Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases Cancer Disease
Drug Drug
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations N.A.
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000106462 Gene ID 2146 Accession 3527
Symbol EZH2 Alias WVS;ENX1;KMT6;WVS2;ENX-1;EZH2b;KMT6A Full Name enhancer of zeste 2 polycomb repressive complex 2 subunit
Status Confidence Length 77065 bases Strand Minus strand
Position 7 : 148807257 - 148884321 RNA binding domain N.A.
Summary This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
33615636 The noncanonical role of EZH2 in cancer. Jinhua Huang 2021-04-01 Cancer science
36494339 Gene amplification-driven lncRNA SNHG6 promotes tumorigenesis via epigenetically suppressing p27 expression and regulating cell cycle in non-small cell lung cancer. Qi Wang 2022-12-09 Cell death discovery
32885590 The long non-coding RNA SNHG1 promotes bladder cancer progression by interacting with miR-143-3p and EZH2. Wei Xiang 2020-10-01 Journal of cellular and molecular medicine
31417274 Long noncoding RNA LINC-PINT promotes proliferation through EZH2 and predicts poor prognosis in clear cell renal cell carcinoma. Junyao Duan 2019-01-01 OncoTargets and therapy
27528797 ExSurv: A Web Resource for Prognostic Analyses of Exons Across Human Cancers Using Clinical Transcriptomes. Seyedsasan Hashemikhabir 2016-01-01 Cancer informatics
30522506 EZH2 variants differentially regulate polycomb repressive complex 2 in histone methylation and cell differentiation. Weipeng Mu 2018-12-06 Epigenetics & chromatin
29258254 Recognizing the SINEs of Infection: Regulation of Retrotransposon Expression and Modulation of Host Cell Processes. William Dunker 2017-12-18 Viruses
34853732 Super-enhancer-driven lncRNA-DAW promotes liver cancer cell proliferation through activation of Wnt/β-catenin pathway. Weicheng Liang 2021-12-03 Molecular therapy. Nucleic acids
36117724 lncRNA HOTTIP Recruits EZH2 to Inhibit PTEN Expression and Participates in IM Resistance in Chronic Myeloid Leukemia. Jing Liu 2022-01-01 Stem cells international
30833789 RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Qi Zhang 2019-03-01 Nature structural & molecular biology
29950518 Identification and removal of sequencing artifacts produced by mispriming during reverse transcription in multiple RNA-seq technologies. Haridha Shivram 2018-09-01 RNA (New York, N.Y.)
35682829 The Disordered EZH2 Loop: Atomic Level Characterization by 1HN- and 1Hα-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA. Lilla Csenge Szabó 2022-05-30 International journal of molecular sciences
26173710 Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen. Roya R Pedram 2015-10-01 Journal of biomolecular screening
27239242 Polycomb repressive complex's evolutionary conserved function: the role of EZH2 status and cellular background. Koraljka K Gall 2016-01-01 Clinical epigenetics
25405465 De-repressing LncRNA-Targeted Genes to Upregulate Gene Expression: Focus on Small Molecule Therapeutics. Pedram Roya Fatemi 2014-11-18 Molecular therapy. Nucleic acids
28854977 Up-regulation of lncRNA CASC9 promotes esophageal squamous cell carcinoma growth by negatively regulating PDCD4 expression through EZH2. Yuanyuan Wu 2017-08-30 Molecular cancer
31335317 Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2. Bo Jia 2019-07-23 Aging
37283223 A monoclonal antibody raised against human EZH2 cross-reacts with the RNA-binding protein SAFB. E Rachel Cherney 2023-06-15 Biology open
26574518 The recruitment of chromatin modifiers by long noncoding RNAs: lessons from PRC2. Chen Davidovich 2015-12-01 RNA (New York, N.Y.)
35541468 Long non-coding RNA PVT1 facilitates cell proliferation by epigenetically regulating FOXF1 in breast cancer. Guangcheng Guo 2018-01-09 RSC advances

Transcripts

Name Transcript ID bp Protein Translation ID
EZH2-214 ENST00000683292 2909 389aa ENSP00000507503
EZH2-209 ENST00000492143 3641 334aa ENSP00000417377
EZH2-201 ENST00000320356 2654 751aa ENSP00000320147
EZH2-206 ENST00000478654 2522 695aa ENSP00000417062
EZH2-203 ENST00000460911 2591 746aa ENSP00000419711
EZH2-202 ENST00000350995 2477 707aa ENSP00000223193
EZH2-218 ENST00000684400 4502 No protein -
EZH2-220 ENST00000684510 2860 No protein -
EZH2-216 ENST00000683744 2707 334aa ENSP00000506949
EZH2-212 ENST00000682317 2535 295aa ENSP00000508286
EZH2-215 ENST00000683293 4189 No protein -
EZH2-211 ENST00000682263 4367 No protein -
EZH2-217 ENST00000684300 2961 295aa ENSP00000508407
EZH2-205 ENST00000476773 2572 695aa ENSP00000419050
EZH2-208 ENST00000483967 2466 737aa ENSP00000419856
EZH2-219 ENST00000684436 2684 No protein -
EZH2-204 ENST00000469631 414 No protein -
EZH2-210 ENST00000498186 1876 No protein -
EZH2-207 ENST00000483012 1491 144aa ENSP00000417704
EZH2-213 ENST00000682401 1732 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
39303Platelet Function Tests3.3300000E-006-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000106462homo_sapiensENSP0000048224019.377710.6082homo_sapiensENSP0000032014718.24239.98668
ENSG00000106462homo_sapiensENSP000003867598.151334.79719homo_sapiensENSP0000032014727.829616.3782
ENSG00000106462homo_sapiensENSP000003988376.961334.01473homo_sapiensENSP0000032014725.166414.514
ENSG00000106462homo_sapiensENSP000004367865.664653.22256homo_sapiensENSP0000032014729.960117.0439
ENSG00000106462homo_sapiensENSP0000031398314.68348.14196homo_sapiensENSP0000032014728.095915.5792
ENSG00000106462homo_sapiensENSP000004742539.867755.84944homo_sapiensENSP0000032014725.832215.3129
ENSG00000106462homo_sapiensENSP0000026251911.13066.67838homo_sapiensENSP0000032014725.299615.1798
ENSG00000106462homo_sapiensENSP0000041798015.48549.24499homo_sapiensENSP0000032014726.764315.9787
ENSG00000106462homo_sapiensENSP000003010674.099692.31172homo_sapiensENSP0000032014730.226417.0439
ENSG00000106462homo_sapiensENSP0000040465876.840764.9264homo_sapiensENSP0000032014776.431464.5806
ENSG00000106462homo_sapiensENSP000003959298.642434.82196homo_sapiensENSP0000032014731.025317.3103
ENSG00000106462homo_sapiensENSP000004974067.957393.7594homo_sapiensENSP0000032014716.91087.98935
ENSG00000106462homo_sapiensENSP0000036468715.70259.75207homo_sapiensENSP0000032014725.299615.7124
ENSG00000106462homo_sapiensENSP000003762047.759784.28475homo_sapiensENSP0000032014730.625816.9108
ENSG00000106462homo_sapiensENSP0000042397215.31148.35165homo_sapiensENSP0000032014727.829615.1798
ENSG00000106462homo_sapiensENSP000002621894.785182.56567homo_sapiensENSP0000032014731.291616.7776
ENSG00000106462homo_sapiensENSP0000034699731.463419.0244homo_sapiensENSP0000032014717.177110.3862
ENSG00000106462homo_sapiensENSP0000050942514.24158.12694homo_sapiensENSP0000032014724.500713.9814
ENSG00000106462homo_sapiensENSP0000036587731.06818.6893homo_sapiensENSP0000032014717.043910.253

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000106462homo_sapiensENSP0000032014799.201199.2011nomascus_leucogenysENSNLEP0000002893699.86699.866
ENSG00000106462homo_sapiensENSP00000320147100100pan_paniscusENSPPAP00000016828100100
ENSG00000106462homo_sapiensENSP00000320147100100pongo_abeliiENSPPYP00000020354100100
ENSG00000106462homo_sapiensENSP0000032014799.201199.2011pan_troglodytesENSPTRP0000007734498.806498.8064
ENSG00000106462homo_sapiensENSP00000320147100100pan_troglodytesENSPTRP00000090461100100
ENSG00000106462homo_sapiensENSP0000032014799.067999.0679gorilla_gorillaENSGGOP0000002464499.731999.7319
ENSG00000106462homo_sapiensENSP0000032014797.336996.2716ornithorhynchus_anatinusENSOANP0000000047596.184295.1316
ENSG00000106462homo_sapiensENSP0000032014797.4796.5379sarcophilus_harrisiiENSSHAP0000002092398.123397.185
ENSG00000106462homo_sapiensENSP0000032014792.676490.9454notamacropus_eugeniiENSMEUP0000000195792.676490.9454
ENSG00000106462homo_sapiensENSP0000032014776.964176.8309choloepus_hoffmanniENSCHOP0000001155279.834379.6961
ENSG00000106462homo_sapiensENSP0000032014798.26997.2037dasypus_novemcinctusENSDNOP0000001756898.927697.8552
ENSG00000106462homo_sapiensENSP0000032014794.940193.0759echinops_telfairiENSETEP0000001649695.576493.6997
ENSG00000106462homo_sapiensENSP0000032014799.733799.6005callithrix_jacchusENSCJAP0000001873999.733799.6005
ENSG00000106462homo_sapiensENSP00000320147100100cercocebus_atysENSCATP00000024565100100
ENSG00000106462homo_sapiensENSP0000032014799.201199.2011macaca_fascicularisENSMFAP0000004338889.435889.4358
ENSG00000106462homo_sapiensENSP0000032014799.201199.2011macaca_mulattaENSMMUP0000006054689.543389.5433
ENSG00000106462homo_sapiensENSP0000032014799.201199.2011macaca_nemestrinaENSMNEP0000003867199.86699.866
ENSG00000106462homo_sapiensENSP0000032014793.209193.0759papio_anubisENSPANP0000003002488.607688.481
ENSG00000106462homo_sapiensENSP0000032014799.201199.2011mandrillus_leucophaeusENSMLEP0000003577499.86699.866
ENSG00000106462homo_sapiensENSP0000032014795.339594.6738tursiops_truncatusENSTTRP0000001646695.339594.6738
ENSG00000106462homo_sapiensENSP0000032014797.869597.47vulpes_vulpesENSVVUP0000002260197.869597.47
ENSG00000106462homo_sapiensENSP0000032014797.869596.9374mus_spretusMGP_SPRETEiJ_P007644898.525597.5871
ENSG00000106462homo_sapiensENSP0000032014790.945488.4154equus_asinusENSEASP0000505088091.432488.8889
ENSG00000106462homo_sapiensENSP0000032014795.206493.4754capra_hircusENSCHIP0000000342095.844594.1019
ENSG00000106462homo_sapiensENSP0000032014797.070695.739loxodonta_africanaENSLAFP0000000131797.721296.3807
ENSG00000106462homo_sapiensENSP0000032014797.869596.6711panthera_leoENSPLOP0000000119598.130896.9292
ENSG00000106462homo_sapiensENSP0000032014710099.6005ailuropoda_melanoleucaENSAMEP0000000300110099.6005
ENSG00000106462homo_sapiensENSP0000032014798.135897.47bos_indicus_hybridENSBIXP0000503135291.100190.4821
ENSG00000106462homo_sapiensENSP0000032014797.603296.9374oryctolagus_cuniculusENSOCUP0000004180695.318694.6684
ENSG00000106462homo_sapiensENSP0000032014799.067998.6684equus_caballusENSECAP0000008484999.298.8
ENSG00000106462homo_sapiensENSP0000032014710099.4674canis_lupus_familiarisENSCAFP0084501695810099.4674
ENSG00000106462homo_sapiensENSP0000032014798.535398.0027panthera_pardusENSPPRP0000002906199.328998.7919
ENSG00000106462homo_sapiensENSP0000032014798.402198.0027marmota_marmota_marmotaENSMMMP0000000818999.061798.6595
ENSG00000106462homo_sapiensENSP0000032014798.934898.1358balaenoptera_musculusENSBMSP0001002174598.934898.1358
ENSG00000106462homo_sapiensENSP0000032014798.135897.8695cavia_porcellusENSCPOP0000000335098.661398.3936
ENSG00000106462homo_sapiensENSP0000032014756.324954.3276felis_catusENSFCAP0000000798891.956588.6957
ENSG00000106462homo_sapiensENSP0000032014799.201198.8016ursus_americanusENSUAMP0000002884799.86699.4638
ENSG00000106462homo_sapiensENSP0000032014784.953483.0892monodelphis_domesticaENSMODP0000003920595.652293.5532
ENSG00000106462homo_sapiensENSP0000032014786.684485.8855monodelphis_domesticaENSMODP0000003372597.894796.9925
ENSG00000106462homo_sapiensENSP0000032014710.918810.6525monodelphis_domesticaENSMODP0000004231397.61995.2381
ENSG00000106462homo_sapiensENSP0000032014782.290379.6272monodelphis_domesticaENSMODP0000000125095.517892.4266
ENSG00000106462homo_sapiensENSP0000032014798.934898.1358bison_bison_bisonENSBBBP0000000949598.934898.1358
ENSG00000106462homo_sapiensENSP0000032014798.934898.269monodon_monocerosENSMMNP0001501711398.934898.269
ENSG00000106462homo_sapiensENSP0000032014798.801698.0027sus_scrofaENSSSCP0000004803597.375396.5879
ENSG00000106462homo_sapiensENSP0000032014710099.6005microcebus_murinusENSMICP0000002792610099.6005
ENSG00000106462homo_sapiensENSP0000032014793.608592.6764jaculus_jaculusENSJJAP0000001139498.047497.0711
ENSG00000106462homo_sapiensENSP0000032014798.934898.1358ovis_aries_rambouilletENSOARP0002000994798.934898.1358
ENSG00000106462homo_sapiensENSP0000032014791.078688.5486ursus_maritimusENSUMAP0000001568791.566389.0228
ENSG00000106462homo_sapiensENSP0000032014799.067998.0027ochotona_princepsENSOPRP0000000714399.067998.0027
ENSG00000106462homo_sapiensENSP0000032014790.679188.016delphinapterus_leucasENSDLEP0000002468191.164788.4873
ENSG00000106462homo_sapiensENSP0000032014798.934898.269physeter_catodonENSPCTP0000502481498.934898.269
ENSG00000106462homo_sapiensENSP0000032014792.410190.5459mus_caroliMGP_CAROLIEiJ_P007359594.808792.8962
ENSG00000106462homo_sapiensENSP0000032014797.869596.9374mus_musculusENSMUSP0000008041998.525597.5871
ENSG00000106462homo_sapiensENSP0000032014798.26997.6032dipodomys_ordiiENSDORP0000002115998.927698.2574
ENSG00000106462homo_sapiensENSP0000032014789.347586.285mustela_putorius_furoENSMPUP0000000719189.110286.0558
ENSG00000106462homo_sapiensENSP0000032014799.201199.0679aotus_nancymaaeENSANAP0000000710599.86699.7319
ENSG00000106462homo_sapiensENSP0000032014799.201199.0679saimiri_boliviensis_boliviensisENSSBOP0000001850199.86699.7319
ENSG00000106462homo_sapiensENSP0000032014774.966773.1025vicugna_pacosENSVPAP0000000133095.585793.2088
ENSG00000106462homo_sapiensENSP0000032014799.201199.2011chlorocebus_sabaeusENSCSAP0000000331599.86699.866
ENSG00000106462homo_sapiensENSP0000032014769.773669.3742tupaia_belangeriENSTBEP0000001359270.147369.7457
ENSG00000106462homo_sapiensENSP0000032014797.603296.2716mesocricetus_auratusENSMAUP0000000703398.389397.047
ENSG00000106462homo_sapiensENSP0000032014790.679188.016phocoena_sinusENSPSNP0000001131191.164788.4873
ENSG00000106462homo_sapiensENSP0000032014798.801697.0706camelus_dromedariusENSCDRP0000501779698.801697.0706
ENSG00000106462homo_sapiensENSP0000032014797.4797.2037carlito_syrichtaENSTSYP0000000076795.937195.675
ENSG00000106462homo_sapiensENSP0000032014797.869597.3369panthera_tigris_altaicaENSPTIP0000000698999.324398.7838
ENSG00000106462homo_sapiensENSP0000032014797.736496.8043rattus_norvegicusENSRNOP0000000814998.391497.4531
ENSG00000106462homo_sapiensENSP0000032014710099.6005prolemur_simusENSPSMP0000002228610099.6005
ENSG00000106462homo_sapiensENSP0000032014789.480787.8828microtus_ochrogasterENSMOCP0000000106997.391395.6522
ENSG00000106462homo_sapiensENSP0000032014797.4796.5379microtus_ochrogasterENSMOCP0000002301797.99297.0549
ENSG00000106462homo_sapiensENSP0000032014788.548687.217peromyscus_maniculatus_bairdiiENSPEMP0000001939497.222295.7602
ENSG00000106462homo_sapiensENSP0000032014781.358280.1598bos_mutusENSBMUP0000002867794.58293.1889
ENSG00000106462homo_sapiensENSP0000032014775.23373.1025mus_spicilegusENSMSIP0000001295994.481691.806
ENSG00000106462homo_sapiensENSP0000032014797.736496.8043cricetulus_griseus_chok1gshdENSCGRP0000100780698.391497.4531
ENSG00000106462homo_sapiensENSP0000032014799.067998.5353pteropus_vampyrusENSPVAP0000000859099.067998.5353
ENSG00000106462homo_sapiensENSP0000032014798.135897.7364myotis_lucifugusENSMLUP0000000227798.397997.9973
ENSG00000106462homo_sapiensENSP0000032014797.4796.5379vombatus_ursinusENSVURP0001002139898.123397.185
ENSG00000106462homo_sapiensENSP0000032014798.668497.8695rhinolophus_ferrumequinumENSRFEP0001000998898.275997.4801
ENSG00000106462homo_sapiensENSP0000032014799.067998.4021neovison_visonENSNVIP0000000519199.298.5333
ENSG00000106462homo_sapiensENSP0000032014798.135897.47bos_taurusENSBTAP0000007305997.35896.6975
ENSG00000106462homo_sapiensENSP0000032014798.26998.0027heterocephalus_glaber_femaleENSHGLP0000005280898.927698.6595
ENSG00000106462homo_sapiensENSP0000032014797.4796.5379rhinopithecus_bietiENSRBIP0000002148895.436894.5241
ENSG00000106462homo_sapiensENSP0000032014793.874893.4754canis_lupus_dingoENSCAFP0002002614399.858499.4334
ENSG00000106462homo_sapiensENSP0000032014798.934898.6684sciurus_vulgarisENSSVLP0000501111298.934898.6684
ENSG00000106462homo_sapiensENSP0000032014790.679190.2796sciurus_vulgarisENSSVLP0000502145098.982698.5465
ENSG00000106462homo_sapiensENSP0000032014797.336996.4048phascolarctos_cinereusENSPCIP0000002109897.989397.0509
ENSG00000106462homo_sapiensENSP0000032014784.953482.8229procavia_capensisENSPCAP0000001518985.066782.9333
ENSG00000106462homo_sapiensENSP0000032014798.535398.0027nannospalax_galiliENSNGAP0000000467598.930598.3957
ENSG00000106462homo_sapiensENSP0000032014798.135897.47bos_grunniensENSBGRP0000002165893.173292.5411
ENSG00000106462homo_sapiensENSP0000032014797.336997.0706chinchilla_lanigeraENSCLAP0000000242997.596897.3298
ENSG00000106462homo_sapiensENSP0000032014798.934897.8695cervus_hanglu_yarkandensisENSCHYP0000001965298.934897.8695
ENSG00000106462homo_sapiensENSP0000032014798.801698.269catagonus_wagneriENSCWAP0000001642998.801698.269
ENSG00000106462homo_sapiensENSP0000032014798.402198.0027ictidomys_tridecemlineatusENSSTOP0000002949397.622297.2259
ENSG00000106462homo_sapiensENSP0000032014799.733799.3342otolemur_garnettiiENSOGAP0000000929699.733799.3342
ENSG00000106462homo_sapiensENSP0000032014799.866899.7337cebus_imitatorENSCCAP0000000311099.866899.7337
ENSG00000106462homo_sapiensENSP0000032014797.203796.8043urocitellus_parryiiENSUPAP0001002596697.593697.1925
ENSG00000106462homo_sapiensENSP0000032014798.801698.0027moschus_moschiferusENSMMSP0000000429898.801698.0027
ENSG00000106462homo_sapiensENSP0000032014797.736497.6032rhinopithecus_roxellanaENSRROP0000002030599.592999.4573
ENSG00000106462homo_sapiensENSP0000032014797.736496.9374mus_pahariMGP_PahariEiJ_P004970498.391497.5871
ENSG00000106462homo_sapiensENSP0000032014799.866899.4674propithecus_coquereliENSPCOP0000001986699.866899.4674
ENSG00000106462homo_sapiensENSP0000032014712.64988.25566caenorhabditis_elegansK09F5.5.124.421615.9383
ENSG00000106462homo_sapiensENSP000003201479.986686.9241caenorhabditis_elegansF34D6.4.126.978418.705
ENSG00000106462homo_sapiensENSP0000032014713.98147.85619caenorhabditis_elegansK12H6.11.126.119414.6766
ENSG00000106462homo_sapiensENSP0000032014719.707110.5193caenorhabditis_elegansW01C8.3.115.52998.28961
ENSG00000106462homo_sapiensENSP0000032014726.231715.4461caenorhabditis_elegansC43E11.3a.112.28187.23192
ENSG00000106462homo_sapiensENSP0000032014714.78039.45406caenorhabditis_elegansF02D10.7.127.272717.4447
ENSG00000106462homo_sapiensENSP0000032014715.57929.18775caenorhabditis_elegansR11E3.4.219.148911.293
ENSG00000106462homo_sapiensENSP0000032014717.443410.1198caenorhabditis_elegansC49F5.2.118.502810.7345
ENSG00000106462homo_sapiensENSP0000032014712.38356.65779caenorhabditis_elegansC41G7.4.117.98849.67118
ENSG00000106462homo_sapiensENSP0000032014713.98147.85619caenorhabditis_elegansY24D9A.2.118.485910.3873
ENSG00000106462homo_sapiensENSP0000032014730.093218.1092drosophila_melanogasterFBpp00736109.568165.75783
ENSG00000106462homo_sapiensENSP0000032014721.038611.984drosophila_melanogasterFBpp03052079.535315.4315
ENSG00000106462homo_sapiensENSP0000032014711.58467.58988drosophila_melanogasterFBpp011212832.34221.1896
ENSG00000106462homo_sapiensENSP0000032014732.623229.6937ciona_intestinalisENSCINP0000001633381.395374.0864
ENSG00000106462homo_sapiensENSP0000032014783.355574.5672petromyzon_marinusENSPMAP0000000490279.948971.5198
ENSG00000106462homo_sapiensENSP0000032014717.709711.3182eptatretus_burgeriENSEBUP0000000439646.180629.5139
ENSG00000106462homo_sapiensENSP0000032014791.344984.9534callorhinchus_miliiENSCMIP0000001509985.429679.4521
ENSG00000106462homo_sapiensENSP0000032014792.410188.5486latimeria_chalumnaeENSLACP0000001112292.533388.6667
ENSG00000106462homo_sapiensENSP0000032014792.27785.486lepisosteus_oculatusENSLOCP0000001643491.064484.3627
ENSG00000106462homo_sapiensENSP0000032014785.086577.763clupea_harengusENSCHAP0000002506881.818274.7759
ENSG00000106462homo_sapiensENSP0000032014791.211784.5539danio_rerioENSDARP0000002369390.131683.5526
ENSG00000106462homo_sapiensENSP0000032014790.545983.755carassius_auratusENSCARP0000013278389.238882.5459
ENSG00000106462homo_sapiensENSP0000032014790.679184.1545carassius_auratusENSCARP0000010380787.87181.5484
ENSG00000106462homo_sapiensENSP0000032014791.344985.3529astyanax_mexicanusENSAMXP0000003365590.026284.1207
ENSG00000106462homo_sapiensENSP0000032014791.078684.9534ictalurus_punctatusENSIPUP0000000955288.946782.9649
ENSG00000106462homo_sapiensENSP0000032014789.480781.8908esox_luciusENSELUP0000003269987.614180.1825
ENSG00000106462homo_sapiensENSP0000032014791.078684.5539electrophorus_electricusENSEEEP0000003534490.118683.6627
ENSG00000106462homo_sapiensENSP0000032014789.347581.225oncorhynchus_kisutchENSOKIP0000511149087.942379.9476
ENSG00000106462homo_sapiensENSP0000032014789.480781.3582oncorhynchus_mykissENSOMYP0000010917687.579.5573
ENSG00000106462homo_sapiensENSP0000032014786.28578.8282salmo_salarENSSSAP0000009457086.63179.1444
ENSG00000106462homo_sapiensENSP0000032014789.081281.0919salmo_salarENSSSAP0000009466087.45179.6078
ENSG00000106462homo_sapiensENSP0000032014789.214481.225salmo_truttaENSSTUP0000010032887.467479.6345
ENSG00000106462homo_sapiensENSP0000032014786.551378.8282salmo_truttaENSSTUP0000006763886.666778.9333
ENSG00000106462homo_sapiensENSP0000032014787.21778.4288gadus_morhuaENSGMOP0000003293075.89868.2503
ENSG00000106462homo_sapiensENSP0000032014788.415481.3582fundulus_heteroclitusENSFHEP0000000023183.732777.0492
ENSG00000106462homo_sapiensENSP0000032014788.149180.2929poecilia_reticulataENSPREP0000001591986.876679.1339
ENSG00000106462homo_sapiensENSP0000032014710.51939.05459xiphophorus_maculatusENSXMAP0000003581185.869673.913
ENSG00000106462homo_sapiensENSP0000032014789.613883.3555oryzias_latipesENSORLP0000003007886.838780.7742
ENSG00000106462homo_sapiensENSP0000032014788.948180.8256cyclopterus_lumpusENSCLMP0000503192087.092679.1395
ENSG00000106462homo_sapiensENSP0000032014789.613883.3555oreochromis_niloticusENSONIP0000002225788.204582.0446
ENSG00000106462homo_sapiensENSP0000032014789.613883.2224haplochromis_burtoniENSHBUP0000001715288.204581.9135
ENSG00000106462homo_sapiensENSP0000032014789.613883.2224astatotilapia_callipteraENSACLP0000003413588.204581.9135
ENSG00000106462homo_sapiensENSP0000032014789.347582.2903sparus_aurataENSSAUP0001004801888.173581.2089
ENSG00000106462homo_sapiensENSP0000032014789.480782.6898lates_calcariferENSLCAP0001005434988.073481.3893
ENSG00000106462homo_sapiensENSP0000032014795.605992.6764xenopus_tropicalisENSXETP0000009463693.125890.2724
ENSG00000106462homo_sapiensENSP0000032014795.73994.2743chrysemys_picta_belliiENSCPBP0000002333095.484794.0239
ENSG00000106462homo_sapiensENSP0000032014785.619282.8229sphenodon_punctatusENSSPUP0000001932096.401893.2534
ENSG00000106462homo_sapiensENSP0000032014796.138594.8069crocodylus_porosusENSCPRP0000501738090.36389.1114
ENSG00000106462homo_sapiensENSP0000032014742.74340.8788laticauda_laticaudataENSLLTP0000000749092.507288.4726
ENSG00000106462homo_sapiensENSP0000032014796.271694.8069notechis_scutatusENSNSUP0000001695095.256993.8076
ENSG00000106462homo_sapiensENSP0000032014795.073293.6085pseudonaja_textilisENSPTXP0000000478695.582394.1098
ENSG00000106462homo_sapiensENSP0000032014797.203795.4727anas_platyrhynchos_platyrhynchosENSAPLP0000001914397.724295.9839
ENSG00000106462homo_sapiensENSP0000032014797.070695.3395gallus_gallusENSGALP0001001147494.064592.3871
ENSG00000106462homo_sapiensENSP0000032014795.206493.2091meleagris_gallopavoENSMGAP0000003100991.315589.3997
ENSG00000106462homo_sapiensENSP0000032014797.203795.2064serinus_canariaENSSCAP0000002169692.875390.9669
ENSG00000106462homo_sapiensENSP0000032014797.203795.3395parus_majorENSPMJP0000002451295.800593.9633
ENSG00000106462homo_sapiensENSP0000032014796.138594.8069anolis_carolinensisENSACAP0000002255290.589789.335
ENSG00000106462homo_sapiensENSP0000032014737.416832.2237neolamprologus_brichardiENSNBRP0000001210380.979869.7406
ENSG00000106462homo_sapiensENSP0000032014796.005394.6738naja_najaENSNNAP0000000631995.750394.4223
ENSG00000106462homo_sapiensENSP0000032014796.537995.2064podarcis_muralisENSPMRP0000002720096.281594.9535
ENSG00000106462homo_sapiensENSP0000032014797.203795.3395geospiza_fortisENSGFOP0000001828597.724295.8501
ENSG00000106462homo_sapiensENSP0000032014791.47887.0839taeniopygia_guttataENSTGUP0000003030489.921585.6021
ENSG00000106462homo_sapiensENSP0000032014782.689876.2983erpetoichthys_calabaricusENSECRP0000002580089.096182.2095
ENSG00000106462homo_sapiensENSP0000032014790.279684.2876kryptolebias_marmoratusENSKMAP0000002402289.328183.3992
ENSG00000106462homo_sapiensENSP0000032014795.472793.8748salvator_merianaeENSSMRP0000002147096.500794.8856
ENSG00000106462homo_sapiensENSP0000032014789.214482.5566oryzias_javanicusENSOJAP0000003044986.451680
ENSG00000106462homo_sapiensENSP0000032014784.021378.1625amphilophus_citrinellusENSACIP0000000343791.316984.9493
ENSG00000106462homo_sapiensENSP0000032014789.347582.6898dicentrarchus_labraxENSDLAP0000500421588.057781.4961
ENSG00000106462homo_sapiensENSP0000032014784.953478.5619amphiprion_perculaENSAPEP0000000548690.496583.6879
ENSG00000106462homo_sapiensENSP0000032014789.480783.2224oryzias_sinensisENSOSIP0000000074986.709780.6452
ENSG00000106462homo_sapiensENSP0000032014795.73993.7417pelodiscus_sinensisENSPSIP0000001695194.109992.1466
ENSG00000106462homo_sapiensENSP0000032014796.937495.4727gopherus_evgoodeiENSGEVP0000501490395.538194.0945
ENSG00000106462homo_sapiensENSP0000032014786.018684.5539chelonoidis_abingdoniiENSCABP0000002919096.99795.3453
ENSG00000106462homo_sapiensENSP0000032014784.420878.1625seriola_dumeriliENSSDUP0000000426091.486384.7042
ENSG00000106462homo_sapiensENSP0000032014796.804395.4727struthio_camelus_australisENSSCUP0000002346897.322695.9839
ENSG00000106462homo_sapiensENSP0000032014797.203795.4727anser_brachyrhynchusENSABRP0000002251595.800594.0945
ENSG00000106462homo_sapiensENSP0000032014785.352979.7603gasterosteus_aculeatusENSGACP0000000729586.738881.0555
ENSG00000106462homo_sapiensENSP0000032014785.352979.7603gasterosteus_aculeatusENSGACP0000001654286.738881.0555
ENSG00000106462homo_sapiensENSP0000032014790.013382.1571cynoglossus_semilaevisENSCSEP0000002526988.830581.0775
ENSG00000106462homo_sapiensENSP0000032014789.613882.4234poecilia_formosaENSPFOP0000000443088.669381.5547
ENSG00000106462homo_sapiensENSP0000032014788.814981.0919myripristis_murdjanENSMMDP0000504680085.622678.1771
ENSG00000106462homo_sapiensENSP0000032014789.480782.024sander_luciopercaENSSLUP0000004219887.386280.104
ENSG00000106462homo_sapiensENSP0000032014796.005394.2743strigops_habroptilaENSSHBP0000500502597.696595.935
ENSG00000106462homo_sapiensENSP0000032014788.149180.9587amphiprion_ocellarisENSAOCP0000000521886.762879.6855
ENSG00000106462homo_sapiensENSP0000032014792.676490.9454terrapene_carolina_triunguisENSTMTP0000000781895.604493.8187
ENSG00000106462homo_sapiensENSP0000032014792.676490.9454terrapene_carolina_triunguisENSTMTP0000001116595.604493.8187
ENSG00000106462homo_sapiensENSP0000032014780.159872.4368hucho_huchoENSHHUP000000029348677.7143
ENSG00000106462homo_sapiensENSP0000032014789.081281.225hucho_huchoENSHHUP0000000730487.565479.8429
ENSG00000106462homo_sapiensENSP0000032014789.214482.4234betta_splendensENSBSLP0000004768388.390581.6623
ENSG00000106462homo_sapiensENSP0000032014791.47884.8202pygocentrus_nattereriENSPNAP0000001209290.27683.7057
ENSG00000106462homo_sapiensENSP0000032014789.347583.0892anabas_testudineusENSATEP0000003159388.522482.3219
ENSG00000106462homo_sapiensENSP0000032014767.776355.2597ciona_savignyiENSCSAVP0000000337067.32854.8942
ENSG00000106462homo_sapiensENSP0000032014789.880282.8229seriola_lalandi_dorsalisENSSLDP0000001223588.699181.7346
ENSG00000106462homo_sapiensENSP0000032014780.159873.7683labrus_bergyltaENSLBEP0000001969189.185282.0741
ENSG00000106462homo_sapiensENSP0000032014783.355577.2304pundamilia_nyerereiENSPNYP0000001778290.462483.815
ENSG00000106462homo_sapiensENSP0000032014789.347582.8229mastacembelus_armatusENSMAMP0000001245988.639482.1664
ENSG00000106462homo_sapiensENSP0000032014790.013383.3555stegastes_partitusENSSPAP0000002245588.830582.2602
ENSG00000106462homo_sapiensENSP0000032014789.347581.225oncorhynchus_tshawytschaENSOTSP0000502338987.942379.9476
ENSG00000106462homo_sapiensENSP0000032014789.880283.0892acanthochromis_polyacanthusENSAPOP0000000071788.699181.9974
ENSG00000106462homo_sapiensENSP0000032014797.203795.3395aquila_chrysaetos_chrysaetosENSACCP0002000576297.724295.8501
ENSG00000106462homo_sapiensENSP0000032014789.480782.4234nothobranchius_furzeriENSNFUP0001501927988.654481.6623
ENSG00000106462homo_sapiensENSP0000032014788.548681.4913cyprinodon_variegatusENSCVAP0000000580887.38580.4205
ENSG00000106462homo_sapiensENSP0000032014791.611284.9534denticeps_clupeoidesENSDCDP0000006349989.700183.1812
ENSG00000106462homo_sapiensENSP0000032014789.613882.8229larimichthys_croceaENSLCRP0000503761980.023873.9596
ENSG00000106462homo_sapiensENSP0000032014790.412886.8176ficedula_albicollisENSFALP0000002915790.533386.9333
ENSG00000106462homo_sapiensENSP0000032014784.287677.4967hippocampus_comesENSHCOP0000001745890.299683.0243
ENSG00000106462homo_sapiensENSP0000032014789.347582.4234cyprinus_carpio_carpioENSCCRP0000007047687.369880.599
ENSG00000106462homo_sapiensENSP0000032014791.344984.4208cyprinus_carpio_carpioENSCCRP0000016252189.908383.0931
ENSG00000106462homo_sapiensENSP0000032014796.937495.2064coturnix_japonicaENSCJPP0000500656497.587195.8445
ENSG00000106462homo_sapiensENSP0000032014789.480782.2903poecilia_latipinnaENSPLAP0000002441388.537681.4229
ENSG00000106462homo_sapiensENSP0000032014786.817679.8935sinocyclocheilus_grahamiENSSGRP0000005417388.707581.6327
ENSG00000106462homo_sapiensENSP0000032014788.948182.024sinocyclocheilus_grahamiENSSGRP0000007126385.861279.1774
ENSG00000106462homo_sapiensENSP0000032014789.613883.2224maylandia_zebraENSMZEP0000501772788.204581.9135
ENSG00000106462homo_sapiensENSP0000032014771.637865.5126maylandia_zebraENSMZEP0000501826686.217978.8462
ENSG00000106462homo_sapiensENSP0000032014712.916111.8509tetraodon_nigroviridisENSTNIP0000000457587.387480.1802
ENSG00000106462homo_sapiensENSP0000032014720.50616.7776tetraodon_nigroviridisENSTNIP0000000475463.636452.0661
ENSG00000106462homo_sapiensENSP0000032014720.772318.2423tetraodon_nigroviridisENSTNIP0000000457678.39268.8442
ENSG00000106462homo_sapiensENSP0000032014739.147834.4874tetraodon_nigroviridisENSTNIP0000000682683.522773.5795
ENSG00000106462homo_sapiensENSP0000032014738.082633.5553tetraodon_nigroviridisENSTNIP0000000677280.79171.1864
ENSG00000106462homo_sapiensENSP0000032014737.549932.8895tetraodon_nigroviridisENSTNIP0000000464082.941272.6471
ENSG00000106462homo_sapiensENSP0000032014724.500721.0386tetraodon_nigroviridisENSTNIP0000000897178.297967.234
ENSG00000106462homo_sapiensENSP0000032014721.038618.9081tetraodon_nigroviridisENSTNIP0000002291386.813278.022
ENSG00000106462homo_sapiensENSP0000032014723.96820.506tetraodon_nigroviridisENSTNIP0000000471084.905772.6415
ENSG00000106462homo_sapiensENSP0000032014713.981412.6498tetraodon_nigroviridisENSTNIP0000000779175.539668.3453
ENSG00000106462homo_sapiensENSP0000032014712.383511.3182tetraodon_nigroviridisENSTNIP0000000424590.291382.5243
ENSG00000106462homo_sapiensENSP0000032014734.886830.4927tetraodon_nigroviridisENSTNIP0000000418883.974473.3974
ENSG00000106462homo_sapiensENSP0000032014761.51852.8629tetraodon_nigroviridisENSTNIP0000000116269.369459.6096
ENSG00000106462homo_sapiensENSP000003201477.723046.79095tetraodon_nigroviridisENSTNIP0000000865990.62579.6875
ENSG00000106462homo_sapiensENSP0000032014711.717710.6525tetraodon_nigroviridisENSTNIP000000042238072.7273
ENSG00000106462homo_sapiensENSP0000032014788.415481.0919paramormyrops_kingsleyaeENSPKIP0000001392291.586284
ENSG00000106462homo_sapiensENSP0000032014789.880283.4887paramormyrops_kingsleyaeENSPKIP0000001452288.120181.8538
ENSG00000106462homo_sapiensENSP0000032014788.548682.6898scleropages_formosusENSSFOP0001502888086.588580.8594
ENSG00000106462homo_sapiensENSP0000032014789.214482.4234scleropages_formosusENSSFOP0001505973286.900180.2853
ENSG00000106462homo_sapiensENSP0000032014794.940192.277leptobrachium_leishanenseENSLLEP0000000999292.118989.5349
ENSG00000106462homo_sapiensENSP0000032014786.817678.9614scophthalmus_maximusENSSMAP0000007039084.020676.4175
ENSG00000106462homo_sapiensENSP0000032014789.347582.9561oryzias_melastigmaENSOMEP0000000516586.580680.3871

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000082involved_in G1/S transition of mitotic cell cycle1IEAHomo_sapiens(9606)Process
GO:0000122involved_in negative regulation of transcription by RNA polymerase II1IDAHomo_sapiens(9606)Process
GO:0000781located_in chromosome, telomeric region1IGIHomo_sapiens(9606)Component
GO:0000785part_of chromatin1IDAHomo_sapiens(9606)Component
GO:0000978enables RNA polymerase II cis-regulatory region sequence-specific DNA binding1IEAHomo_sapiens(9606)Function
GO:0000979enables RNA polymerase II core promoter sequence-specific DNA binding1IEAHomo_sapiens(9606)Function
GO:0001222enables transcription corepressor binding1IPIHomo_sapiens(9606)Function
GO:0003682enables chromatin binding2IBA,IDAHomo_sapiens(9606)Function
GO:0003714enables transcription corepressor activity1ISSHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005677part_of chromatin silencing complex1IEAHomo_sapiens(9606)Component
GO:0005721part_of pericentric heterochromatin1IEAHomo_sapiens(9606)Component
GO:0006306involved_in DNA methylation1IEAHomo_sapiens(9606)Process
GO:0006325involved_in chromatin organization1TASHomo_sapiens(9606)Process
GO:0006355involved_in regulation of DNA-templated transcription1TASHomo_sapiens(9606)Process
GO:0008284involved_in positive regulation of cell population proliferation1IMPHomo_sapiens(9606)Process
GO:0010718involved_in positive regulation of epithelial to mesenchymal transition1IDAHomo_sapiens(9606)Process
GO:0014013involved_in regulation of gliogenesis1IEAHomo_sapiens(9606)Process
GO:0014834involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration1IEAHomo_sapiens(9606)Process
GO:0014898involved_in cardiac muscle hypertrophy in response to stress1IEAHomo_sapiens(9606)Process
GO:0016279enables protein-lysine N-methyltransferase activity2IDA,TASHomo_sapiens(9606)Function
GO:0021695involved_in cerebellar cortex development1IEAHomo_sapiens(9606)Process
GO:0021766involved_in hippocampus development1IEAHomo_sapiens(9606)Process
GO:0030183involved_in B cell differentiation1IEAHomo_sapiens(9606)Process
GO:0030216involved_in keratinocyte differentiation1IEAHomo_sapiens(9606)Process
GO:0031490enables chromatin DNA binding1IDAHomo_sapiens(9606)Function
GO:0031507involved_in heterochromatin formation1IBAHomo_sapiens(9606)Process
GO:0031509involved_in subtelomeric heterochromatin formation1IGIHomo_sapiens(9606)Process
GO:0032355involved_in response to estradiol1IEAHomo_sapiens(9606)Process
GO:0034244involved_in negative regulation of transcription elongation by RNA polymerase II1IEAHomo_sapiens(9606)Process
GO:0035098part_of ESC/E(Z) complex2IBA,IDAHomo_sapiens(9606)Component
GO:0035984involved_in cellular response to trichostatin A1IEAHomo_sapiens(9606)Process
GO:0036333involved_in hepatocyte homeostasis1IEAHomo_sapiens(9606)Process
GO:0042054enables histone methyltransferase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0042752involved_in regulation of circadian rhythm1IMPHomo_sapiens(9606)Process
GO:0043021enables ribonucleoprotein complex binding1IEAHomo_sapiens(9606)Function
GO:0043406involved_in positive regulation of MAP kinase activity1IDAHomo_sapiens(9606)Process
GO:0043433involved_in negative regulation of DNA-binding transcription factor activity1IEAHomo_sapiens(9606)Process
GO:0043547involved_in positive regulation of GTPase activity1IDAHomo_sapiens(9606)Process
GO:0045120located_in pronucleus1IEAHomo_sapiens(9606)Component
GO:0045202located_in synapse1IEAHomo_sapiens(9606)Component
GO:0045617involved_in negative regulation of keratinocyte differentiation1IEAHomo_sapiens(9606)Process
GO:0045814involved_in negative regulation of gene expression, epigenetic3IDA,IMP,TASHomo_sapiens(9606)Process
GO:0045892involved_in negative regulation of DNA-templated transcription1IMPHomo_sapiens(9606)Process
GO:0046976enables histone H3K27 methyltransferase activity4IBA,IDA,IMP,TASHomo_sapiens(9606)Function
GO:0048387involved_in negative regulation of retinoic acid receptor signaling pathway1IMPHomo_sapiens(9606)Process
GO:0048511involved_in rhythmic process1IEAHomo_sapiens(9606)Process
GO:0048863involved_in stem cell differentiation1IEAHomo_sapiens(9606)Process
GO:0051154involved_in negative regulation of striated muscle cell differentiation1IEAHomo_sapiens(9606)Process
GO:0051932involved_in synaptic transmission, GABAergic1IEAHomo_sapiens(9606)Process
GO:0070301involved_in cellular response to hydrogen peroxide1IEAHomo_sapiens(9606)Process
GO:0070314involved_in G1 to G0 transition1IEAHomo_sapiens(9606)Process
GO:0070734involved_in histone H3-K27 methylation1IEAHomo_sapiens(9606)Process
GO:0070878enables primary miRNA binding1IEAHomo_sapiens(9606)Function
GO:0071168involved_in protein localization to chromatin1IEAHomo_sapiens(9606)Process
GO:0071902involved_in positive regulation of protein serine/threonine kinase activity1IDAHomo_sapiens(9606)Process
GO:0090183involved_in regulation of kidney development1IEAHomo_sapiens(9606)Process
GO:0097421involved_in liver regeneration1IEAHomo_sapiens(9606)Process
GO:0106222enables lncRNA binding1IEAHomo_sapiens(9606)Function
GO:0140718involved_in facultative heterochromatin formation1IEAHomo_sapiens(9606)Process
GO:0140951enables histone H3K27 trimethyltransferase activity1IEAHomo_sapiens(9606)Function
GO:1900006involved_in positive regulation of dendrite development1IEAHomo_sapiens(9606)Process
GO:1900016involved_in negative regulation of cytokine production involved in inflammatory response1IEAHomo_sapiens(9606)Process
GO:1902808involved_in positive regulation of cell cycle G1/S phase transition1IMPHomo_sapiens(9606)Process
GO:1904772involved_in response to tetrachloromethane1IEAHomo_sapiens(9606)Process
GO:1990841enables promoter-specific chromatin binding1IDAHomo_sapiens(9606)Function
GO:2000134involved_in negative regulation of G1/S transition of mitotic cell cycle1IEAHomo_sapiens(9606)Process
GO:2000737involved_in negative regulation of stem cell differentiation1IEAHomo_sapiens(9606)Process

Expression