RBP Type
Canonical_RBPs
Diseases
Flaviviruses Dengue
Drug
N.A.
Main interacting RNAs
mRNA
Moonlighting functions
TF
Localizations
Stress granucle
BulkPerturb-seq
Ensembl ID ENSG00000105127 Gene ID
10270 Accession
378
Symbol
AKAP8
Alias
AKAP-8;AKAP95;AKAP95;AKAP-95
Full Name
A-kinase anchoring protein 8
Status
Confidence
Length
26431 bases
Strand
Minus strand
Position
19 : 15353385 - 15379815
RNA binding domain
AKAP95
Summary
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
RNA binding domains (RBDs)
Protein
Domain
Pfam ID
E-value
Domain number
ENSP00000504982
AKAP95
PF04988 2.6e-54
1
ENSP00000269701
AKAP95
PF04988 2.7e-54
1
RNA binding proteomes (RBPomes)
Pubmed ID
Full Name
Cell
Author
Time
Doi
Literatures on RNA binding capacity
Pubmed ID
Title
Author
Time
Journal
Name
Transcript ID
bp
Protein
Translation ID
AKAP8-201
ENST00000269701
3665
692aa
ENSP00000269701
AKAP8-207
ENST00000680199
2670
No protein
-
AKAP8-206
ENST00000679798
3890
No protein
-
AKAP8-211
ENST00000681018
4196
No protein
-
AKAP8-208
ENST00000680245
3609
679aa
ENSP00000504982
AKAP8-212
ENST00000681812
3667
372aa
ENSP00000506597
AKAP8-209
ENST00000680336
4311
No protein
-
AKAP8-210
ENST00000680461
3381
133aa
ENSP00000506081
AKAP8-204
ENST00000598597
3715
364aa
ENSP00000469908
AKAP8-205
ENST00000599883
2265
364aa
ENSP00000468902
AKAP8-202
ENST00000537303
1350
No protein
-
AKAP8-203
ENST00000595416
557
No protein
-
Pathway ID
Pathway Name
Source
ensgID
Trait
pValue
Pubmed ID
ensgID SNP Chromosome Position
Trait PubmedID Or or BEAT
EFO ID
Protein-Protein Interaction (PPI)
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000105127 homo_sapiens ENSP00000380557 48.1424 33.2817 homo_sapiens ENSP00000269701 44.9422 31.0694 ENSG00000105127 homo_sapiens ENSP00000340796 41.4089 27.4914 homo_sapiens ENSP00000269701 34.8266 23.1214
Ensembl ID
Source
Target
Species
Protein ID
Perc_pos
Perc_id
Species
Protein ID
Perc_pos
Perc_id
ENSG00000105127 homo_sapiens ENSP00000269701 97.6879 97.1098 nomascus_leucogenys ENSNLEP00000006362 97.6879 97.1098 ENSG00000105127 homo_sapiens ENSP00000269701 99.711 99.422 pan_paniscus ENSPPAP00000024755 99.711 99.422 ENSG00000105127 homo_sapiens ENSP00000269701 98.4104 97.2543 pongo_abelii ENSPPYP00000010838 98.4104 97.2543 ENSG00000105127 homo_sapiens ENSP00000269701 99.5665 99.422 pan_troglodytes ENSPTRP00000083023 99.5665 99.422 ENSG00000105127 homo_sapiens ENSP00000269701 98.9884 97.9769 gorilla_gorilla ENSGGOP00000013102 98.9884 97.9769 ENSG00000105127 homo_sapiens ENSP00000269701 70.9538 59.6821 ornithorhynchus_anatinus ENSOANP00000048090 72.8487 61.276 ENSG00000105127 homo_sapiens ENSP00000269701 74.711 61.7052 sarcophilus_harrisii ENSSHAP00000043559 74.2816 61.3506 ENSG00000105127 homo_sapiens ENSP00000269701 45.5202 40.0289 notamacropus_eugenii ENSMEUP00000007856 51.1364 44.9675 ENSG00000105127 homo_sapiens ENSP00000269701 76.7341 68.9306 dasypus_novemcinctus ENSDNOP00000019902 78.5503 70.5621 ENSG00000105127 homo_sapiens ENSP00000269701 81.3584 72.6879 dasypus_novemcinctus ENSDNOP00000012639 83.0383 74.1888 ENSG00000105127 homo_sapiens ENSP00000269701 53.9017 48.1214 echinops_telfairi ENSETEP00000011170 74.4511 66.4671 ENSG00000105127 homo_sapiens ENSP00000269701 92.1965 89.1618 callithrix_jacchus ENSCJAP00000003998 94.5185 91.4074 ENSG00000105127 homo_sapiens ENSP00000269701 90.6069 89.3064 cercocebus_atys ENSCATP00000042548 97.6636 96.2617 ENSG00000105127 homo_sapiens ENSP00000269701 97.2543 95.9538 macaca_fascicularis ENSMFAP00000030497 97.5362 96.2319 ENSG00000105127 homo_sapiens ENSP00000269701 97.2543 95.9538 macaca_mulatta ENSMMUP00000023637 97.5362 96.2319 ENSG00000105127 homo_sapiens ENSP00000269701 88.1503 86.8497 macaca_nemestrina ENSMNEP00000016804 97.2887 95.8533 ENSG00000105127 homo_sapiens ENSP00000269701 96.3873 94.9422 mandrillus_leucophaeus ENSMLEP00000021066 97.6574 96.1933 ENSG00000105127 homo_sapiens ENSP00000269701 88.0058 83.6705 tursiops_truncatus ENSTTRP00000015162 89.1654 84.7731 ENSG00000105127 homo_sapiens ENSP00000269701 83.6705 78.1792 vulpes_vulpes ENSVVUP00000027915 85.5244 79.9114 ENSG00000105127 homo_sapiens ENSP00000269701 87.4277 80.2023 mus_spretus MGP_SPRETEiJ_P0045805 88.064 80.786 ENSG00000105127 homo_sapiens ENSP00000269701 90.3179 85.1156 equus_asinus ENSEASP00005004796 90.0576 84.8703 ENSG00000105127 homo_sapiens ENSP00000269701 83.815 77.4566 capra_hircus ENSCHIP00000004499 88.4146 81.7073 ENSG00000105127 homo_sapiens ENSP00000269701 85.6936 78.6127 loxodonta_africana ENSLAFP00000024139 85.0789 78.0488 ENSG00000105127 homo_sapiens ENSP00000269701 89.8844 84.104 panthera_leo ENSPLOP00000000639 88.8571 83.1429 ENSG00000105127 homo_sapiens ENSP00000269701 88.7283 83.9595 ailuropoda_melanoleuca ENSAMEP00000002397 89.7661 84.9415 ENSG00000105127 homo_sapiens ENSP00000269701 83.3815 74.5665 oryctolagus_cuniculus ENSOCUP00000003511 86.7669 77.594 ENSG00000105127 homo_sapiens ENSP00000269701 86.9942 81.5029 canis_lupus_familiaris ENSCAFP00845024676 87.6274 82.0961 ENSG00000105127 homo_sapiens ENSP00000269701 90.0289 84.2486 panthera_pardus ENSPPRP00000018386 88.873 83.1669 ENSG00000105127 homo_sapiens ENSP00000269701 90.7514 84.6821 marmota_marmota_marmota ENSMMMP00000025585 90.4899 84.438 ENSG00000105127 homo_sapiens ENSP00000269701 91.6185 87.4277 balaenoptera_musculus ENSBMSP00010001684 91.7511 87.5543 ENSG00000105127 homo_sapiens ENSP00000269701 85.1156 78.7572 cavia_porcellus ENSCPOP00000008718 87.9104 81.3433 ENSG00000105127 homo_sapiens ENSP00000269701 89.7399 84.104 felis_catus ENSFCAP00000012654 89.3525 83.741 ENSG00000105127 homo_sapiens ENSP00000269701 84.2486 79.3353 ursus_americanus ENSUAMP00000000753 87.5375 82.4324 ENSG00000105127 homo_sapiens ENSP00000269701 74.711 62.4277 monodelphis_domestica ENSMODP00000018202 76.9345 64.2857 ENSG00000105127 homo_sapiens ENSP00000269701 89.8844 84.6821 bison_bison_bison ENSBBBP00000010983 91.2023 85.9238 ENSG00000105127 homo_sapiens ENSP00000269701 90.896 86.9942 monodon_monoceros ENSMMNP00015005293 90.1146 86.2464 ENSG00000105127 homo_sapiens ENSP00000269701 83.237 78.3237 sus_scrofa ENSSSCP00000014710 89.7196 84.4237 ENSG00000105127 homo_sapiens ENSP00000269701 88.4393 83.3815 microcebus_murinus ENSMICP00000011571 85.2368 80.3621 ENSG00000105127 homo_sapiens ENSP00000269701 89.8844 82.5145 octodon_degus ENSODEP00000015332 90.1449 82.7536 ENSG00000105127 homo_sapiens ENSP00000269701 84.2486 76.4451 jaculus_jaculus ENSJJAP00000007196 86.3704 78.3704 ENSG00000105127 homo_sapiens ENSP00000269701 89.1618 83.3815 ovis_aries_rambouillet ENSOARP00020004623 90.4692 84.6041 ENSG00000105127 homo_sapiens ENSP00000269701 85.2601 80.3468 ursus_maritimus ENSUMAP00000002130 86.6373 81.6446 ENSG00000105127 homo_sapiens ENSP00000269701 66.474 59.2486 ochotona_princeps ENSOPRP00000012258 71.0974 63.3694 ENSG00000105127 homo_sapiens ENSP00000269701 87.5723 83.815 delphinapterus_leucas ENSDLEP00000009851 88.3382 84.5481 ENSG00000105127 homo_sapiens ENSP00000269701 91.185 86.9942 physeter_catodon ENSPCTP00005008929 91.3169 87.1201 ENSG00000105127 homo_sapiens ENSP00000269701 87.1387 80.0578 mus_caroli MGP_CAROLIEiJ_P0043893 87.7729 80.6405 ENSG00000105127 homo_sapiens ENSP00000269701 86.8497 79.6243 mus_musculus ENSMUSP00000002699 87.4818 80.2038 ENSG00000105127 homo_sapiens ENSP00000269701 51.5896 47.5434 dipodomys_ordii ENSDORP00000025467 85.6115 78.8969 ENSG00000105127 homo_sapiens ENSP00000269701 89.3064 83.815 mustela_putorius_furo ENSMPUP00000015974 89.1775 83.6941 ENSG00000105127 homo_sapiens ENSP00000269701 93.7861 90.7514 aotus_nancymaae ENSANAP00000038211 95.5817 92.489 ENSG00000105127 homo_sapiens ENSP00000269701 93.0636 89.4509 saimiri_boliviensis_boliviensis ENSSBOP00000011336 94.2899 90.6296 ENSG00000105127 homo_sapiens ENSP00000269701 77.1676 76.1561 chlorocebus_sabaeus ENSCSAP00000002388 98.7061 97.4122 ENSG00000105127 homo_sapiens ENSP00000269701 85.5491 78.9017 mesocricetus_auratus ENSMAUP00000025434 86.4234 79.708 ENSG00000105127 homo_sapiens ENSP00000269701 91.0405 86.8497 phocoena_sinus ENSPSNP00000003320 91.4369 87.2279 ENSG00000105127 homo_sapiens ENSP00000269701 90.3179 85.5491 camelus_dromedarius ENSCDRP00005005581 90.843 86.0465 ENSG00000105127 homo_sapiens ENSP00000269701 92.052 87.1387 carlito_syrichta ENSTSYP00000008310 92.8571 87.9009 ENSG00000105127 homo_sapiens ENSP00000269701 88.1503 82.659 panthera_tigris_altaica ENSPTIP00000009615 88.0231 82.5397 ENSG00000105127 homo_sapiens ENSP00000269701 87.1387 79.9133 rattus_norvegicus ENSRNOP00000008827 87.7729 80.4949 ENSG00000105127 homo_sapiens ENSP00000269701 92.6301 88.1503 prolemur_simus ENSPSMP00000012903 93.3042 88.7918 ENSG00000105127 homo_sapiens ENSP00000269701 86.1272 79.1908 microtus_ochrogaster ENSMOCP00000002033 86.3768 79.4203 ENSG00000105127 homo_sapiens ENSP00000269701 80.4913 72.3988 sorex_araneus ENSSARP00000009688 83.6336 75.2252 ENSG00000105127 homo_sapiens ENSP00000269701 85.4046 79.0462 peromyscus_maniculatus_bairdii ENSPEMP00000017856 87.1681 80.6785 ENSG00000105127 homo_sapiens ENSP00000269701 89.8844 84.6821 bos_mutus ENSBMUP00000015921 91.2023 85.9238 ENSG00000105127 homo_sapiens ENSP00000269701 86.7052 78.6127 mus_spicilegus ENSMSIP00000007142 85.592 77.6034 ENSG00000105127 homo_sapiens ENSP00000269701 87.2832 80.0578 mus_spicilegus ENSMSIP00000006204 87.7907 80.5233 ENSG00000105127 homo_sapiens ENSP00000269701 85.5491 78.1792 cricetulus_griseus_chok1gshd ENSCGRP00001015655 85.7971 78.4058 ENSG00000105127 homo_sapiens ENSP00000269701 90.3179 84.3931 pteropus_vampyrus ENSPVAP00000015955 90.5797 84.6377 ENSG00000105127 homo_sapiens ENSP00000269701 70.0867 61.1272 myotis_lucifugus ENSMLUP00000018808 70.5968 61.5721 ENSG00000105127 homo_sapiens ENSP00000269701 71.0983 67.052 myotis_lucifugus ENSMLUP00000004984 89.2922 84.2105 ENSG00000105127 homo_sapiens ENSP00000269701 74.711 62.2832 vombatus_ursinus ENSVURP00010032615 74.6032 62.1934 ENSG00000105127 homo_sapiens ENSP00000269701 89.3064 83.9595 rhinolophus_ferrumequinum ENSRFEP00010015723 85.7143 80.5825 ENSG00000105127 homo_sapiens ENSP00000269701 89.3064 84.104 neovison_vison ENSNVIP00000014971 89.1775 83.9827 ENSG00000105127 homo_sapiens ENSP00000269701 90.3179 83.526 heterocephalus_glaber_female ENSHGLP00000009589 90.3179 83.526 ENSG00000105127 homo_sapiens ENSP00000269701 90.6069 89.3064 rhinopithecus_bieti ENSRBIP00000012249 97.0588 95.6656 ENSG00000105127 homo_sapiens ENSP00000269701 83.526 78.0347 canis_lupus_dingo ENSCAFP00020011659 85.3767 79.7637 ENSG00000105127 homo_sapiens ENSP00000269701 90.3179 84.5376 sciurus_vulgaris ENSSVLP00005019073 91.2409 85.4015 ENSG00000105127 homo_sapiens ENSP00000269701 74.5665 62.1387 phascolarctos_cinereus ENSPCIP00000004846 74.4589 62.0491 ENSG00000105127 homo_sapiens ENSP00000269701 83.526 75.1445 procavia_capensis ENSPCAP00000003612 83.526 75.1445 ENSG00000105127 homo_sapiens ENSP00000269701 87.2832 80.4913 nannospalax_galili ENSNGAP00000007703 86.7816 80.0287 ENSG00000105127 homo_sapiens ENSP00000269701 89.8844 84.6821 bos_grunniens ENSBGRP00000035145 91.2023 85.9238 ENSG00000105127 homo_sapiens ENSP00000269701 91.6185 84.6821 chinchilla_lanigera ENSCLAP00000011830 91.7511 84.8046 ENSG00000105127 homo_sapiens ENSP00000269701 87.8613 82.948 catagonus_wagneri ENSCWAP00000011601 88.1159 83.1884 ENSG00000105127 homo_sapiens ENSP00000269701 90.3179 84.2486 ictidomys_tridecemlineatus ENSSTOP00000006051 91.2409 85.1095 ENSG00000105127 homo_sapiens ENSP00000269701 91.185 86.2717 otolemur_garnettii ENSOGAP00000020772 93.0678 88.0531 ENSG00000105127 homo_sapiens ENSP00000269701 89.3064 85.6936 cebus_imitator ENSCCAP00000038606 94.9309 91.0906 ENSG00000105127 homo_sapiens ENSP00000269701 90.6069 84.3931 urocitellus_parryii ENSUPAP00010001060 90.0862 83.908 ENSG00000105127 homo_sapiens ENSP00000269701 89.3064 83.237 moschus_moschiferus ENSMMSP00000027630 90.4832 84.3338 ENSG00000105127 homo_sapiens ENSP00000269701 96.9653 95.5202 rhinopithecus_roxellana ENSRROP00000014475 97.2464 95.7971 ENSG00000105127 homo_sapiens ENSP00000269701 86.5607 78.9017 mus_pahari MGP_PahariEiJ_P0043457 87.064 79.3605 ENSG00000105127 homo_sapiens ENSP00000269701 92.1965 87.7168 propithecus_coquereli ENSPCOP00000009673 92.8675 88.3552 ENSG00000105127 homo_sapiens ENSP00000269701 30.4913 16.3295 eptatretus_burgeri ENSEBUP00000003059 36.0684 19.3162 ENSG00000105127 homo_sapiens ENSP00000269701 36.2717 27.8902 callorhinchus_milii ENSCMIP00000017369 52.9536 40.7173 ENSG00000105127 homo_sapiens ENSP00000269701 62.8613 50.8671 latimeria_chalumnae ENSLACP00000010312 62.2318 50.3577 ENSG00000105127 homo_sapiens ENSP00000269701 14.3064 10.5491 lepisosteus_oculatus ENSLOCP00000008156 49.5 36.5 ENSG00000105127 homo_sapiens ENSP00000269701 66.6185 54.9133 chrysemys_picta_bellii ENSCPBP00000029544 61.7135 50.8701 ENSG00000105127 homo_sapiens ENSP00000269701 63.7283 50.289 laticauda_laticaudata ENSLLTP00000007054 64.3796 50.8029 ENSG00000105127 homo_sapiens ENSP00000269701 58.0925 45.9538 notechis_scutatus ENSNSUP00000025134 65.154 51.5397 ENSG00000105127 homo_sapiens ENSP00000269701 64.0173 50.578 pseudonaja_textilis ENSPTXP00000013915 64.2961 50.7983 ENSG00000105127 homo_sapiens ENSP00000269701 64.0173 53.1792 anas_platyrhynchos_platyrhynchos ENSAPLP00000006837 57.0142 47.3616 ENSG00000105127 homo_sapiens ENSP00000269701 65.0289 54.0462 gallus_gallus ENSGALP00010005294 57.6184 47.8873 ENSG00000105127 homo_sapiens ENSP00000269701 51.0116 42.4855 meleagris_gallopavo ENSMGAP00000009365 56.2998 46.89 ENSG00000105127 homo_sapiens ENSP00000269701 49.422 37.5723 serinus_canaria ENSSCAP00000003942 38.9522 29.6128 ENSG00000105127 homo_sapiens ENSP00000269701 58.6705 47.1098 anolis_carolinensis ENSACAP00000017030 61.8902 49.6951 ENSG00000105127 homo_sapiens ENSP00000269701 64.3064 51.1561 naja_naja ENSNNAP00000015788 64.9635 51.6788 ENSG00000105127 homo_sapiens ENSP00000269701 47.6879 39.3064 podarcis_muralis ENSPMRP00000028249 70.2128 57.8723 ENSG00000105127 homo_sapiens ENSP00000269701 59.104 45.6647 erpetoichthys_calabaricus ENSECRP00000031568 56.4138 43.5862 ENSG00000105127 homo_sapiens ENSP00000269701 62.5723 50.289 salvator_merianae ENSSMRP00000007208 61.5057 49.4318 ENSG00000105127 homo_sapiens ENSP00000269701 66.185 54.4798 pelodiscus_sinensis ENSPSIP00000006604 65.0568 53.5511 ENSG00000105127 homo_sapiens ENSP00000269701 66.0405 54.3353 gopherus_evgoodei ENSGEVP00005018140 61.3423 50.4698 ENSG00000105127 homo_sapiens ENSP00000269701 60.6936 50 chelonoidis_abingdonii ENSCABP00000016069 62.9685 51.8741 ENSG00000105127 homo_sapiens ENSP00000269701 63.5838 53.3237 struthio_camelus_australis ENSSCUP00000012863 58.1242 48.745 ENSG00000105127 homo_sapiens ENSP00000269701 67.1965 56.3584 anser_brachyrhynchus ENSABRP00000005521 57.5495 48.2673 ENSG00000105127 homo_sapiens ENSP00000269701 66.474 55.4913 strigops_habroptila ENSSHBP00005020194 60.7662 50.7266 ENSG00000105127 homo_sapiens ENSP00000269701 67.1965 55.3468 terrapene_carolina_triunguis ENSTMTP00000006850 63.2653 52.1088 ENSG00000105127 homo_sapiens ENSP00000269701 66.0405 56.0694 aquila_chrysaetos_chrysaetos ENSACCP00020004554 59.7386 50.719 ENSG00000105127 homo_sapiens ENSP00000269701 64.7399 54.0462 coturnix_japonica ENSCJPP00005004943 56.7807 47.4018 ENSG00000105127 homo_sapiens ENSP00000269701 40.4624 26.8786 paramormyrops_kingsleyae ENSPKIP00000023104 39.3258 26.1236 ENSG00000105127 homo_sapiens ENSP00000269701 41.3295 29.6243 scleropages_formosus ENSSFOP00015009116 41.033 29.4118
Go ID
Go term
No. evidence
Entries
Species
Category
GO:0000278 involved_in mitotic cell cycle 1 TAS Homo_sapiens(9606) Process GO:0000793 located_in condensed chromosome 1 IEA Homo_sapiens(9606) Component GO:0001939 located_in female pronucleus 1 IEA Homo_sapiens(9606) Component GO:0003690 enables double-stranded DNA binding 1 IEA Homo_sapiens(9606) Function GO:0003723 enables RNA binding 1 HDA Homo_sapiens(9606) Function GO:0005515 enables protein binding 1 IPI Homo_sapiens(9606) Function GO:0005634 is_active_in nucleus 1 IBA Homo_sapiens(9606) Component GO:0005654 located_in nucleoplasm 1 IDA Homo_sapiens(9606) Component GO:0005730 located_in nucleolus 1 IDA Homo_sapiens(9606) Component GO:0005737 located_in cytoplasm 1 IEA Homo_sapiens(9606) Component GO:0007076 involved_in mitotic chromosome condensation 1 IEA Homo_sapiens(9606) Process GO:0007165 involved_in signal transduction 1 TAS Homo_sapiens(9606) Process GO:0008270 enables zinc ion binding 1 IEA Homo_sapiens(9606) Function GO:0015031 involved_in protein transport 1 IEA Homo_sapiens(9606) Process GO:0016020 located_in membrane 1 HDA Homo_sapiens(9606) Component GO:0016363 is_active_in nuclear matrix 2 IBA,ISS Homo_sapiens(9606) Component GO:0032720 involved_in negative regulation of tumor necrosis factor production 1 IEA Homo_sapiens(9606) Process GO:0034237 enables protein kinase A regulatory subunit binding 2 IBA,IPI Homo_sapiens(9606) Function GO:0042826 enables histone deacetylase binding 1 IDA Homo_sapiens(9606) Function GO:0044839 involved_in cell cycle G2/M phase transition 1 IMP Homo_sapiens(9606) Process GO:0045087 involved_in innate immune response 1 IEA Homo_sapiens(9606) Process GO:0051059 enables NF-kappaB binding 1 IEA Homo_sapiens(9606) Function GO:0071222 involved_in cellular response to lipopolysaccharide 1 IEA Homo_sapiens(9606) Process GO:0071380 involved_in cellular response to prostaglandin E stimulus 1 IEA Homo_sapiens(9606) Process
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