Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer
Drug N.A.
Main interacting RNAs mRNA
Moonlighting functions N.A.
Localizations Stress granule or P-body
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000003756 Gene ID 10181 Accession 9902
Symbol RBM5 Alias G15;H37;RMB5;LUCA15;LUCA-15 Full Name RNA binding motif protein 5
Status Confidence Length 30103 bases Strand Plus strand
Position 3 : 50088919 - 50119021 RNA binding domain G-patch , OCRE , zf-RanBP , RRM_1
Summary This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000343054 RRM_1 PF00076 7.8e-14 1
ENSP00000343054 G-patch PF01585 2.1e-18 2
ENSP00000343054 OCRE PF17780 3.5e-18 3
ENSP00000343054 zf-RanBP PF00641 3.9e-09 4

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal
25540638 Molecular pathways involved in pregnancy-induced prevention against breast cancer. Maria Barton 2014-01-01 Frontiers in endocrinology
22025034 Pregnancy-induced chromatin remodeling in the breast of postmenopausal women. Jose Russo 2012-09-01 International journal of cancer
28061901 RBM5 inhibits tumorigenesis of gliomas through inhibition of Wnt/β-catenin signaling and induction of apoptosis. Yuanpei Jiang 2017-01-06 World journal of surgical oncology
28662214 RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5. J Julie Loiselle 2017-01-01 PloS one
24486491 The RNA recognition motif domains of RBM5 are required for RNA binding and cancer cell proliferation inhibition. Lei Zhang 2014-02-14 Biochemical and biophysical research communications
28728573 Splicing arrays reveal novel RBM10 targets, including SMN2 pre-mRNA. C Leslie Sutherland 2017-07-20 BMC molecular biology
36535993 A bacterial virulence factor interacts with the splicing factor RBM5 and stimulates formation of nuclear RBM5 granules. Renaud Pourpre 2022-12-19 Scientific reports
33209649 Primary tumor and metastasis-sectioning the different steps of the metastatic cascade. Helmut Popper 2020-10-01 Translational lung cancer research
37454201 Structural basis for specific RNA recognition by the alternative splicing factor RBM5. Komal Soni 2023-07-15 Nature communications
27894420 Structural basis for the recognition of spliceosomal SmN/B/B' proteins by the RBM5 OCRE domain in splicing regulation. André Mourão 2016-11-29 eLife
26273588 Splicing Regulators and Their Roles in Cancer Biology and Therapy. Roméria Maria MR da 2015-01-01 BioMed research international
36193508 hsa_circ_0003176 Suppresses the Progression of Non-Small-Cell Lung Cancer via Regulating miR-182-5p/RBM5 Axis. Fangfang Yang 2022-01-01 Disease markers
26784654 Co- and post-transcriptional regulation of Rbm5 and Rbm10 in mouse cells as evidenced by tissue-specific, developmental and disease-associated variation of splice variant and protein expression levels. Bartholomew Ozuemba 2016-04-10 Gene
23158838 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis. Lijing Zhao 2012-11-16 World journal of surgical oncology
27018053 Progression and metastasis of lung cancer. H Helmut Popper 2016-03-01 Cancer metastasis reviews
27957556 RBM5 reduces small cell lung cancer growth, increases cisplatin sensitivity and regulates key transformation-associated pathways. J Julie Loiselle 2016-11-01 Heliyon
31892844 The Function of Pre-mRNA Alternative Splicing in Mammal Spermatogenesis. Huibin Song 2020-01-01 International journal of biological sciences
22162216 Targeting zinc finger domains with small molecules: solution structure and binding studies of the RanBP2-type zinc finger of RBM5. Biancamaria Farina 2011-12-16 Chembiochem : a European journal of chemical biology
37055552 Novel thrombospondin-1 transcript exhibits distinctive expression and activity in thyroid tumorigenesis. Yukyung Hong 2023-06-01 Oncogene
33515724 RBM10: Structure, functions, and associated diseases. Akira Inoue 2021-05-30 Gene
30295127 RBM-5 modulates U2AF large subunit-dependent alternative splicing in C. elegans. Chuanman Zhou 2018-01-01 RNA biology
30675268 Role of RNA-binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer. Yanling Xu 2019-02-01 Oncology letters
26659391 Post-transcriptional regulation of Rbm5 expression in undifferentiated H9c2 myoblasts. J Julie Loiselle 2016-03-01 In vitro cellular & developmental biology. Animal

Transcripts

Name Transcript ID bp Protein Translation ID
RBM5-214 ENST00000469838 2716 143aa ENSP00000419534
RBM5-203 ENST00000404526 580 138aa ENSP00000384872
RBM5-201 ENST00000347869 3177 815aa ENSP00000343054
RBM5-208 ENST00000441305 569 137aa ENSP00000390711
RBM5-205 ENST00000433556 567 No protein -
RBM5-207 ENST00000438369 560 81aa ENSP00000414218
RBM5-212 ENST00000464087 5616 No protein -
RBM5-223 ENST00000492472 902 No protein -
RBM5-206 ENST00000437500 582 105aa ENSP00000394622
RBM5-204 ENST00000417905 427 120aa ENSP00000406119
RBM5-202 ENST00000395174 938 56aa ENSP00000378603
RBM5-226 ENST00000496179 1406 No protein -
RBM5-211 ENST00000462025 573 No protein -
RBM5-215 ENST00000471995 762 No protein -
RBM5-217 ENST00000474818 832 No protein -
RBM5-225 ENST00000494360 585 No protein -
RBM5-209 ENST00000441812 583 No protein -
RBM5-221 ENST00000489437 625 No protein -
RBM5-216 ENST00000474470 434 No protein -
RBM5-218 ENST00000475128 1371 No protein -
RBM5-224 ENST00000493993 476 No protein -
RBM5-219 ENST00000475590 704 No protein -
RBM5-222 ENST00000492430 580 No protein -
RBM5-220 ENST00000479275 1683 No protein -
RBM5-213 ENST00000464988 877 No protein -
RBM5-210 ENST00000461242 275 No protein -

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
16657Alcoholism4.44E-05-
94479Cholesterol, HDL9E-1224097068

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000003756homo_sapiensENSP0000026602233.303622.0837homo_sapiensENSP0000034305445.889630.4294
ENSG00000003756homo_sapiensENSP0000036682962.473149.1398homo_sapiensENSP0000034305471.288356.0736

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000003756homo_sapiensENSP0000034305499.018498.6503nomascus_leucogenysENSNLEP0000000847198.294897.9294
ENSG00000003756homo_sapiensENSP0000034305499.386599.0184pan_paniscusENSPPAP0000004083198.420498.0559
ENSG00000003756homo_sapiensENSP0000034305499.877399.7546pongo_abeliiENSPPYP0000003426199.877399.7546
ENSG00000003756homo_sapiensENSP0000034305499.386599.0184pan_troglodytesENSPTRP0000007098098.420498.0559
ENSG00000003756homo_sapiensENSP0000034305499.877399.7546gorilla_gorillaENSGGOP0000001414699.877399.7546
ENSG00000003756homo_sapiensENSP0000034305497.423395.092ornithorhynchus_anatinusENSOANP0000001046697.54395.2088
ENSG00000003756homo_sapiensENSP0000034305497.423394.7239sarcophilus_harrisiiENSSHAP0000002155797.423394.7239
ENSG00000003756homo_sapiensENSP0000034305490.674887.6074notamacropus_eugeniiENSMEUP0000001185991.122188.0395
ENSG00000003756homo_sapiensENSP0000034305471.533771.2883choloepus_hoffmanniENSCHOP0000000835275.32375.0646
ENSG00000003756homo_sapiensENSP0000034305499.754699.1411dasypus_novemcinctusENSDNOP0000000912099.754699.1411
ENSG00000003756homo_sapiensENSP0000034305486.380485.7669erinaceus_europaeusENSEEUP0000000543787.02186.403
ENSG00000003756homo_sapiensENSP0000034305487.852885.8896echinops_telfairiENSETEP0000001035987.745185.7843
ENSG00000003756homo_sapiensENSP0000034305493.86592.8834callithrix_jacchusENSCJAP0000008770992.391391.4251
ENSG00000003756homo_sapiensENSP0000034305410099.8773cercocebus_atysENSCATP0000003649010099.8773
ENSG00000003756homo_sapiensENSP0000034305410099.8773macaca_fascicularisENSMFAP0000005431710099.8773
ENSG00000003756homo_sapiensENSP0000034305410099.8773macaca_mulattaENSMMUP0000000653010099.8773
ENSG00000003756homo_sapiensENSP0000034305410099.7546macaca_nemestrinaENSMNEP0000004342810099.7546
ENSG00000003756homo_sapiensENSP0000034305410099.8773papio_anubisENSPANP0000000365310099.8773
ENSG00000003756homo_sapiensENSP0000034305496.31995.9509mandrillus_leucophaeusENSMLEP0000002128698.002597.628
ENSG00000003756homo_sapiensENSP0000034305493.128892.638tursiops_truncatusENSTTRP0000000730094.168793.6725
ENSG00000003756homo_sapiensENSP0000034305499.754699.5092vulpes_vulpesENSVVUP0000004011299.754699.5092
ENSG00000003756homo_sapiensENSP0000034305499.018498.1595mus_spretusMGP_SPRETEiJ_P009348299.018498.1595
ENSG00000003756homo_sapiensENSP0000034305499.877399.6319equus_asinusENSEASP0000501708998.906498.6634
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865capra_hircusENSCHIP0000001942399.754699.3865
ENSG00000003756homo_sapiensENSP0000034305499.631999.2638loxodonta_africanaENSLAFP0000000565699.509899.1422
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865panthera_leoENSPLOP0000002838999.754699.3865
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865ailuropoda_melanoleucaENSAMEP0000001267591.657391.3191
ENSG00000003756homo_sapiensENSP0000034305499.631999.1411bos_indicus_hybridENSBIXP0000500502899.631999.1411
ENSG00000003756homo_sapiensENSP0000034305499.141197.7914oryctolagus_cuniculusENSOCUP0000001002299.141197.7914
ENSG00000003756homo_sapiensENSP0000034305499.877399.6319equus_caballusENSECAP0000005953296.789596.5517
ENSG00000003756homo_sapiensENSP0000034305499.754699.5092canis_lupus_familiarisENSCAFP0084503233699.754699.5092
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865panthera_pardusENSPPRP0000001160299.754699.3865
ENSG00000003756homo_sapiensENSP0000034305499.509299.0184marmota_marmota_marmotaENSMMMP0000000407299.509299.0184
ENSG00000003756homo_sapiensENSP0000034305499.754699.0184balaenoptera_musculusENSBMSP0001001601499.754699.0184
ENSG00000003756homo_sapiensENSP0000034305498.895798.2822cavia_porcellusENSCPOP0000000732999.017298.4029
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865felis_catusENSFCAP0000001358099.754699.3865
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865ursus_americanusENSUAMP0000003743599.754699.3865
ENSG00000003756homo_sapiensENSP0000034305497.54694.6012monodelphis_domesticaENSMODP0000001540797.307294.3696
ENSG00000003756homo_sapiensENSP0000034305499.631999.1411bison_bison_bisonENSBBBP0000002065499.631999.1411
ENSG00000003756homo_sapiensENSP0000034305499.509299.0184monodon_monocerosENSMMNP0001501890399.75499.262
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865sus_scrofaENSSSCP0000003187091.041490.7055
ENSG00000003756homo_sapiensENSP0000034305499.877399.5092microcebus_murinusENSMICP0000001474899.877399.5092
ENSG00000003756homo_sapiensENSP0000034305467.116666.135octodon_degusENSODEP0000002485698.381396.9424
ENSG00000003756homo_sapiensENSP0000034305499.263898.773octodon_degusENSODEP0000002213099.50899.016
ENSG00000003756homo_sapiensENSP0000034305494.723991.411octodon_degusENSODEP0000002579395.544692.203
ENSG00000003756homo_sapiensENSP0000034305499.509298.8957jaculus_jaculusENSJJAP0000000433899.509298.8957
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865ovis_aries_rambouilletENSOARP0002002008399.754699.3865
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865ursus_maritimusENSUMAP0000003049699.754699.3865
ENSG00000003756homo_sapiensENSP0000034305489.447988.7117ochotona_princepsENSOPRP0000001385889.447988.7117
ENSG00000003756homo_sapiensENSP0000034305499.509299.0184delphinapterus_leucasENSDLEP0000001740199.75499.262
ENSG00000003756homo_sapiensENSP0000034305499.509299.0184physeter_catodonENSPCTP0000501203499.509299.0184
ENSG00000003756homo_sapiensENSP0000034305498.895797.9141mus_caroliMGP_CAROLIEiJ_P008976298.895797.9141
ENSG00000003756homo_sapiensENSP0000034305498.895798.0368mus_musculusENSMUSP0000013837998.895798.0368
ENSG00000003756homo_sapiensENSP0000034305499.509299.1411dipodomys_ordiiENSDORP0000002756599.509299.1411
ENSG00000003756homo_sapiensENSP0000034305496.932595.9509aotus_nancymaaeENSANAP0000001470492.614391.6764
ENSG00000003756homo_sapiensENSP0000034305499.877399.7546saimiri_boliviensis_boliviensisENSSBOP0000000139099.877399.7546
ENSG00000003756homo_sapiensENSP0000034305489.079888.589vicugna_pacosENSVPAP0000000873699.31698.7688
ENSG00000003756homo_sapiensENSP0000034305410099.8773chlorocebus_sabaeusENSCSAP0000001052710099.8773
ENSG00000003756homo_sapiensENSP0000034305492.269991.1656tupaia_belangeriENSTBEP0000000471792.954391.8418
ENSG00000003756homo_sapiensENSP0000034305499.141197.7914mesocricetus_auratusENSMAUP0000002344597.584596.256
ENSG00000003756homo_sapiensENSP0000034305498.895798.4049phocoena_sinusENSPSNP0000001460998.895798.4049
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865camelus_dromedariusENSCDRP0000501043499.754699.3865
ENSG00000003756homo_sapiensENSP0000034305484.785384.4172carlito_syrichtaENSTSYP0000000381799.711499.2785
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865panthera_tigris_altaicaENSPTIP0000000039199.754699.3865
ENSG00000003756homo_sapiensENSP0000034305498.77398.0368rattus_norvegicusENSRNOP0000002452999.01698.278
ENSG00000003756homo_sapiensENSP0000034305499.754699.6319prolemur_simusENSPSMP0000002022399.754699.6319
ENSG00000003756homo_sapiensENSP0000034305499.386598.4049microtus_ochrogasterENSMOCP0000001952999.386598.4049
ENSG00000003756homo_sapiensENSP0000034305459.386559.1411sorex_araneusENSSARP0000000879163.020862.7604
ENSG00000003756homo_sapiensENSP0000034305499.263898.1595peromyscus_maniculatus_bairdiiENSPEMP0000002948899.263898.1595
ENSG00000003756homo_sapiensENSP0000034305499.631999.1411bos_mutusENSBMUP0000002863799.631999.1411
ENSG00000003756homo_sapiensENSP0000034305499.018498.0368mus_spicilegusENSMSIP0000002784899.018498.0368
ENSG00000003756homo_sapiensENSP0000034305499.263898.2822cricetulus_griseus_chok1gshdENSCGRP0000100824899.263898.2822
ENSG00000003756homo_sapiensENSP0000034305497.055296.4417pteropus_vampyrusENSPVAP0000000643097.055296.4417
ENSG00000003756homo_sapiensENSP0000034305499.141198.1595myotis_lucifugusENSMLUP0000000721299.141198.1595
ENSG00000003756homo_sapiensENSP0000034305497.54695.092vombatus_ursinusENSVURP0001002331697.307294.8592
ENSG00000003756homo_sapiensENSP0000034305499.754698.8957rhinolophus_ferrumequinumENSRFEP0001003104099.754698.8957
ENSG00000003756homo_sapiensENSP0000034305499.509298.6503neovison_visonENSNVIP0000000075499.509298.6503
ENSG00000003756homo_sapiensENSP0000034305499.631999.1411bos_taurusENSBTAP0000000830599.631999.1411
ENSG00000003756homo_sapiensENSP0000034305499.631999.0184heterocephalus_glaber_femaleENSHGLP0000002075099.509898.8971
ENSG00000003756homo_sapiensENSP0000034305410099.3865rhinopithecus_bietiENSRBIP0000000294899.269298.6602
ENSG00000003756homo_sapiensENSP0000034305499.754699.5092canis_lupus_dingoENSCAFP0002002821599.754699.5092
ENSG00000003756homo_sapiensENSP0000034305499.509299.0184sciurus_vulgarisENSSVLP0000500690999.509299.0184
ENSG00000003756homo_sapiensENSP0000034305497.423394.7239phascolarctos_cinereusENSPCIP0000002884397.184894.492
ENSG00000003756homo_sapiensENSP0000034305461.963260.9816procavia_capensisENSPCAP0000000518275.148873.9583
ENSG00000003756homo_sapiensENSP0000034305498.77398.0368nannospalax_galiliENSNGAP0000000899798.170797.439
ENSG00000003756homo_sapiensENSP0000034305499.631999.1411bos_grunniensENSBGRP0000003729499.631999.1411
ENSG00000003756homo_sapiensENSP0000034305499.386598.8957chinchilla_lanigeraENSCLAP0000001141499.63199.139
ENSG00000003756homo_sapiensENSP0000034305499.754699.3865cervus_hanglu_yarkandensisENSCHYP0000003645799.754699.3865
ENSG00000003756homo_sapiensENSP0000034305499.754699.1411catagonus_wagneriENSCWAP0000002670599.754699.1411
ENSG00000003756homo_sapiensENSP0000034305499.631999.1411ictidomys_tridecemlineatusENSSTOP0000002498799.631999.1411
ENSG00000003756homo_sapiensENSP0000034305481.717880.4908otolemur_garnettiiENSOGAP0000001702687.631686.3158
ENSG00000003756homo_sapiensENSP0000034305499.386599.1411cebus_imitatorENSCCAP0000001741898.780598.5366
ENSG00000003756homo_sapiensENSP0000034305499.631999.1411urocitellus_parryiiENSUPAP0001002871599.631999.1411
ENSG00000003756homo_sapiensENSP0000034305499.509299.2638moschus_moschiferusENSMMSP0000002548299.509299.2638
ENSG00000003756homo_sapiensENSP0000034305410099.3865rhinopithecus_roxellanaENSRROP0000003579399.269298.6602
ENSG00000003756homo_sapiensENSP0000034305499.018498.2822mus_pahariMGP_PahariEiJ_P002544299.018498.2822
ENSG00000003756homo_sapiensENSP0000034305499.509299.3865propithecus_coquereliENSPCOP0000002686299.509299.3865
ENSG00000003756homo_sapiensENSP0000034305444.90827.6074caenorhabditis_elegansT08B2.5b.139.567624.3243
ENSG00000003756homo_sapiensENSP0000034305449.447931.2883drosophila_melanogasterFBpp030372440.139425.3984
ENSG00000003756homo_sapiensENSP0000034305448.711731.9018drosophila_melanogasterFBpp007763341.833527.3973
ENSG00000003756homo_sapiensENSP0000034305447.607431.5337ciona_intestinalisENSCINP0000000526050.785333.6387
ENSG00000003756homo_sapiensENSP0000034305464.171850.0613petromyzon_marinusENSPMAP0000000222258.111145.3333
ENSG00000003756homo_sapiensENSP0000034305415.337410.9202eptatretus_burgeriENSEBUP0000000370859.523842.381
ENSG00000003756homo_sapiensENSP0000034305460.245447.362eptatretus_burgeriENSEBUP0000002784765.466751.4667
ENSG00000003756homo_sapiensENSP0000034305474.355860.4908callorhinchus_miliiENSCMIP0000004317359.763348.6193
ENSG00000003756homo_sapiensENSP0000034305486.13575.3374latimeria_chalumnaeENSLACP0000001882785.714374.9695
ENSG00000003756homo_sapiensENSP0000034305480.245469.8159lepisosteus_oculatusENSLOCP0000001320275.606965.7803
ENSG00000003756homo_sapiensENSP0000034305474.846664.4172clupea_harengusENSCHAP0000004401871.512361.5475
ENSG00000003756homo_sapiensENSP0000034305469.570558.8957danio_rerioENSDARP0000013612768.14957.6923
ENSG00000003756homo_sapiensENSP0000034305477.423367.2393carassius_auratusENSCARP0000005706175.388365.4719
ENSG00000003756homo_sapiensENSP0000034305476.932566.5031carassius_auratusENSCARP0000005324775.179964.988
ENSG00000003756homo_sapiensENSP0000034305464.785356.319astyanax_mexicanusENSAMXP0000000837574.681864.9222
ENSG00000003756homo_sapiensENSP0000034305477.54667.6074ictalurus_punctatusENSIPUP0000000089775.688665.988
ENSG00000003756homo_sapiensENSP0000034305478.159567.7301esox_luciusENSELUP0000002363574.677664.7128
ENSG00000003756homo_sapiensENSP0000034305472.392663.0675electrophorus_electricusENSEEEP0000001282573.934864.411
ENSG00000003756homo_sapiensENSP0000034305477.055265.7669oncorhynchus_kisutchENSOKIP0000502455975.209664.1916
ENSG00000003756homo_sapiensENSP0000034305476.196365.5215oncorhynchus_kisutchENSOKIP000050022217564.4928
ENSG00000003756homo_sapiensENSP0000034305474.478562.8221oncorhynchus_kisutchENSOKIP0000502618870.417659.3968
ENSG00000003756homo_sapiensENSP0000034305476.31965.6442oncorhynchus_mykissENSOMYP0000012219174.580364.1487
ENSG00000003756homo_sapiensENSP0000034305474.601262.8221oncorhynchus_mykissENSOMYP0000010690870.533659.3968
ENSG00000003756homo_sapiensENSP0000034305477.177966.0123oncorhynchus_mykissENSOMYP0000001628775.329364.4311
ENSG00000003756homo_sapiensENSP0000034305410.30677.60736salmo_salarENSSSAP0000014732257.142942.1769
ENSG00000003756homo_sapiensENSP0000034305465.889657.546salmo_salarENSSSAP0000007279873.966964.6005
ENSG00000003756homo_sapiensENSP0000034305473.987762.2086salmo_salarENSSSAP0000011909969.791758.6806
ENSG00000003756homo_sapiensENSP0000034305476.564465.6442salmo_salarENSSSAP000000644097564.3029
ENSG00000003756homo_sapiensENSP0000034305474.233162.5767salmo_truttaENSSTUP0000006336066.483556.044
ENSG00000003756homo_sapiensENSP0000034305476.564465.5215salmo_truttaENSSTUP000000427917564.1827
ENSG00000003756homo_sapiensENSP0000034305477.423366.3804salmo_truttaENSSTUP0000004097474.06163.4977
ENSG00000003756homo_sapiensENSP0000034305433.742326.8712salmo_truttaENSSTUP0000005030465.789552.3923
ENSG00000003756homo_sapiensENSP0000034305470.306757.9141gadus_morhuaENSGMOP0000000835368.622856.5269
ENSG00000003756homo_sapiensENSP0000034305476.073665.5215gadus_morhuaENSGMOP0000005675169.584759.9327
ENSG00000003756homo_sapiensENSP0000034305476.073665.7669fundulus_heteroclitusENSFHEP0000003054773.372863.432
ENSG00000003756homo_sapiensENSP0000034305476.31965.6442poecilia_reticulataENSPREP0000000543272.833762.6464
ENSG00000003756homo_sapiensENSP0000034305476.564466.0123xiphophorus_maculatusENSXMAP0000001644473.067962.9977
ENSG00000003756homo_sapiensENSP0000034305472.024560.8589oryzias_latipesENSORLP0000000418772.11360.9337
ENSG00000003756homo_sapiensENSP0000034305469.202556.1963oryzias_latipesENSORLP0000000130068.613155.7178
ENSG00000003756homo_sapiensENSP000003430548.957066.87117oryzias_latipesENSORLP0000003227661.344547.0588
ENSG00000003756homo_sapiensENSP0000034305471.533761.8405cyclopterus_lumpusENSCLMP0000500042869.736860.2871
ENSG00000003756homo_sapiensENSP0000034305476.687164.4172cyclopterus_lumpusENSCLMP0000503952773.877162.0567
ENSG00000003756homo_sapiensENSP0000034305477.914166.2577oreochromis_niloticusENSONIP0000000517774.095763.0105
ENSG00000003756homo_sapiensENSP0000034305472.883460.6135oreochromis_niloticusENSONIP0000002393271.308559.3037
ENSG00000003756homo_sapiensENSP0000034305472.024559.7546haplochromis_burtoniENSHBUP0000002823170.637858.6041
ENSG00000003756homo_sapiensENSP0000034305477.914166.135haplochromis_burtoniENSHBUP0000000075574.095762.8938
ENSG00000003756homo_sapiensENSP0000034305477.791466.135astatotilapia_callipteraENSACLP0000001868974.588263.4118
ENSG00000003756homo_sapiensENSP0000034305472.147259.6319astatotilapia_callipteraENSACLP0000003573270.758158.4838
ENSG00000003756homo_sapiensENSP0000034305476.809866.0123sparus_aurataENSSAUP0001005239774.258663.8197
ENSG00000003756homo_sapiensENSP0000034305467.116655.8282sparus_aurataENSSAUP0001003071270.671858.7855
ENSG00000003756homo_sapiensENSP0000034305467.239357.9141lates_calcariferENSLCAP0001004402574.154363.8701
ENSG00000003756homo_sapiensENSP0000034305478.282266.8712lates_calcariferENSLCAP0001001899374.272463.4459
ENSG00000003756homo_sapiensENSP0000034305487.975578.1595xenopus_tropicalisENSXETP0000001591185.560976.0143
ENSG00000003756homo_sapiensENSP0000034305494.969388.8344chrysemys_picta_belliiENSCPBP0000000299293.704687.6513
ENSG00000003756homo_sapiensENSP0000034305493.251584.908sphenodon_punctatusENSSPUP0000000248481.023573.774
ENSG00000003756homo_sapiensENSP0000034305494.233186.2577laticauda_laticaudataENSLLTP0000002504392.753684.9034
ENSG00000003756homo_sapiensENSP0000034305490.797583.0675notechis_scutatusENSNSUP0000000695591.47183.6836
ENSG00000003756homo_sapiensENSP0000034305490.920283.0675pseudonaja_textilisENSPTXP0000001193591.594683.6836
ENSG00000003756homo_sapiensENSP0000034305491.288383.681anas_platyrhynchos_platyrhynchosENSAPLP0000002968680.606773.8895
ENSG00000003756homo_sapiensENSP0000034305494.723987.362gallus_gallusENSGALP0001004087284.74278.1559
ENSG00000003756homo_sapiensENSP0000034305489.693382.6994meleagris_gallopavoENSMGAP0000000380886.101379.3875
ENSG00000003756homo_sapiensENSP0000034305494.846687.362serinus_canariaENSSCAP0000002403985.320178.5872
ENSG00000003756homo_sapiensENSP0000034305494.969387.362parus_majorENSPMJP0000001659385.430578.5872
ENSG00000003756homo_sapiensENSP0000034305494.846687.4847anolis_carolinensisENSACAP0000000851993.470486.2152
ENSG00000003756homo_sapiensENSP0000034305411.4118.22086neolamprologus_brichardiENSNBRP0000000014868.382449.2647
ENSG00000003756homo_sapiensENSP0000034305468.957157.0552neolamprologus_brichardiENSNBRP0000000561772.422759.9227
ENSG00000003756homo_sapiensENSP0000034305477.914166.0123neolamprologus_brichardiENSNBRP0000002363674.095762.7771
ENSG00000003756homo_sapiensENSP0000034305419.386517.6687naja_najaENSNNAP0000001143581.025673.8462
ENSG00000003756homo_sapiensENSP0000034305464.785359.2638naja_najaENSNNAP0000001132193.61785.6383
ENSG00000003756homo_sapiensENSP0000034305494.355887.362podarcis_muralisENSPMRP0000000678491.985685.1675
ENSG00000003756homo_sapiensENSP0000034305487.852881.1043geospiza_fortisENSGFOP0000000054494.960287.6658
ENSG00000003756homo_sapiensENSP0000034305455.337450.3067taeniopygia_guttataENSTGUP0000000663076.05469.14
ENSG00000003756homo_sapiensENSP0000034305478.036866.2577erpetoichthys_calabaricusENSECRP000000236727563.6792
ENSG00000003756homo_sapiensENSP0000034305477.300665.7669kryptolebias_marmoratusENSKMAP0000000888374.380263.2822
ENSG00000003756homo_sapiensENSP0000034305494.110487.4847salvator_merianaeENSSMRP0000000994592.187585.6971
ENSG00000003756homo_sapiensENSP0000034305474.233162.9448oryzias_javanicusENSOJAP0000000292072.54261.5108
ENSG00000003756homo_sapiensENSP0000034305467.484754.6012oryzias_javanicusENSOJAP0000001063369.008855.8344
ENSG00000003756homo_sapiensENSP0000034305468.58957.7914amphilophus_citrinellusENSACIP0000002753371.758760.4621
ENSG00000003756homo_sapiensENSP0000034305413.742311.5337amphilophus_citrinellusENSACIP0000000962774.172262.2517
ENSG00000003756homo_sapiensENSP0000034305453.619646.9939amphilophus_citrinellusENSACIP0000000968582.452872.2642
ENSG00000003756homo_sapiensENSP0000034305477.54665.8896dicentrarchus_labraxENSDLAP0000505455874.440563.2509
ENSG00000003756homo_sapiensENSP0000034305469.938758.8957dicentrarchus_labraxENSDLAP0000506998769.938758.8957
ENSG00000003756homo_sapiensENSP0000034305470.184159.0184amphiprion_perculaENSAPEP0000001659968.014357.1938
ENSG00000003756homo_sapiensENSP0000034305472.63862.0859amphiprion_perculaENSAPEP0000002567370.983260.6715
ENSG00000003756homo_sapiensENSP0000034305413.496910.6748oryzias_sinensisENSOSIP0000000434768.7554.375
ENSG00000003756homo_sapiensENSP0000034305456.687149.0798oryzias_sinensisENSOSIP0000001863972.413862.6959
ENSG00000003756homo_sapiensENSP0000034305483.190277.6687pelodiscus_sinensisENSPSIP0000001807095.358789.0295
ENSG00000003756homo_sapiensENSP0000034305489.325282.6994gopherus_evgoodeiENSGEVP0000501621290.886484.1448
ENSG00000003756homo_sapiensENSP0000034305490.674884.908chelonoidis_abingdoniiENSCABP0000002116893.073187.1537
ENSG00000003756homo_sapiensENSP0000034305477.791466.135seriola_dumeriliENSSDUP0000002731174.676163.4865
ENSG00000003756homo_sapiensENSP0000034305415.950911.9018seriola_dumeriliENSSDUP0000001745873.446354.8023
ENSG00000003756homo_sapiensENSP0000034305476.564464.1718cottoperca_gobioENSCGOP0000000757074.197462.1879
ENSG00000003756homo_sapiensENSP0000034305468.58958.1595cottoperca_gobioENSCGOP0000004114667.512157.2464
ENSG00000003756homo_sapiensENSP0000034305484.662678.1595struthio_camelus_australisENSSCUP0000000880687.231480.531
ENSG00000003756homo_sapiensENSP0000034305494.969387.2393anser_brachyrhynchusENSABRP0000001509084.868477.9605
ENSG00000003756homo_sapiensENSP0000034305469.693359.1411gasterosteus_aculeatusENSGACP0000000111669.607859.0686
ENSG00000003756homo_sapiensENSP0000034305476.196364.0491gasterosteus_aculeatusENSGACP0000001384275.639563.581
ENSG00000003756homo_sapiensENSP0000034305474.478563.0675cynoglossus_semilaevisENSCSEP0000000085365.906655.8089
ENSG00000003756homo_sapiensENSP0000034305475.214764.908poecilia_formosaENSPFOP0000001698168.186958.8432
ENSG00000003756homo_sapiensENSP0000034305457.055248.589poecilia_formosaENSPFOP0000001682472.7761.9718
ENSG00000003756homo_sapiensENSP0000034305478.036867.7301myripristis_murdjanENSMMDP000050082577565.0943
ENSG00000003756homo_sapiensENSP0000034305474.969365.2761myripristis_murdjanENSMMDP0000503193771.96762.662
ENSG00000003756homo_sapiensENSP0000034305476.809864.2945sander_luciopercaENSSLUP0000003182873.560561.5746
ENSG00000003756homo_sapiensENSP0000034305472.269961.9632sander_luciopercaENSSLUP0000002380770.202660.1907
ENSG00000003756homo_sapiensENSP0000034305494.723987.4847strigops_habroptilaENSSHBP0000500822585.398278.8717
ENSG00000003756homo_sapiensENSP0000034305469.938759.1411amphiprion_ocellarisENSAOCP0000001276571.518260.4768
ENSG00000003756homo_sapiensENSP0000034305476.932565.7669amphiprion_ocellarisENSAOCP0000001946273.247762.6168
ENSG00000003756homo_sapiensENSP0000034305495.09288.8344terrapene_carolina_triunguisENSTMTP0000001209293.825787.6513
ENSG00000003756homo_sapiensENSP0000034305476.441765.2761hucho_huchoENSHHUP0000008413875.060264.0964
ENSG00000003756homo_sapiensENSP0000034305477.300666.3804hucho_huchoENSHHUP0000001755473.770563.3489
ENSG00000003756homo_sapiensENSP0000034305474.601262.8221hucho_huchoENSHHUP0000008546170.7859.6042
ENSG00000003756homo_sapiensENSP0000034305477.668766.135betta_splendensENSBSLP0000002899974.558363.4865
ENSG00000003756homo_sapiensENSP0000034305472.269961.3497betta_splendensENSBSLP0000002591070.370459.7372
ENSG00000003756homo_sapiensENSP0000034305477.055267.4847pygocentrus_nattereriENSPNAP0000000599674.407665.1659
ENSG00000003756homo_sapiensENSP0000034305472.515361.3497anabas_testudineusENSATEP0000000541370.1959.3824
ENSG00000003756homo_sapiensENSP0000034305477.423365.7669anabas_testudineusENSATEP0000003588874.410463.2075
ENSG00000003756homo_sapiensENSP0000034305427.484720.1227ciona_savignyiENSCSAVP0000001150261.878545.3039
ENSG00000003756homo_sapiensENSP0000034305477.914166.2577seriola_lalandi_dorsalisENSSLDP0000000290474.793963.6042
ENSG00000003756homo_sapiensENSP0000034305472.760762.5767seriola_lalandi_dorsalisENSSLDP0000002043370.34460.4982
ENSG00000003756homo_sapiensENSP0000034305469.815959.1411labrus_bergyltaENSLBEP0000001403264.148854.3405
ENSG00000003756homo_sapiensENSP0000034305476.809864.908labrus_bergyltaENSLBEP0000002748673.560562.1622
ENSG00000003756homo_sapiensENSP0000034305443.558336.5644labrus_bergyltaENSLBEP0000000327666.604155.9099
ENSG00000003756homo_sapiensENSP0000034305477.914166.0123pundamilia_nyerereiENSPNYP0000001956874.095762.7771
ENSG00000003756homo_sapiensENSP0000034305413.37429.57055pundamilia_nyerereiENSPNYP0000000832872.185451.6556
ENSG00000003756homo_sapiensENSP0000034305460.613551.1656pundamilia_nyerereiENSPNYP0000000830070.370459.4017
ENSG00000003756homo_sapiensENSP0000034305477.055266.3804mastacembelus_armatusENSMAMP0000002578073.708963.4977
ENSG00000003756homo_sapiensENSP0000034305473.128863.4356mastacembelus_armatusENSMAMP0000003562866.222257.4444
ENSG00000003756homo_sapiensENSP0000034305476.932565.3988stegastes_partitusENSSPAP0000002601573.851662.7797
ENSG00000003756homo_sapiensENSP0000034305473.619663.3129stegastes_partitusENSSPAP0000002658271.428661.4286
ENSG00000003756homo_sapiensENSP0000034305476.687165.5215oncorhynchus_tshawytschaENSOTSP0000507017773.356862.6761
ENSG00000003756homo_sapiensENSP0000034305477.177965.8896oncorhynchus_tshawytschaENSOTSP0000508766375.329364.3114
ENSG00000003756homo_sapiensENSP0000034305476.31965.6442oncorhynchus_tshawytschaENSOTSP0000509210774.759664.3029
ENSG00000003756homo_sapiensENSP0000034305474.355862.6994oncorhynchus_tshawytschaENSOTSP0000504618570.301659.2807
ENSG00000003756homo_sapiensENSP0000034305472.883462.454acanthochromis_polyacanthusENSAPOP0000000435271.22361.0312
ENSG00000003756homo_sapiensENSP0000034305477.055266.0123acanthochromis_polyacanthusENSAPOP0000003022173.622563.0715
ENSG00000003756homo_sapiensENSP0000034305494.846687.4847aquila_chrysaetos_chrysaetosENSACCP0002001678884.758878.1798
ENSG00000003756homo_sapiensENSP0000034305475.214764.5399nothobranchius_furzeriENSNFUP0001501458472.202661.9552
ENSG00000003756homo_sapiensENSP0000034305476.441765.6442cyprinodon_variegatusENSCVAP0000002276073.46763.0896
ENSG00000003756homo_sapiensENSP0000034305476.809866.5031denticeps_clupeoidesENSDCDP0000005116674.523864.5238
ENSG00000003756homo_sapiensENSP0000034305465.766954.3558larimichthys_croceaENSLCRP0000504158268.106756.2897
ENSG00000003756homo_sapiensENSP0000034305477.177965.3988larimichthys_croceaENSLCRP0000504808873.653462.4122
ENSG00000003756homo_sapiensENSP0000034305475.460164.0491takifugu_rubripesENSTRUP0000002074273.040461.9953
ENSG00000003756homo_sapiensENSP0000034305494.969387.362ficedula_albicollisENSFALP0000000920985.430578.5872
ENSG00000003756homo_sapiensENSP0000034305470.429559.6319hippocampus_comesENSHCOP0000002630070.951860.0742
ENSG00000003756homo_sapiensENSP0000034305468.711756.5644hippocampus_comesENSHCOP0000000324964.889953.4183
ENSG00000003756homo_sapiensENSP0000034305477.055266.6258cyprinus_carpio_carpioENSCCRP0000009194075.299865.1079
ENSG00000003756homo_sapiensENSP0000034305477.423366.9939cyprinus_carpio_carpioENSCCRP0000009195375.388365.233
ENSG00000003756homo_sapiensENSP0000034305493.251585.7669coturnix_japonicaENSCJPP0000501465693.827286.2963
ENSG00000003756homo_sapiensENSP000003430549.938658.58896poecilia_latipinnaENSPLAP0000000280077.884667.3077
ENSG00000003756homo_sapiensENSP0000034305476.441765.7669poecilia_latipinnaENSPLAP0000000460372.865562.6901
ENSG00000003756homo_sapiensENSP0000034305453.619646.2577sinocyclocheilus_grahamiENSSGRP0000004314574.067863.8983
ENSG00000003756homo_sapiensENSP0000034305477.055266.3804sinocyclocheilus_grahamiENSSGRP0000009997275.753965.2593
ENSG00000003756homo_sapiensENSP0000034305472.147259.3865maylandia_zebraENSMZEP0000501334770.758158.2431
ENSG00000003756homo_sapiensENSP0000034305477.791466.135maylandia_zebraENSMZEP0000502044474.588263.4118
ENSG00000003756homo_sapiensENSP0000034305461.104350.184tetraodon_nigroviridisENSTNIP0000001777761.7150.6815
ENSG00000003756homo_sapiensENSP0000034305478.650366.3804paramormyrops_kingsleyaeENSPKIP0000000993474.795863.1272
ENSG00000003756homo_sapiensENSP0000034305416.441713.0061paramormyrops_kingsleyaeENSPKIP0000000561072.826157.6087
ENSG00000003756homo_sapiensENSP0000034305452.515343.9264paramormyrops_kingsleyaeENSPKIP0000000060974.305662.1528
ENSG00000003756homo_sapiensENSP0000034305478.404967.7301scleropages_formosusENSSFOP0001503066175.176564.9412
ENSG00000003756homo_sapiensENSP0000034305478.895768.0982scleropages_formosusENSSFOP0001502965171.523961.7353
ENSG00000003756homo_sapiensENSP0000034305477.423369.2025leptobrachium_leishanenseENSLLEP0000001958583.465674.6032
ENSG00000003756homo_sapiensENSP0000034305476.932565.1534scophthalmus_maximusENSSMAP0000002796274.201262.8402
ENSG00000003756homo_sapiensENSP0000034305412.14728.71166oryzias_melastigmaENSOMEP0000002794462.264244.6541
ENSG00000003756homo_sapiensENSP0000034305450.18441.3497oryzias_melastigmaENSOMEP0000000943469.32257.1186
ENSG00000003756homo_sapiensENSP0000034305476.809864.7853oryzias_melastigmaENSOMEP0000000131673.216461.7544

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0000245involved_in spliceosomal complex assembly1IDAHomo_sapiens(9606)Process
GO:0000381involved_in regulation of alternative mRNA splicing, via spliceosome1IDAHomo_sapiens(9606)Process
GO:0000398involved_in mRNA splicing, via spliceosome1IBAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1TASHomo_sapiens(9606)Function
GO:0003723enables RNA binding2HDA,IBAHomo_sapiens(9606)Function
GO:0003729enables mRNA binding1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005634is_active_in nucleus2IBA,IDAHomo_sapiens(9606)Component
GO:0005654located_in nucleoplasm2IDA,TASHomo_sapiens(9606)Component
GO:0005681part_of spliceosomal complex1TASHomo_sapiens(9606)Component
GO:0006396involved_in RNA processing1TASHomo_sapiens(9606)Process
GO:0006915involved_in apoptotic process1IEAHomo_sapiens(9606)Process
GO:0008285involved_in negative regulation of cell population proliferation1TASHomo_sapiens(9606)Process
GO:0043065involved_in positive regulation of apoptotic process2IDA,TASHomo_sapiens(9606)Process
GO:0046872enables metal ion binding1IEAHomo_sapiens(9606)Function

Expression