Drugs target to MAPK14

Drug name Drug type Disease/phenotype Mechanism of action(MoA) Phase Status Source
DILMAPIMODSmall moleculenoneMAP kinase p38 alpha inhibitor2['Completed', 'Completed', 'Completed', 'Completed', 'Completed', 'Completed', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
KC-706Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed']['ClinicalTrials']
LOSMAPIMODSmall moleculenoneMAP kinase p38 alpha inhibitor3['Completed', 'Completed', 'Completed', 'Active, not recruiting', 'Completed', 'Completed', 'Completed', 'Completed', 'Completed', 'Terminated', 'Completed', 'Completed', 'Completed', 'Completed', 'Completed', 'Terminated', 'Completed', 'Recruiting']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
PF-03715455Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed', 'Terminated', 'Terminated']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
SEMAPIMODSmall moleculenoneMAP kinase p38 alpha inhibitor2['Terminated', 'Completed']['ClinicalTrials', 'ClinicalTrials']
VX-702Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed']['ClinicalTrials']
BMS-582949Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed', 'Completed', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
ACUMAPIMODSmall moleculenoneMAP kinase p38 alpha inhibitor2['Completed']['ClinicalTrials']
PH-797804Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed', 'Completed', 'Completed', 'Completed', 'Withdrawn', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
RALIMETINIBSmall moleculenoneMAP kinase p38 alpha inhibitor2['Terminated', 'Completed', 'Completed', 'Completed', 'Completed', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
AZD-7624Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed', 'Completed', 'Completed', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
GSK-610677Small moleculenoneMAP kinase p38 alpha inhibitor1['Completed']['ClinicalTrials']
ARRY-797Small moleculenoneMAP kinase p38 alpha inhibitor3['Completed', 'Active, not recruiting', 'Completed', 'Terminated', 'Completed', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
PG-760564Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed']['ClinicalTrials']
TALMAPIMODSmall moleculenoneMAP kinase p38 alpha inhibitor2['Completed', 'Completed', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
NEFLAMAPIMODSmall moleculenoneMAP kinase p38 alpha inhibitor2['Recruiting', 'Completed', 'Completed', 'Terminated', 'Completed']['ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials', 'ClinicalTrials']
PEXMETINIBSmall moleculenoneMAP kinase p38 alpha inhibitor1['Completed']['ClinicalTrials']
LY-3007113Small moleculenoneMAP kinase p38 alpha inhibitor1['Completed']['ClinicalTrials']
TAK-715Small moleculenoneMAP kinase p38 alpha inhibitor2['Completed']['ClinicalTrials']
DORAMAPIMODSmall moleculenoneMAP kinase p38 alpha inhibitor2['Terminated', 'Completed']['ClinicalTrials', 'ClinicalTrials']
FX-005Small moleculenoneMAP kinase p38 alpha inhibitor1['Completed']['ClinicalTrials']