Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerCHIKVSARS-COV-OC43FlavivirusesHIVRVSARS-COV-2SINVDengueZika
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq DataSet_01_172 DataSet_01_402

Description

Ensembl ID ENSG00000114867 Gene ID 1981 Accession 3296
Symbol EIF4G1 Alias P220;EIF4F;EIF4G;EIF4GI;PARK18;EIF-4G1 Full Name eukaryotic translation initiation factor 4 gamma 1
Status Confidence Length 20864 bases Strand Plus strand
Position 3 : 184314495 - 184335358 RNA binding domain W2 , MIF4G , MA3
Summary The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000411826 MA3 PF02847 2.1e-29 1
ENSP00000411826 MIF4G PF02854 1.7e-68 2
ENSP00000411826 W2 PF02020 3.8e-18 3
ENSP00000317600 MA3 PF02847 2.2e-29 1
ENSP00000317600 MIF4G PF02854 1.8e-68 2
ENSP00000317600 W2 PF02020 3.9e-18 3
ENSP00000399858 MA3 PF02847 2.2e-29 1
ENSP00000399858 MIF4G PF02854 1.8e-68 2
ENSP00000399858 W2 PF02020 3.9e-18 3
ENSP00000376320 MA3 PF02847 2.4e-29 1
ENSP00000376320 MIF4G PF02854 1.9e-68 2
ENSP00000376320 W2 PF02020 4.2e-18 3
ENSP00000407682 MA3 PF02847 2.4e-29 1
ENSP00000407682 MIF4G PF02854 1.9e-68 2
ENSP00000407682 W2 PF02020 4.2e-18 3
ENSP00000391935 MA3 PF02847 2.5e-29 1
ENSP00000391935 MIF4G PF02854 2e-68 2
ENSP00000391935 W2 PF02020 4.3e-18 3
ENSP00000395974 MA3 PF02847 2.5e-29 1
ENSP00000395974 MIF4G PF02854 2e-68 2
ENSP00000395974 W2 PF02020 4.3e-18 3
ENSP00000404754 MA3 PF02847 2.6e-29 1
ENSP00000404754 MIF4G PF02854 2.1e-68 2
ENSP00000404754 W2 PF02020 4.4e-18 3
ENSP00000316879 MA3 PF02847 2.7e-29 1
ENSP00000316879 MIF4G PF02854 2.1e-68 2
ENSP00000316879 W2 PF02020 4.5e-18 3
ENSP00000343450 MA3 PF02847 2.7e-29 1
ENSP00000343450 MIF4G PF02854 2.1e-68 2
ENSP00000343450 W2 PF02020 4.5e-18 3
ENSP00000338020 MA3 PF02847 2.8e-29 1
ENSP00000338020 MIF4G PF02854 2.1e-68 2
ENSP00000338020 W2 PF02020 4.5e-18 3
ENSP00000371767 MA3 PF02847 2.8e-29 1
ENSP00000371767 MIF4G PF02854 2.1e-68 2
ENSP00000371767 W2 PF02020 4.5e-18 3
ENSP00000416255 MA3 PF02847 2.8e-29 1
ENSP00000416255 MIF4G PF02854 2.1e-68 2
ENSP00000416255 W2 PF02020 4.5e-18 3
ENSP00000396888 MA3 PF02847 2e-09 1
ENSP00000403269 MIF4G PF02854 2.6e-58 1
ENSP00000398145 MIF4G PF02854 5.6e-42 1
ENSP00000413159 MIF4G PF02854 8.4e-26 1
ENSP00000391412 MIF4G PF02854 2.9e-18 1
ENSP00000392908 MIF4G PF02854 7.6e-09 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
24157614 Depletion of hnRNP A2/B1 overrides the nuclear retention of the HIV-1 genomic RNA. Heather Gordon 2013-11-01 RNA biology
27668427 Characterization of the Expression of the RNA Binding Protein eIF4G1 and Its Clinicopathological Correlation with Serous Ovarian Cancer. Lanfang Li 2016-01-01 PloS one
33510277 A translation enhancer element from black beetle virus engages yeast eIF4G1 to drive cap-independent translation initiation. M Brandon Trainor 2021-01-28 Scientific reports
35291721 Short and Sweet: Viral 5`-UTR as a Canonical and Non-Canonical Translation Initiation Switch. M Brandon Trainor 2021-01-01 Journal of cellular immunology
24183571 Dynamic recognition of the mRNA cap by Saccharomyces cerevisiae eIF4E. E Seán O'Leary 2013-12-03 Structure (London, England : 1993)
28546148 Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs. Boris Zinshteyn 2017-09-01 RNA (New York, N.Y.)
33396899 Role of Host-Mediated Post-Translational Modifications (PTMs) in RNA Virus Pathogenesis. Ramesh Kumar 2020-12-30 International journal of molecular sciences
28738064 Species A rotavirus NSP3 acquires its translation inhibitory function prior to stable dimer formation. I Hugo Contreras-Treviño 2017-01-01 PloS one
35018467 Ribosomal leaky scanning through a translated uORF requires eIF4G2. V Victoria Smirnova 2022-01-25 Nucleic acids research
33523588 Elevation of EIF4G1 promotes non-small cell lung cancer progression by activating mTOR signalling. Ying Lu 2021-03-01 Journal of cellular and molecular medicine
35041803 Direct analysis of ribosome targeting illuminates thousand-fold regulation of translation initiation. O Rachel Niederer 2022-03-16 Cell systems
31157589 RGG-motif self-association regulates eIF4G-binding translation repressor protein Scd6. Gopalakrishna Poornima 2019-09-01 RNA biology
29603493 Long non-coding RNA-CTD-2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor. Mozhi Wang 2018-06-01 Cancer science

Transcripts

Name Transcript ID bp Protein Translation ID
EIF4G1-204 ENST00000352767 5484 1606aa ENSP00000338020
EIF4G1-209 ENST00000414031 5569 1559aa ENSP00000391935
EIF4G1-206 ENST00000392537 5229 1512aa ENSP00000376320
EIF4G1-223 ENST00000444134 558 127aa ENSP00000407244
EIF4G1-222 ENST00000442406 5129 50aa ENSP00000400351
EIF4G1-226 ENST00000450424 2658 833aa ENSP00000391412
EIF4G1-210 ENST00000421110 2755 869aa ENSP00000413159
EIF4G1-219 ENST00000435046 5042 1577aa ENSP00000404754
EIF4G1-205 ENST00000382330 5129 1606aa ENSP00000371767
EIF4G1-208 ENST00000413967 2808 71aa ENSP00000390755
EIF4G1-213 ENST00000426123 2907 903aa ENSP00000403269
EIF4G1-202 ENST00000346169 5405 1599aa ENSP00000316879
EIF4G1-203 ENST00000350481 4990 1435aa ENSP00000317600
EIF4G1-227 ENST00000455679 542 87aa ENSP00000415842
EIF4G1-237 ENST00000485712 474 No protein -
EIF4G1-220 ENST00000440448 578 143aa ENSP00000407240
EIF4G1-214 ENST00000427141 730 92aa ENSP00000411214
EIF4G1-216 ENST00000427845 5038 1513aa ENSP00000407682
EIF4G1-201 ENST00000342981 5667 1600aa ENSP00000343450
EIF4G1-212 ENST00000424196 5653 1606aa ENSP00000416255
EIF4G1-228 ENST00000456033 694 160aa ENSP00000415943
EIF4G1-207 ENST00000411531 4683 1560aa ENSP00000395974
EIF4G1-224 ENST00000444861 2384 757aa ENSP00000398145
EIF4G1-236 ENST00000484862 590 No protein -
EIF4G1-239 ENST00000676206 702 103aa ENSP00000502064
EIF4G1-221 ENST00000441154 4311 1436aa ENSP00000399858
EIF4G1-217 ENST00000428387 524 143aa ENSP00000411707
EIF4G1-218 ENST00000434061 5026 1404aa ENSP00000411826
EIF4G1-215 ENST00000427607 596 163aa ENSP00000409545
EIF4G1-229 ENST00000457456 983 285aa ENSP00000399969
EIF4G1-238 ENST00000493299 559 No protein -
EIF4G1-240 ENST00000676453 4590 525aa ENSP00000501695
EIF4G1-225 ENST00000448284 677 226aa ENSP00000392908
EIF4G1-232 ENST00000466311 573 No protein -
EIF4G1-235 ENST00000482303 493 No protein -
EIF4G1-211 ENST00000422614 750 180aa ENSP00000396888
EIF4G1-230 ENST00000460829 1804 No protein -
EIF4G1-233 ENST00000475721 1271 No protein -
EIF4G1-231 ENST00000464548 637 No protein -
EIF4G1-234 ENST00000478291 564 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
77582Menarche3E-1225231870

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000114867homo_sapiensENSP0000047351057.099346.1304homo_sapiensENSP0000031687958.599147.3421
ENSG00000114867homo_sapiensENSP0000034028144.873228.8864homo_sapiensENSP0000031687925.453416.3852

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000114867homo_sapiensENSP0000031687995.747395.3096nomascus_leucogenysENSNLEP0000003581998.26797.8177
ENSG00000114867homo_sapiensENSP0000031687999.437199.3121pan_paniscusENSPPAP0000004028099.003798.8792
ENSG00000114867homo_sapiensENSP0000031687999.18799.1245pongo_abeliiENSPPYP0000002353098.754798.6924
ENSG00000114867homo_sapiensENSP0000031687997.248397.1232pan_troglodytesENSPTRP0000002699599.743499.6151
ENSG00000114867homo_sapiensENSP0000031687999.312199.187gorilla_gorillaENSGGOP0000001358799.064398.9395
ENSG00000114867homo_sapiensENSP0000031687984.677979.2996ornithorhynchus_anatinusENSOANP0000005135783.528778.2233
ENSG00000114867homo_sapiensENSP0000031687988.367783.4897sarcophilus_harrisiiENSSHAP0000003198387.3382.5093
ENSG00000114867homo_sapiensENSP0000031687983.114478.8618notamacropus_eugeniiENSMEUP0000000990783.375279.1092
ENSG00000114867homo_sapiensENSP0000031687976.610474.7342choloepus_hoffmanniENSCHOP0000000152383.333381.2925
ENSG00000114867homo_sapiensENSP0000031687988.492886.8668dasypus_novemcinctusENSDNOP0000002467195.414793.6615
ENSG00000114867homo_sapiensENSP0000031687968.918167.4171erinaceus_europaeusENSEEUP0000000359984.509282.6687
ENSG00000114867homo_sapiensENSP0000031687965.353363.0394echinops_telfairiENSETEP0000000346767.419465.0323
ENSG00000114867homo_sapiensENSP0000031687997.998797.3108callithrix_jacchusENSCJAP0000002788797.632496.947
ENSG00000114867homo_sapiensENSP0000031687998.811898.6241cercocebus_atysENSCATP0000000219598.503798.3167
ENSG00000114867homo_sapiensENSP0000031687998.624198.4365macaca_fascicularisENSMFAP0000003596298.194398.0075
ENSG00000114867homo_sapiensENSP0000031687998.686798.4991macaca_mulattaENSMMUP0000001433898.379198.192
ENSG00000114867homo_sapiensENSP0000031687998.686798.4991macaca_nemestrinaENSMNEP0000002846898.379198.192
ENSG00000114867homo_sapiensENSP0000031687998.936898.5616papio_anubisENSPANP0000002813298.56798.1931
ENSG00000114867homo_sapiensENSP0000031687998.999498.7492mandrillus_leucophaeusENSMLEP0000002276599.061398.811
ENSG00000114867homo_sapiensENSP0000031687978.048876.3602tursiops_truncatusENSTTRP0000001066681.197179.4405
ENSG00000114867homo_sapiensENSP0000031687996.935695.0594vulpes_vulpesENSVVUP0000001652496.273394.4099
ENSG00000114867homo_sapiensENSP0000031687993.933791.0569mus_spretusMGP_SPRETEiJ_P004283793.87591
ENSG00000114867homo_sapiensENSP0000031687996.497895.3721equus_asinusENSEASP0000502037795.719694.603
ENSG00000114867homo_sapiensENSP0000031687995.622393.8086capra_hircusENSCHIP0000000594595.146293.3416
ENSG00000114867homo_sapiensENSP0000031687990.806888.4303loxodonta_africanaENSLAFP0000000459594.163491.6991
ENSG00000114867homo_sapiensENSP0000031687996.74894.9343panthera_leoENSPLOP0000001355896.08794.2857
ENSG00000114867homo_sapiensENSP0000031687996.87394.7467ailuropoda_melanoleucaENSAMEP0000001811296.211294.0994
ENSG00000114867homo_sapiensENSP0000031687995.809994.1839bos_indicus_hybridENSBIXP0000503934195.332993.715
ENSG00000114867homo_sapiensENSP0000031687996.622994.9343oryctolagus_cuniculusENSOCUP0000003299296.082194.403
ENSG00000114867homo_sapiensENSP0000031687996.685495.4972equus_caballusENSECAP0000000684896.32495.1402
ENSG00000114867homo_sapiensENSP0000031687996.87394.9969canis_lupus_familiarisENSCAFP0084503862496.211294.3478
ENSG00000114867homo_sapiensENSP0000031687996.74894.9343panthera_pardusENSPPRP0000001460296.08794.2857
ENSG00000114867homo_sapiensENSP0000031687996.185194.3715marmota_marmota_marmotaENSMMMP0000000850695.409493.6104
ENSG00000114867homo_sapiensENSP0000031687996.435394.6842balaenoptera_musculusENSBMSP0001001045695.955294.2128
ENSG00000114867homo_sapiensENSP0000031687993.120790.4941cavia_porcellusENSCPOP0000000661394.300291.6403
ENSG00000114867homo_sapiensENSP0000031687996.810594.9343felis_catusENSFCAP0000000721896.508794.6384
ENSG00000114867homo_sapiensENSP0000031687982.426580.2376ursus_americanusENSUAMP0000000392395.162592.6354
ENSG00000114867homo_sapiensENSP0000031687959.349649.656monodelphis_domesticaENSMODP0000003247763.056552.7575
ENSG00000114867homo_sapiensENSP0000031687977.861272.4828monodelphis_domesticaENSMODP0000004694882.341376.6534
ENSG00000114867homo_sapiensENSP0000031687995.434693.8086bison_bison_bisonENSBBBP0000002105194.959593.3416
ENSG00000114867homo_sapiensENSP0000031687996.310294.8093monodon_monocerosENSMMNP0001500532695.830794.3373
ENSG00000114867homo_sapiensENSP0000031687992.870591.4321sus_scrofaENSSSCP0000005279392.064590.6386
ENSG00000114867homo_sapiensENSP0000031687996.435395.3721microcebus_murinusENSMICP0000005131396.074895.0156
ENSG00000114867homo_sapiensENSP0000031687911.882411.8824octodon_degusENSODEP0000001726294.059494.0594
ENSG00000114867homo_sapiensENSP0000031687976.547873.8587octodon_degusENSODEP0000001882093.079889.8099
ENSG00000114867homo_sapiensENSP0000031687962.851861.0381jaculus_jaculusENSJJAP0000000788193.837591.1298
ENSG00000114867homo_sapiensENSP0000031687912.0712.0075jaculus_jaculusENSJJAP0000001928092.344591.866
ENSG00000114867homo_sapiensENSP0000031687995.747393.8712ovis_aries_rambouilletENSOARP0002000390395.270793.4039
ENSG00000114867homo_sapiensENSP0000031687996.685494.6216ursus_maritimusENSUMAP0000000689996.444294.3855
ENSG00000114867homo_sapiensENSP0000031687990.431588.4928ochotona_princepsENSOPRP0000001363289.869587.9428
ENSG00000114867homo_sapiensENSP0000031687996.310294.8093delphinapterus_leucasENSDLEP0000001305195.830794.3373
ENSG00000114867homo_sapiensENSP0000031687992.495390.8068physeter_catodonENSPCTP0000502537495.728293.9806
ENSG00000114867homo_sapiensENSP0000031687994.121391.2445mus_caroliMGP_CAROLIEiJ_P004098094.062591.1875
ENSG00000114867homo_sapiensENSP0000031687993.933791.2445mus_musculusENSMUSP0000011112093.87591.1875
ENSG00000114867homo_sapiensENSP0000031687912.195112.1326dipodomys_ordiiENSDORP0000001924293.301492.823
ENSG00000114867homo_sapiensENSP0000031687978.111376.6729dipodomys_ordiiENSDORP0000000961295.635593.8744
ENSG00000114867homo_sapiensENSP0000031687991.18287.9925mustela_putorius_furoENSMPUP0000000280085.96782.9599
ENSG00000114867homo_sapiensENSP0000031687997.498496.748aotus_nancymaaeENSANAP0000002421796.532595.7895
ENSG00000114867homo_sapiensENSP0000031687998.123897.3734saimiri_boliviensis_boliviensisENSSBOP0000001956097.696196.9489
ENSG00000114867homo_sapiensENSP0000031687940.83840.025vicugna_pacosENSVPAP0000000837846.944646.0101
ENSG00000114867homo_sapiensENSP0000031687996.122695.935chlorocebus_sabaeusENSCSAP0000000986098.210998.0192
ENSG00000114867homo_sapiensENSP0000031687962.288960.6629tupaia_belangeriENSTBEP0000000172673.723271.7987
ENSG00000114867homo_sapiensENSP0000031687967.9866.2289mesocricetus_auratusENSMAUP0000002467394.60492.1671
ENSG00000114867homo_sapiensENSP0000031687912.007511.8199mesocricetus_auratusENSMAUP0000000691991.86690.4306
ENSG00000114867homo_sapiensENSP0000031687994.183992.5578phocoena_sinusENSPSNP0000000470080.277278.8913
ENSG00000114867homo_sapiensENSP0000031687996.372794.8093camelus_dromedariusENSCDRP0000500450195.952794.396
ENSG00000114867homo_sapiensENSP0000031687996.810595.1219carlito_syrichtaENSTSYP0000003163296.268794.5896
ENSG00000114867homo_sapiensENSP0000031687994.996993.0582panthera_tigris_altaicaENSPTIP0000002036694.465292.5373
ENSG00000114867homo_sapiensENSP0000031687993.683690.8693rattus_norvegicusENSRNOP0000006749291.285888.5436
ENSG00000114867homo_sapiensENSP0000031687996.372795.3096prolemur_simusENSPSMP0000003007195.952794.8941
ENSG00000114867homo_sapiensENSP0000031687994.058891.995microtus_ochrogasterENSMOCP0000001757594.058891.995
ENSG00000114867homo_sapiensENSP000003168798.880558.56785microtus_ochrogasterENSMOCP0000000065883.040980.117
ENSG00000114867homo_sapiensENSP0000031687966.041362.7892sorex_araneusENSSARP0000000300869.980166.5341
ENSG00000114867homo_sapiensENSP0000031687993.808691.6198peromyscus_maniculatus_bairdiiENSPEMP0000001880193.63391.4482
ENSG00000114867homo_sapiensENSP0000031687995.997594.3715bos_mutusENSBMUP0000002612195.519693.9017
ENSG00000114867homo_sapiensENSP000003168795.816135.81613mus_spicilegusENSMSIP0000001842093.939493.9394
ENSG00000114867homo_sapiensENSP0000031687993.996291.9325cricetulus_griseus_chok1gshdENSCGRP0000102695194.172992.1053
ENSG00000114867homo_sapiensENSP0000031687994.43492.3702pteropus_vampyrusENSPVAP0000000459193.788891.7391
ENSG00000114867homo_sapiensENSP0000031687991.307188.9931myotis_lucifugusENSMLUP0000001167493.709991.335
ENSG00000114867homo_sapiensENSP0000031687988.555383.4897vombatus_ursinusENSVURP0001003032087.623882.6114
ENSG00000114867homo_sapiensENSP0000031687992.307789.9312rhinolophus_ferrumequinumENSRFEP0001002964992.771890.3834
ENSG00000114867homo_sapiensENSP0000031687996.435394.434neovison_visonENSNVIP0000001918595.716993.7306
ENSG00000114867homo_sapiensENSP0000031687995.872494.2464bos_taurusENSBTAP0000003215095.395193.7772
ENSG00000114867homo_sapiensENSP0000031687994.746792.1826heterocephalus_glaber_femaleENSHGLP0000001940893.924491.3825
ENSG00000114867homo_sapiensENSP0000031687935.084433.3959heterocephalus_glaber_femaleENSHGLP0000001218390.923886.5478
ENSG00000114867homo_sapiensENSP0000031687997.686197.1857rhinopithecus_bietiENSRBIP0000002683898.548998.0442
ENSG00000114867homo_sapiensENSP0000031687996.935695.0594canis_lupus_dingoENSCAFP0002000299396.693794.8222
ENSG00000114867homo_sapiensENSP0000031687996.560395.3096sciurus_vulgarisENSSVLP0000501676695.781694.5409
ENSG00000114867homo_sapiensENSP0000031687988.617983.3646phascolarctos_cinereusENSPCIP0000003466787.903282.6923
ENSG00000114867homo_sapiensENSP0000031687986.804383.3021procavia_capensisENSPCAP0000001380389.260585.6592
ENSG00000114867homo_sapiensENSP0000031687910.318910.3189nannospalax_galiliENSNGAP0000002368997.058897.0588
ENSG00000114867homo_sapiensENSP0000031687976.672973.546nannospalax_galiliENSNGAP0000001084489.423885.7768
ENSG00000114867homo_sapiensENSP0000031687976.985674.7967nannospalax_galiliENSNGAP0000002134794.401891.7178
ENSG00000114867homo_sapiensENSP0000031687993.683692.1201bos_grunniensENSBGRP0000000804495.596794.0013
ENSG00000114867homo_sapiensENSP0000031687994.559191.5572chinchilla_lanigeraENSCLAP0000001890293.91390.9317
ENSG00000114867homo_sapiensENSP0000031687995.684893.621cervus_hanglu_yarkandensisENSCHYP0000001204795.208593.1549
ENSG00000114867homo_sapiensENSP0000031687995.434694.0588catagonus_wagneriENSCWAP0000001949394.782693.4161
ENSG00000114867homo_sapiensENSP0000031687996.247794.5591ictidomys_tridecemlineatusENSSTOP0000002697495.530793.8548
ENSG00000114867homo_sapiensENSP0000031687996.497895.3096otolemur_garnettiiENSOGAP0000001370194.953893.7846
ENSG00000114867homo_sapiensENSP0000031687998.248997.3734cebus_imitatorENSCCAP0000003893897.881697.0093
ENSG00000114867homo_sapiensENSP0000031687996.310294.6216urocitellus_parryiiENSUPAP0001000392595.592893.9168
ENSG00000114867homo_sapiensENSP0000031687995.809993.9962moschus_moschiferusENSMMSP0000001568195.332993.5283
ENSG00000114867homo_sapiensENSP0000031687998.874398.4365rhinopithecus_roxellanaENSRROP0000000142698.566198.1297
ENSG00000114867homo_sapiensENSP000003168794.752974.69043mus_pahariMGP_PahariEiJ_P002835296.202594.9367
ENSG00000114867homo_sapiensENSP0000031687996.685495.6223propithecus_coquereliENSPCOP0000002824496.32495.2648
ENSG00000114867homo_sapiensENSP0000031687921.763615.3846ciona_intestinalisENSCINP0000001066850.50835.7039
ENSG00000114867homo_sapiensENSP0000031687937.460929.9562eptatretus_burgeriENSEBUP0000001852848.189938.5358
ENSG00000114867homo_sapiensENSP0000031687963.352152.6579callorhinchus_miliiENSCMIP0000002002768.307556.7768
ENSG00000114867homo_sapiensENSP0000031687977.673566.6041latimeria_chalumnaeENSLACP0000000545475.731764.939
ENSG00000114867homo_sapiensENSP0000031687969.355959.7248lepisosteus_oculatusENSLOCP0000001062964.891755.8806
ENSG00000114867homo_sapiensENSP0000031687970.481659.6623clupea_harengusENSCHAP0000001994362.680853.059
ENSG00000114867homo_sapiensENSP0000031687920.012516.4478danio_rerioENSDARP0000015239374.766461.4486
ENSG00000114867homo_sapiensENSP0000031687923.389619.0744carassius_auratusENSCARP0000009740772.340458.9942
ENSG00000114867homo_sapiensENSP0000031687970.41959.3496astyanax_mexicanusENSAMXP0000001991866.002355.6272
ENSG00000114867homo_sapiensENSP0000031687967.542257.536ictalurus_punctatusENSIPUP0000002176668.26858.1542
ENSG00000114867homo_sapiensENSP0000031687963.039452.0951ictalurus_punctatusENSIPUP0000002283463.396252.3899
ENSG00000114867homo_sapiensENSP0000031687969.543557.7236esox_luciusENSELUP0000000497962.542251.9123
ENSG00000114867homo_sapiensENSP0000031687965.228354.9093electrophorus_electricusENSEEEP0000003074664.462354.2645
ENSG00000114867homo_sapiensENSP0000031687923.20214.384oncorhynchus_kisutchENSOKIP0000508362348.307329.9479
ENSG00000114867homo_sapiensENSP0000031687923.327114.384oncorhynchus_kisutchENSOKIP0000501129847.881929.525
ENSG00000114867homo_sapiensENSP0000031687923.389614.4465oncorhynchus_mykissENSOMYP0000002009747.826129.5396
ENSG00000114867homo_sapiensENSP0000031687921.263313.571oncorhynchus_mykissENSOMYP0000011552947.552430.3496
ENSG00000114867homo_sapiensENSP0000031687914.57169.00563salmo_salarENSSSAP0000013207145.596928.18
ENSG00000114867homo_sapiensENSP0000031687926.579116.4478salmo_salarENSSSAP0000009656946.245928.6181
ENSG00000114867homo_sapiensENSP0000031687926.516616.3852salmo_truttaENSSTUP0000005176747.21629.1759
ENSG00000114867homo_sapiensENSP0000031687922.951814.0088salmo_truttaENSSTUP0000005555147.848829.2047
ENSG00000114867homo_sapiensENSP0000031687968.167655.222fundulus_heteroclitusENSFHEP0000002098464.49752.2485
ENSG00000114867homo_sapiensENSP0000031687966.729254.2839poecilia_reticulataENSPREP0000000438362.215750.6122
ENSG00000114867homo_sapiensENSP0000031687966.916854.3465xiphophorus_maculatusENSXMAP0000004064262.646450.8782
ENSG00000114867homo_sapiensENSP0000031687966.35455.4096oryzias_latipesENSORLP0000003560661.865951.6618
ENSG00000114867homo_sapiensENSP0000031687969.918756.7229cyclopterus_lumpusENSCLMP0000503221060.04348.7111
ENSG00000114867homo_sapiensENSP0000031687965.290854.5966oreochromis_niloticusENSONIP0000006104562.06951.9025
ENSG00000114867homo_sapiensENSP0000031687966.47955.4096haplochromis_burtoniENSHBUP0000002300664.074753.4057
ENSG00000114867homo_sapiensENSP0000031687966.35455.3471astatotilapia_callipteraENSACLP0000003512261.829851.5734
ENSG00000114867homo_sapiensENSP0000031687969.856258.4115sparus_aurataENSSAUP0001001712962.367452.1496
ENSG00000114867homo_sapiensENSP0000031687970.856859.7248lates_calcariferENSLCAP0001002827866.686356.2095
ENSG00000114867homo_sapiensENSP0000031687973.983763.9149xenopus_tropicalisENSXETP0000009819573.523963.5177
ENSG00000114867homo_sapiensENSP0000031687979.111970.8568chrysemys_picta_belliiENSCPBP0000002164777.990169.852
ENSG00000114867homo_sapiensENSP0000031687969.293361.3508sphenodon_punctatusENSSPUP0000001798174.864966.2838
ENSG00000114867homo_sapiensENSP0000031687976.672967.6673crocodylus_porosusENSCPRP0000501648376.196467.2467
ENSG00000114867homo_sapiensENSP0000031687967.917459.4747laticauda_laticaudataENSLLTP0000001800274.485665.2263
ENSG00000114867homo_sapiensENSP0000031687972.420363.0394notechis_scutatusENSNSUP0000001158876.034166.1852
ENSG00000114867homo_sapiensENSP0000031687974.671765.6035pseudonaja_textilisENSPTXP0000002396476.83467.5032
ENSG00000114867homo_sapiensENSP0000031687960.162652.6579anas_platyrhynchos_platyrhynchosENSAPLP0000001663868.323959.8011
ENSG00000114867homo_sapiensENSP0000031687978.236469.3559gallus_gallusENSGALP0001002488975.956367.3345
ENSG00000114867homo_sapiensENSP0000031687976.360268.0425meleagris_gallopavoENSMGAP0000003371178.87670.2842
ENSG00000114867homo_sapiensENSP0000031687978.674269.5435serinus_canariaENSSCAP0000001956877.94368.8971
ENSG00000114867homo_sapiensENSP0000031687976.172666.7917parus_majorENSPMJP0000000196974.132765.003
ENSG00000114867homo_sapiensENSP0000031687977.923769.2308anolis_carolinensisENSACAP0000000219076.961168.3755
ENSG00000114867homo_sapiensENSP0000031687965.916254.7217neolamprologus_brichardiENSNBRP0000001984266.289355.0314
ENSG00000114867homo_sapiensENSP0000031687973.045764.2276naja_najaENSNNAP0000002840275.893466.7316
ENSG00000114867homo_sapiensENSP0000031687975.359667.5422podarcis_muralisENSPMRP0000000996578.501670.3583
ENSG00000114867homo_sapiensENSP0000031687975.859968.0425geospiza_fortisENSGFOP0000002035578.460570.3752
ENSG00000114867homo_sapiensENSP0000031687978.799269.2933taeniopygia_guttataENSTGUP0000001943676.782467.5198
ENSG00000114867homo_sapiensENSP0000031687972.795562.7267erpetoichthys_calabaricusENSECRP0000000767071.71961.7991
ENSG00000114867homo_sapiensENSP0000031687968.230156.4103kryptolebias_marmoratusENSKMAP0000001577363.913352.8412
ENSG00000114867homo_sapiensENSP0000031687977.61169.4184salvator_merianaeENSSMRP0000003074177.320969.1589
ENSG00000114867homo_sapiensENSP0000031687962.976952.7205oryzias_javanicusENSOJAP0000004063466.032855.2787
ENSG00000114867homo_sapiensENSP0000031687967.16756.5353amphilophus_citrinellusENSACIP0000001903865.889655.4601
ENSG00000114867homo_sapiensENSP0000031687969.731158.4115dicentrarchus_labraxENSDLAP0000507226862.570152.413
ENSG00000114867homo_sapiensENSP0000031687967.041956.5979amphiprion_perculaENSAPEP0000001014069.746358.8809
ENSG00000114867homo_sapiensENSP0000031687953.220844.9031oryzias_sinensisENSOSIP0000004775761.666752.029
ENSG00000114867homo_sapiensENSP0000031687918.761715.9475pelodiscus_sinensisENSPSIP0000001870287.976574.7801
ENSG00000114867homo_sapiensENSP0000031687920.575418.0738pelodiscus_sinensisENSPSIP0000001867863.269255.5769
ENSG00000114867homo_sapiensENSP0000031687979.23770.7317gopherus_evgoodeiENSGEVP0000500647878.793570.3358
ENSG00000114867homo_sapiensENSP0000031687978.986970.6066chelonoidis_abingdoniiENSCABP0000001741878.789870.4304
ENSG00000114867homo_sapiensENSP0000031687971.544759.975seriola_dumeriliENSSDUP0000001207666.318855.5942
ENSG00000114867homo_sapiensENSP0000031687969.668558.0363cottoperca_gobioENSCGOP0000001802063.986253.3027
ENSG00000114867homo_sapiensENSP0000031687974.108865.3533struthio_camelus_australisENSSCUP0000001955776.99867.9012
ENSG00000114867homo_sapiensENSP0000031687978.048869.2933anser_brachyrhynchusENSABRP0000000153776.004967.4787
ENSG00000114867homo_sapiensENSP0000031687969.230857.4734gasterosteus_aculeatusENSGACP0000001788269.05857.33
ENSG00000114867homo_sapiensENSP0000031687964.540353.2833cynoglossus_semilaevisENSCSEP0000002626870.395658.1173
ENSG00000114867homo_sapiensENSP0000031687965.728653.7211poecilia_formosaENSPFOP0000000920365.279553.354
ENSG00000114867homo_sapiensENSP0000031687970.731760.1001myripristis_murdjanENSMMDP0000503196167.724557.5449
ENSG00000114867homo_sapiensENSP0000031687967.792457.0982sander_luciopercaENSSLUP0000005242663.802253.7375
ENSG00000114867homo_sapiensENSP0000031687976.485367.6048strigops_habroptilaENSSHBP0000501821176.966668.0302
ENSG00000114867homo_sapiensENSP0000031687967.917457.5985amphiprion_ocellarisENSAOCP0000000690468.647358.2174
ENSG00000114867homo_sapiensENSP0000031687979.23770.8568terrapene_carolina_triunguisENSTMTP0000001505578.793570.4602
ENSG00000114867homo_sapiensENSP0000031687926.766716.3227hucho_huchoENSHHUP0000003489447.450128.9357
ENSG00000114867homo_sapiensENSP000003168795.628522.75172hucho_huchoENSHHUP0000007655338.626618.8841
ENSG00000114867homo_sapiensENSP0000031687968.667957.0982betta_splendensENSBSLP0000004338163.911553.1432
ENSG00000114867homo_sapiensENSP0000031687931.20726.5791pygocentrus_nattereriENSPNAP0000003106578.213266.6144
ENSG00000114867homo_sapiensENSP0000031687970.356558.7867anabas_testudineusENSATEP0000001613566.924455.9191
ENSG00000114867homo_sapiensENSP0000031687971.482259.8499seriola_lalandi_dorsalisENSSLDP0000000883164.980154.4059
ENSG00000114867homo_sapiensENSP0000031687929.643524.828labrus_bergyltaENSLBEP0000002424077.832565.1888
ENSG00000114867homo_sapiensENSP0000031687966.541655.4722pundamilia_nyerereiENSPNYP0000001501263.750753.1456
ENSG00000114867homo_sapiensENSP0000031687968.918156.9731mastacembelus_armatusENSMAMP0000001862465.869754.4531
ENSG00000114867homo_sapiensENSP0000031687927.517223.6398stegastes_partitusENSSPAP0000002850680.882469.4853
ENSG00000114867homo_sapiensENSP0000031687915.00949.13071oncorhynchus_tshawytschaENSOTSP0000500595543.95626.7399
ENSG00000114867homo_sapiensENSP0000031687912.57047.75485oncorhynchus_tshawytschaENSOTSP0000504790143.040726.5525
ENSG00000114867homo_sapiensENSP0000031687923.264514.3215oncorhynchus_tshawytschaENSOTSP0000507754948.437529.8177
ENSG00000114867homo_sapiensENSP0000031687917.886214.4465oncorhynchus_tshawytschaENSOTSP0000509329680.79165.2542
ENSG00000114867homo_sapiensENSP0000031687969.355958.8493acanthochromis_polyacanthusENSAPOP0000003305466.1356.1121
ENSG00000114867homo_sapiensENSP0000031687973.983765.6035aquila_chrysaetos_chrysaetosENSACCP0002000483673.845265.4807
ENSG00000114867homo_sapiensENSP0000031687966.416554.7842nothobranchius_furzeriENSNFUP0001502608060.135949.6036
ENSG00000114867homo_sapiensENSP0000031687966.979454.0963cyprinodon_variegatusENSCVAP0000002191063.223151.0626
ENSG00000114867homo_sapiensENSP0000031687969.981259.2245denticeps_clupeoidesENSDCDP0000002537267.572557.186
ENSG00000114867homo_sapiensENSP0000031687922.764219.6373denticeps_clupeoidesENSDCDP0000002752381.614370.4036
ENSG00000114867homo_sapiensENSP0000031687971.169559.0369larimichthys_croceaENSLCRP0000506172166.510855.1724
ENSG00000114867homo_sapiensENSP0000031687969.60655.9725takifugu_rubripesENSTRUP0000007647364.223951.6445
ENSG00000114867homo_sapiensENSP0000031687978.173969.0432ficedula_albicollisENSFALP0000000843078.12569
ENSG00000114867homo_sapiensENSP0000031687966.979455.3471hippocampus_comesENSHCOP0000001086064.285753.1213
ENSG00000114867homo_sapiensENSP0000031687967.041956.4103cyprinus_carpio_carpioENSCCRP0000016259264.153253.9797
ENSG00000114867homo_sapiensENSP0000031687966.979456.9106cyprinus_carpio_carpioENSCCRP0000001169563.940354.3284
ENSG00000114867homo_sapiensENSP0000031687978.486669.4809coturnix_japonicaENSCJPP0000501676877.041168.2013
ENSG00000114867homo_sapiensENSP0000031687966.791754.5966poecilia_latipinnaENSPLAP0000003159363.458151.8717
ENSG00000114867homo_sapiensENSP0000031687929.330824.7655poecilia_latipinnaENSPLAP0000001794968.869358.1498
ENSG00000114867homo_sapiensENSP0000031687966.979456.4728sinocyclocheilus_grahamiENSSGRP0000008024166.72956.2617
ENSG00000114867homo_sapiensENSP0000031687963.352152.783sinocyclocheilus_grahamiENSSGRP0000002236462.569552.1309
ENSG00000114867homo_sapiensENSP0000031687966.35455.3471maylandia_zebraENSMZEP0000503403463.877253.2812
ENSG00000114867homo_sapiensENSP0000031687912.82059.31832tetraodon_nigroviridisENSTNIP0000001108367.880849.3377
ENSG00000114867homo_sapiensENSP0000031687970.669260.1626paramormyrops_kingsleyaeENSPKIP0000003402768.360658.1972
ENSG00000114867homo_sapiensENSP0000031687970.856860.2251scleropages_formosusENSSFOP0001502997268.459258.1873
ENSG00000114867homo_sapiensENSP0000031687971.607362.2889leptobrachium_leishanenseENSLLEP0000002530970.116360.992
ENSG00000114867homo_sapiensENSP0000031687969.668558.4115scophthalmus_maximusENSSMAP0000000031462.973452.7982
ENSG00000114867homo_sapiensENSP0000031687966.729255.9099oryzias_melastigmaENSOMEP0000003620864.045653.6615

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001662involved_in behavioral fear response1IEAHomo_sapiens(9606)Process
GO:0002191involved_in cap-dependent translational initiation1TASHomo_sapiens(9606)Process
GO:0003723enables RNA binding2HDA,TASHomo_sapiens(9606)Function
GO:0003729enables mRNA binding2IBA,IDAHomo_sapiens(9606)Function
GO:0003743enables translation initiation factor activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IDAHomo_sapiens(9606)Function
GO:0005634located_in nucleus2IDA,IMPHomo_sapiens(9606)Component
GO:0005737located_in cytoplasm2IDA,IMPHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005844part_of polysome1IMPHomo_sapiens(9606)Component
GO:0006412involved_in translation2IMP,IPIHomo_sapiens(9606)Process
GO:0006413involved_in translational initiation3IDA,NAS,TASHomo_sapiens(9606)Process
GO:0006446involved_in regulation of translational initiation2IMP,NASHomo_sapiens(9606)Process
GO:0008135enables translation factor activity, RNA binding1IMPHomo_sapiens(9606)Function
GO:0008190enables eukaryotic initiation factor 4E binding2IDA,TASHomo_sapiens(9606)Function
GO:0009059involved_in macromolecule biosynthetic process1IGIHomo_sapiens(9606)Process
GO:0010494located_in cytoplasmic stress granule1IDAHomo_sapiens(9606)Component
GO:0010507involved_in negative regulation of autophagy1IMPHomo_sapiens(9606)Process
GO:0010801involved_in negative regulation of peptidyl-threonine phosphorylation1IMPHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016281part_of eukaryotic translation initiation factor 4F complex3IBA,IDA,NASHomo_sapiens(9606)Component
GO:0030182involved_in neuron differentiation1IEAHomo_sapiens(9606)Process
GO:0030307involved_in positive regulation of cell growth1IMPHomo_sapiens(9606)Process
GO:0030324involved_in lung development1IEAHomo_sapiens(9606)Process
GO:0031369enables translation initiation factor binding1TASHomo_sapiens(9606)Function
GO:0031669involved_in cellular response to nutrient levels1IMPHomo_sapiens(9606)Process
GO:0033138involved_in positive regulation of peptidyl-serine phosphorylation1IMPHomo_sapiens(9606)Process
GO:0035278involved_in miRNA-mediated gene silencing by inhibition of translation1IDAHomo_sapiens(9606)Process
GO:0036493involved_in positive regulation of translation in response to endoplasmic reticulum stress1IMPHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0045471involved_in response to ethanol1IEAHomo_sapiens(9606)Process
GO:0045666involved_in positive regulation of neuron differentiation1IEAHomo_sapiens(9606)Process
GO:0051247involved_in positive regulation of protein metabolic process1IMPHomo_sapiens(9606)Process
GO:0060090enables molecular adaptor activity1TASHomo_sapiens(9606)Function
GO:0060964involved_in regulation of miRNA-mediated gene silencing1TASHomo_sapiens(9606)Process
GO:0080135involved_in regulation of cellular response to stress1TASHomo_sapiens(9606)Process
GO:0097009involved_in energy homeostasis1IMPHomo_sapiens(9606)Process
GO:0098794located_in postsynapse1IEAHomo_sapiens(9606)Component
GO:1900087involved_in positive regulation of G1/S transition of mitotic cell cycle1IMPHomo_sapiens(9606)Process
GO:1901215involved_in negative regulation of neuron death1TASHomo_sapiens(9606)Process
GO:1905537involved_in positive regulation of eukaryotic translation initiation factor 4F complex assembly1IMPHomo_sapiens(9606)Process
GO:1905606involved_in regulation of presynapse assembly1IGIHomo_sapiens(9606)Process
GO:1905612involved_in positive regulation of mRNA cap binding1IDAHomo_sapiens(9606)Process
GO:1905696involved_in regulation of polysome binding1IMPHomo_sapiens(9606)Process

Expression