Ensembl ID ENSG00000114127 Gene ID 54464 Accession 30654
Gene Symbol XRN1 Alias SEP1 Full Name 5'-3' exoribonuclease 1
Position 3 : 142306607 - 142448062 Length 141456 bases Strand Minus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

ENSG00000114127 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000114127 XRN1 tumor 12426100
ENSG00000114127 XRN1 prostate cancer 25797256
ENSG00000114127 XRN1 cancer 27438705
ENSG00000114127 XRN1 tumor 27994032
ENSG00000114127 XRN1 tumors 29434928
ENSG00000114127 XRN1 prostate cancer 30029628
ENSG00000114127 XRN1 prostate cancer 30504123
ENSG00000114127 XRN1 tumour 31572192
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000114127 XRN1 SARC 0.013 high
ENSG00000114127 XRN1 CHOL 0.024 low
ENSG00000114127 XRN1 PAAD 0.00079 high
ENSG00000114127 XRN1 UCEC 0.0077 high
ENSG00000114127 XRN1 THCA 0.024 high
ENSG00000114127 XRN1 LGG 0.036 high
ENSG00000114127 XRN1 HNSC 0.008 low
ENSG00000114127 XRN1 READ 0.0098 low
ENSG00000114127 XRN1 KIRP 0.026 high
ENSG00000114127 XRN1 KICH 0.023 high
ENSG00000114127 XRN1 UCS 0.021 low
ENSG00000114127 XRN1 OV 0.028 low
ENSG00000114127 XRN1 KIRC 0.028 low
ENSG00000114127 XRN1 BLCA 0.042 low
ENSG00000114127 XRN1 LAML 0.045 low
ENSG00000114127 XRN1 GBM 0.017 low
ENSG00000114127 XRN1 CESC 0.031 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000114127 XRN1 LUSC Amp 20.981265 0.558807 0.828598 0.804391
ENSG00000114127 XRN1 CESC Amp 7.659095 0.321354 0.934158 0.681356
ENSG00000114127 XRN1 ESCA Amp 2.900413 0.383121 0.763366 0.565217
ENSG00000114127 XRN1 HNSC Amp 11.342157 0.296373 0.679339 0.626437
ENSG00000114127 XRN1 PRAD Amp 3.296283 0.080765 0.486257 0.148374
ENSG00000114127 XRN1 UCEC Amp 1.542272 0.123446 0.602696 0.224490
ENSG00000114127 XRN1 OV Amp 9.867094 0.544804 0.814188 0.654577