RBP Type
Canonical_RBPs
Diseases
Drug
N.A.
Main interacting RNAs
ncRNA
Moonlighting functions
N.A.
Localizations
Stress granucle
BulkPerturb-seq
N.A.
Ensembl ID ENSG00000111335 Gene ID
4939 Accession
8087
Symbol
OAS2
Alias
NA
Full Name
2'-5'-oligoadenylate synthetase 2
Status
Confidence
Length
33329 bases
Strand
Plus strand
Position
12 : 112978395 - 113011723
RNA binding domain
OAS1_C
Summary
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000376362
OAS1_C
PF10421 2.3e-164
1
ENSP00000376362
OAS1_C
PF10421 2.3e-164
2
ENSP00000342278
OAS1_C
PF10421 2.7e-164
1
ENSP00000342278
OAS1_C
PF10421 2.7e-164
2
ENSP00000446977
OAS1_C
PF10421 3.2e-164
1
ENSP00000446977
OAS1_C
PF10421 3.2e-164
2
ENSP00000483679
OAS1_C
PF10421 3.9e-164
1
ENSP00000483679
OAS1_C
PF10421 3.9e-164
2
ENSP00000505194
OAS1_C
PF10421 8.7e-139
1
ENSP00000505194
OAS1_C
PF10421 8.7e-139
2
ENSP00000505771
OAS1_C
PF10421 1.1e-75
1
ENSP00000506262
OAS1_C
PF10421 1.1e-75
1
ENSP00000450307
OAS1_C
PF10421 1.4e-75
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
29526487 Innate Antiviral Immunity in the Skin.
Chelsea Handfield
2018-04-01
Trends in immunology
30989826 RNA regulation of the antiviral protein 2'-5'-oligoadenylate synthetase.
L Samantha Schwartz
2019-07-01
Wiley interdisciplinary reviews. RNA
36833454 Genetic Ethnic Differences in Human 2'-5'-Oligoadenylate Synthetase and Disease Associations: A Systematic Review.
Anmol Gokul
2023-02-19
Genes
Name
Transcript ID
bp
Protein
Translation ID
OAS2-201
ENST00000342315
3613
719aa
ENSP00000342278
OAS2-212
ENST00000680685
2199
92aa
ENSP00000505554
OAS2-206
ENST00000620097
2019
647aa
ENSP00000483679
OAS2-203
ENST00000449768
2072
172aa
ENSP00000411763
OAS2-215
ENST00000681673
1421
No protein
-
OAS2-209
ENST00000680138
4676
456aa
ENSP00000506262
OAS2-202
ENST00000392583
4622
687aa
ENSP00000376362
OAS2-210
ENST00000680514
3453
456aa
ENSP00000505771
OAS2-205
ENST00000552756
1893
608aa
ENSP00000446977
OAS2-204
ENST00000551603
2257
505aa
ENSP00000450307
OAS2-208
ENST00000680122
5613
643aa
ENSP00000505194
OAS2-213
ENST00000680898
5062
No protein
-
OAS2-207
ENST00000679877
4919
60aa
ENSP00000506110
OAS2-211
ENST00000680666
2959
No protein
-
OAS2-214
ENST00000681023
4397
No protein
-
Pathway ID
Pathway Name
Source
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000111335 homo_sapiens ENSP00000228928 40.5704 30.5428 homo_sapiens ENSP00000376362 64.1921 48.3261 ENSG00000111335 homo_sapiens ENSP00000202917 61.75 46.5 homo_sapiens ENSP00000376362 35.9534 27.0742 ENSG00000111335 homo_sapiens ENSP00000257570 38.716 24.5136 homo_sapiens ENSP00000376362 28.9665 18.3406
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000111335 homo_sapiens ENSP00000376362 97.0888 94.3231 nomascus_leucogenys ENSNLEP00000000162 92.7677 90.1252 ENSG00000111335 homo_sapiens ENSP00000376362 99.7089 98.1077 pan_paniscus ENSPPAP00000022926 95.2712 93.7413 ENSG00000111335 homo_sapiens ENSP00000376362 97.8166 96.5066 pongo_abelii ENSPPYP00000005681 97.8166 96.5066 ENSG00000111335 homo_sapiens ENSP00000376362 99.7089 98.3988 pan_troglodytes ENSPTRP00000049895 95.2712 94.0195 ENSG00000111335 homo_sapiens ENSP00000376362 99.4178 98.9811 gorilla_gorilla ENSGGOP00000007968 99.4178 98.9811 ENSG00000111335 homo_sapiens ENSP00000376362 14.7016 10.3348 ornithorhynchus_anatinus ENSOANP00000043941 61.5854 43.2927 ENSG00000111335 homo_sapiens ENSP00000376362 50.655 40.0291 sarcophilus_harrisii ENSSHAP00000019099 68.3694 54.0275 ENSG00000111335 homo_sapiens ENSP00000376362 40.0291 30.8588 notamacropus_eugenii ENSMEUP00000004677 41.1061 31.6891 ENSG00000111335 homo_sapiens ENSP00000376362 28.9665 21.5429 choloepus_hoffmanni ENSCHOP00000000131 36.2477 26.9581 ENSG00000111335 homo_sapiens ENSP00000376362 40.6114 34.2067 erinaceus_europaeus ENSEEUP00000010728 48.8616 41.1559 ENSG00000111335 homo_sapiens ENSP00000376362 35.3712 28.6754 echinops_telfairi ENSETEP00000004970 37.0427 30.0305 ENSG00000111335 homo_sapiens ENSP00000376362 91.9942 86.3173 callithrix_jacchus ENSCJAP00000023223 87.0523 81.6804 ENSG00000111335 homo_sapiens ENSP00000376362 95.9243 91.2664 cercocebus_atys ENSCATP00000036453 91.7827 87.3259 ENSG00000111335 homo_sapiens ENSP00000376362 96.0699 91.5575 macaca_fascicularis ENSMFAP00000009212 96.4912 91.9591 ENSG00000111335 homo_sapiens ENSP00000376362 96.361 91.5575 macaca_mulatta ENSMMUP00000011144 92.0723 87.4826 ENSG00000111335 homo_sapiens ENSP00000376362 96.2154 91.8486 macaca_nemestrina ENSMNEP00000013226 96.2154 91.8486 ENSG00000111335 homo_sapiens ENSP00000376362 96.0699 91.4119 papio_anubis ENSPANP00000000980 90.784 86.3824 ENSG00000111335 homo_sapiens ENSP00000376362 96.2154 92.1397 mandrillus_leucophaeus ENSMLEP00000001842 91.9332 88.0389 ENSG00000111335 homo_sapiens ENSP00000376362 78.3115 67.9767 tursiops_truncatus ENSTTRP00000002253 77.6335 67.3882 ENSG00000111335 homo_sapiens ENSP00000376362 81.3683 70.8879 vulpes_vulpes ENSVVUP00000014084 77.6389 67.6389 ENSG00000111335 homo_sapiens ENSP00000376362 73.2169 60.9898 mus_spretus MGP_SPRETEiJ_P0073066 67.8812 56.5452 ENSG00000111335 homo_sapiens ENSP00000376362 81.3683 68.9956 equus_asinus ENSEASP00005013620 78.0726 66.2011 ENSG00000111335 homo_sapiens ENSP00000376362 56.7686 50.2183 capra_hircus ENSCHIP00000016994 76.0234 67.2515 ENSG00000111335 homo_sapiens ENSP00000376362 78.8937 67.8311 capra_hircus ENSCHIP00000028144 76.4457 65.7264 ENSG00000111335 homo_sapiens ENSP00000376362 77.5837 65.2111 loxodonta_africana ENSLAFP00000021061 75.389 63.3663 ENSG00000111335 homo_sapiens ENSP00000376362 80.3493 70.1601 panthera_leo ENSPLOP00000021243 80.5839 70.365 ENSG00000111335 homo_sapiens ENSP00000376362 82.2416 70.8879 ailuropoda_melanoleuca ENSAMEP00000009144 78.0387 67.2652 ENSG00000111335 homo_sapiens ENSP00000376362 78.3115 67.3945 bos_indicus_hybrid ENSBIXP00005042598 74.9304 64.4847 ENSG00000111335 homo_sapiens ENSP00000376362 79.9127 66.6667 oryctolagus_cuniculus ENSOCUP00000013595 80.146 66.8613 ENSG00000111335 homo_sapiens ENSP00000376362 80.9316 68.4134 equus_caballus ENSECAP00000012529 78.0899 66.0112 ENSG00000111335 homo_sapiens ENSP00000376362 81.5138 70.3057 canis_lupus_familiaris ENSCAFP00845030857 78.8732 68.0282 ENSG00000111335 homo_sapiens ENSP00000376362 79.6215 69.2868 panthera_pardus ENSPPRP00000022117 78.3668 68.1948 ENSG00000111335 homo_sapiens ENSP00000376362 81.0771 67.2489 marmota_marmota_marmota ENSMMMP00000025417 81.1953 67.3469 ENSG00000111335 homo_sapiens ENSP00000376362 81.5138 71.3246 balaenoptera_musculus ENSBMSP00010025227 78.1032 68.3403 ENSG00000111335 homo_sapiens ENSP00000376362 64.1921 53.2751 cavia_porcellus ENSCPOP00000022545 73.5 61 ENSG00000111335 homo_sapiens ENSP00000376362 80.4949 70.1601 felis_catus ENSFCAP00000000294 78.1073 68.0791 ENSG00000111335 homo_sapiens ENSP00000376362 82.3872 71.179 ursus_americanus ENSUAMP00000037509 82.6277 71.3869 ENSG00000111335 homo_sapiens ENSP00000376362 61.2809 49.6361 monodelphis_domestica ENSMODP00000045870 66.7195 54.0412 ENSG00000111335 homo_sapiens ENSP00000376362 78.7482 67.6856 bison_bison_bison ENSBBBP00000004950 75.2434 64.6732 ENSG00000111335 homo_sapiens ENSP00000376362 74.9636 64.9199 monodon_monoceros ENSMMNP00015000809 77.5602 67.1687 ENSG00000111335 homo_sapiens ENSP00000376362 80.0582 68.1223 sus_scrofa ENSSSCP00000010548 77.1388 65.6381 ENSG00000111335 homo_sapiens ENSP00000376362 82.3872 68.1223 microcebus_murinus ENSMICP00000007771 81.9103 67.7279 ENSG00000111335 homo_sapiens ENSP00000376362 70.0146 57.4964 octodon_degus ENSODEP00000018009 80.3005 65.9432 ENSG00000111335 homo_sapiens ENSP00000376362 75.6914 64.0466 jaculus_jaculus ENSJJAP00000002550 77.8443 65.8683 ENSG00000111335 homo_sapiens ENSP00000376362 79.3304 68.1223 ovis_aries_rambouillet ENSOARP00020022593 75.0689 64.4628 ENSG00000111335 homo_sapiens ENSP00000376362 82.5328 71.179 ursus_maritimus ENSUMAP00000013784 79.7468 68.7764 ENSG00000111335 homo_sapiens ENSP00000376362 75.1092 65.3566 delphinapterus_leucas ENSDLEP00000028412 77.594 67.5188 ENSG00000111335 homo_sapiens ENSP00000376362 81.2227 71.4702 physeter_catodon ENSPCTP00005019258 81.4599 71.6788 ENSG00000111335 homo_sapiens ENSP00000376362 73.3624 60.9898 mus_caroli MGP_CAROLIEiJ_P0070378 67.2897 55.9413 ENSG00000111335 homo_sapiens ENSP00000376362 73.9447 61.7176 mus_musculus ENSMUSP00000080209 67.6431 56.4581 ENSG00000111335 homo_sapiens ENSP00000376362 80.4949 69.1412 mustela_putorius_furo ENSMPUP00000002521 80.7299 69.3431 ENSG00000111335 homo_sapiens ENSP00000376362 92.4309 87.0451 aotus_nancymaae ENSANAP00000022978 89.3108 84.1069 ENSG00000111335 homo_sapiens ENSP00000376362 90.9753 85.5895 saimiri_boliviensis_boliviensis ENSSBOP00000029913 86.9263 81.7803 ENSG00000111335 homo_sapiens ENSP00000376362 96.0699 91.8486 chlorocebus_sabaeus ENSCSAP00000015584 96.0699 91.8486 ENSG00000111335 homo_sapiens ENSP00000376362 72.3435 61.5721 tupaia_belangeri ENSTBEP00000000500 72.9809 62.1145 ENSG00000111335 homo_sapiens ENSP00000376362 74.3814 61.4265 mesocricetus_auratus ENSMAUP00000008629 70.4828 58.2069 ENSG00000111335 homo_sapiens ENSP00000376362 38.4279 32.46 phocoena_sinus ENSPSNP00000011838 79.0419 66.7665 ENSG00000111335 homo_sapiens ENSP00000376362 81.2227 68.2678 carlito_syrichta ENSTSYP00000008479 78.5916 66.0563 ENSG00000111335 homo_sapiens ENSP00000376362 80.2038 69.869 panthera_tigris_altaica ENSPTIP00000013902 78.49 68.3761 ENSG00000111335 homo_sapiens ENSP00000376362 71.7613 59.6798 rattus_norvegicus ENSRNOP00000066845 67.2578 55.9345 ENSG00000111335 homo_sapiens ENSP00000376362 86.4629 74.5269 prolemur_simus ENSPSMP00000001835 86.9693 74.9634 ENSG00000111335 homo_sapiens ENSP00000376362 72.9258 61.1354 peromyscus_maniculatus_bairdii ENSPEMP00000036835 68.5363 57.4555 ENSG00000111335 homo_sapiens ENSP00000376362 78.1659 67.9767 bos_mutus ENSBMUP00000025322 79.2035 68.8791 ENSG00000111335 homo_sapiens ENSP00000376362 73.508 61.2809 mus_spicilegus ENSMSIP00000035001 67.6944 56.4343 ENSG00000111335 homo_sapiens ENSP00000376362 71.6157 59.6798 cricetulus_griseus_chok1gshd ENSCGRP00001024651 70.3863 58.6552 ENSG00000111335 homo_sapiens ENSP00000376362 68.1223 60.5531 pteropus_vampyrus ENSPVAP00000016361 65.5462 58.2633 ENSG00000111335 homo_sapiens ENSP00000376362 66.9578 53.2751 vombatus_ursinus ENSVURP00010005801 64.6976 51.4768 ENSG00000111335 homo_sapiens ENSP00000376362 78.7482 67.54 rhinolophus_ferrumequinum ENSRFEP00010015622 76.6289 65.7224 ENSG00000111335 homo_sapiens ENSP00000376362 80.3493 68.9956 neovison_vison ENSNVIP00000019626 80.7018 69.2982 ENSG00000111335 homo_sapiens ENSP00000376362 78.4571 67.54 bos_taurus ENSBTAP00000019477 75.4902 64.986 ENSG00000111335 homo_sapiens ENSP00000376362 77.0015 63.0277 heterocephalus_glaber_female ENSHGLP00000052367 76.2248 62.3919 ENSG00000111335 homo_sapiens ENSP00000376362 96.5066 92.1397 rhinopithecus_bieti ENSRBIP00000025492 96.5066 92.1397 ENSG00000111335 homo_sapiens ENSP00000376362 80.786 70.0146 canis_lupus_dingo ENSCAFP00020022304 81.4978 70.6314 ENSG00000111335 homo_sapiens ENSP00000376362 78.7482 64.6288 sciurus_vulgaris ENSSVLP00005018907 79.2094 65.0073 ENSG00000111335 homo_sapiens ENSP00000376362 67.1033 53.5662 phascolarctos_cinereus ENSPCIP00000024716 64.1168 51.1822 ENSG00000111335 homo_sapiens ENSP00000376362 63.4643 53.7118 procavia_capensis ENSPCAP00000009027 69.2064 58.5714 ENSG00000111335 homo_sapiens ENSP00000376362 71.6157 58.8064 nannospalax_galili ENSNGAP00000000681 72.0351 59.1508 ENSG00000111335 homo_sapiens ENSP00000376362 78.7482 67.9767 bos_grunniens ENSBGRP00000029892 75.3482 65.0418 ENSG00000111335 homo_sapiens ENSP00000376362 77.7293 64.7744 chinchilla_lanigera ENSCLAP00000019022 69.7128 58.094 ENSG00000111335 homo_sapiens ENSP00000376362 77.147 64.7744 cervus_hanglu_yarkandensis ENSCHYP00000000243 76.7004 64.3994 ENSG00000111335 homo_sapiens ENSP00000376362 79.3304 66.9578 catagonus_wagneri ENSCWAP00000023231 80.0294 67.5477 ENSG00000111335 homo_sapiens ENSP00000376362 73.7991 61.4265 ictidomys_tridecemlineatus ENSSTOP00000008817 79.5918 66.248 ENSG00000111335 homo_sapiens ENSP00000376362 79.476 66.9578 otolemur_garnettii ENSOGAP00000003754 79.708 67.1533 ENSG00000111335 homo_sapiens ENSP00000376362 92.5764 87.1907 cebus_imitator ENSCCAP00000011600 87.6033 82.5069 ENSG00000111335 homo_sapiens ENSP00000376362 81.9505 67.6856 urocitellus_parryii ENSUPAP00010010587 82.07 67.7843 ENSG00000111335 homo_sapiens ENSP00000376362 79.6215 68.1223 moschus_moschiferus ENSMMSP00000024071 75.3444 64.4628 ENSG00000111335 homo_sapiens ENSP00000376362 96.5066 92.1397 rhinopithecus_roxellana ENSRROP00000035127 96.5066 92.1397 ENSG00000111335 homo_sapiens ENSP00000376362 28.9665 25.1819 mus_pahari MGP_PahariEiJ_P0058596 81.893 71.1934 ENSG00000111335 homo_sapiens ENSP00000376362 84.425 72.6346 propithecus_coquereli ENSPCOP00000023518 82.3864 70.8807 ENSG00000111335 homo_sapiens ENSP00000376362 16.885 9.60699 ciona_intestinalis ENSCINP00000035099 39.5904 22.5256 ENSG00000111335 homo_sapiens ENSP00000376362 30.2766 23.1441 callorhinchus_milii ENSCMIP00000039908 47.9263 36.6359 ENSG00000111335 homo_sapiens ENSP00000376362 32.3144 24.163 chrysemys_picta_bellii ENSCPBP00000009567 62.0112 46.3687 ENSG00000111335 homo_sapiens ENSP00000376362 32.6055 26.492 chrysemys_picta_bellii ENSCPBP00000009576 63.8177 51.8519 ENSG00000111335 homo_sapiens ENSP00000376362 33.4789 25.6186 sphenodon_punctatus ENSSPUP00000010175 52.9954 40.553 ENSG00000111335 homo_sapiens ENSP00000376362 33.0422 23.4352 laticauda_laticaudata ENSLLTP00000006709 57.4684 40.7595 ENSG00000111335 homo_sapiens ENSP00000376362 32.1688 24.0175 notechis_scutatus ENSNSUP00000021414 61.2188 45.7064 ENSG00000111335 homo_sapiens ENSP00000376362 32.0233 24.0175 pseudonaja_textilis ENSPTXP00000023508 51.7647 38.8235 ENSG00000111335 homo_sapiens ENSP00000376362 25.1819 17.9039 naja_naja ENSNNAP00000024444 57.0957 40.5941 ENSG00000111335 homo_sapiens ENSP00000376362 32.3144 23.5808 naja_naja ENSNNAP00000024429 62.8895 45.8924 ENSG00000111335 homo_sapiens ENSP00000376362 30.8588 21.9796 naja_naja ENSNNAP00000025074 49.4172 35.1981 ENSG00000111335 homo_sapiens ENSP00000376362 34.0611 26.7831 podarcis_muralis ENSPMRP00000024205 62.5668 49.1979 ENSG00000111335 homo_sapiens ENSP00000376362 33.9156 26.9287 pelodiscus_sinensis ENSPSIP00000005672 55.7416 44.2584 ENSG00000111335 homo_sapiens ENSP00000376362 29.4032 22.853 gopherus_evgoodei ENSGEVP00005021621 30.1043 23.3979 ENSG00000111335 homo_sapiens ENSP00000376362 20.2329 13.246 gopherus_evgoodei ENSGEVP00005018500 39.9425 26.1494 ENSG00000111335 homo_sapiens ENSP00000376362 32.3144 25.6186 chelonoidis_abingdonii ENSCABP00000016733 44.489 35.2705 ENSG00000111335 homo_sapiens ENSP00000376362 32.0233 24.7453 chelonoidis_abingdonii ENSCABP00000016721 49.3274 38.1166 ENSG00000111335 homo_sapiens ENSP00000376362 33.3333 26.492 struthio_camelus_australis ENSSCUP00000012917 63.6111 50.5556 ENSG00000111335 homo_sapiens ENSP00000376362 33.0422 24.5997 terrapene_carolina_triunguis ENSTMTP00000005772 53.9192 40.1425
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0001730 enables 2-5-oligoadenylate synthetase activity 3 IBA,IDA,IMP Homo_sapiens(9606) Function GO:0003725 enables double-stranded RNA binding 3 IBA,IDA,IMP Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005524 enables ATP binding 1 IMP Homo_sapiens(9606) Function GO:0005654 is_active_in nucleoplasm 1 IBA Homo_sapiens(9606) Component GO:0005829 is_active_in cytosol 2 IBA,TAS Homo_sapiens(9606) Component GO:0006139 involved_in nucleobase-containing compound metabolic process 1 TAS Homo_sapiens(9606) Process GO:0006401 involved_in RNA catabolic process 1 IEA Homo_sapiens(9606) Process GO:0009615 involved_in response to virus 1 TAS Homo_sapiens(9606) Process GO:0016020 located_in membrane 2 HDA,IBA Homo_sapiens(9606) Component GO:0032728 involved_in positive regulation of interferon-beta production 1 IMP Homo_sapiens(9606) Process GO:0032760 involved_in positive regulation of tumor necrosis factor production 1 IMP Homo_sapiens(9606) Process GO:0042742 involved_in defense response to bacterium 1 IMP Homo_sapiens(9606) Process GO:0043231 located_in intracellular membrane-bounded organelle 1 TAS Homo_sapiens(9606) Component GO:0045071 involved_in negative regulation of viral genome replication 1 IBA Homo_sapiens(9606) Process GO:0046872 enables metal ion binding 1 IEA Homo_sapiens(9606) Function GO:0048471 located_in perinuclear region of cytoplasm 1 IDA Homo_sapiens(9606) Component GO:0051607 involved_in defense response to virus 2 IBA,ISS Homo_sapiens(9606) Process GO:0060337 involved_in type I interferon-mediated signaling pathway 1 ISS Homo_sapiens(9606) Process GO:0060700 involved_in regulation of ribonuclease activity 1 IBA Homo_sapiens(9606) Process GO:0070106 involved_in interleukin-27-mediated signaling pathway 1 IDA Homo_sapiens(9606) Process GO:1903487 involved_in regulation of lactation 1 ISS Homo_sapiens(9606) Process
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