Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs diverse
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq DataSet_02_85

Description

Ensembl ID ENSG00000114127 Gene ID 54464 Accession 30654
Symbol XRN1 Alias SEP1 Full Name 5'-3' exoribonuclease 1
Status Confidence Length 141456 bases Strand Minus strand
Position 3 : 142306607 - 142448062 RNA binding domain SH3_12 , XRN_N , XRN1_D1
Summary This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000419683 SH3_12 PF18129 1.8e-18 1
ENSP00000419683 XRN1_D1 PF18332 2.5e-33 2
ENSP00000376707 SH3_12 PF18129 3.3e-18 1
ENSP00000376707 XRN1_D1 PF18332 1.3e-33 2
ENSP00000376707 XRN_N PF03159 3.9e-93 3
ENSP00000264951 SH3_12 PF18129 3.4e-18 1
ENSP00000264951 XRN1_D1 PF18332 1.3e-33 2
ENSP00000264951 XRN_N PF03159 1.5e-93 3
ENSP00000418404 XRN_N PF03159 1.8e-94 1
ENSP00000420786 XRN_N PF03159 3.8e-42 1
ENSP00000420634 XRN_N PF03159 1.9e-36 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
32518284 EXOSC9 depletion attenuates P-body formation, stress resistance, and tumorigenicity of cancer cells. Seiko Yoshino 2020-06-09 Scientific reports
35193946 Minding the message: tactics controlling RNA decay, modification, and translation in virus-infected cells. M Hannah Burgess 2022-02-01 Genes & development
24473339 Noncoding subgenomic flavivirus RNA: multiple functions in West Nile virus pathogenesis and modulation of host responses. A Justin Roby 2014-01-27 Viruses
27334583 Opposing Roles of Double-Stranded RNA Effector Pathways and Viral Defense Proteins Revealed with CRISPR-Cas9 Knockout Cell Lines and Vaccinia Virus Mutants. Ruikang Liu 2016-09-01 Journal of virology
35904778 Identification of a novel deFADding activity in human, yeast and bacterial 5' to 3' exoribonucleases. Sunny Sharma 2022-08-26 Nucleic acids research
27074834 Tristetraprolin inhibits gastric cancer progression through suppression of IL-33. Kaiyuan Deng 2016-04-14 Scientific reports
34266995 Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identify disease-relevant transcripts containing G-rich motifs. L Amy Pashler 2021-10-01 RNA (New York, N.Y.)
34085923 Cytoplasmic mRNA decay represses RNA polymerase II transcription during early apoptosis. Christopher Duncan-Lewis 2021-06-04 eLife
32032393 RNA decay during gammaherpesvirus infection reduces RNA polymerase II occupancy of host promoters but spares viral promoters. Ella Hartenian 2020-02-01 PLoS pathogens
30252202 A recap of RNA recapping. B Jackson Trotman 2019-01-01 Wiley interdisciplinary reviews. RNA
25818028 Nuclear proteins hijacked by mammalian cytoplasmic plus strand RNA viruses. E Richard Lloyd 2015-05-01 Virology
30916337 Integrative transcriptomic analysis suggests new autoregulatory splicing events coupled with nonsense-mediated mRNA decay. Dmitri Pervouchine 2019-06-04 Nucleic acids research
32034313 Spatio-temporal characterization of the antiviral activity of the XRN1-DCP1/2 aggregation against cytoplasmic RNA viruses to prevent cell death. Seng Chen Ng 2020-08-01 Cell death and differentiation
26368052 Standing your ground to exoribonucleases: Function of Flavivirus long non-coding RNAs. A Phillida Charley 2016-01-02 Virus research
34741027 Pseudoknot length modulates the folding, conformational dynamics, and robustness of Xrn1 resistance of flaviviral xrRNAs. Xiaolin Niu 2021-11-05 Nature communications

Transcripts

Name Transcript ID bp Protein Translation ID
XRN1-201 ENST00000264951 10143 1706aa ENSP00000264951
XRN1-214 ENST00000498077 5600 1160aa ENSP00000419683
XRN1-202 ENST00000392981 10079 1694aa ENSP00000376707
XRN1-213 ENST00000489241 393 63aa ENSP00000419219
XRN1-207 ENST00000468894 318 No protein -
XRN1-206 ENST00000467077 674 No protein -
XRN1-209 ENST00000472625 420 No protein -
XRN1-210 ENST00000472697 2652 No protein -
XRN1-205 ENST00000465507 322 No protein -
XRN1-203 ENST00000463916 2075 459aa ENSP00000418404
XRN1-212 ENST00000486211 1180 107aa ENSP00000420786
XRN1-211 ENST00000477237 686 165aa ENSP00000420634
XRN1-208 ENST00000470537 669 No protein -
XRN1-204 ENST00000465074 643 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
39954Platelet Function Tests1.7736100E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000114127homo_sapiensENSP0000036639649.789534.7368homo_sapiensENSP0000037670727.922119.4805

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000114127homo_sapiensENSP0000037670799.055598.17nomascus_leucogenysENSNLEP0000000580198.358797.4795
ENSG00000114127homo_sapiensENSP0000037670799.468799.2326pan_paniscusENSPPAP0000000237998.769198.5346
ENSG00000114127homo_sapiensENSP0000037670799.055598.2881pongo_abeliiENSPPYP0000001585198.358797.5967
ENSG00000114127homo_sapiensENSP0000037670799.527799.2326pan_troglodytesENSPTRP0000002665498.827798.5346
ENSG00000114127homo_sapiensENSP0000037670799.409799.0555gorilla_gorillaENSGGOP0000003590098.652698.3011
ENSG00000114127homo_sapiensENSP0000037670786.009478.4534ornithorhynchus_anatinusENSOANP0000003740184.268476.8652
ENSG00000114127homo_sapiensENSP0000037670788.783982.0543sarcophilus_harrisiiENSSHAP0000001909184.63778.2217
ENSG00000114127homo_sapiensENSP0000037670760.920955.9622notamacropus_eugeniiENSMEUP0000001324560.813255.8633
ENSG00000114127homo_sapiensENSP0000037670751.121648.6423choloepus_hoffmanniENSCHOP0000001237151.949649.4301
ENSG00000114127homo_sapiensENSP0000037670763.636461.157dasypus_novemcinctusENSDNOP0000001925391.744788.1702
ENSG00000114127homo_sapiensENSP000003767076.021255.96222dasypus_novemcinctusENSDNOP0000002032799.029198.0583
ENSG00000114127homo_sapiensENSP000003767077.733187.20189dasypus_novemcinctusENSDNOP0000002093295.620489.0511
ENSG00000114127homo_sapiensENSP0000037670775.206671.3695erinaceus_europaeusENSEEUP0000001042275.073771.2434
ENSG00000114127homo_sapiensENSP0000037670773.671870.2479echinops_telfairiENSETEP0000000326774.241570.7912
ENSG00000114127homo_sapiensENSP0000037670797.933996.281callithrix_jacchusENSCJAP0000008271495.126193.5206
ENSG00000114127homo_sapiensENSP0000037670798.819497.5797cercocebus_atysENSCATP0000003820598.066896.8366
ENSG00000114127homo_sapiensENSP0000037670798.878497.5797macaca_fascicularisENSMFAP0000001922698.125496.8366
ENSG00000114127homo_sapiensENSP0000037670798.878497.6387macaca_mulattaENSMMUP0000003854698.125496.8951
ENSG00000114127homo_sapiensENSP0000037670798.760397.4616macaca_nemestrinaENSMNEP0000002087498.008296.7194
ENSG00000114127homo_sapiensENSP0000037670798.819497.5207papio_anubisENSPANP0000000548598.066896.778
ENSG00000114127homo_sapiensENSP0000037670726.859526.5643mandrillus_leucophaeusENSMLEP0000003438699.128598.0392
ENSG00000114127homo_sapiensENSP0000037670765.112264.2267mandrillus_leucophaeusENSMLEP0000001438797.180695.859
ENSG00000114127homo_sapiensENSP0000037670791.617588.6659tursiops_truncatusENSTTRP0000001225591.294188.3529
ENSG00000114127homo_sapiensENSP0000037670796.399193.8017vulpes_vulpesENSVVUP0000003639294.338591.7966
ENSG00000114127homo_sapiensENSP0000037670793.034288.1346mus_spretusMGP_SPRETEiJ_P009280991.468486.6512
ENSG00000114127homo_sapiensENSP0000037670794.45191.4404equus_asinusENSEASP0000500468693.62290.6378
ENSG00000114127homo_sapiensENSP0000037670795.454591.8536capra_hircusENSCHIP0000002062294.175990.6232
ENSG00000114127homo_sapiensENSP0000037670761.983560.5667loxodonta_africanaENSLAFP0000001293398.406796.1574
ENSG00000114127homo_sapiensENSP0000037670791.381388.5478panthera_leoENSPLOP0000002090195.673792.707
ENSG00000114127homo_sapiensENSP0000037670794.569192.0897ailuropoda_melanoleucaENSAMEP0000003654795.985693.4691
ENSG00000114127homo_sapiensENSP0000037670795.749791.9126bos_indicus_hybridENSBIXP0000502811093.218489.4828
ENSG00000114127homo_sapiensENSP0000037670795.218492.0307oryctolagus_cuniculusENSOCUP0000000160894.770991.5981
ENSG00000114127homo_sapiensENSP0000037670794.569191.3223equus_caballusENSECAP0000005282794.569191.3223
ENSG00000114127homo_sapiensENSP0000037670796.103993.6246canis_lupus_familiarisENSCAFP0084503967594.21391.7824
ENSG00000114127homo_sapiensENSP0000037670796.399193.3884panthera_pardusENSPPRP0000001403196.342293.3333
ENSG00000114127homo_sapiensENSP0000037670793.152390.4959marmota_marmota_marmotaENSMMMP0000001972094.040591.3588
ENSG00000114127homo_sapiensENSP0000037670796.044992.9162balaenoptera_musculusENSBMSP0001000381095.593492.4794
ENSG00000114127homo_sapiensENSP000003767076.080286.08028cavia_porcellusENSCPOP00000023532100100
ENSG00000114127homo_sapiensENSP0000037670774.970570.7792cavia_porcellusENSCPOP0000000312391.630686.5079
ENSG00000114127homo_sapiensENSP0000037670796.458193.5065felis_catusENSFCAP0000004786695.723592.7944
ENSG00000114127homo_sapiensENSP0000037670795.277592.3849ursus_americanusENSUAMP0000000704294.001291.1473
ENSG00000114127homo_sapiensENSP0000037670789.610482.7037monodelphis_domesticaENSMODP0000002654188.875982.0258
ENSG00000114127homo_sapiensENSP0000037670795.631691.7355bison_bison_bisonENSBBBP0000000870295.238191.358
ENSG00000114127homo_sapiensENSP0000037670796.103993.0933monodon_monocerosENSMMNP0001500155495.652292.6557
ENSG00000114127homo_sapiensENSP0000037670796.044992.8571sus_scrofaENSSSCP0000006702495.537392.3664
ENSG00000114127homo_sapiensENSP0000037670797.107494.1558microcebus_murinusENSMICP0000005076396.198893.2749
ENSG00000114127homo_sapiensENSP000003767076.080286.08028octodon_degusENSODEP00000011860100100
ENSG00000114127homo_sapiensENSP0000037670791.440487.1901jaculus_jaculusENSJJAP0000000622690.373486.1727
ENSG00000114127homo_sapiensENSP0000037670795.867892.2668ovis_aries_rambouilletENSOARP0002000921093.38789.8792
ENSG00000114127homo_sapiensENSP0000037670796.871394.3329ursus_maritimusENSUMAP0000001856094.040191.5759
ENSG00000114127homo_sapiensENSP0000037670763.282260.3306ochotona_princepsENSOPRP0000000674763.319560.3662
ENSG00000114127homo_sapiensENSP0000037670796.22293.2113delphinapterus_leucasENSDLEP0000000356695.489292.5015
ENSG00000114127homo_sapiensENSP0000037670795.926892.8571physeter_catodonENSPCTP0000500014195.53292.475
ENSG00000114127homo_sapiensENSP0000037670788.370783.8253mus_caroliMGP_CAROLIEiJ_P008911391.00386.3222
ENSG00000114127homo_sapiensENSP0000037670793.211388.1346mus_musculusENSMUSP0000003498191.642586.6512
ENSG00000114127homo_sapiensENSP0000037670793.329488.3707dipodomys_ordiiENSDORP0000001301292.945388.0071
ENSG00000114127homo_sapiensENSP0000037670796.103993.1523mustela_putorius_furoENSMPUP0000001194895.427992.4971
ENSG00000114127homo_sapiensENSP0000037670798.288196.4581aotus_nancymaaeENSANAP0000002294997.539595.7235
ENSG00000114127homo_sapiensENSP0000037670797.874995.9858saimiri_boliviensis_boliviensisENSSBOP0000002646697.186495.3107
ENSG00000114127homo_sapiensENSP0000037670793.270490.3188vicugna_pacosENSVPAP0000000435193.105590.1591
ENSG00000114127homo_sapiensENSP0000037670798.819497.5797chlorocebus_sabaeusENSCSAP0000000747298.066896.8366
ENSG00000114127homo_sapiensENSP0000037670775.619873.4357tupaia_belangeriENSTBEP0000000286978.252975.9927
ENSG00000114127homo_sapiensENSP000003767076.257386.13932mesocricetus_auratusENSMAUP0000001452910098.1132
ENSG00000114127homo_sapiensENSP0000037670795.985892.9162phocoena_sinusENSPSNP0000001193095.534792.4794
ENSG00000114127homo_sapiensENSP0000037670796.162993.0933camelus_dromedariusENSCDRP0000501407993.566990.5801
ENSG00000114127homo_sapiensENSP0000037670796.871393.9197carlito_syrichtaENSTSYP0000000250096.814293.8643
ENSG00000114127homo_sapiensENSP0000037670796.399193.4475panthera_tigris_altaicaENSPTIP0000002526396.342293.3923
ENSG00000114127homo_sapiensENSP0000037670793.919788.7249rattus_norvegicusENSRNOP0000001448192.338987.2316
ENSG00000114127homo_sapiensENSP0000037670797.225594.0968prolemur_simusENSPSMP0000000991096.428693.3255
ENSG00000114127homo_sapiensENSP0000037670755.253853.778microtus_ochrogasterENSMOCP0000000865296.794294.2089
ENSG00000114127homo_sapiensENSP0000037670757.556154.6635sorex_araneusENSSARP0000000704171.796868.1885
ENSG00000114127homo_sapiensENSP0000037670794.155889.5514peromyscus_maniculatus_bairdiiENSPEMP0000003722892.356787.8402
ENSG00000114127homo_sapiensENSP0000037670795.690791.7946bos_mutusENSBMUP0000002743493.160989.3678
ENSG00000114127homo_sapiensENSP0000037670792.916287.9575mus_spicilegusENSMSIP0000001899591.564986.6783
ENSG00000114127homo_sapiensENSP0000037670793.978889.5514cricetulus_griseus_chok1gshdENSCGRP0000102023292.236487.8911
ENSG00000114127homo_sapiensENSP0000037670785.24282.5266pteropus_vampyrusENSPVAP0000001534984.741882.0423
ENSG00000114127homo_sapiensENSP0000037670794.628190.9681myotis_lucifugusENSMLUP0000001540592.981489.3851
ENSG00000114127homo_sapiensENSP0000037670788.783981.9953vombatus_ursinusENSVURP0001001296686.139779.5533
ENSG00000114127homo_sapiensENSP0000037670792.266888.3117rhinolophus_ferrumequinumENSRFEP0001000747494.498290.4474
ENSG00000114127homo_sapiensENSP0000037670796.162993.4475neovison_visonENSNVIP0000001731295.486592.7902
ENSG00000114127homo_sapiensENSP0000037670795.749791.9126bos_taurusENSBTAP0000001531895.243791.4269
ENSG00000114127homo_sapiensENSP0000037670794.864291.2633heterocephalus_glaber_femaleENSHGLP0000002023693.375989.8315
ENSG00000114127homo_sapiensENSP0000037670798.11196.8713rhinopithecus_bietiENSRBIP0000003560297.47896.2463
ENSG00000114127homo_sapiensENSP0000037670796.28193.7426canis_lupus_dingoENSCAFP0002001140294.277591.7919
ENSG00000114127homo_sapiensENSP0000037670795.690792.2078sciurus_vulgarisENSSVLP0000501136295.129191.6667
ENSG00000114127homo_sapiensENSP0000037670725.619824.2031phascolarctos_cinereusENSPCIP0000003977896.444491.1111
ENSG00000114127homo_sapiensENSP0000037670777.331873.7308procavia_capensisENSPCAP0000000552385.509181.5274
ENSG00000114127homo_sapiensENSP0000037670754.014252.7155nannospalax_galiliENSNGAP0000002626697.652195.3042
ENSG00000114127homo_sapiensENSP0000037670795.572691.6765bos_grunniensENSBGRP0000000149295.179391.2992
ENSG00000114127homo_sapiensENSP0000037670794.037889.7875chinchilla_lanigeraENSCLAP0000000198092.294388.1228
ENSG00000114127homo_sapiensENSP0000037670795.572691.6175cervus_hanglu_yarkandensisENSCHYP0000003579895.179391.2404
ENSG00000114127homo_sapiensENSP0000037670795.808792.3259catagonus_wagneriENSCWAP0000001671295.302491.8379
ENSG00000114127homo_sapiensENSP0000037670796.103993.4475ictidomys_tridecemlineatusENSSTOP0000001215694.049791.45
ENSG00000114127homo_sapiensENSP0000037670794.864290.9681otolemur_garnettiiENSOGAP0000000015194.19790.3283
ENSG00000114127homo_sapiensENSP0000037670798.22996.6352cebus_imitatorENSCCAP0000003367297.48195.8992
ENSG00000114127homo_sapiensENSP0000037670796.044993.0933urocitellus_parryiiENSUPAP0001001034793.991991.1034
ENSG00000114127homo_sapiensENSP0000037670795.749792.0307moschus_moschiferusENSMMSP0000000808091.174887.6335
ENSG00000114127homo_sapiensENSP0000037670726.859526.6234rhinopithecus_roxellanaENSRROP0000001952699.128598.2571
ENSG00000114127homo_sapiensENSP0000037670752.833552.1251rhinopithecus_roxellanaENSRROP0000004205196.652395.3564
ENSG00000114127homo_sapiensENSP0000037670793.093388.0165mus_pahariMGP_PahariEiJ_P002477791.792886.787
ENSG00000114127homo_sapiensENSP0000037670797.284594.451propithecus_coquereliENSPCOP0000000475196.600293.7866
ENSG00000114127homo_sapiensENSP0000037670748.760333.412caenorhabditis_elegansY39G8C.1.151.91735.5751
ENSG00000114127homo_sapiensENSP0000037670748.878433.353drosophila_melanogasterFBpp029129251.332935.0279
ENSG00000114127homo_sapiensENSP000003767075.489963.65998ciona_intestinalisENSCINP0000003452662.416141.6107
ENSG00000114127homo_sapiensENSP0000037670721.015316.1747ciona_intestinalisENSCINP0000000260470.634954.3651
ENSG00000114127homo_sapiensENSP0000037670745.513636.6588petromyzon_marinusENSPMAP0000000325066.237153.3505
ENSG00000114127homo_sapiensENSP0000037670739.492328.1582eptatretus_burgeriENSEBUP0000001294052.718737.5887
ENSG00000114127homo_sapiensENSP0000037670769.185457.0838callorhinchus_miliiENSCMIP0000001440169.431357.2867
ENSG00000114127homo_sapiensENSP0000037670782.467571.9599latimeria_chalumnaeENSLACP0000001023980.42670.1785
ENSG00000114127homo_sapiensENSP0000037670777.449865.5844lepisosteus_oculatusENSLOCP0000000965473.998962.6622
ENSG00000114127homo_sapiensENSP0000037670773.671862.1606clupea_harengusENSCHAP0000003294573.411861.9412
ENSG00000114127homo_sapiensENSP0000037670775.088563.9315danio_rerioENSDARP0000010548774.955863.8185
ENSG00000114127homo_sapiensENSP0000037670775.560864.1086carassius_auratusENSCARP0000002012975.516264.0708
ENSG00000114127homo_sapiensENSP0000037670775.029563.5773carassius_auratusENSCARP0000003305174.985363.5398
ENSG00000114127homo_sapiensENSP0000037670771.251561.039astyanax_mexicanusENSAMXP0000001995373.151562.6667
ENSG00000114127homo_sapiensENSP0000037670773.317662.3377ictalurus_punctatusENSIPUP0000002254874.594663.4234
ENSG00000114127homo_sapiensENSP0000037670773.966962.3377esox_luciusENSELUP0000006812772.302460.9348
ENSG00000114127homo_sapiensENSP0000037670773.730862.3377electrophorus_electricusENSEEEP0000003304273.949162.5222
ENSG00000114127homo_sapiensENSP0000037670773.199560.9209oncorhynchus_kisutchENSOKIP0000507810673.156360.885
ENSG00000114127homo_sapiensENSP0000037670771.782860.2715oncorhynchus_kisutchENSOKIP0000509982873.786461.9539
ENSG00000114127homo_sapiensENSP0000037670772.25559.7403oncorhynchus_mykissENSOMYP0000001017172.127359.6347
ENSG00000114127homo_sapiensENSP0000037670768.59555.3719oncorhynchus_mykissENSOMYP0000001035540.459632.6602
ENSG00000114127homo_sapiensENSP0000037670773.730861.7473salmo_salarENSSSAP0000013772673.427461.4932
ENSG00000114127homo_sapiensENSP0000037670773.140560.8619salmo_salarENSSSAP0000010564372.968260.7185
ENSG00000114127homo_sapiensENSP0000037670773.317661.098salmo_truttaENSSTUP0000010670473.360961.1341
ENSG00000114127homo_sapiensENSP0000037670773.022460.9799salmo_truttaENSSTUP0000009591174.249762.0048
ENSG00000114127homo_sapiensENSP0000037670769.539657.32gadus_morhuaENSGMOP0000005672670.454558.0742
ENSG00000114127homo_sapiensENSP000003767076.021255.78512fundulus_heteroclitusENSFHEP0000001561499.029195.1456
ENSG00000114127homo_sapiensENSP0000037670723.317620.6612fundulus_heteroclitusENSFHEP0000001562186.433376.5864
ENSG00000114127homo_sapiensENSP0000037670773.789861.7473poecilia_reticulataENSPREP0000003126173.313861.349
ENSG00000114127homo_sapiensENSP0000037670770.484159.9764xiphophorus_maculatusENSXMAP0000001837876.587665.17
ENSG00000114127homo_sapiensENSP0000037670773.199561.8064oryzias_latipesENSORLP0000004051671.634960.4853
ENSG00000114127homo_sapiensENSP0000037670772.786360.3896cyclopterus_lumpusENSCLMP0000504722272.401660.0705
ENSG00000114127homo_sapiensENSP0000037670773.730861.7473oreochromis_niloticusENSONIP0000003680073.169361.2771
ENSG00000114127homo_sapiensENSP0000037670772.491160.1535haplochromis_burtoniENSHBUP0000000424873.621161.0911
ENSG00000114127homo_sapiensENSP0000037670773.848961.2751astatotilapia_callipteraENSACLP0000000712773.329460.8441
ENSG00000114127homo_sapiensENSP0000037670771.723759.209sparus_aurataENSSAUP0001003901172.754560.0599
ENSG00000114127homo_sapiensENSP0000037670771.251560.2125lates_calcariferENSLCAP0001000373277.471165.4686
ENSG00000114127homo_sapiensENSP0000037670722.19618.8312sphenodon_punctatusENSSPUP0000001406262.354952.9022
ENSG00000114127homo_sapiensENSP000003767076.021255.84416sphenodon_punctatusENSSPUP0000001394499.029196.1165
ENSG00000114127homo_sapiensENSP0000037670726.859524.3802sphenodon_punctatusENSSPUP0000001404090.457382.1074
ENSG00000114127homo_sapiensENSP0000037670727.331825.5018sphenodon_punctatusENSSPUP0000001402891.321585.2071
ENSG00000114127homo_sapiensENSP0000037670787.07278.2172crocodylus_porosusENSCPRP0000500236185.358876.6782
ENSG00000114127homo_sapiensENSP0000037670762.92857.0248laticauda_laticaudataENSLLTP0000001628288.24579.9669
ENSG00000114127homo_sapiensENSP0000037670777.922169.7757notechis_scutatusENSNSUP0000002517380.389871.9854
ENSG00000114127homo_sapiensENSP0000037670783.116974.085pseudonaja_textilisENSPTXP0000000567379.323970.7042
ENSG00000114127homo_sapiensENSP0000037670761.393257.0248anas_platyrhynchos_platyrhynchosENSAPLP0000000448190.277883.8542
ENSG00000114127homo_sapiensENSP0000037670782.054374.8524gallus_gallusENSGALP0001002184978.531171.6384
ENSG00000114127homo_sapiensENSP0000037670777.68669.4215meleagris_gallopavoENSMGAP0000000637982.767373.9623
ENSG00000114127homo_sapiensENSP0000037670784.238576.4463serinus_canariaENSSCAP0000000096780.439772.9989
ENSG00000114127homo_sapiensENSP0000037670782.290474.2031parus_majorENSPMJP0000002538283.975975.7229
ENSG00000114127homo_sapiensENSP0000037670784.592775.7379anolis_carolinensisENSACAP0000000490581.006272.5268
ENSG00000114127homo_sapiensENSP000003767075.962225.78512neolamprologus_brichardiENSNBRP0000000185197.115494.2308
ENSG00000114127homo_sapiensENSP0000037670716.410914.1086neolamprologus_brichardiENSNBRP0000000187085.538573.5385
ENSG00000114127homo_sapiensENSP000003767076.139325.90319naja_najaENSNNAP0000001739798.113294.3396
ENSG00000114127homo_sapiensENSP0000037670772.491163.9906naja_najaENSNNAP0000001722277.038968.005
ENSG00000114127homo_sapiensENSP0000037670785.005976.8005podarcis_muralisENSPMRP0000001245281.44873.586
ENSG00000114127homo_sapiensENSP0000037670781.641173.9669geospiza_fortisENSGFOP0000001149484.483876.5425
ENSG00000114127homo_sapiensENSP0000037670781.995374.7934taeniopygia_guttataENSTGUP0000000877978.563371.6629
ENSG00000114127homo_sapiensENSP0000037670778.394365.8205erpetoichthys_calabaricusENSECRP0000002072675.454563.3523
ENSG00000114127homo_sapiensENSP0000037670771.015458.9138kryptolebias_marmoratusENSKMAP0000002892073.803761.227
ENSG00000114127homo_sapiensENSP0000037670784.710776.1511salvator_merianaeENSSMRP0000002108181.395373.1707
ENSG00000114127homo_sapiensENSP0000037670769.893758.8548oryzias_javanicusENSOJAP0000004343073.815562.1571
ENSG00000114127homo_sapiensENSP0000037670772.963461.039amphilophus_citrinellusENSACIP0000000161574.682862.4773
ENSG00000114127homo_sapiensENSP0000037670774.321161.8064dicentrarchus_labraxENSDLAP0000507752674.102461.6245
ENSG00000114127homo_sapiensENSP0000037670774.675362.0425amphiprion_perculaENSAPEP0000000924873.67561.2114
ENSG00000114127homo_sapiensENSP0000037670766.58855.7261oryzias_sinensisENSOSIP0000001853471.347359.709
ENSG00000114127homo_sapiensENSP0000037670787.721479.0437pelodiscus_sinensisENSPSIP0000002040785.060176.6457
ENSG00000114127homo_sapiensENSP0000037670787.957579.3979gopherus_evgoodeiENSGEVP0000501286483.849275.6894
ENSG00000114127homo_sapiensENSP0000037670786.127577.9221chelonoidis_abingdoniiENSCABP0000001130386.382578.1528
ENSG00000114127homo_sapiensENSP0000037670770.129958.7367seriola_dumeriliENSSDUP0000001424775.765363.4566
ENSG00000114127homo_sapiensENSP0000037670772.491160.6257cottoperca_gobioENSCGOP0000005374275.383763.0448
ENSG00000114127homo_sapiensENSP0000037670785.419177.0366struthio_camelus_australisENSSCUP0000001986583.160975
ENSG00000114127homo_sapiensENSP0000037670780.932774.2621anser_brachyrhynchusENSABRP0000001274082.14575.3745
ENSG00000114127homo_sapiensENSP0000037670772.491160.7438gasterosteus_aculeatusENSGACP0000001891471.395359.8256
ENSG00000114127homo_sapiensENSP0000037670767.709656.9067cynoglossus_semilaevisENSCSEP0000003315670.8959.5797
ENSG00000114127homo_sapiensENSP0000037670769.480558.8548poecilia_formosaENSPFOP0000001430075.642764.0745
ENSG00000114127homo_sapiensENSP000003767076.021255.84416myripristis_murdjanENSMMDP0000501433999.029196.1165
ENSG00000114127homo_sapiensENSP0000037670726.387223.0815myripristis_murdjanENSMMDP0000501433487.992176.9685
ENSG00000114127homo_sapiensENSP0000037670773.317661.3341sander_luciopercaENSSLUP0000003831072.759260.867
ENSG00000114127homo_sapiensENSP0000037670782.290474.8524strigops_habroptilaENSSHBP0000502272781.615974.2389
ENSG00000114127homo_sapiensENSP0000037670773.494761.3341amphiprion_ocellarisENSAOCP0000000960774.01961.7717
ENSG00000114127homo_sapiensENSP0000037670787.780479.8111terrapene_carolina_triunguisENSTMTP0000002726483.680476.0833
ENSG00000114127homo_sapiensENSP0000037670768.299957.379hucho_huchoENSHHUP0000006635777.391365.0167
ENSG00000114127homo_sapiensENSP0000037670767.768657.2019hucho_huchoENSHHUP0000005645976.892264.9029
ENSG00000114127homo_sapiensENSP0000037670773.258661.2751betta_splendensENSBSLP0000003306372.871460.9513
ENSG00000114127homo_sapiensENSP0000037670773.258660.8028pygocentrus_nattereriENSPNAP0000001677974.045361.4558
ENSG00000114127homo_sapiensENSP0000037670773.081560.8028anabas_testudineusENSATEP0000004391772.4460.2692
ENSG00000114127homo_sapiensENSP0000037670746.162934.2975ciona_savignyiENSCSAVP0000001469062.014346.0745
ENSG00000114127homo_sapiensENSP0000037670745.631629.2208saccharomyces_cerevisiaeYGL173C50.58932.3953
ENSG00000114127homo_sapiensENSP0000037670772.963460.6848seriola_lalandi_dorsalisENSSLDP0000002803674.727962.1524
ENSG00000114127homo_sapiensENSP0000037670773.140561.4522labrus_bergyltaENSLBEP0000002455174.864162.9003
ENSG00000114127homo_sapiensENSP0000037670773.258660.8619pundamilia_nyerereiENSPNYP0000001419973.388560.9698
ENSG00000114127homo_sapiensENSP0000037670770.543159.4451mastacembelus_armatusENSMAMP0000002000276.848964.7588
ENSG00000114127homo_sapiensENSP0000037670727.390823.8489stegastes_partitusENSSPAP0000001315582.562371.8861
ENSG00000114127homo_sapiensENSP0000037670763.754451.889oncorhynchus_tshawytschaENSOTSP0000509843764.477652.4776
ENSG00000114127homo_sapiensENSP0000037670773.022460.7438oncorhynchus_tshawytschaENSOTSP0000508495173.325460.9958
ENSG00000114127homo_sapiensENSP0000037670772.550260.7438acanthochromis_polyacanthusENSAPOP0000003319676.812564.3125
ENSG00000114127homo_sapiensENSP0000037670782.290475.0885aquila_chrysaetos_chrysaetosENSACCP0002000655278.757171.8644
ENSG00000114127homo_sapiensENSP0000037670773.435761.5702nothobranchius_furzeriENSNFUP0001503567872.876461.1013
ENSG00000114127homo_sapiensENSP0000037670755.312948.3471cyprinodon_variegatusENSCVAP0000001084585.884575.0687
ENSG00000114127homo_sapiensENSP0000037670774.321162.6328denticeps_clupeoidesENSDCDP0000002704274.940563.1548
ENSG00000114127homo_sapiensENSP0000037670773.730861.157larimichthys_croceaENSLCRP0000504774273.513860.977
ENSG00000114127homo_sapiensENSP0000037670771.841859.327takifugu_rubripesENSTRUP0000008431272.268459.6793
ENSG00000114127homo_sapiensENSP0000037670781.46474.6163ficedula_albicollisENSFALP0000002769481.947775.0594
ENSG00000114127homo_sapiensENSP000003767076.552546.25738hippocampus_comesENSHCOP0000001122196.521792.1739
ENSG00000114127homo_sapiensENSP0000037670773.553762.6919cyprinus_carpio_carpioENSCCRP0000013740473.815262.9147
ENSG00000114127homo_sapiensENSP0000037670775.206664.1086cyprinus_carpio_carpioENSCCRP0000016756575.073763.9953
ENSG00000114127homo_sapiensENSP0000037670782.231475.0295coturnix_japonicaENSCJPP0000501315081.319374.1973
ENSG00000114127homo_sapiensENSP0000037670769.539658.8548poecilia_latipinnaENSPLAP0000003052075.95164.2811
ENSG00000114127homo_sapiensENSP0000037670768.654158.5006sinocyclocheilus_grahamiENSSGRP0000008249469.3559.0936
ENSG00000114127homo_sapiensENSP0000037670773.553762.6919sinocyclocheilus_grahamiENSSGRP0000002392076.394965.1134
ENSG00000114127homo_sapiensENSP0000037670773.789861.157maylandia_zebraENSMZEP0000502012473.270860.7268
ENSG00000114127homo_sapiensENSP0000037670770.956358.5006tetraodon_nigroviridisENSTNIP0000000488670.087557.7843
ENSG00000114127homo_sapiensENSP000003767077.260926.6706paramormyrops_kingsleyaeENSPKIP0000003140193.893186.2595
ENSG00000114127homo_sapiensENSP0000037670773.317661.7473scleropages_formosusENSSFOP0001503804875.685663.7416
ENSG00000114127homo_sapiensENSP0000037670779.338868.7131leptobrachium_leishanenseENSLLEP0000001543178.734668.1898
ENSG00000114127homo_sapiensENSP0000037670768.47756.8477scophthalmus_maximusENSSMAP0000005748370.861358.8271
ENSG00000114127homo_sapiensENSP0000037670773.022461.4522oryzias_melastigmaENSOMEP0000003083173.412561.7804

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000932located_in P-body1IEAHomo_sapiens(9606)Component
GO:0000956involved_in nuclear-transcribed mRNA catabolic process2IBA,IMPHomo_sapiens(9606)Process
GO:0002151enables G-quadruplex RNA binding1ISSHomo_sapiens(9606)Function
GO:0003723enables RNA binding2HDA,IBAHomo_sapiens(9606)Function
GO:0004534enables 5-3 RNA exonuclease activity3IBA,IMP,ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus1IBAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005886located_in plasma membrane1IDAHomo_sapiens(9606)Component
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016075involved_in rRNA catabolic process2IBA,IMPHomo_sapiens(9606)Process
GO:0017148involved_in negative regulation of translation1IEAHomo_sapiens(9606)Process
GO:0030425located_in dendrite1IEAHomo_sapiens(9606)Component
GO:0032211involved_in negative regulation of telomere maintenance via telomerase1ICHomo_sapiens(9606)Process
GO:0033574involved_in response to testosterone1IEAHomo_sapiens(9606)Process
GO:0043025located_in neuronal cell body1IEAHomo_sapiens(9606)Component
GO:0051880enables G-quadruplex DNA binding1ISSHomo_sapiens(9606)Function
GO:0070034enables telomerase RNA binding1ICHomo_sapiens(9606)Function
GO:0071028involved_in nuclear mRNA surveillance1IMPHomo_sapiens(9606)Process
GO:0071044involved_in histone mRNA catabolic process1IMPHomo_sapiens(9606)Process
GO:0071409involved_in cellular response to cycloheximide1IEAHomo_sapiens(9606)Process
GO:1905795involved_in cellular response to puromycin1IEAHomo_sapiens(9606)Process

Expression