Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases N.A.
Drug Drug
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq

Description

Ensembl ID ENSG00000112062 Gene ID 1432 Accession 6876
Symbol MAPK14 Alias RK;p38;CSBP;EXIP;Mxi2;CSBP1;CSBP2;CSPB1;PRKM14;PRKM15;SAPK2A;p38ALPHA Full Name mitogen-activated protein kinase 14
Status Confidence Length 83455 bases Strand Plus strand
Position 6 : 36027782 - 36111236 RNA binding domain N.A.
Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33986259 Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression. Li Zhang 2021-05-13 Cell death & disease
36030691 Circular RNA circESPL1 knockdown alleviates lipopolysaccharide (LPS)-induced lung cell injury via sponging miR-326 to regulate MAPK14. Yamei Liang 2022-11-01 International immunopharmacology

Transcripts

Name Transcript ID bp Protein Translation ID

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
4316Cholesterol, LDL9.54011576599356E-517903299
35994Platelet Function Tests1.0781400E-005-
36001Platelet Function Tests1.2364800E-005-
47032Platelet Function Tests5.1430000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000077involved_in DNA damage checkpoint signaling1IEAHomo_sapiens(9606)Process
GO:0000902involved_in cell morphogenesis1IEAHomo_sapiens(9606)Process
GO:0000922located_in spindle pole1IEAHomo_sapiens(9606)Component
GO:0001502involved_in cartilage condensation1IEAHomo_sapiens(9606)Process
GO:0001525involved_in angiogenesis1IEAHomo_sapiens(9606)Process
GO:0001649involved_in osteoblast differentiation1IEAHomo_sapiens(9606)Process
GO:0001890involved_in placenta development1IEAHomo_sapiens(9606)Process
GO:0002021involved_in response to dietary excess1IEAHomo_sapiens(9606)Process
GO:0002062involved_in chondrocyte differentiation1IEAHomo_sapiens(9606)Process
GO:0002862involved_in negative regulation of inflammatory response to antigenic stimulus1TASHomo_sapiens(9606)Process
GO:0004674enables protein serine/threonine kinase activity3IBA,IDA,TASHomo_sapiens(9606)Function
GO:0004707enables MAP kinase activity1IDAHomo_sapiens(9606)Function
GO:0004708enables MAP kinase kinase activity1TASHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005634is_active_in nucleus3IBA,IDA,ISSHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm1TASHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm2IBA,ISSHomo_sapiens(9606)Component
GO:0005739located_in mitochondrion1IEAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0006006involved_in glucose metabolic process1IEAHomo_sapiens(9606)Process
GO:0006357involved_in regulation of transcription by RNA polymerase II1ISSHomo_sapiens(9606)Process
GO:0006366involved_in transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0006935involved_in chemotaxis1TASHomo_sapiens(9606)Process
GO:0007165involved_in signal transduction1TASHomo_sapiens(9606)Process
GO:0007166involved_in cell surface receptor signaling pathway1TASHomo_sapiens(9606)Process
GO:0007178involved_in transmembrane receptor protein serine/threonine kinase signaling pathway1IEAHomo_sapiens(9606)Process
GO:0007519involved_in skeletal muscle tissue development1IEAHomo_sapiens(9606)Process
GO:0010628involved_in positive regulation of gene expression2IGI,IMPHomo_sapiens(9606)Process
GO:0010831involved_in positive regulation of myotube differentiation1ISSHomo_sapiens(9606)Process
GO:0016607located_in nuclear speck1IDAHomo_sapiens(9606)Component
GO:0018105involved_in peptidyl-serine phosphorylation1ISSHomo_sapiens(9606)Process
GO:0019395involved_in fatty acid oxidation1IEAHomo_sapiens(9606)Process
GO:0019899enables enzyme binding1IPIHomo_sapiens(9606)Function
GO:0019903enables protein phosphatase binding1IPIHomo_sapiens(9606)Function
GO:0030168involved_in platelet activation1TASHomo_sapiens(9606)Process
GO:0030278involved_in regulation of ossification1IEAHomo_sapiens(9606)Process
GO:0030316involved_in osteoclast differentiation1ISSHomo_sapiens(9606)Process
GO:0031098involved_in stress-activated protein kinase signaling cascade1IDAHomo_sapiens(9606)Process
GO:0031281involved_in positive regulation of cyclase activity1IMPHomo_sapiens(9606)Process
GO:0031663involved_in lipopolysaccharide-mediated signaling pathway1IEAHomo_sapiens(9606)Process
GO:0032495involved_in response to muramyl dipeptide1IEAHomo_sapiens(9606)Process
GO:0032735involved_in positive regulation of interleukin-12 production1IMPHomo_sapiens(9606)Process
GO:0032868involved_in response to insulin1IEAHomo_sapiens(9606)Process
GO:0034774located_in secretory granule lumen1TASHomo_sapiens(9606)Component
GO:0035331involved_in negative regulation of hippo signaling1IMPHomo_sapiens(9606)Process
GO:0035556involved_in intracellular signal transduction2IBA,IDAHomo_sapiens(9606)Process
GO:0035924involved_in cellular response to vascular endothelial growth factor stimulus1IMPHomo_sapiens(9606)Process
GO:0035994involved_in response to muscle stretch1IEAHomo_sapiens(9606)Process
GO:0038066involved_in p38MAPK cascade2ISS,TASHomo_sapiens(9606)Process
GO:0042307involved_in positive regulation of protein import into nucleus1IEAHomo_sapiens(9606)Process
GO:0042770involved_in signal transduction in response to DNA damage1IMPHomo_sapiens(9606)Process
GO:0043536NOT involved_in positive regulation of blood vessel endothelial cell migration1IMPHomo_sapiens(9606)Process
GO:0045648involved_in positive regulation of erythrocyte differentiation1IMPHomo_sapiens(9606)Process
GO:0045663involved_in positive regulation of myoblast differentiation1ISSHomo_sapiens(9606)Process
GO:0045944involved_in positive regulation of transcription by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0046323involved_in glucose import1IEAHomo_sapiens(9606)Process
GO:0046326involved_in positive regulation of glucose import1IEAHomo_sapiens(9606)Process
GO:0048010involved_in vascular endothelial growth factor receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0048273enables mitogen-activated protein kinase p38 binding1IPIHomo_sapiens(9606)Function
GO:0048863involved_in stem cell differentiation1IEAHomo_sapiens(9606)Process
GO:0051146involved_in striated muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0051149involved_in positive regulation of muscle cell differentiation1TASHomo_sapiens(9606)Process
GO:0051403involved_in stress-activated MAPK cascade1IDAHomo_sapiens(9606)Process
GO:0051525enables NFAT protein binding1ISSHomo_sapiens(9606)Function
GO:0060045involved_in positive regulation of cardiac muscle cell proliferation1IEAHomo_sapiens(9606)Process
GO:0060348involved_in bone development1IEAHomo_sapiens(9606)Process
GO:0070935involved_in 3-UTR-mediated mRNA stabilization1TASHomo_sapiens(9606)Process
GO:0071222acts_upstream_of_or_within cellular response to lipopolysaccharide1IDAHomo_sapiens(9606)Process
GO:0071223involved_in cellular response to lipoteichoic acid1IMPHomo_sapiens(9606)Process
GO:0071356involved_in cellular response to tumor necrosis factor1IEAHomo_sapiens(9606)Process
GO:0071479involved_in cellular response to ionizing radiation1IMPHomo_sapiens(9606)Process
GO:0071493involved_in cellular response to UV-B1IDAHomo_sapiens(9606)Process
GO:0090090involved_in negative regulation of canonical Wnt signaling pathway1IEAHomo_sapiens(9606)Process
GO:0090336involved_in positive regulation of brown fat cell differentiation1IEAHomo_sapiens(9606)Process
GO:0090398involved_in cellular senescence1TASHomo_sapiens(9606)Process
GO:0090400involved_in stress-induced premature senescence1IMPHomo_sapiens(9606)Process
GO:0098586involved_in cellular response to virus1IMPHomo_sapiens(9606)Process
GO:0098978located_in glutamatergic synapse1IEAHomo_sapiens(9606)Component
GO:0099179involved_in regulation of synaptic membrane adhesion1IEAHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:1900015involved_in regulation of cytokine production involved in inflammatory response1IDAHomo_sapiens(9606)Process
GO:1901741involved_in positive regulation of myoblast fusion1ISSHomo_sapiens(9606)Process
GO:1904813located_in ficolin-1-rich granule lumen1TASHomo_sapiens(9606)Component
GO:2000379involved_in positive regulation of reactive oxygen species metabolic process1IMPHomo_sapiens(9606)Process

Expression