Functions and Diseases

RBP Type Canonical_RBPs
Diseases CancerSARS-COV-OC43SARS-COV-2
Drug N.A.
Main interacting RNAs ncRNA
Moonlighting functions N.A.
Localizations Stress granucleP-body
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000055332 Gene ID 5610 Accession 9437
Symbol EIF2AK2 Alias PKR;PRKR;DYT33;LEUDEN;EIF2AK1;PPP1R83 Full Name eukaryotic translation initiation factor 2 alpha kinase 2
Status Confidence Length 57983 bases Strand Minus strand
Position 2 : 37099210 - 37157192 RNA binding domain dsrm
Summary The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000385014 dsrm PF00035 7e-28 1
ENSP00000385014 dsrm PF00035 7e-28 2
ENSP00000506203 dsrm PF00035 1.4e-27 1
ENSP00000506203 dsrm PF00035 1.4e-27 2
ENSP00000506455 dsrm PF00035 1.7e-27 1
ENSP00000506455 dsrm PF00035 1.7e-27 2
ENSP00000506573 dsrm PF00035 2.2e-27 1
ENSP00000506573 dsrm PF00035 2.2e-27 2
ENSP00000233057 dsrm PF00035 2.4e-27 1
ENSP00000233057 dsrm PF00035 2.4e-27 2
ENSP00000378559 dsrm PF00035 2.4e-27 1
ENSP00000378559 dsrm PF00035 2.4e-27 2
ENSP00000497534 dsrm PF00035 2.4e-27 1
ENSP00000497534 dsrm PF00035 2.4e-27 2
ENSP00000505138 dsrm PF00035 2.4e-27 1
ENSP00000505138 dsrm PF00035 2.4e-27 2
ENSP00000505772 dsrm PF00035 2.4e-27 1
ENSP00000505772 dsrm PF00035 2.4e-27 2
ENSP00000506024 dsrm PF00035 2.4e-27 1
ENSP00000506024 dsrm PF00035 2.4e-27 2

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
37107677 The Potential Regulation of A-to-I RNA Editing on Genes in Parkinson's Disease. Sijia Wu 2023-04-15 Genes
34007060 A novel cripavirus of an ectoparasitoid wasp increases pupal duration and fecundity of the wasp's Drosophila melanogaster host. Jiao Zhang 2021-11-01 The ISME journal
32202492 Long non-coding RNA GRASLND enhances chondrogenesis via suppression of the interferon type II signaling pathway. Pt Nguyen Huynh 2020-03-23 eLife
29538447 Molecular evolution and functional divergence of eukaryotic translation initiation factor 2-alpha kinases. Hari K Krishna 2018-01-01 PloS one
29429924 The TIA1 RNA-Binding Protein Family Regulates EIF2AK2-Mediated Stress Response and Cell Cycle Progression. Cindy Meyer 2018-02-15 Molecular cell
33068416 Structural analysis of SARS-CoV-2 genome and predictions of the human interactome. Andrea Vandelli 2020-11-18 Nucleic acids research
20454906 Pro-autophagic signal induction by bacterial pore-forming toxins. Nicole Kloft 2010-11-01 Medical microbiology and immunology
33236446 EIF2AK2 Missense Variants Associated with Early Onset Generalized Dystonia. S J Demy Kuipers 2021-03-01 Annals of neurology
34860583 DDX17 is an essential mediator of sterile NLRC4 inflammasome activation by retrotransposon RNAs. Shao-Bin Wang 2021-12-03 Science immunology
20668695 Innate immune suppression enables frequent transfection with RNA encoding reprogramming proteins. Matthew Angel 2010-07-23 PloS one
31652893 Chaperone-Mediated Autophagy in the Liver: Good or Bad? Srikanta Dash 2019-10-24 Cells
37365211 A novel computational method enables RNA editome profiling during human hematopoiesis from scRNA-seq data. Yan Wu 2023-06-26 Scientific reports
28273136 DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. C Sean Shadle 2017-03-01 PLoS genetics

Transcripts

Name Transcript ID bp Protein Translation ID
EIF2AK2-214 ENST00000681516 9837 541aa ENSP00000506573
EIF2AK2-210 ENST00000680273 9766 494aa ENSP00000506203
EIF2AK2-201 ENST00000233057 9975 551aa ENSP00000233057
EIF2AK2-209 ENST00000679979 9846 508aa ENSP00000506455
EIF2AK2-208 ENST00000679507 9835 551aa ENSP00000506024
EIF2AK2-212 ENST00000681463 9931 551aa ENSP00000505138
EIF2AK2-213 ENST00000681507 10103 551aa ENSP00000505772
EIF2AK2-211 ENST00000681329 10058 No protein -
EIF2AK2-207 ENST00000647926 2235 551aa ENSP00000497534
EIF2AK2-202 ENST00000395127 4343 551aa ENSP00000378559
EIF2AK2-203 ENST00000405334 1533 510aa ENSP00000385014
EIF2AK2-205 ENST00000462861 411 No protein -
EIF2AK2-204 ENST00000411537 1272 No protein -
EIF2AK2-206 ENST00000496059 845 No protein -

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
28409Nutritional and Metabolic Diseases9.1250000E-005-
34354Smoking9.5400000E-006-
97515Glucose2E-625524916
97516Insulin Resistance2E-625524916

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000055332homo_sapiensENSP0000037089130.149817.4157homo_sapiensENSP0000023305729.219616.8784
ENSG00000055332homo_sapiensENSP0000019938930.952417.9365homo_sapiensENSP0000023305735.390220.5082
ENSG00000055332homo_sapiensENSP0000030723521.953413.7097homo_sapiensENSP0000023305744.464627.7677
ENSG00000055332homo_sapiensENSP0000038067529.629618.1658homo_sapiensENSP0000023305730.4918.6933
ENSG00000055332homo_sapiensENSP0000036338736.363619.9413homo_sapiensENSP0000023305722.504512.3412
ENSG00000055332homo_sapiensENSP0000026230027.254515.8317homo_sapiensENSP0000023305724.682414.3376
ENSG00000055332homo_sapiensENSP0000040208426.780216.0991homo_sapiensENSP0000023305731.397518.8748
ENSG00000055332homo_sapiensENSP0000026379114.61498.91449homo_sapiensENSP0000023305743.738726.6788

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000055332homo_sapiensENSP0000023305788.566283.6661nomascus_leucogenysENSNLEP0000004276289.871184.8987
ENSG00000055332homo_sapiensENSP0000023305799.455598.7296pan_paniscusENSPPAP0000002314999.275498.5507
ENSG00000055332homo_sapiensENSP0000023305794.555492.0145pongo_abeliiENSPPYP0000002883394.555492.0145
ENSG00000055332homo_sapiensENSP0000023305799.455598.7296pan_troglodytesENSPTRP0000006574199.275498.5507
ENSG00000055332homo_sapiensENSP0000023305799.092698.5481gorilla_gorillaENSGGOP0000001916099.092698.5481
ENSG00000055332homo_sapiensENSP0000023305759.709644.8276ornithorhynchus_anatinusENSOANP0000004670458.645344.0285
ENSG00000055332homo_sapiensENSP0000023305762.431946.461sarcophilus_harrisiiENSSHAP0000000162462.659446.6302
ENSG00000055332homo_sapiensENSP0000023305756.624348.6388choloepus_hoffmanniENSCHOP0000000388758.100649.9069
ENSG00000055332homo_sapiensENSP0000023305772.776860.4356dasypus_novemcinctusENSDNOP0000000813973.84961.326
ENSG00000055332homo_sapiensENSP0000023305740.834834.6642erinaceus_europaeusENSEEUP0000000507046.487639.4628
ENSG00000055332homo_sapiensENSP0000023305755.535443.9201echinops_telfairiENSETEP0000000794556.877344.9814
ENSG00000055332homo_sapiensENSP0000023305789.473784.5735callithrix_jacchusENSCJAP0000000697989.311684.4203
ENSG00000055332homo_sapiensENSP0000023305787.295880.2178cercocebus_atysENSCATP0000002666187.295880.2178
ENSG00000055332homo_sapiensENSP0000023305787.840380.5808macaca_fascicularisENSMFAP0000001483087.364680.1444
ENSG00000055332homo_sapiensENSP0000023305787.840380.5808macaca_mulattaENSMMUP0000005138887.364680.1444
ENSG00000055332homo_sapiensENSP0000023305777.676972.5953macaca_nemestrinaENSMNEP0000003371887.704981.9672
ENSG00000055332homo_sapiensENSP0000023305788.384882.0327papio_anubisENSPANP0000001230488.868682.4818
ENSG00000055332homo_sapiensENSP0000023305786.569980.0363mandrillus_leucophaeusENSMLEP0000001868786.569980.0363
ENSG00000055332homo_sapiensENSP0000023305773.139763.7024tursiops_truncatusENSTTRP0000000650774.768165.1206
ENSG00000055332homo_sapiensENSP0000023305772.958360.98vulpes_vulpesENSVVUP0000002576775.422163.0394
ENSG00000055332homo_sapiensENSP0000023305769.14756.2613mus_spretusMGP_SPRETEiJ_P004757873.980660.1942
ENSG00000055332homo_sapiensENSP0000023305772.958361.1615equus_asinusENSEASP0000505905072.04360.3943
ENSG00000055332homo_sapiensENSP0000023305772.413861.1615capra_hircusENSCHIP0000001588273.480762.0626
ENSG00000055332homo_sapiensENSP0000023305769.691560.6171loxodonta_africanaENSLAFP0000001559773.704464.1075
ENSG00000055332homo_sapiensENSP0000023305775.680662.7949panthera_leoENSPLOP0000002306471.404159.2466
ENSG00000055332homo_sapiensENSP0000023305774.591759.5281ailuropoda_melanoleucaENSAMEP0000001855475.830360.5166
ENSG00000055332homo_sapiensENSP0000023305773.139761.706bos_indicus_hybridENSBIXP0000502429975.894564.0301
ENSG00000055332homo_sapiensENSP0000023305776.58866.6062oryctolagus_cuniculusENSOCUP0000000624577.148167.0932
ENSG00000055332homo_sapiensENSP0000023305772.776861.5245equus_caballusENSECAP0000008745171.863860.7527
ENSG00000055332homo_sapiensENSP0000023305772.958361.1615canis_lupus_familiarisENSCAFP0084502600375.563963.3459
ENSG00000055332homo_sapiensENSP0000023305775.680662.7949panthera_pardusENSPPRP0000000847477.079563.9556
ENSG00000055332homo_sapiensENSP0000023305769.87358.8022marmota_marmota_marmotaENSMMMP0000001984371.033259.7786
ENSG00000055332homo_sapiensENSP0000023305774.410264.7913balaenoptera_musculusENSBMSP0001002094576.066866.2338
ENSG00000055332homo_sapiensENSP0000023305767.150652.9946cavia_porcellusENSCPOP0000001097171.290956.262
ENSG00000055332homo_sapiensENSP0000023305775.499162.7949felis_catusENSFCAP0000000589176.894663.9556
ENSG00000055332homo_sapiensENSP0000023305756.987346.6425ursus_americanusENSUAMP0000001917375.299861.6307
ENSG00000055332homo_sapiensENSP0000023305761.524545.5535monodelphis_domesticaENSMODP0000002891552.073738.5561
ENSG00000055332homo_sapiensENSP0000023305773.139761.706bison_bison_bisonENSBBBP0000001856275.894564.0301
ENSG00000055332homo_sapiensENSP0000023305773.684263.7024monodon_monocerosENSMMNP0001502049675.324765.1206
ENSG00000055332homo_sapiensENSP0000023305773.139761.343sus_scrofaENSSSCP0000005707373.809561.9048
ENSG00000055332homo_sapiensENSP0000023305776.95166.6062microcebus_murinusENSMICP0000000301472.602762.8425
ENSG00000055332homo_sapiensENSP0000023305757.713246.6425jaculus_jaculusENSJJAP0000001176569.584256.2363
ENSG00000055332homo_sapiensENSP0000023305771.869360.4356ovis_aries_rambouilletENSOARP0002000108772.928261.326
ENSG00000055332homo_sapiensENSP0000023305774.773159.3466ursus_maritimusENSUMAP0000002015676.014860.3321
ENSG00000055332homo_sapiensENSP0000023305752.813144.2831ochotona_princepsENSOPRP0000000747053.988945.269
ENSG00000055332homo_sapiensENSP0000023305774.047263.8838delphinapterus_leucasENSDLEP0000001835175.695765.3061
ENSG00000055332homo_sapiensENSP0000023305772.958363.5209physeter_catodonENSPCTP0000502124374.582664.9351
ENSG00000055332homo_sapiensENSP0000023305760.9850.4537mus_caroliMGP_CAROLIEiJ_P004567574.008861.2335
ENSG00000055332homo_sapiensENSP0000023305769.5156.8058mus_musculusENSMUSP0000002488474.368960.7767
ENSG00000055332homo_sapiensENSP0000023305764.065353.902dipodomys_ordiiENSDORP0000000891174.159762.395
ENSG00000055332homo_sapiensENSP0000023305770.235956.6243mustela_putorius_furoENSMPUP0000000981874.710460.2317
ENSG00000055332homo_sapiensENSP0000023305779.128972.0508aotus_nancymaaeENSANAP0000003560384.169976.6409
ENSG00000055332homo_sapiensENSP0000023305788.566281.1252saimiri_boliviensis_boliviensisENSSBOP0000002027888.405880.9783
ENSG00000055332homo_sapiensENSP0000023305773.865762.4319vicugna_pacosENSVPAP0000000305775.932864.1791
ENSG00000055332homo_sapiensENSP0000023305789.836783.1216chlorocebus_sabaeusENSCSAP0000000824789.028882.3741
ENSG00000055332homo_sapiensENSP0000023305753.90245.1906tupaia_belangeriENSTBEP0000001267054.098445.3552
ENSG00000055332homo_sapiensENSP0000023305768.602557.5318mesocricetus_auratusENSMAUP0000000034473.114161.3153
ENSG00000055332homo_sapiensENSP0000023305773.321262.9764phocoena_sinusENSPSNP0000001919174.953664.3785
ENSG00000055332homo_sapiensENSP0000023305768.239657.1688camelus_dromedariusENSCDRP0000502493172.727360.9284
ENSG00000055332homo_sapiensENSP0000023305774.591763.7024carlito_syrichtaENSTSYP0000001223177.255665.9774
ENSG00000055332homo_sapiensENSP0000023305775.499162.9764panthera_tigris_altaicaENSPTIP0000002111476.894664.1405
ENSG00000055332homo_sapiensENSP0000023305769.14756.8058rattus_norvegicusENSRNOP0000009492171.482258.7242
ENSG00000055332homo_sapiensENSP0000023305779.854869.147prolemur_simusENSPSMP0000002890980.438869.6526
ENSG00000055332homo_sapiensENSP0000023305749.183337.3866microtus_ochrogasterENSMOCP0000002553067.58151.3716
ENSG00000055332homo_sapiensENSP0000023305766.606254.4465peromyscus_maniculatus_bairdiiENSPEMP0000000873675.359361.6016
ENSG00000055332homo_sapiensENSP0000023305773.139761.343bos_mutusENSBMUP0000001815875.609863.4146
ENSG00000055332homo_sapiensENSP0000023305769.328557.1688mus_spicilegusENSMSIP0000000980574.319161.284
ENSG00000055332homo_sapiensENSP0000023305770.780458.9837cricetulus_griseus_chok1gshdENSCGRP0000102353174.003861.6698
ENSG00000055332homo_sapiensENSP0000023305772.232360.98pteropus_vampyrusENSPVAP0000001304374.115562.5698
ENSG00000055332homo_sapiensENSP0000023305745.372136.4791myotis_lucifugusENSMLUP0000001958972.046157.9251
ENSG00000055332homo_sapiensENSP0000023305768.965556.4428myotis_lucifugusENSMLUP0000000319968.716156.2387
ENSG00000055332homo_sapiensENSP0000023305753.357542.2868myotis_lucifugusENSMLUP0000002163065.62552.0089
ENSG00000055332homo_sapiensENSP0000023305763.157947.3684vombatus_ursinusENSVURP0001002164853.374240.0307
ENSG00000055332homo_sapiensENSP0000023305771.143457.5318rhinolophus_ferrumequinumENSRFEP0001001755872.727358.8126
ENSG00000055332homo_sapiensENSP0000023305772.413858.8022neovison_visonENSNVIP0000002761174.02660.1113
ENSG00000055332homo_sapiensENSP0000023305773.321261.706bos_taurusENSBTAP0000001146975.797463.7899
ENSG00000055332homo_sapiensENSP0000023305764.609852.8131heterocephalus_glaber_femaleENSHGLP0000003134274.47760.8787
ENSG00000055332homo_sapiensENSP0000023305786.932882.0327rhinopithecus_bietiENSRBIP0000002102689.033584.0149
ENSG00000055332homo_sapiensENSP0000023305772.958361.1615canis_lupus_dingoENSCAFP0002002924575.563963.3459
ENSG00000055332homo_sapiensENSP0000023305776.769565.3358sciurus_vulgarisENSSVLP0000502310678.478766.7904
ENSG00000055332homo_sapiensENSP0000023305762.250547.3684phascolarctos_cinereusENSPCIP0000001404252.526839.9694
ENSG00000055332homo_sapiensENSP0000023305762.794951.9056procavia_capensisENSPCAP0000001221865.037653.7594
ENSG00000055332homo_sapiensENSP0000023305772.595360.6171nannospalax_galiliENSNGAP0000001693876.923164.2308
ENSG00000055332homo_sapiensENSP0000023305773.139761.343bos_grunniensENSBGRP0000001985575.609863.4146
ENSG00000055332homo_sapiensENSP0000023305761.161549.5463chinchilla_lanigeraENSCLAP0000001219475.730361.3483
ENSG00000055332homo_sapiensENSP0000023305771.324961.1615cervus_hanglu_yarkandensisENSCHYP0000000966273.733663.227
ENSG00000055332homo_sapiensENSP0000023305773.139759.8911catagonus_wagneriENSCWAP0000001776775.046661.4525
ENSG00000055332homo_sapiensENSP0000023305774.773162.2505ictidomys_tridecemlineatusENSSTOP0000001244276.579963.7546
ENSG00000055332homo_sapiensENSP0000023305780.943769.51otolemur_garnettiiENSOGAP0000000229080.797169.3841
ENSG00000055332homo_sapiensENSP0000023305784.75579.4918cebus_imitatorENSCCAP0000004001988.614883.112
ENSG00000055332homo_sapiensENSP0000023305774.410261.706urocitellus_parryiiENSUPAP0001000584576.350163.3147
ENSG00000055332homo_sapiensENSP0000023305772.776860.7985moschus_moschiferusENSMMSP0000001974574.535362.2677
ENSG00000055332homo_sapiensENSP0000023305790.381185.4809rhinopithecus_roxellanaENSRROP0000003305490.545585.6364
ENSG00000055332homo_sapiensENSP0000023305770.417457.3503mus_pahariMGP_PahariEiJ_P004518175.193861.2403
ENSG00000055332homo_sapiensENSP0000023305779.673368.4211propithecus_coquereliENSPCOP0000000605879.963668.6703
ENSG00000055332homo_sapiensENSP0000023305728.130716.8784drosophila_melanogasterFBpp030460725.451615.2709
ENSG00000055332homo_sapiensENSP0000023305730.85317.6044ciona_intestinalisENSCINP0000002217922.880213.0552
ENSG00000055332homo_sapiensENSP0000023305748.275932.3049lepisosteus_oculatusENSLOCP0000001959738.550725.7971
ENSG00000055332homo_sapiensENSP0000023305752.087134.8457poecilia_reticulataENSPREP0000001156541.654627.8665
ENSG00000055332homo_sapiensENSP0000023305748.820333.0309astatotilapia_callipteraENSACLP0000003510441.835128.3048
ENSG00000055332homo_sapiensENSP0000023305749.546333.2123astatotilapia_callipteraENSACLP000000354484228.1538
ENSG00000055332homo_sapiensENSP0000023305749.546334.8457lates_calcariferENSLCAP0001001161139.50827.7858
ENSG00000055332homo_sapiensENSP0000023305751.542633.2123xenopus_tropicalisENSXETP0000006976150.987432.8546
ENSG00000055332homo_sapiensENSP0000023305717.241412.8857sphenodon_punctatusENSSPUP0000001926047.738735.6784
ENSG00000055332homo_sapiensENSP0000023305758.257740.4719crocodylus_porosusENSCPRP0000501913859.554741.3729
ENSG00000055332homo_sapiensENSP0000023305742.649729.4011anas_platyrhynchos_platyrhynchosENSAPLP0000002392248.654233.5404
ENSG00000055332homo_sapiensENSP0000023305751.724136.6606gallus_gallusENSGALP0001000972551.818236.7273
ENSG00000055332homo_sapiensENSP0000023305751.361236.4791serinus_canariaENSSCAP0000001613441.495629.4721
ENSG00000055332homo_sapiensENSP0000023305752.268636.2976parus_majorENSPMJP0000002036252.268636.2976
ENSG00000055332homo_sapiensENSP0000023305752.450137.5681anolis_carolinensisENSACAP0000003154848.571434.7899
ENSG00000055332homo_sapiensENSP0000023305749.909332.8494neolamprologus_brichardiENSNBRP0000002536942.635728.062
ENSG00000055332homo_sapiensENSP0000023305752.813136.8421naja_najaENSNNAP0000000030153.296737.1795
ENSG00000055332homo_sapiensENSP0000023305747.912932.8494podarcis_muralisENSPMRP0000000038954.885737.6299
ENSG00000055332homo_sapiensENSP0000023305744.646131.7604geospiza_fortisENSGFOP0000000133255.782339.6825
ENSG00000055332homo_sapiensENSP0000023305746.82431.9419taeniopygia_guttataENSTGUP0000000905050.390634.375
ENSG00000055332homo_sapiensENSP0000023305720.508215.4265erpetoichthys_calabaricusENSECRP0000002571862.087946.7033
ENSG00000055332homo_sapiensENSP0000023305747.368431.3975erpetoichthys_calabaricusENSECRP0000002541339.908326.4526
ENSG00000055332homo_sapiensENSP0000023305750.453733.9383kryptolebias_marmoratusENSKMAP0000001119441.679228.036
ENSG00000055332homo_sapiensENSP0000023305744.464630.127salvator_merianaeENSSMRP0000001273850.724634.3685
ENSG00000055332homo_sapiensENSP0000023305753.357536.4791amphiprion_perculaENSAPEP0000003363842.241428.8793
ENSG00000055332homo_sapiensENSP0000023305752.994635.2087amphiprion_perculaENSAPEP0000003367141.068927.2855
ENSG00000055332homo_sapiensENSP0000023305755.353940.2904pelodiscus_sinensisENSPSIP0000002040053.602839.0158
ENSG00000055332homo_sapiensENSP0000023305757.531840.8348gopherus_evgoodeiENSGEVP0000501571555.908339.6825
ENSG00000055332homo_sapiensENSP0000023305750.453737.5681chelonoidis_abingdoniiENSCABP0000002674459.148944.0426
ENSG00000055332homo_sapiensENSP0000023305750.453734.4828seriola_dumeriliENSSDUP0000000389839.885227.2597
ENSG00000055332homo_sapiensENSP0000023305753.357539.02struthio_camelus_australisENSSCUP0000002137850.777237.133
ENSG00000055332homo_sapiensENSP0000023305751.361235.5717anser_brachyrhynchusENSABRP0000002134950.99135.3153
ENSG00000055332homo_sapiensENSP0000023305744.283131.9419strigops_habroptilaENSSHBP0000500983450.517636.4389
ENSG00000055332homo_sapiensENSP0000023305750.453733.9383amphiprion_ocellarisENSAOCP0000000052243.302229.1277
ENSG00000055332homo_sapiensENSP0000023305752.450136.1162amphiprion_ocellarisENSAOCP0000000053046.2431.84
ENSG00000055332homo_sapiensENSP0000023305757.894740.6534terrapene_carolina_triunguisENSTMTP0000000665456.360439.576
ENSG00000055332homo_sapiensENSP0000023305737.749524.3194hucho_huchoENSHHUP0000000805831.515220.303
ENSG00000055332homo_sapiensENSP0000023305716.333911.0708betta_splendensENSBSLP0000001440049.450633.5165
ENSG00000055332homo_sapiensENSP0000023305746.642530.853betta_splendensENSBSLP0000001428449.613932.8185
ENSG00000055332homo_sapiensENSP0000023305729.038116.8784ciona_savignyiENSCSAVP0000001026629.250517.0018
ENSG00000055332homo_sapiensENSP0000023305748.638831.9419mastacembelus_armatusENSMAMP0000002580445.733830.0341
ENSG00000055332homo_sapiensENSP0000023305751.361235.0272stegastes_partitusENSSPAP0000000990441.253628.1341
ENSG00000055332homo_sapiensENSP0000023305750.816734.6642stegastes_partitusENSSPAP0000001005639.942927.2468
ENSG00000055332homo_sapiensENSP0000023305752.813135.7532acanthochromis_polyacanthusENSAPOP0000000855142.606128.8433
ENSG00000055332homo_sapiensENSP0000023305751.905637.2051aquila_chrysaetos_chrysaetosENSACCP0002001156948.805534.9829
ENSG00000055332homo_sapiensENSP0000023305741.016326.8603nothobranchius_furzeriENSNFUP0001503948342.322127.7154
ENSG00000055332homo_sapiensENSP0000023305751.542633.9383denticeps_clupeoidesENSDCDP0000000914342.261927.8274
ENSG00000055332homo_sapiensENSP0000023305750.272233.9383denticeps_clupeoidesENSDCDP0000002226540.915827.6219
ENSG00000055332homo_sapiensENSP0000023305739.927428.1307takifugu_rubripesENSTRUP0000000648642.145629.6935
ENSG00000055332homo_sapiensENSP0000023305751.179735.0272ficedula_albicollisENSFALP0000001242252.51435.9404
ENSG00000055332homo_sapiensENSP0000023305750.272236.1162cyprinus_carpio_carpioENSCCRP0000002377827.050819.4336
ENSG00000055332homo_sapiensENSP0000023305750.272235.0272cyprinus_carpio_carpioENSCCRP0000015135839.856127.7698
ENSG00000055332homo_sapiensENSP0000023305752.087137.3866coturnix_japonicaENSCJPP0000501457552.276937.5228
ENSG00000055332homo_sapiensENSP0000023305739.0226.6788poecilia_latipinnaENSPLAP0000003145539.814827.2222
ENSG00000055332homo_sapiensENSP0000023305752.268634.6642maylandia_zebraENSMZEP0000501297233.21822.03
ENSG00000055332homo_sapiensENSP0000023305740.653429.0381tetraodon_nigroviridisENSTNIP0000000362647.863234.188
ENSG00000055332homo_sapiensENSP0000023305751.179735.5717scleropages_formosusENSSFOP0001501393741.839829.0801
ENSG00000055332homo_sapiensENSP0000023305752.087135.0272scophthalmus_maximusENSSMAP0000001676241.47427.8902

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001819involved_in positive regulation of cytokine production1ISSHomo_sapiens(9606)Process
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0003725enables double-stranded RNA binding1IDAHomo_sapiens(9606)Function
GO:0004672enables protein kinase activity2IDA,IMPHomo_sapiens(9606)Function
GO:0004674enables protein serine/threonine kinase activity1TASHomo_sapiens(9606)Function
GO:0004694enables eukaryotic translation initiation factor 2alpha kinase activity2IBA,IMPHomo_sapiens(9606)Function
GO:0004715enables non-membrane spanning protein tyrosine kinase activity1IEAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005524enables ATP binding1IEAHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IEAHomo_sapiens(9606)Component
GO:0005737is_active_in cytoplasm3IBA,IDAHomo_sapiens(9606)Component
GO:0005829located_in cytosol2IDA,TASHomo_sapiens(9606)Component
GO:0005840located_in ribosome1TASHomo_sapiens(9606)Component
GO:0006412involved_in translation1IEAHomo_sapiens(9606)Process
GO:0006468involved_in protein phosphorylation2IBA,IDAHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1TASHomo_sapiens(9606)Process
GO:0009615involved_in response to virus1IMPHomo_sapiens(9606)Process
GO:0010998involved_in regulation of translational initiation by eIF2 alpha phosphorylation1IEAHomo_sapiens(9606)Process
GO:0016020located_in membrane1HDAHomo_sapiens(9606)Component
GO:0016301enables kinase activity1IDAHomo_sapiens(9606)Function
GO:0017148involved_in negative regulation of translation2IDA,IMPHomo_sapiens(9606)Process
GO:0019888enables protein phosphatase regulator activity1TASHomo_sapiens(9606)Function
GO:0030968involved_in endoplasmic reticulum unfolded protein response1IEAHomo_sapiens(9606)Process
GO:0032722involved_in positive regulation of chemokine production1ISSHomo_sapiens(9606)Process
GO:0032874involved_in positive regulation of stress-activated MAPK cascade1ISSHomo_sapiens(9606)Process
GO:0033689involved_in negative regulation of osteoblast proliferation1IMPHomo_sapiens(9606)Process
GO:0034198involved_in cellular response to amino acid starvation1IMPHomo_sapiens(9606)Process
GO:0035455involved_in response to interferon-alpha1IDAHomo_sapiens(9606)Process
GO:0042802enables identical protein binding1IPIHomo_sapiens(9606)Function
GO:0043066involved_in negative regulation of apoptotic process1IEAHomo_sapiens(9606)Process
GO:0043410involved_in positive regulation of MAPK cascade1IMPHomo_sapiens(9606)Process
GO:0045071involved_in negative regulation of viral genome replication1IMPHomo_sapiens(9606)Process
GO:0046777involved_in protein autophosphorylation2IDA,IMPHomo_sapiens(9606)Process
GO:0048471located_in perinuclear region of cytoplasm1IDAHomo_sapiens(9606)Component
GO:0051092involved_in positive regulation of NF-kappaB transcription factor activity1IDAHomo_sapiens(9606)Process
GO:0051607involved_in defense response to virus1IEPHomo_sapiens(9606)Process
GO:0106310enables protein serine kinase activity1IEAHomo_sapiens(9606)Function
GO:0140374involved_in antiviral innate immune response1IDAHomo_sapiens(9606)Process
GO:1900225involved_in regulation of NLRP3 inflammasome complex assembly1ISSHomo_sapiens(9606)Process
GO:1901224involved_in positive regulation of NIK/NF-kappaB signaling1ISSHomo_sapiens(9606)Process
GO:1901532involved_in regulation of hematopoietic progenitor cell differentiation1ISSHomo_sapiens(9606)Process
GO:1902033involved_in regulation of hematopoietic stem cell proliferation1ISSHomo_sapiens(9606)Process
GO:1902036involved_in regulation of hematopoietic stem cell differentiation1ISSHomo_sapiens(9606)Process

Expression