Ensembl ID ENSG00000110107 Gene ID 27339 Accession 17896
Gene Symbol PRPF19 Alias PSO4;SNEV;PRP19;UBOX4;hPSO4;NMP200 Full Name pre-mRNA processing factor 19
Position 11 : 60890547 - 60906585 Length 16039 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary Enables identical protein binding activity and ubiquitin-ubiquitin ligase activity. Involved in several processes, including DNA damage checkpoint signaling; cellular protein metabolic process; and mRNA splicing, via spliceosome. Acts upstream of or within protein polyubiquitination. Located in cytoplasm; nuclear speck; and site of double-strand break. Part of Prp19 complex and U2-type catalytic step 2 spliceosome. Colocalizes with DNA replication factor A complex. [provided by Alliance of Genome Resources, Apr 2022]

ENSG00000110107 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000110107 PRPF19 0.70 2.86e-43 BRCA
ENSG00000110107 PRPF19 0.63 2.89e-15 COAD
ENSG00000110107 PRPF19 1.09 1.35e-67 LUSC
ENSG00000110107 PRPF19 -1.0 1.39e-12 GBM
ENSG00000110107 PRPF19 0.63 7.90e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000110107 PRPF19 breast cancer 16388800
ENSG00000110107 PRPF19 cancer 18083760
ENSG00000110107 PRPF19 tumor 24731397
ENSG00000110107 PRPF19 gastric cancer 26745502
ENSG00000110107 PRPF19 ovarian cancer 28122348
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000110107 PRPF19 SARC 0.00071 high
ENSG00000110107 PRPF19 CHOL 0.021 low
ENSG00000110107 PRPF19 ACC 0.015 high
ENSG00000110107 PRPF19 HNSC 0.012 high
ENSG00000110107 PRPF19 READ 0.037 low
ENSG00000110107 PRPF19 KICH 0.011 high
ENSG00000110107 PRPF19 LUAD 0.015 high
ENSG00000110107 PRPF19 THYM 0.042 low
ENSG00000110107 PRPF19 BRCA 0.033 low
ENSG00000110107 PRPF19 COAD 0.033 high
ENSG00000110107 PRPF19 OV 0.01 low
ENSG00000110107 PRPF19 DLBC 0.038 low
ENSG00000110107 PRPF19 BLCA 0.00022 high
ENSG00000110107 PRPF19 LAML 0.00014 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000110107 PRPF19 HNSC Amp 0.815572 0.118743 0.398609 0.226054
ENSG00000110107 PRPF19 BRCA Del 1.650216 0.071876 0.420291 0.206481