Ensembl ID ENSG00000111335 Gene ID 4939 Accession 8087
Gene Symbol OAS2 Alias NA Full Name 2'-5'-oligoadenylate synthetase 2
Position 12 : 112978395 - 113011723 Length 33329 bases Strand Plus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

ENSG00000111335 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000111335 OAS2 1.31 1.08e-39 KIRC
ENSG00000111335 OAS2 1.72 1.76e-20 HNSC
ENSG00000111335 OAS2 1.67 1.48e-37 BRCA
ENSG00000111335 OAS2 1.71 4.32e-12 UCEC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000111335 OAS2 prostate cancer 23272139
ENSG00000111335 OAS2 tumors 25884794
ENSG00000111335 OAS2 tumours 26595239
ENSG00000111335 OAS2 tumours 27572959
ENSG00000111335 OAS2 endometrial cancer 28443095
ENSG00000111335 OAS2 breast tumors 28533483
ENSG00000111335 OAS2 cancer 29331675
ENSG00000111335 OAS2 colorectal cancer 30148861
ENSG00000111335 OAS2 breast cancer 30646630
ENSG00000111335 OAS2 oral cancer 31538341
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000111335 OAS2 MESO 0.0013 low
ENSG00000111335 OAS2 SARC 6e-04 low
ENSG00000111335 OAS2 CHOL 0.016 low
ENSG00000111335 OAS2 UVM 0.0068 high
ENSG00000111335 OAS2 PAAD 0.00031 high
ENSG00000111335 OAS2 UCEC 0.014 high
ENSG00000111335 OAS2 ACC 0.0053 high
ENSG00000111335 OAS2 HNSC 0.025 low
ENSG00000111335 OAS2 READ 0.026 low
ENSG00000111335 OAS2 KIRP 0.001 high
ENSG00000111335 OAS2 LUAD 0.011 high
ENSG00000111335 OAS2 PCPG 0.021 low
ENSG00000111335 OAS2 THYM 0.029 high
ENSG00000111335 OAS2 COAD 0.034 high
ENSG00000111335 OAS2 OV 0.014 low
ENSG00000111335 OAS2 DLBC 0.0026 high
ENSG00000111335 OAS2 KIRC 0.0025 high
ENSG00000111335 OAS2 TGCT 0.007 low
ENSG00000111335 OAS2 BLCA 0.0092 low
ENSG00000111335 OAS2 CESC 0.032 low
ENSG00000111335 OAS2 LIHC 0.048 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000111335 OAS2 CHOL Del 0.852100 0.219537 0.589045 0.222222
ENSG00000111335 OAS2 LUAD Del 0.629436 0.050146 0.277419 0.242248
ENSG00000111335 OAS2 PAAD Del 1.313562 0.058251 0.351339 0.222826
ENSG00000111335 OAS2 BRCA Del 2.963014 0.081199 0.380697 0.191667
ENSG00000111335 OAS2 UCEC Del 1.205201 0.054635 0.408074 0.107607
ENSG00000111335 OAS2 OV Del 2.993042 0.219148 0.563127 0.324698