RBP Type	Canonical_RBPs
Diseases	CancerCHIKVFlavivirusesHIVRVSARS-COV-2Dengue
Drug	N.A.
Main interacting RNAs	mRNA
Moonlighting functions	E3 ligase
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000110107	Gene ID	27339	Accession	17896
Symbol	PRPF19	Alias	PSO4;SNEV;PRP19;UBOX4;hPSO4;NMP200	Full Name	pre-mRNA processing factor 19
Status	Confidence	Length	16039 bases	Strand	Minus strand
Position	11 : 60890547 - 60906585	RNA binding domain	Prp19
Summary	Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; cellular protein metabolic process; and mRNA splicing, via spliceosome. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear speck; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000440266	Prp19	PF08606	2e-32	1
ENSP00000227524	Prp19	PF08606	2.5e-32	1
ENSP00000446259	Prp19	PF08606	7.2e-21	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal
34065983	Biology of the mRNA Splicing Machinery and Its Dysregulation in Cancer Providing Therapeutic Opportunities.	Maxime Blijlevens	2021-05-12	International journal of molecular sciences
32256340	Protein-Protein Interactions in Alpha-Synuclein Biogenesis: New Potential Targets in Parkinson's Disease.	M Sarah Hernandez	2020-01-01	Frontiers in aging neuroscience
29921876	Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role.	Shao-Ming Shen	2018-06-19	Nature communications
31237920	A repertoire of 124 potential autoantigens for autoimmune kidney diseases identified by dermatan sulfate affinity enrichment of kidney tissue proteins.	Wei Zhang	2019-01-01	PloS one
26130721	CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.	Febe F van	2015-08-18	Nucleic acids research
29185492	Interaction profiling of RNA-binding ubiquitin ligases reveals a link between posttranscriptional regulation and the ubiquitin system.	Andrea Hildebrandt	2017-11-29	Scientific reports

Name	Transcript ID	bp	Protein	Translation ID
PRPF19-201	ENST00000227524	2337	504aa	ENSP00000227524
PRPF19-205	ENST00000540473	169	45aa	ENSP00000443031
PRPF19-202	ENST00000535326	779	119aa	ENSP00000445435
PRPF19-204	ENST00000539960	796	No protein	-
PRPF19-203	ENST00000539180	441	No protein	-
PRPF19-206	ENST00000541371	943	252aa	ENSP00000440266
PRPF19-207	ENST00000546152	814	104aa	ENSP00000446259

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000110107	homo_sapiens	ENSP00000424628	23.2402	11.5084	homo_sapiens	ENSP00000227524	41.2698	20.4365

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	nomascus_leucogenys	ENSNLEP00000031951	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	98.4127	pan_paniscus	ENSPPAP00000014271	98.0354	97.446
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	pongo_abelii	ENSPPYP00000003692	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	98.4127	pan_troglodytes	ENSPTRP00000089367	98.0354	97.446
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	98.4127	gorilla_gorilla	ENSGGOP00000035693	95.229	94.6565
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.6032	ornithorhynchus_anatinus	ENSOANP00000015372	99.604	99.4059
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	99.0079	sarcophilus_harrisii	ENSSHAP00000010978	96.1686	95.5939
ENSG00000110107	homo_sapiens	ENSP00000227524	70.0397	69.8413	notamacropus_eugenii	ENSMEUP00000008528	70.0397	69.8413
ENSG00000110107	homo_sapiens	ENSP00000227524	54.3651	54.3651	choloepus_hoffmanni	ENSCHOP00000005169	88.1029	88.1029
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	dasypus_novemcinctus	ENSDNOP00000004485	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	66.4683	66.2698	erinaceus_europaeus	ENSEEUP00000007129	66.4683	66.2698
ENSG00000110107	homo_sapiens	ENSP00000227524	87.3016	86.9048	echinops_telfairi	ENSETEP00000009974	87.3016	86.9048
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	callithrix_jacchus	ENSCJAP00000030447	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	98.4127	98.4127	cercocebus_atys	ENSCATP00000038509	96.875	96.875
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	macaca_fascicularis	ENSMFAP00000031520	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	98.4127	98.4127	macaca_mulatta	ENSMMUP00000019079	96.875	96.875
ENSG00000110107	homo_sapiens	ENSP00000227524	98.4127	98.4127	macaca_nemestrina	ENSMNEP00000043735	96.875	96.875
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	papio_anubis	ENSPANP00000026971	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	mandrillus_leucophaeus	ENSMLEP00000038547	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	99.4048	tursiops_truncatus	ENSTTRP00000011838	99.8012	99.6024
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	vulpes_vulpes	ENSVVUP00000006900	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	mus_spretus	MGP_SPRETEiJ_P0050150	96.1759	95.7935
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.6032	equus_asinus	ENSEASP00005011449	100	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	capra_hircus	ENSCHIP00000019231	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.6032	loxodonta_africana	ENSLAFP00000002210	96.737	96.3532
ENSG00000110107	homo_sapiens	ENSP00000227524	84.127	79.5635	panthera_leo	ENSPLOP00000008239	78.2288	73.9852
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	ailuropoda_melanoleuca	ENSAMEP00000007799	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	bos_indicus_hybrid	ENSBIXP00005028827	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	oryctolagus_cuniculus	ENSOCUP00000013482	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.6032	equus_caballus	ENSECAP00000005876	100	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	98.6111	canis_lupus_familiaris	ENSCAFP00845025053	95.7854	95.2107
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	panthera_pardus	ENSPPRP00000007274	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	99.4048	marmota_marmota_marmota	ENSMMMP00000001016	99.6032	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	97.4206	96.627	balaenoptera_musculus	ENSBMSP00010009999	55.9226	55.467
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	cavia_porcellus	ENSCPOP00000020974	98.0507	97.6608
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	felis_catus	ENSFCAP00000012676	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	ursus_americanus	ENSUAMP00000014046	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.6032	monodelphis_domestica	ENSMODP00000025440	99.8016	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	bison_bison_bison	ENSBBBP00000013110	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.6032	monodon_monoceros	ENSMMNP00015023266	100	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.4048	sus_scrofa	ENSSSCP00000081208	99.4083	98.8166
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	microcebus_murinus	ENSMICP00000032645	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	98.8095	octodon_degus	ENSODEP00000005350	99.6032	98.8095
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	jaculus_jaculus	ENSJJAP00000019763	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	ovis_aries_rambouillet	ENSOARP00020019358	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	89.4841	86.5079	ursus_maritimus	ENSUMAP00000015808	88.9546	85.9961
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	94.4444	ochotona_princeps	ENSOPRP00000007909	95.7747	95.7747
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.6032	delphinapterus_leucas	ENSDLEP00000001808	100	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	physeter_catodon	ENSPCTP00005031354	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	mus_caroli	MGP_CAROLIEiJ_P0048169	96.1759	95.7935
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	mus_musculus	ENSMUSP00000136858	96.1759	95.7935
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	99.4048	dipodomys_ordii	ENSDORP00000006476	99.6032	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	mustela_putorius_furo	ENSMPUP00000014325	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	98.4127	aotus_nancymaae	ENSANAP00000007519	99.0099	98.2178
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	saimiri_boliviensis_boliviensis	ENSSBOP00000012169	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	89.6825	89.2857	vicugna_pacos	ENSVPAP00000009787	99.5595	99.1189
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	chlorocebus_sabaeus	ENSCSAP00000002546	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	80.1587	80.1587	tupaia_belangeri	ENSTBEP00000013695	81.2877	81.2877
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	mesocricetus_auratus	ENSMAUP00000012238	96.1759	95.7935
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.6032	phocoena_sinus	ENSPSNP00000014963	100	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	camelus_dromedarius	ENSCDRP00005016168	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	99.4048	98.2143	carlito_syrichta	ENSTSYP00000029944	99.2079	98.0198
ENSG00000110107	homo_sapiens	ENSP00000227524	98.4127	98.0159	panthera_tigris_altaica	ENSPTIP00000003926	98.4127	98.0159
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	rattus_norvegicus	ENSRNOP00000028373	96.1759	95.7935
ENSG00000110107	homo_sapiens	ENSP00000227524	100	100	prolemur_simus	ENSPSMP00000030085	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	microtus_ochrogaster	ENSMOCP00000010189	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.2064	peromyscus_maniculatus_bairdii	ENSPEMP00000021712	96.1759	95.6023
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	bos_mutus	ENSBMUP00000020301	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	98.8095	mus_spicilegus	ENSMSIP00000036682	96.1538	95.7692
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	cricetulus_griseus_chok1gshd	ENSCGRP00001002485	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.6032	pteropus_vampyrus	ENSPVAP00000013828	100	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	97.8175	myotis_lucifugus	ENSMLUP00000016049	96.7245	94.9904
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.6032	vombatus_ursinus	ENSVURP00010004408	99.8016	99.6032
ENSG00000110107	homo_sapiens	ENSP00000227524	97.0238	95.6349	rhinolophus_ferrumequinum	ENSRFEP00010003014	53.914	53.1422
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	neovison_vison	ENSNVIP00000028610	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	bos_taurus	ENSBTAP00000019100	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	97.8175	97.619	rhinopithecus_bieti	ENSRBIP00000025639	95.1737	94.9807
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	canis_lupus_dingo	ENSCAFP00020015628	99.8016	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	99.4048	sciurus_vulgaris	ENSSVLP00005012909	99.6032	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	99.4048	phascolarctos_cinereus	ENSPCIP00000004231	99.6032	99.4048
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	procavia_capensis	ENSPCAP00000001827	100	99.6024
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	98.8095	nannospalax_galili	ENSNGAP00000010214	99.6032	98.8095
ENSG00000110107	homo_sapiens	ENSP00000227524	97.2222	96.0317	bos_grunniens	ENSBGRP00000033202	94.0499	92.8983
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	98.4127	chinchilla_lanigera	ENSCLAP00000004691	97.8431	97.2549
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	cervus_hanglu_yarkandensis	ENSCHYP00000005916	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	catagonus_wagneri	ENSCWAP00000029265	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	98.8095	98.4127	ictidomys_tridecemlineatus	ENSSTOP00000031412	97.2656	96.875
ENSG00000110107	homo_sapiens	ENSP00000227524	97.619	96.0317	otolemur_garnettii	ENSOGAP00000015001	97.2332	95.6522
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	cebus_imitator	ENSCCAP00000016094	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	99.6032	99.2064	urocitellus_parryii	ENSUPAP00010005037	99.6032	99.2064
ENSG00000110107	homo_sapiens	ENSP00000227524	100	99.8016	moschus_moschiferus	ENSMMSP00000025661	100	99.8016
ENSG00000110107	homo_sapiens	ENSP00000227524	97.8175	97.619	rhinopithecus_roxellana	ENSRROP00000036220	95.1737	94.9807
ENSG00000110107	homo_sapiens	ENSP00000227524	99.8016	99.4048	mus_pahari	MGP_PahariEiJ_P0021162	96.1759	95.7935
ENSG00000110107	homo_sapiens	ENSP00000227524	93.6508	93.6508	propithecus_coquereli	ENSPCOP00000005922	100	100
ENSG00000110107	homo_sapiens	ENSP00000227524	69.0476	51.5873	caenorhabditis_elegans	T10F2.4.1	70.7317	52.8455
ENSG00000110107	homo_sapiens	ENSP00000227524	81.9444	66.6667	drosophila_melanogaster	FBpp0085902	81.7822	66.5347
ENSG00000110107	homo_sapiens	ENSP00000227524	72.8175	58.7302	ciona_intestinalis	ENSCINP00000013154	83.9817	67.7346
ENSG00000110107	homo_sapiens	ENSP00000227524	74.8016	64.2857	eptatretus_burgeri	ENSEBUP00000021153	89.9761	77.327
ENSG00000110107	homo_sapiens	ENSP00000227524	96.4286	90.0794	latimeria_chalumnae	ENSLACP00000003857	96.4286	90.0794
ENSG00000110107	homo_sapiens	ENSP00000227524	78.373	69.246	lepisosteus_oculatus	ENSLOCP00000009868	84.9462	75.0538
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.9127	clupea_harengus	ENSCHAP00000012961	94.6429	85.9127
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	85.5159	danio_rerio	ENSDARP00000097371	94.6535	85.3465
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	85.3175	carassius_auratus	ENSCARP00000005414	94.6535	85.1485
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	84.5238	carassius_auratus	ENSCARP00000106641	94.6535	84.3564
ENSG00000110107	homo_sapiens	ENSP00000227524	95.4365	85.9127	astyanax_mexicanus	ENSAMXP00000052404	95.2475	85.7426
ENSG00000110107	homo_sapiens	ENSP00000227524	94.246	85.3175	ictalurus_punctatus	ENSIPUP00000019388	93.6884	84.8126
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	84.127	esox_lucius	ENSELUP00000043741	93.8614	83.9604
ENSG00000110107	homo_sapiens	ENSP00000227524	93.6508	84.5238	esox_lucius	ENSELUP00000021030	93.4653	84.3564
ENSG00000110107	homo_sapiens	ENSP00000227524	93.8492	84.5238	electrophorus_electricus	ENSEEEP00000050651	94.7896	85.3707
ENSG00000110107	homo_sapiens	ENSP00000227524	94.246	85.7143	oncorhynchus_kisutch	ENSOKIP00005040763	86.2069	78.4029
ENSG00000110107	homo_sapiens	ENSP00000227524	93.6508	85.119	oncorhynchus_kisutch	ENSOKIP00005030682	92.7308	84.2829
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.9206	oncorhynchus_kisutch	ENSOKIP00005016662	94.2574	84.7525
ENSG00000110107	homo_sapiens	ENSP00000227524	93.6508	83.3333	oncorhynchus_kisutch	ENSOKIP00005060092	92.9134	82.6772
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	83.7302	oncorhynchus_mykiss	ENSOMYP00000010615	93.3071	83.0709
ENSG00000110107	homo_sapiens	ENSP00000227524	94.246	84.7222	oncorhynchus_mykiss	ENSOMYP00000065788	94.0594	84.5545
ENSG00000110107	homo_sapiens	ENSP00000227524	93.4524	84.7222	oncorhynchus_mykiss	ENSOMYP00000044140	93.8247	85.0598
ENSG00000110107	homo_sapiens	ENSP00000227524	93.8492	85.3175	oncorhynchus_mykiss	ENSOMYP00000037940	92.9273	84.4794
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.9206	salmo_salar	ENSSSAP00000154066	94.2574	84.7525
ENSG00000110107	homo_sapiens	ENSP00000227524	94.246	85.7143	salmo_salar	ENSSSAP00000163919	94.0594	85.5446
ENSG00000110107	homo_sapiens	ENSP00000227524	89.0873	77.7778	salmo_salar	ENSSSAP00000113426	93.1535	81.3278
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	85.5159	salmo_salar	ENSSSAP00000006391	90.9789	82.7255
ENSG00000110107	homo_sapiens	ENSP00000227524	86.9048	78.7698	salmo_trutta	ENSSTUP00000098057	86.5613	78.4585
ENSG00000110107	homo_sapiens	ENSP00000227524	86.7064	78.7698	salmo_trutta	ENSSTUP00000085692	84.6899	76.938
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	83.7302	salmo_trutta	ENSSTUP00000074597	77.0732	68.6179
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.9206	salmo_trutta	ENSSTUP00000094341	94.2574	84.7525
ENSG00000110107	homo_sapiens	ENSP00000227524	95.6349	86.5079	gadus_morhua	ENSGMOP00000041213	95.4455	86.3366
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	84.9206	fundulus_heteroclitus	ENSFHEP00000020164	94.4554	84.7525
ENSG00000110107	homo_sapiens	ENSP00000227524	83.5317	75.5952	poecilia_reticulata	ENSPREP00000003500	91.9214	83.1878
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.5238	xiphophorus_maculatus	ENSXMAP00000008514	94.2574	84.3564
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	85.119	oryzias_latipes	ENSORLP00000005873	94.2574	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	95.2381	85.5159	cyclopterus_lumpus	ENSCLMP00005035648	95.0495	85.3465
ENSG00000110107	homo_sapiens	ENSP00000227524	64.4841	50	oreochromis_niloticus	ENSONIP00000042668	21.8267	16.9241
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.119	haplochromis_burtoni	ENSHBUP00000026021	94.4554	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.119	astatotilapia_calliptera	ENSACLP00000013785	94.4554	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	85.7143	sparus_aurata	ENSSAUP00010043121	94.6535	85.5446
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.7143	lates_calcarifer	ENSLCAP00010006798	94.8515	85.5446
ENSG00000110107	homo_sapiens	ENSP00000227524	92.6587	83.5317	xenopus_tropicalis	ENSXETP00000074704	93.5872	84.3687
ENSG00000110107	homo_sapiens	ENSP00000227524	90.6746	87.3016	chrysemys_picta_bellii	ENSCPBP00000039282	88.3946	85.1064
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	97.0238	sphenodon_punctatus	ENSSPUP00000025238	99.0079	97.0238
ENSG00000110107	homo_sapiens	ENSP00000227524	96.8254	93.254	laticauda_laticaudata	ENSLLTP00000007663	91.215	87.8505
ENSG00000110107	homo_sapiens	ENSP00000227524	54.3651	52.381	notechis_scutatus	ENSNSUP00000002873	99.2754	95.6522
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	95.8333	pseudonaja_textilis	ENSPTXP00000017225	99.0079	95.8333
ENSG00000110107	homo_sapiens	ENSP00000227524	32.5397	31.3492	anas_platyrhynchos_platyrhynchos	ENSAPLP00000020287	85.8639	82.7225
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	97.619	gallus_gallus	ENSGALP00010029236	99.2064	97.619
ENSG00000110107	homo_sapiens	ENSP00000227524	98.2143	96.2302	meleagris_gallopavo	ENSMGAP00000002894	99.1984	97.1944
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	97.619	serinus_canaria	ENSSCAP00000013113	99.2064	97.619
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	97.4206	parus_major	ENSPMJP00000008493	99.2064	97.4206
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	97.4206	anolis_carolinensis	ENSACAP00000017527	99.2064	97.4206
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	85.119	neolamprologus_brichardi	ENSNBRP00000000036	94.6535	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	92.6587	89.881	naja_naja	ENSNNAP00000003373	99.1507	96.1783
ENSG00000110107	homo_sapiens	ENSP00000227524	98.0159	94.8413	naja_naja	ENSNNAP00000003344	97.8218	94.6535
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	97.0238	podarcis_muralis	ENSPMRP00000000227	97.0817	95.1362
ENSG00000110107	homo_sapiens	ENSP00000227524	82.7381	79.9603	geospiza_fortis	ENSGFOP00000016629	87.0564	84.1336
ENSG00000110107	homo_sapiens	ENSP00000227524	98.8095	96.8254	taeniopygia_guttata	ENSTGUP00000034372	78.4252	76.8504
ENSG00000110107	homo_sapiens	ENSP00000227524	91.2698	82.1429	erpetoichthys_calabaricus	ENSECRP00000015545	93.6864	84.3177
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	85.3175	kryptolebias_marmoratus	ENSKMAP00000013702	94.2574	85.1485
ENSG00000110107	homo_sapiens	ENSP00000227524	99.2064	97.4206	salvator_merianae	ENSSMRP00000002047	99.2064	97.4206
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.5238	oryzias_javanicus	ENSOJAP00000040173	94.2574	84.3564
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	84.7222	amphilophus_citrinellus	ENSACIP00000020439	93.6759	84.3874
ENSG00000110107	homo_sapiens	ENSP00000227524	90.873	81.9444	dicentrarchus_labrax	ENSDLAP00005082853	84.658	76.3401
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	86.1111	amphiprion_percula	ENSAPEP00000022626	94.8515	85.9406
ENSG00000110107	homo_sapiens	ENSP00000227524	93.6508	84.3254	oryzias_sinensis	ENSOSIP00000013888	93.2806	83.9921
ENSG00000110107	homo_sapiens	ENSP00000227524	82.5397	80.9524	pelodiscus_sinensis	ENSPSIP00000008382	99.284	97.3747
ENSG00000110107	homo_sapiens	ENSP00000227524	99.4048	97.8175	gopherus_evgoodei	ENSGEVP00005014726	99.4048	97.8175
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	93.254	chelonoidis_abingdonii	ENSCABP00000019429	98.3539	96.7078
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.7143	seriola_dumerili	ENSSDUP00000004471	94.8515	85.5446
ENSG00000110107	homo_sapiens	ENSP00000227524	92.6587	83.3333	cottoperca_gobio	ENSCGOP00000007325	94.5344	85.0202
ENSG00000110107	homo_sapiens	ENSP00000227524	98.4127	96.0317	struthio_camelus_australis	ENSSCUP00000018269	99.002	96.6068
ENSG00000110107	homo_sapiens	ENSP00000227524	95.8333	93.4524	anser_brachyrhynchus	ENSABRP00000026277	76.183	74.2902
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.119	gasterosteus_aculeatus	ENSGACP00000023748	94.4554	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	85.119	cynoglossus_semilaevis	ENSCSEP00000016173	94.8413	85.119
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.3254	poecilia_formosa	ENSPFOP00000002554	94.2574	84.1584
ENSG00000110107	homo_sapiens	ENSP00000227524	95.6349	86.3095	myripristis_murdjan	ENSMMDP00005003799	95.4455	86.1386
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.9127	sander_lucioperca	ENSSLUP00000029163	94.8515	85.7426
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	97.2222	strigops_habroptila	ENSSHBP00005022242	99.0079	97.2222
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.7222	amphiprion_ocellaris	ENSAOCP00000029842	93.5167	83.89
ENSG00000110107	homo_sapiens	ENSP00000227524	99.4048	97.619	terrapene_carolina_triunguis	ENSTMTP00000021934	99.4048	97.619
ENSG00000110107	homo_sapiens	ENSP00000227524	94.246	84.127	hucho_hucho	ENSHHUP00000086880	85.2783	76.1221
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	84.5238	hucho_hucho	ENSHHUP00000059520	93.8614	84.3564
ENSG00000110107	homo_sapiens	ENSP00000227524	83.3333	75.1984	hucho_hucho	ENSHHUP00000018881	90.1288	81.3305
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.9127	hucho_hucho	ENSHHUP00000065401	94.6429	85.9127
ENSG00000110107	homo_sapiens	ENSP00000227524	92.4603	82.9365	betta_splendens	ENSBSLP00000041520	92.0949	82.6087
ENSG00000110107	homo_sapiens	ENSP00000227524	95.6349	86.3095	pygocentrus_nattereri	ENSPNAP00000013399	95.4455	86.1386
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	86.1111	anabas_testudineus	ENSATEP00000012709	94.8515	85.9406
ENSG00000110107	homo_sapiens	ENSP00000227524	83.7302	67.8571	ciona_savignyi	ENSCSAVP00000003406	81.1538	65.7692
ENSG00000110107	homo_sapiens	ENSP00000227524	36.3095	20.2381	saccharomyces_cerevisiae	YLL036C	36.3817	20.2783
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.7143	seriola_lalandi_dorsalis	ENSSLDP00000003879	94.8515	85.5446
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.5159	labrus_bergylta	ENSLBEP00000036706	94.4554	85.3465
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.119	pundamilia_nyererei	ENSPNYP00000001029	94.4554	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	85.5159	mastacembelus_armatus	ENSMAMP00000010182	94.6535	85.3465
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.9127	stegastes_partitus	ENSSPAP00000011277	94.8515	85.7426
ENSG00000110107	homo_sapiens	ENSP00000227524	93.8492	84.3254	oncorhynchus_tshawytscha	ENSOTSP00005006049	93.2939	83.8264
ENSG00000110107	homo_sapiens	ENSP00000227524	93.8492	83.5317	oncorhynchus_tshawytscha	ENSOTSP00005008771	93.1102	82.874
ENSG00000110107	homo_sapiens	ENSP00000227524	93.4524	84.7222	oncorhynchus_tshawytscha	ENSOTSP00005034236	92.1722	83.5616
ENSG00000110107	homo_sapiens	ENSP00000227524	93.254	84.7222	oncorhynchus_tshawytscha	ENSOTSP00005015444	91.9765	83.5616
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	86.1111	acanthochromis_polyacanthus	ENSAPOP00000030871	94.8515	85.9406
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	97.4206	aquila_chrysaetos_chrysaetos	ENSACCP00020017040	99.0079	97.4206
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	84.7222	nothobranchius_furzeri	ENSNFUP00015049190	94.6535	84.5545
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.9206	cyprinodon_variegatus	ENSCVAP00000009933	94.2574	84.7525
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	85.119	denticeps_clupeoides	ENSDCDP00000041412	94.2346	85.2883
ENSG00000110107	homo_sapiens	ENSP00000227524	90.2778	80.3571	denticeps_clupeoides	ENSDCDP00000048176	88.5214	78.7938
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.5159	larimichthys_crocea	ENSLCRP00005003518	94.8515	85.3465
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	84.3254	takifugu_rubripes	ENSTRUP00000021300	94.6429	84.3254
ENSG00000110107	homo_sapiens	ENSP00000227524	99.0079	97.2222	ficedula_albicollis	ENSFALP00000023048	90.7273	89.0909
ENSG00000110107	homo_sapiens	ENSP00000227524	93.6508	83.5317	hippocampus_comes	ENSHCOP00000026102	93.4653	83.3663
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	84.7222	cyprinus_carpio_carpio	ENSCCRP00000080452	94.6535	84.5545
ENSG00000110107	homo_sapiens	ENSP00000227524	94.8413	85.7143	cyprinus_carpio_carpio	ENSCCRP00000049070	84.6018	76.4602
ENSG00000110107	homo_sapiens	ENSP00000227524	95.8333	93.8492	coturnix_japonica	ENSCJPP00005015974	92.7063	90.7869
ENSG00000110107	homo_sapiens	ENSP00000227524	94.4444	84.3254	poecilia_latipinna	ENSPLAP00000014258	94.2574	84.1584
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	84.9206	sinocyclocheilus_grahami	ENSSGRP00000087157	94.8515	84.7525
ENSG00000110107	homo_sapiens	ENSP00000227524	72.619	63.8889	sinocyclocheilus_grahami	ENSSGRP00000112991	86.3208	75.9434
ENSG00000110107	homo_sapiens	ENSP00000227524	94.6429	85.119	maylandia_zebra	ENSMZEP00005017769	94.4554	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	82.1429	71.2302	tetraodon_nigroviridis	ENSTNIP00000017232	94.3052	81.7768
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.119	paramormyrops_kingsleyae	ENSPKIP00000001431	94.8515	84.9505
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	84.127	scleropages_formosus	ENSSFOP00015074389	93.8614	83.9604
ENSG00000110107	homo_sapiens	ENSP00000227524	93.4524	85.5159	leptobrachium_leishanense	ENSLLEP00000034082	93.6382	85.6859
ENSG00000110107	homo_sapiens	ENSP00000227524	95.0397	85.9127	scophthalmus_maximus	ENSSMAP00000003776	94.8515	85.7426
ENSG00000110107	homo_sapiens	ENSP00000227524	94.0476	84.3254	oryzias_melastigma	ENSOMEP00000024022	93.8614	84.1584

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0000077	involved_in DNA damage checkpoint signaling	1	IMP	Homo_sapiens(9606)	Process
GO:0000209	acts_upstream_of_or_within protein polyubiquitination	1	IDA	Homo_sapiens(9606)	Process
GO:0000244	involved_in spliceosomal tri-snRNP complex assembly	1	IDA	Homo_sapiens(9606)	Process
GO:0000245	involved_in spliceosomal complex assembly	1	IMP	Homo_sapiens(9606)	Process
GO:0000398	involved_in mRNA splicing, via spliceosome	4	IBA,IC,IDA,NAS	Homo_sapiens(9606)	Process
GO:0000974	part_of Prp19 complex	3	IBA,IDA,IPI	Homo_sapiens(9606)	Component
GO:0004842	enables ubiquitin-protein transferase activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005634	located_in nucleus	1	IDA	Homo_sapiens(9606)	Component
GO:0005654	located_in nucleoplasm	1	TAS	Homo_sapiens(9606)	Component
GO:0005681	part_of spliceosomal complex	1	IPI	Homo_sapiens(9606)	Component
GO:0005737	is_active_in cytoplasm	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0005811	located_in lipid droplet	1	IEA	Homo_sapiens(9606)	Component
GO:0005819	located_in spindle	1	IEA	Homo_sapiens(9606)	Component
GO:0006303	involved_in double-strand break repair via nonhomologous end joining	1	IMP	Homo_sapiens(9606)	Process
GO:0008104	involved_in protein localization	1	IMP	Homo_sapiens(9606)	Process
GO:0008610	involved_in lipid biosynthetic process	1	IEA	Homo_sapiens(9606)	Process
GO:0010498	involved_in proteasomal protein catabolic process	1	IMP	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0016607	located_in nuclear speck	1	IDA	Homo_sapiens(9606)	Component
GO:0034450	enables ubiquitin-ubiquitin ligase activity	1	IDA	Homo_sapiens(9606)	Function
GO:0035861	located_in site of double-strand break	1	IDA	Homo_sapiens(9606)	Component
GO:0042802	enables identical protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0048026	involved_in positive regulation of mRNA splicing, via spliceosome	1	IEA	Homo_sapiens(9606)	Process
GO:0061630	enables ubiquitin protein ligase activity	2	IDA,IMP	Homo_sapiens(9606)	Function
GO:0070534	involved_in protein K63-linked ubiquitination	1	IMP	Homo_sapiens(9606)	Process
GO:0071006	part_of U2-type catalytic step 1 spliceosome	1	IBA	Homo_sapiens(9606)	Component
GO:0071007	part_of U2-type catalytic step 2 spliceosome	1	IDA	Homo_sapiens(9606)	Component
GO:0071013	part_of catalytic step 2 spliceosome	1	IDA	Homo_sapiens(9606)	Component