Ensembl ID ENSG00000055332 Gene ID 5610 Accession 9437
Gene Symbol EIF2AK2 Alias PKR;PRKR;DYT33;LEUDEN;EIF2AK1;PPP1R83 Full Name eukaryotic translation initiation factor 2 alpha kinase 2
Position 2 : 37099210 - 37157192 Length 57983 bases Strand Minus strand
Status Confidence Main interacting RNAsncRNARBP type Canonical_RBPs
Summary The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses. [provided by RefSeq, Jul 2021]

ENSG00000055332 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000055332 EIF2AK2 1.13 2.39e-28 HNSC
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000055332 EIF2AK2 tumor 10026221
ENSG00000055332 EIF2AK2 tumour 10070309
ENSG00000055332 EIF2AK2 tumor 10191197
ENSG00000055332 EIF2AK2 cancer 10216948
ENSG00000055332 EIF2AK2 tumor 10216952
ENSG00000055332 EIF2AK2 tumor 10400746
ENSG00000055332 EIF2AK2 tumour 10432301
ENSG00000055332 EIF2AK2 tumor 10497873
ENSG00000055332 EIF2AK2 cancer 10807049
ENSG00000055332 EIF2AK2 breast cancer 10871861
ENSG00000055332 EIF2AK2 tumor 10923918
ENSG00000055332 EIF2AK2 tumor 11068051
ENSG00000055332 EIF2AK2 tumor 11156368
ENSG00000055332 EIF2AK2 cancer 11232238
ENSG00000055332 EIF2AK2 tumor 11333223
ENSG00000055332 EIF2AK2 tumor 11447118
ENSG00000055332 EIF2AK2 tumor 11593389
ENSG00000055332 EIF2AK2 tumor 11861913
ENSG00000055332 EIF2AK2 cancer 11904180
ENSG00000055332 EIF2AK2 lung cancer 11956076
ENSG00000055332 EIF2AK2 tumor 12034040
ENSG00000055332 EIF2AK2 tumour 12083824
ENSG00000055332 EIF2AK2 tumor 12205508
ENSG00000055332 EIF2AK2 cancer 12214268
ENSG00000055332 EIF2AK2 Tumour 12440939
ENSG00000055332 EIF2AK2 colon cancer 12483527
ENSG00000055332 EIF2AK2 Tumors 12522435
ENSG00000055332 EIF2AK2 breast cancer 12860279
ENSG00000055332 EIF2AK2 tumor 12928526
ENSG00000055332 EIF2AK2 cancer 14563126
ENSG00000055332 EIF2AK2 tumour 14593443
ENSG00000055332 EIF2AK2 tumor 14638359
ENSG00000055332 EIF2AK2 tumour 14979937
ENSG00000055332 EIF2AK2 tumour 15094767
ENSG00000055332 EIF2AK2 tumor 15122791
ENSG00000055332 EIF2AK2 tumor 15174900
ENSG00000055332 EIF2AK2 tumor 15564140
ENSG00000055332 EIF2AK2 tumor 15607693
ENSG00000055332 EIF2AK2 cancer 15794745
ENSG00000055332 EIF2AK2 lung cancer 15851010
ENSG00000055332 EIF2AK2 cancer 16084774
ENSG00000055332 EIF2AK2 cancer 16123598
ENSG00000055332 EIF2AK2 rectal cancer 16148023
ENSG00000055332 EIF2AK2 esophageal cancer 16153435
ENSG00000055332 EIF2AK2 tumor 16271080
ENSG00000055332 EIF2AK2 tumors 16275992
ENSG00000055332 EIF2AK2 tumors 16317085
ENSG00000055332 EIF2AK2 pancreatic cancer 16357160
ENSG00000055332 EIF2AK2 tumor 16414988
ENSG00000055332 EIF2AK2 tumor 16434881
ENSG00000055332 EIF2AK2 tumor 16470838
ENSG00000055332 EIF2AK2 tumor 16857398
ENSG00000055332 EIF2AK2 lung cancer 17024233
ENSG00000055332 EIF2AK2 tumor 17190817
ENSG00000055332 EIF2AK2 cancer 17213191
ENSG00000055332 EIF2AK2 tumor 17215292
ENSG00000055332 EIF2AK2 cancer 17267064
ENSG00000055332 EIF2AK2 tumor 17274815
ENSG00000055332 EIF2AK2 cancer 17387345
ENSG00000055332 EIF2AK2 tumour 17623010
ENSG00000055332 EIF2AK2 tumors 17804745
ENSG00000055332 EIF2AK2 tumour 17845542
ENSG00000055332 EIF2AK2 tumor 17868458
ENSG00000055332 EIF2AK2 tumor 17927520
ENSG00000055332 EIF2AK2 tumor 17936498
ENSG00000055332 EIF2AK2 cancer 18087277
ENSG00000055332 EIF2AK2 tumour 18088246
ENSG00000055332 EIF2AK2 cancers 18096616
ENSG00000055332 EIF2AK2 cancer 18217692
ENSG00000055332 EIF2AK2 cancer 18328829
ENSG00000055332 EIF2AK2 tumour 18418049
ENSG00000055332 EIF2AK2 breast cancer 18490711
ENSG00000055332 EIF2AK2 tumor 18535617
ENSG00000055332 EIF2AK2 tumour 18553083
ENSG00000055332 EIF2AK2 breast cancer 18559534
ENSG00000055332 EIF2AK2 cancer 18728285
ENSG00000055332 EIF2AK2 cancer 19066342
ENSG00000055332 EIF2AK2 cancer 19106640
ENSG00000055332 EIF2AK2 tumour 19210572
ENSG00000055332 EIF2AK2 tumor 19259124
ENSG00000055332 EIF2AK2 tumor 19416861
ENSG00000055332 EIF2AK2 tumor 19440231
ENSG00000055332 EIF2AK2 tumor 19507191
ENSG00000055332 EIF2AK2 tumor 19715403
ENSG00000055332 EIF2AK2 tumour 19901967
ENSG00000055332 EIF2AK2 cancer 19918173
ENSG00000055332 EIF2AK2 Tumor 20029030
ENSG00000055332 EIF2AK2 cancer 20038797
ENSG00000055332 EIF2AK2 tumor 20107314
ENSG00000055332 EIF2AK2 colon cancer 20130018
ENSG00000055332 EIF2AK2 cancer 20232306
ENSG00000055332 EIF2AK2 tumor 20924113
ENSG00000055332 EIF2AK2 lung cancer 20930042
ENSG00000055332 EIF2AK2 cancers 21072047
ENSG00000055332 EIF2AK2 tumor 21081700
ENSG00000055332 EIF2AK2 tumour 21338484
ENSG00000055332 EIF2AK2 cancer 21518807
ENSG00000055332 EIF2AK2 breast cancer 21537465
ENSG00000055332 EIF2AK2 Tumor 21626603
ENSG00000055332 EIF2AK2 colon cancer 21887339
ENSG00000055332 EIF2AK2 tumor 21917954
ENSG00000055332 EIF2AK2 cancer 22064321
ENSG00000055332 EIF2AK2 Non-Small Cell Lung Cancer 22102852
ENSG00000055332 EIF2AK2 cancer 22132188
ENSG00000055332 EIF2AK2 colorectal cancer 22268531
ENSG00000055332 EIF2AK2 cancer 22575970
ENSG00000055332 EIF2AK2 tumour 22894766
ENSG00000055332 EIF2AK2 head and neck cancer 22920673
ENSG00000055332 EIF2AK2 cancer 22926522
ENSG00000055332 EIF2AK2 Breast Cancer 23029376
ENSG00000055332 EIF2AK2 breast cancer 23045272
ENSG00000055332 EIF2AK2 breast cancer 23112838
ENSG00000055332 EIF2AK2 tumour 23148689
ENSG00000055332 EIF2AK2 tumour 23155228
ENSG00000055332 EIF2AK2 Tumor 23202496
ENSG00000055332 EIF2AK2 tumor 23202942
ENSG00000055332 EIF2AK2 tumor 23254370
ENSG00000055332 EIF2AK2 tumors 23294542
ENSG00000055332 EIF2AK2 cancer 23320119
ENSG00000055332 EIF2AK2 breast cancer 23370279
ENSG00000055332 EIF2AK2 lung cancer 23370317
ENSG00000055332 EIF2AK2 tumors 23405127
ENSG00000055332 EIF2AK2 tumor 23450706
ENSG00000055332 EIF2AK2 tumor 23527187
ENSG00000055332 EIF2AK2 tumour 23557442
ENSG00000055332 EIF2AK2 prostate tumors 23732991
ENSG00000055332 EIF2AK2 cancer 23784735
ENSG00000055332 EIF2AK2 liver cancer 23844083
ENSG00000055332 EIF2AK2 tumor 24013665
ENSG00000055332 EIF2AK2 DLBCL 24023754
ENSG00000055332 EIF2AK2 cancer 24069557
ENSG00000055332 EIF2AK2 tumor 24194639
ENSG00000055332 EIF2AK2 cancer 24347309
ENSG00000055332 EIF2AK2 tumor 24377906
ENSG00000055332 EIF2AK2 cancer 24522206
ENSG00000055332 EIF2AK2 Tumor 24589629
ENSG00000055332 EIF2AK2 HNSCC 24634103
ENSG00000055332 EIF2AK2 pancreatic cancer 24699326
ENSG00000055332 EIF2AK2 tumor 24834430
ENSG00000055332 EIF2AK2 tumor 24900593
ENSG00000055332 EIF2AK2 gastric cancer 25003254
ENSG00000055332 EIF2AK2 tumor 25175769
ENSG00000055332 EIF2AK2 liver tumor 25360179
ENSG00000055332 EIF2AK2 breast cancer 25412417
ENSG00000055332 EIF2AK2 cancer 25761777
ENSG00000055332 EIF2AK2 lung cancer 25798539
ENSG00000055332 EIF2AK2 colon cancer 25856684
ENSG00000055332 EIF2AK2 tumor 26056588
ENSG00000055332 EIF2AK2 tumors 26123823
ENSG00000055332 EIF2AK2 tumor 26138562
ENSG00000055332 EIF2AK2 tumor 26168134
ENSG00000055332 EIF2AK2 cancer 26175659
ENSG00000055332 EIF2AK2 tumors 26202421
ENSG00000055332 EIF2AK2 cancer 26269597
ENSG00000055332 EIF2AK2 cancer 26318295
ENSG00000055332 EIF2AK2 gallbladder cancer 26361144
ENSG00000055332 EIF2AK2 acute myeloid leukemia (AML) 26405214
ENSG00000055332 EIF2AK2 tumor 26436135
ENSG00000055332 EIF2AK2 Tumor 26462293
ENSG00000055332 EIF2AK2 tumor 26490959
ENSG00000055332 EIF2AK2 tumor 26539644
ENSG00000055332 EIF2AK2 tumor 26719429
ENSG00000055332 EIF2AK2 tumor 26964062
ENSG00000055332 EIF2AK2 cancer 27011200
ENSG00000055332 EIF2AK2 lung cancer 27203671
ENSG00000055332 EIF2AK2 gastric cancer 27419625
ENSG00000055332 EIF2AK2 cancer 27480630
ENSG00000055332 EIF2AK2 tumor 27486347
ENSG00000055332 EIF2AK2 tumor 27502501
ENSG00000055332 EIF2AK2 pancreatic cancer 27512661
ENSG00000055332 EIF2AK2 cancer 27512673
ENSG00000055332 EIF2AK2 tumor 27515027
ENSG00000055332 EIF2AK2 thyroid cancer 27612419
ENSG00000055332 EIF2AK2 tumor 27696637
ENSG00000055332 EIF2AK2 tumor 28238174
ENSG00000055332 EIF2AK2 tumor 28298621
ENSG00000055332 EIF2AK2 liver cancer 28442604
ENSG00000055332 EIF2AK2 prostate cancer 28445962
ENSG00000055332 EIF2AK2 tumors 28548066
ENSG00000055332 EIF2AK2 tumors 28567163
ENSG00000055332 EIF2AK2 cancer 28596815
ENSG00000055332 EIF2AK2 cancer 28601430
ENSG00000055332 EIF2AK2 tumor 28695111
ENSG00000055332 EIF2AK2 cancer 28703114
ENSG00000055332 EIF2AK2 cancer 28724458
ENSG00000055332 EIF2AK2 tumor 28817603
ENSG00000055332 EIF2AK2 cancer 28820388
ENSG00000055332 EIF2AK2 tumor 28884088
ENSG00000055332 EIF2AK2 cancer 28944853
ENSG00000055332 EIF2AK2 cancer 28955655
ENSG00000055332 EIF2AK2 tumour 29022489
ENSG00000055332 EIF2AK2 cancer 29024602
ENSG00000055332 EIF2AK2 breast cancer 29053414
ENSG00000055332 EIF2AK2 cancer 29146961
ENSG00000055332 EIF2AK2 cancer 29156834
ENSG00000055332 EIF2AK2 tumor 29216507
ENSG00000055332 EIF2AK2 cancer 29345572
ENSG00000055332 EIF2AK2 cancer 29348517
ENSG00000055332 EIF2AK2 tumor 29394925
ENSG00000055332 EIF2AK2 tumor 29416786
ENSG00000055332 EIF2AK2 Cancer 29420123
ENSG00000055332 EIF2AK2 tumor 29478262
ENSG00000055332 EIF2AK2 cancer 29486283
ENSG00000055332 EIF2AK2 tumor 29510614
ENSG00000055332 EIF2AK2 tumors 29537336
ENSG00000055332 EIF2AK2 tumour 29665325
ENSG00000055332 EIF2AK2 tumor 29673125
ENSG00000055332 EIF2AK2 endometrial cancer 29844817
ENSG00000055332 EIF2AK2 tumor 29888320
ENSG00000055332 EIF2AK2 tumor 29903988
ENSG00000055332 EIF2AK2 breast cancer 29904116
ENSG00000055332 EIF2AK2 cancer 29973939
ENSG00000055332 EIF2AK2 cancer 30020475
ENSG00000055332 EIF2AK2 tumours 30103501
ENSG00000055332 EIF2AK2 tumor 30132553
ENSG00000055332 EIF2AK2 tumor 30159133
ENSG00000055332 EIF2AK2 cancer 30204503
ENSG00000055332 EIF2AK2 Colorectal Cancer 30275201
ENSG00000055332 EIF2AK2 cancer 30278522
ENSG00000055332 EIF2AK2 tumor 30386928
ENSG00000055332 EIF2AK2 tumour 30420615
ENSG00000055332 EIF2AK2 cancer 30518569
ENSG00000055332 EIF2AK2 cancer 30548229
ENSG00000055332 EIF2AK2 tumour 30559380
ENSG00000055332 EIF2AK2 tumor 30559422
ENSG00000055332 EIF2AK2 cancer 30575730
ENSG00000055332 EIF2AK2 tumor 30585209
ENSG00000055332 EIF2AK2 ovarian cancer 30613350
ENSG00000055332 EIF2AK2 DLBCL 30617217
ENSG00000055332 EIF2AK2 tumor 30686999
ENSG00000055332 EIF2AK2 tumour 30800296
ENSG00000055332 EIF2AK2 cancer 30846715
ENSG00000055332 EIF2AK2 tumor 30900824
ENSG00000055332 EIF2AK2 cancer 30948645
ENSG00000055332 EIF2AK2 cancer 31047907
ENSG00000055332 EIF2AK2 tumour 31059592
ENSG00000055332 EIF2AK2 tumor 31086176
ENSG00000055332 EIF2AK2 cancer 31091555
ENSG00000055332 EIF2AK2 esophageal cancer 31162820
ENSG00000055332 EIF2AK2 tumor 31174840
ENSG00000055332 EIF2AK2 cancer 31231984
ENSG00000055332 EIF2AK2 Colorectal Cancer 31387675
ENSG00000055332 EIF2AK2 tumor 31546103
ENSG00000055332 EIF2AK2 cancer 31554935
ENSG00000055332 EIF2AK2 tumors 31666439
ENSG00000055332 EIF2AK2 tumor 31723025
ENSG00000055332 EIF2AK2 tumor 31951974
ENSG00000055332 EIF2AK2 tumor 7510087
ENSG00000055332 EIF2AK2 tumor 7514301
ENSG00000055332 EIF2AK2 tumors 7539103
ENSG00000055332 EIF2AK2 tumour 7541351
ENSG00000055332 EIF2AK2 tumor 7543195
ENSG00000055332 EIF2AK2 tumor 7568028
ENSG00000055332 EIF2AK2 tumor 7641700
ENSG00000055332 EIF2AK2 tumors 7678339
ENSG00000055332 EIF2AK2 tumor 7961637
ENSG00000055332 EIF2AK2 tumor 8552671
ENSG00000055332 EIF2AK2 tumor 8557029
ENSG00000055332 EIF2AK2 tumor 8622878
ENSG00000055332 EIF2AK2 tumor 8806499
ENSG00000055332 EIF2AK2 tumours 8813468
ENSG00000055332 EIF2AK2 tumor 9041199
ENSG00000055332 EIF2AK2 tumor 9333018
ENSG00000055332 EIF2AK2 tumor 9335428
ENSG00000055332 EIF2AK2 tumour 9375375
ENSG00000055332 EIF2AK2 tumor 9422082
ENSG00000055332 EIF2AK2 tumor 9442091
ENSG00000055332 EIF2AK2 tumor 9528799
ENSG00000055332 EIF2AK2 tumor 9806790
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000055332 EIF2AK2 MESO 0.005 low
ENSG00000055332 EIF2AK2 CHOL 0.039 low
ENSG00000055332 EIF2AK2 PAAD 0.00016 high
ENSG00000055332 EIF2AK2 THCA 0.041 high
ENSG00000055332 EIF2AK2 ACC 0.00058 high
ENSG00000055332 EIF2AK2 HNSC 0.034 high
ENSG00000055332 EIF2AK2 KIRP 0.0011 high
ENSG00000055332 EIF2AK2 KICH 0.00028 high
ENSG00000055332 EIF2AK2 BRCA 0.021 high
ENSG00000055332 EIF2AK2 DLBC 0.041 high
ENSG00000055332 EIF2AK2 KIRC 0.013 low
ENSG00000055332 EIF2AK2 BLCA 0.048 high
ENSG00000055332 EIF2AK2 LAML 0.038 high
ENSG00000055332 EIF2AK2 SKCM 0.00052 low
ENSG00000055332 EIF2AK2 LIHC 0.0016 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000055332 EIF2AK2 TGCT Amp 1.046174 0.133845 0.430798 0.386667