299.274698.7723macaca_fascicularisENSMFAP0000003883099.385598.8827
ENSG00000122257homo_sapiensENSP0000031787299.274698.6607macaca_mulattaENSMMUP0000002091599.3398.7158
ENSG00000122257homo_sapiensENSP0000031787299.274698.7723macaca_nemestrinaENSMNEP0000001979999.274698.7723
ENSG00000122257homo_sapiensENSP0000031787299.330498.8839papio_anubisENSPANP0000001241699.330498.8839
ENSG00000122257homo_sapiensENSP0000031787299.330498.8839mandrillus_leucophaeusENSMLEP0000001204299.330498.8839
ENSG00000122257homo_sapiensENSP0000031787295.424192.5781tursiops_truncatusENSTTRP0000000252896.013593.1499
ENSG00000122257homo_sapiensENSP0000031787296.930894.5312vulpes_vulpesENSVVUP0000000721696.768894.3733
ENSG00000122257homo_sapiensENSP0000031787293.303688.3371mus_spretusMGP_SPRETEiJ_P008538293.512388.5347
ENSG00000122257homo_sapiensENSP0000031787297.600495.0893equus_asinusENSEASP0000505692397.54695.0363
ENSG00000122257homo_sapiensENSP0000031787296.930893.9174capra_hircusENSCHIP0000001168196.661193.6561
ENSG00000122257homo_sapiensENSP0000031787296.59693.5826loxodonta_africanaENSLAFP0000000799296.59693.5826
ENSG00000122257homo_sapiensENSP0000031787296.763494.5312panthera_leoENSPLOP0000003022896.763494.5312
ENSG00000122257homo_sapiensENSP0000031787296.149693.75ailuropoda_melanoleucaENSAMEP0000000979996.25793.8548
ENSG00000122257homo_sapiensENSP0000031787297.15494.2522bos_indicus_hybridENSBIXP0000501688396.883793.99
ENSG00000122257homo_sapiensENSP0000031787297.042494.1406oryctolagus_cuniculusENSOCUP0000000375997.042494.1406
ENSG00000122257homo_sapiensENSP0000031787297.712195.1451equus_caballusENSECAP0000005421595.578693.0677
ENSG00000122257homo_sapiensENSP0000031787296.930894.5871canis_lupus_familiarisENSCAFP0084500171596.768894.429
ENSG00000122257homo_sapiensENSP0000031787296.707694.4754panthera_pardusENSPPRP0000000960296.707694.4754
ENSG00000122257homo_sapiensENSP0000031787297.43394.7545marmota_marmota_marmotaENSMMMP0000002666397.324494.6488
ENSG00000122257homo_sapiensENSP0000031787297.823795.4799balaenoptera_musculusENSBMSP0001002901397.551595.2142
ENSG00000122257homo_sapiensENSP0000031787295.424191.3504cavia_porcellusENSCPOP0000002678095.530791.4525
ENSG00000122257homo_sapiensENSP0000031787296.819294.5871felis_catusENSFCAP0000004737296.819294.5871
ENSG00000122257homo_sapiensENSP0000031787212.77912.4442ursus_americanusENSUAMP0000000774896.218593.6975
ENSG00000122257homo_sapiensENSP0000031787259.93357.7009ursus_americanusENSUAMP0000000775195.381991.8295
ENSG00000122257homo_sapiensENSP0000031787290.290284.8772monodelphis_domesticaENSMODP0000002039991.206385.7384
ENSG00000122257homo_sapiensENSP0000031787213.616111.942monodelphis_domesticaENSMODP0000004920784.722274.3056
ENSG00000122257homo_sapiensENSP0000031787297.15494.2522bison_bison_bisonENSBBBP0000001181396.883793.99
ENSG00000122257homo_sapiensENSP0000031787297.600495.1451monodon_monocerosENSMMNP0001501454497.383194.9332
ENSG00000122257homo_sapiensENSP0000031787296.484493.471sus_scrofaENSSSCP0000003309896.376893.3668
ENSG00000122257homo_sapiensENSP0000031787297.823795.9263microcebus_murinusENSMICP0000004296695.897294.0372
ENSG00000122257homo_sapiensENSP0000031787291.741186.9978octodon_degusENSODEP0000001672692.100887.3389
ENSG00000122257homo_sapiensENSP0000031787293.303689.0067jaculus_jaculusENSJJAP0000001117394.623790.266
ENSG00000122257homo_sapiensENSP0000031787296.930893.75ovis_aries_rambouilletENSOARP0002003275988.532185.6269
ENSG00000122257homo_sapiensENSP0000031787295.535793.0804ursus_maritimusENSUMAP0000001153596.668594.1841
ENSG00000122257homo_sapiensENSP0000031787260.546957.8125ochotona_princepsENSOPRP0000001486961.507958.7302
ENSG00000122257homo_sapiensENSP0000031787295.424192.9688delphinapterus_leucasENSDLEP0000001435296.392393.9121
ENSG00000122257homo_sapiensENSP0000031787297.712195.3683physeter_catodonENSPCTP0000501127497.440295.103
ENSG00000122257homo_sapiensENSP0000031787265.06760.4353mus_caroliMGP_CAROLIEiJ_P008199391.16584.6755
ENSG00000122257homo_sapiensENSP0000031787293.359488.5603mus_musculusENSMUSP0000004952893.463788.6592
ENSG00000122257homo_sapiensENSP0000031787292.968889.2299dipodomys_ordiiENSDORP0000000966895.582391.7384
ENSG00000122257homo_sapiensENSP0000031787295.089392.4665mustela_putorius_furoENSMPUP0000001222296.380193.7217
ENSG00000122257homo_sapiensENSP0000031787299.051398.1027aotus_nancymaaeENSANAP0000004008198.996198.048
ENSG00000122257homo_sapiensENSP0000031787298.381797.5446saimiri_boliviensis_boliviensisENSSBOP0000000980099.100698.2574
ENSG00000122257homo_sapiensENSP0000031787262.946462.1652vicugna_pacosENSVPAP0000000599574.801173.8727
ENSG00000122257homo_sapiensENSP0000031787299.274698.8281chlorocebus_sabaeusENSCSAP0000000285799.274698.8281
ENSG00000122257homo_sapiensENSP0000031787260.100457.5335tupaia_belangeriENSTBEP0000000070460.201257.63
ENSG00000122257homo_sapiensENSP0000031787297.321494.8103phocoena_sinusENSPSNP0000000718497.104794.5991
ENSG00000122257homo_sapiensENSP0000031787297.321494.8661camelus_dromedariusENSCDRP0000500649697.158894.7075
ENSG00000122257homo_sapiensENSP0000031787297.600495.4799carlito_syrichtaENSTSYP0000000075997.54695.4267
ENSG00000122257homo_sapiensENSP0000031787296.707694.4196panthera_tigris_altaicaENSPTIP0000000928896.707694.4196
ENSG00000122257homo_sapiensENSP0000031787288.392983.6496rattus_norvegicusENSRNOP0000003613993.506588.4888
ENSG00000122257homo_sapiensENSP0000031787297.600495.5357prolemur_simusENSPSMP0000002773797.709595.6425
ENSG00000122257homo_sapiensENSP0000031787288.671985.3795sorex_araneusENSSARP0000000452993.032889.5785
ENSG00000122257homo_sapiensENSP000003178725.691965.02232peromyscus_maniculatus_bairdiiENSPEMP0000003648981.672
ENSG00000122257homo_sapiensENSP0000031787293.415289.3973peromyscus_maniculatus_bairdiiENSPEMP0000003539093.571889.5472
ENSG00000122257homo_sapiensENSP0000031787297.265694.4196bos_mutusENSBMUP0000002688996.99594.1569
ENSG00000122257homo_sapiensENSP0000031787293.136288.1696mus_spicilegusENSMSIP0000003399893.240288.2682
ENSG00000122257homo_sapiensENSP0000031787293.861689.6205cricetulus_griseus_chok1gshdENSCGRP0000101706194.071689.821
ENSG00000122257homo_sapiensENSP0000031787279.631775.558pteropus_vampyrusENSPVAP0000000104879.498675.4318
ENSG00000122257homo_sapiensENSP0000031787211.662910.9375myotis_lucifugusENSMLUP0000001861487.447782.0084
ENSG00000122257homo_sapiensENSP000003178729.765628.98438myotis_lucifugusENSMLUP0000001756776.419270.3057
ENSG00000122257homo_sapiensENSP0000031787212.555811.942myotis_lucifugusENSMLUP0000001674892.975288.4297
ENSG00000122257homo_sapiensENSP0000031787231.752228.7388myotis_lucifugusENSMLUP0000001995480.594972.9462
ENSG00000122257homo_sapiensENSP0000031787213.281212.1652myotis_lucifugusENSMLUP0000002276384.697577.5801
ENSG00000122257homo_sapiensENSP0000031787212.77911.7188myotis_lucifugusENSMLUP0000001667981.494774.7331
ENSG00000122257homo_sapiensENSP0000031787295.814792.0201myotis_lucifugusENSMLUP0000000967795.921892.1229
ENSG00000122257homo_sapiensENSP0000031787290.457685.2121vombatus_ursinusENSVURP0001002267387.954482.854
ENSG00000122257homo_sapiensENSP0000031787294.810390.4576rhinolophus_ferrumequinumENSRFEP0001002384094.810390.4576
ENSG00000122257homo_sapiensENSP0000031787296.484494.0848neovison_visonENSNVIP0000003170396.430694.0323
ENSG00000122257homo_sapiensENSP0000031787297.15494.2522bos_taurusENSBTAP0000001242396.883793.99
ENSG00000122257homo_sapiensENSP0000031787211.607111.1049heterocephalus_glaber_femaleENSHGLP0000005152589.655285.7759
ENSG00000122257homo_sapiensENSP0000031787291.462188.2812heterocephalus_glaber_femaleENSHGLP0000001160793.979490.711
ENSG00000122257homo_sapiensENSP0000031787289.955489.3973rhinopithecus_bietiENSRBIP0000000092899.444898.8279
ENSG00000122257homo_sapiensENSP0000031787211.94211.6629canis_lupus_dingoENSCAFP0002002711498.165195.8716
ENSG00000122257homo_sapiensENSP0000031787260.156258.0357canis_lupus_dingoENSCAFP0002002711095.737192.3623
ENSG00000122257homo_sapiensENSP0000031787297.377294.7545sciurus_vulgarisENSSVLP0000503314797.160494.5434
ENSG00000122257homo_sapiensENSP0000031787290.401884.933phascolarctos_cinereusENSPCIP0000001830289.305483.903
ENSG00000122257homo_sapiensENSP0000031787285.658581.8638procavia_capensisENSPCAP0000001400385.802182.0011
ENSG00000122257homo_sapiensENSP0000031787294.30890.1228nannospalax_galiliENSNGAP0000000265895.534291.2945
ENSG00000122257homo_sapiensENSP0000031787297.265694.4196bos_grunniensENSBGRP0000003443294.986492.2071
ENSG00000122257homo_sapiensENSP0000031787295.089391.0156chinchilla_lanigeraENSCLAP0000001432195.195591.1173
ENSG00000122257homo_sapiensENSP0000031787297.15494.2522cervus_hanglu_yarkandensisENSCHYP0000000336196.829893.9377
ENSG00000122257homo_sapiensENSP0000031787294.363891.2388catagonus_wagneriENSCWAP0000000344894.311291.188
ENSG00000122257homo_sapiensENSP0000031787297.488894.7545ictidomys_tridecemlineatusENSSTOP0000002665995.412392.7362
ENSG00000122257homo_sapiensENSP0000031787298.270196.4844otolemur_garnettiiENSOGAP0000002086798.160596.3768
ENSG00000122257homo_sapiensENSP0000031787298.883997.6562cebus_imitatorENSCCAP0000001125598.828897.6018
ENSG00000122257homo_sapiensENSP0000031787297.377294.6987urocitellus_parryiiENSUPAP0001001374295.043692.4292
ENSG00000122257homo_sapiensENSP0000031787297.265694.3638moschus_moschiferusENSMMSP0000003207296.94194.0489
ENSG00000122257homo_sapiensENSP0000031787299.274698.6607rhinopithecus_roxellanaENSRROP0000001588799.274698.6607
ENSG00000122257homo_sapiensENSP0000031787293.247888.1696mus_pahariMGP_PahariEiJ_P001877693.35288.2682
ENSG00000122257homo_sapiensENSP0000031787297.879596.0938propithecus_coquereliENSPCOP0000001997697.988896.2011
ENSG00000122257homo_sapiensENSP0000031787216.908510.9933petromyzon_marinusENSPMAP0000000979843.786128.4682
ENSG00000122257homo_sapiensENSP0000031787276.060364.5647latimeria_chalumnaeENSLACP0000001401176.102764.6008
ENSG00000122257homo_sapiensENSP0000031787268.247855.6362lepisosteus_oculatusENSLOCP0000000661967.494555.0221
ENSG00000122257homo_sapiensENSP0000031787228.236616.7411oncorhynchus_kisutchENSOKIP0000508724633.598919.9203
ENSG00000122257homo_sapiensENSP0000031787239.118325.558salmo_truttaENSSTUP0000006111737.85124.73
ENSG00000122257homo_sapiensENSP0000031787231.919621.3728cyclopterus_lumpusENSCLMP0000503882336.549524.4728
ENSG00000122257homo_sapiensENSP0000031787229.129520.0335oreochromis_niloticusENSONIP0000000418142.473629.2107
ENSG00000122257homo_sapiensENSP0000031787238.225424.8884haplochromis_burtoniENSHBUP0000003101240.773826.5476
ENSG00000122257homo_sapiensENSP0000031787234.542428.0134sparus_aurataENSSAUP0001002189556.841146.0973
ENSG00000122257homo_sapiensENSP0000031787286.104977.6786chrysemys_picta_belliiENSCPBP0000000225586.929678.4225
ENSG00000122257homo_sapiensENSP0000031787242.187537.3884sphenodon_punctatusENSSPUP0000001392185.520475.7919
ENSG00000122257homo_sapiensENSP0000031787281.863873.9397crocodylus_porosusENSCPRP0000501598185.439777.1695
ENSG00000122257homo_sapiensENSP0000031787278.850468.6942laticauda_laticaudataENSLLTP0000001059880.147569.8242
ENSG00000122257homo_sapiensENSP0000031787265.011254.8549notechis_scutatusENSNSUP0000002556078.29366.0618
ENSG00000122257homo_sapiensENSP0000031787273.883963.5045pseudonaja_textilisENSPTXP0000000553679.424168.2663
ENSG00000122257homo_sapiensENSP0000031787278.794670.9263anas_platyrhynchos_platyrhynchosENSAPLP0000000929875.995768.4069
ENSG00000122257homo_sapiensENSP0000031787283.81775.5022gallus_gallusENSGALP0001002514576.359968.785
ENSG00000122257homo_sapiensENSP0000031787282.700973.9397serinus_canariaENSSCAP0000000428083.445974.6059
ENSG00000122257homo_sapiensENSP0000031787282.589374.2188parus_majorENSPMJP0000002671082.727874.3432
ENSG00000122257homo_sapiensENSP0000031787249.832644.308anolis_carolinensisENSACAP0000001158579.732170.8929
ENSG00000122257homo_sapiensENSP0000031787270.926361.2165naja_najaENSNNAP0000001952878.456867.716
ENSG00000122257homo_sapiensENSP0000031787267.968859.096podarcis_muralisENSPMRP0000003644479.090968.7662
ENSG00000122257homo_sapiensENSP0000031787267.801361.1049geospiza_fortisENSGFOP0000000898985.38376.9501
ENSG00000122257homo_sapiensENSP0000031787282.700974.1071taeniopygia_guttataENSTGUP0000002523282.932374.3145
ENSG00000122257homo_sapiensENSP0000031787251.562537.8906kryptolebias_marmoratusENSKMAP0000000943449.650736.4858
ENSG00000122257homo_sapiensENSP0000031787278.180869.1406salvator_merianaeENSSMRP0000002163680.332671.0436
ENSG00000122257homo_sapiensENSP0000031787280.97172.433pelodiscus_sinensisENSPSIP0000000436585.705876.6686
ENSG00000122257homo_sapiensENSP0000031787284.709876.1719gopherus_evgoodeiENSGEVP0000502055387.593878.7651
ENSG00000122257homo_sapiensENSP0000031787285.770177.2879chelonoidis_abingdoniiENSCABP0000000893087.929179.2334
ENSG00000122257homo_sapiensENSP0000031787280.078172.2656struthio_camelus_australisENSSCUP0000000150284.86176.5819
ENSG00000122257homo_sapiensENSP0000031787283.872875.8929anser_brachyrhynchusENSABRP0000002528082.086374.2764
ENSG00000122257homo_sapiensENSP0000031787242.912931.5848cynoglossus_semilaevisENSCSEP0000000631151.854438.1659
ENSG00000122257homo_sapiensENSP0000031787283.370575.279strigops_habroptilaENSSHBP0000502406480.887973.0374
ENSG00000122257homo_sapiensENSP0000031787271.87563.7277terrapene_carolina_triunguisENSTMTP0000002754786.038776.2859
ENSG00000122257homo_sapiensENSP0000031787230.357120.4241labrus_bergyltaENSLBEP0000000597741.910628.1972
ENSG00000122257homo_sapiensENSP0000031787281.361673.4933aquila_chrysaetos_chrysaetosENSACCP0002001815185.263277.0175
ENSG00000122257homo_sapiensENSP0000031787282.756774.1629ficedula_albicollisENSFALP0000000391183.034774.4121
ENSG00000122257homo_sapiensENSP0000031787283.984475.8929coturnix_japonicaENSCJPP0000501198277.457569.9949
ENSG00000122257homo_sapiensENSP0000031787268.415253.5156paramormyrops_kingsleyaeENSPKIP0000001169765.282251.065
ENSG00000122257homo_sapiensENSP0000031787260.714346.4286scleropages_formosusENSSFOP0001502223965.149749.8204
ENSG00000122257homo_sapiensENSP000003178727.700896.25leptobrachium_leishanenseENSLLEP0000001957385.714369.5652
ENSG00000122257homo_sapiensENSP0000031787267.968855.6362leptobrachium_leishanenseENSLLEP0000002744568.388555.9798

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001701involved_in in utero embryonic development1IEAHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0004842enables ubiquitin-protein transferase activity1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005694located_in chromosome1IEAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus1IEAHomo_sapiens(9606)Component
GO:0005813colocalizes_with centrosome1IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006260involved_in DNA replication1IEAHomo_sapiens(9606)Process
GO:0006275involved_in regulation of DNA replication1IMPHomo_sapiens(9606)Process
GO:0006397involved_in mRNA processing1IEAHomo_sapiens(9606)Process
GO:0006511involved_in ubiquitin-dependent protein catabolic process3IBA,IDA,IMPHomo_sapiens(9606)Process
GO:0006974involved_in DNA damage response1IMPHomo_sapiens(9606)Process
GO:0008270enables zinc ion binding1IEAHomo_sapiens(9606)Function
GO:0016567involved_in protein ubiquitination2IBA,IEAHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0019901enables protein kinase binding1IPIHomo_sapiens(9606)Function
GO:0032991part_of protein-containing complex1IDAHomo_sapiens(9606)Component
GO:0035264involved_in multicellular organism growth1IEAHomo_sapiens(9606)Process
GO:0048568involved_in embryonic organ development1IEAHomo_sapiens(9606)Process
GO:0061053involved_in somite development1IEAHomo_sapiens(9606)Process
GO:0061630enables ubiquitin protein ligase activity2IBA,IMPHomo_sapiens(9606)Function

Expression