Ensembl ID ENSG00000114867 Gene ID 1981 Accession 3296
Gene Symbol EIF4G1 Alias P220;EIF4F;EIF4G;EIF4GI;PARK18;EIF-4G1 Full Name eukaryotic translation initiation factor 4 gamma 1
Position 3 : 184314495 - 184335358 Length 20864 bases Strand Plus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a component of the multi-subunit protein complex EIF4F. This complex facilitates the recruitment of mRNA to the ribosome, which is a rate-limiting step during the initiation phase of protein synthesis. The recognition of the mRNA cap and the ATP-dependent unwinding of 5'-terminal secondary structure is catalyzed by factors in this complex. The subunit encoded by this gene is a large scaffolding protein that contains binding sites for other members of the EIF4F complex. A domain at its N-terminus can also interact with the poly(A)-binding protein, which may mediate the circularization of mRNA during translation. Alternative splicing results in multiple transcript variants, some of which are derived from alternative promoter usage. [provided by RefSeq, Aug 2010]

ENSG00000114867 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000114867 EIF4G1 0.47 3.10e-23 BRCA
ENSG00000114867 EIF4G1 1.24 8.85e-38 LUSC
ENSG00000114867 EIF4G1 0.39 3.05e-11 PRAD
ENSG00000114867 EIF4G1 0.81 1.52e-18 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000114867 EIF4G1 tumors 11857405
ENSG00000114867 EIF4G1 tumor 20398343
ENSG00000114867 EIF4G1 tumor 20517637
ENSG00000114867 EIF4G1 breast cancer 23112151
ENSG00000114867 EIF4G1 cervical cancer 24844222
ENSG00000114867 EIF4G1 breast cancer 25115391
ENSG00000114867 EIF4G1 tumor 25993439
ENSG00000114867 EIF4G1 tumor 26779407
ENSG00000114867 EIF4G1 tumor 27003362
ENSG00000114867 EIF4G1 lung cancer 27026610
ENSG00000114867 EIF4G1 breast cancer 27108909
ENSG00000114867 EIF4G1 cancers 27123489
ENSG00000114867 EIF4G1 Ovarian Cancer 27668427
ENSG00000114867 EIF4G1 tumor 27714564
ENSG00000114867 EIF4G1 tumor 28903455
ENSG00000114867 EIF4G1 Tumor 29383199
ENSG00000114867 EIF4G1 tumor 29717265
ENSG00000114867 EIF4G1 tumor 29748619
ENSG00000114867 EIF4G1 AML 29781401
ENSG00000114867 EIF4G1 Cancer 30970654
ENSG00000114867 EIF4G1 tumor 31043796
ENSG00000114867 EIF4G1 cancer 31427592
ENSG00000114867 EIF4G1 cancer 31496918
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000114867 EIF4G1 MESO 0.0063 high
ENSG00000114867 EIF4G1 UVM 0.00086 low
ENSG00000114867 EIF4G1 PAAD 0.00048 high
ENSG00000114867 EIF4G1 UCEC 0.034 high
ENSG00000114867 EIF4G1 LUSC 0.017 low
ENSG00000114867 EIF4G1 HNSC 0.0019 high
ENSG00000114867 EIF4G1 READ 0.032 low
ENSG00000114867 EIF4G1 KIRP 0.00034 high
ENSG00000114867 EIF4G1 KICH 0.021 high
ENSG00000114867 EIF4G1 BRCA 0.0095 high
ENSG00000114867 EIF4G1 COAD 0.021 high
ENSG00000114867 EIF4G1 ESCA 0.043 low
ENSG00000114867 EIF4G1 PRAD 0.0045 low
ENSG00000114867 EIF4G1 BLCA 0.0035 high
ENSG00000114867 EIF4G1 LAML 0.008 high
ENSG00000114867 EIF4G1 SKCM 0.0014 high
ENSG00000114867 EIF4G1 CESC 0.035 low
ENSG00000114867 EIF4G1 LIHC 0.00067 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000114867 EIF4G1 LUSC Amp 166.176630 1.891116 1.359047 0.896208
ENSG00000114867 EIF4G1 LUAD Amp 2.100166 0.151547 0.455210 0.277132
ENSG00000114867 EIF4G1 LGG Amp 1.705683 0.058623 0.824699 0.037037
ENSG00000114867 EIF4G1 CESC Amp 25.551679 0.635632 1.058405 0.749153
ENSG00000114867 EIF4G1 UCS Amp 2.173603 0.715627 0.958897 0.607143
ENSG00000114867 EIF4G1 GBM Amp 11.070407 0.205844 0.670959 0.181976
ENSG00000114867 EIF4G1 ESCA Amp 11.350160 0.713001 0.871047 0.652174
ENSG00000114867 EIF4G1 HNSC Amp 46.679726 0.668711 0.822697 0.722222
ENSG00000114867 EIF4G1 LIHC Amp 0.629998 0.109628 0.498525 0.164865
ENSG00000114867 EIF4G1 PCPG Del 2.602850 0.095567 0.639075 0.580247
ENSG00000114867 EIF4G1 TGCT Amp 3.115907 0.223405 0.539658 0.320000
ENSG00000114867 EIF4G1 BLCA Amp 1.131626 0.180296 0.492112 0.534314
ENSG00000114867 EIF4G1 BRCA Amp 3.800759 0.196379 0.540902 0.292593
ENSG00000114867 EIF4G1 STAD Amp 5.045378 0.238407 0.497015 0.349206
ENSG00000114867 EIF4G1 UCEC Amp 20.759676 0.360093 0.825764 0.283859
ENSG00000114867 EIF4G1 KIRC Amp 1.404341 0.042058 0.388029 0.159091
ENSG00000114867 EIF4G1 UVM Del 0.709713 0.058192 0.806385 0.550000
ENSG00000114867 EIF4G1 OV Amp 59.150038 1.129449 1.001184 0.766839