Ensembl ID ENSG00000105127 Gene ID 10270 Accession 378
Gene Symbol AKAP8 Alias AKAP-8;AKAP95;AKAP95;AKAP-95 Full Name A-kinase anchoring protein 8
Position 19 : 15353385 - 15379815 Length 26431 bases Strand Minus strand
Status Confidence Main interacting RNAsmRNARBP type Canonical_RBPs
Summary This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]

ENSG00000105127 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000105127 AKAP8 0.76 1.45e-41 KIRC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000105127 AKAP8 lung cancer 23256994
ENSG00000105127 AKAP8 lung cancer 24370359
ENSG00000105127 AKAP8 rectal cancer 25973052
ENSG00000105127 AKAP8 esophageal cancer 26221272
ENSG00000105127 AKAP8 breast cancer 26272591
ENSG00000105127 AKAP8 lung cancer 26622460
ENSG00000105127 AKAP8 ovarian cancer 26823747
ENSG00000105127 AKAP8 lung cancer 26880274
ENSG00000105127 AKAP8 lung cancer 27158371
ENSG00000105127 AKAP8 breast cancer 28755423
ENSG00000105127 AKAP8 esophagus cancer 28771997
ENSG00000105127 AKAP8 tumor 29433456
ENSG00000105127 AKAP8 lung cancer 29528086
ENSG00000105127 AKAP8 esophageal cancer 30990963
ENSG00000105127 AKAP8 tumor 31980632
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000105127 AKAP8 STAD 0.00021 low
ENSG00000105127 AKAP8 THCA 0.012 high
ENSG00000105127 AKAP8 ACC 0.001 high
ENSG00000105127 AKAP8 LGG 0.00052 high
ENSG00000105127 AKAP8 LUSC 0.046 low
ENSG00000105127 AKAP8 HNSC 0.025 low
ENSG00000105127 AKAP8 READ 0.014 low
ENSG00000105127 AKAP8 KICH 0.022 high
ENSG00000105127 AKAP8 LUAD 0.02 low
ENSG00000105127 AKAP8 PCPG 0.03 low
ENSG00000105127 AKAP8 THYM 0.0044 low
ENSG00000105127 AKAP8 BRCA 0.011 low
ENSG00000105127 AKAP8 DLBC 0.038 high
ENSG00000105127 AKAP8 KIRC 0.021 high
ENSG00000105127 AKAP8 PRAD 0.011 high
ENSG00000105127 AKAP8 BLCA 0.05 low
ENSG00000105127 AKAP8 CESC 0.0053 low
ENSG00000105127 AKAP8 LIHC 0.0074 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000105127 AKAP8 ACC Amp 1.440584 0.354890 1.114240 0.644444
ENSG00000105127 AKAP8 LIHC Amp 2.050444 0.147315 0.565592 0.186486
ENSG00000105127 AKAP8 UCEC Amp 11.430540 0.262958 0.880227 0.176252
ENSG00000105127 AKAP8 OV Amp 35.254731 0.881647 1.017755 0.540587