Ensembl ID
ENSG00000003756
Gene ID
10181
Accession
9902
Gene Symbol
RBM5
Alias
G15;H37;RMB5;LUCA15;LUCA-15
Full Name
RNA binding motif protein 5
Position
3 : 50088919 - 50119021
Length
30103 bases
Strand
Plus strand
Status
Confidence
Main interacting RNAs mRNA RBP type
Canonical_RBPs
Summary
This gene is a candidate tumor suppressor gene which encodes a nuclear RNA binding protein that is a component of the spliceosome A complex. The encoded protein plays a role in the induction of cell cycle arrest and apoptosis through pre-mRNA splicing of multiple target genes including the tumor suppressor protein p53. This gene is located within the tumor suppressor region 3p21.3, and may play a role in the inhibition of tumor transformation and progression of several malignancies including lung cancer. [provided by RefSeq, Oct 2011]
ENSG00000003756 Expression In 33 Tumors
Ensembl ID
Gene symbol
Log2 Foldchange
Pvaue
Cancer
ENSG00000003756
RBM5
-0.3
7.87e-15
BRCA
ENSG00000003756
RBM5
-0.5
1.31e-12
LUSC
Ensembl ID
Gene symbol
Disease/phenotype
Mutation type
Mutated / Total samples
Literature
Ensembl ID
Gene symbol
Cancer
P-value
Which worse
show
ENSG00000003756
RBM5
UVM
0.019
low
show
ENSG00000003756
RBM5
PAAD
0.00057
low
show
ENSG00000003756
RBM5
UCEC
0.043
high
show
ENSG00000003756
RBM5
ACC
0.031
high
show
ENSG00000003756
RBM5
LUSC
0.05
high
show
ENSG00000003756
RBM5
HNSC
0.0037
low
show
ENSG00000003756
RBM5
KIRP
0.005
high
show
ENSG00000003756
RBM5
KICH
0.012
high
show
ENSG00000003756
RBM5
LUAD
0.00046
low
show
ENSG00000003756
RBM5
THYM
0.00058
low
show
ENSG00000003756
RBM5
BRCA
0.0019
low
show
ENSG00000003756
RBM5
COAD
0.0025
high
show
ENSG00000003756
RBM5
KIRC
0.00086
high
show
ENSG00000003756
RBM5
BLCA
0.0068
low
show
ENSG00000003756
RBM5
LAML
0.01
low
show
ENSG00000003756
RBM5
SKCM
0.015
low
show
ENSG00000003756
RBM5
LIHC
0.0032
high
show
Ensembl ID
Gene symbol
Cancer
CNV type
-log10(q-value)
G-score
average amplitude
frequency
ENSG00000003756
RBM5
CHOL
Del
1.070478
0.237582
0.628335
0.833333
ENSG00000003756
RBM5
LUSC
Del
5.142725
0.114532
0.414902
0.866267
ENSG00000003756
RBM5
LUAD
Del
1.677356
0.063784
0.327139
0.478682
ENSG00000003756
RBM5
LGG
Del
2.354276
0.055504
0.522236
0.091618
ENSG00000003756
RBM5
CESC
Del
0.733225
0.067528
0.536131
0.413559
ENSG00000003756
RBM5
COAD
Del
1.846842
0.054733
0.432284
0.161863
ENSG00000003756
RBM5
UCS
Del
1.777093
0.293862
0.519973
0.607143
ENSG00000003756
RBM5
SARC
Del
2.122000
0.160081
0.529337
0.249027
ENSG00000003756
RBM5
PAAD
Del
1.513405
0.061782
0.307140
0.271739
ENSG00000003756
RBM5
ESCA
Del
2.523689
0.146511
0.451261
0.668478
ENSG00000003756
RBM5
HNSC
Del
1.245014
0.060769
0.435971
0.722222
ENSG00000003756
RBM5
BLCA
Del
7.548429
0.158683
0.422525
0.301471
ENSG00000003756
RBM5
BRCA
Del
29.217666
0.174828
0.460909
0.321296
ENSG00000003756
RBM5
STAD
Del
6.389530
0.120049
0.351364
0.337868
ENSG00000003756
RBM5
UCEC
Del
2.234284
0.065682
0.495014
0.133581
ENSG00000003756
RBM5
MESO
Del
16.637312
0.531370
0.567339
0.505747
ENSG00000003756
RBM5
KIRC
Del
48.925842
0.174290
0.516127
0.876894
ENSG00000003756
RBM5
OV
Del
1.020401
0.182312
0.481278
0.326425
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