Functions and Diseases

RBP Type Non-canonical_RBPs
Diseases CancerSARS-COV-2
Drug N.A.
Main interacting RNAs N.A.
Moonlighting functions N.A.
Localizations Stress granucle
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000261150 Gene ID 83481 Accession 15577
Symbol EPPK1 Alias EPIPL;EPIPL1 Full Name epiplakin 1
Status Confidence Length 21144 bases Strand Minus strand
Position 8 : 143857324 - 143878467 RNA binding domain N.A.
Summary The protein encoded by this gene belongs to the plakin family of proteins, which play a role in the organization of cytoskeletal architecture. This family member is composed of several highly homologous plakin repeats. It may function to maintain the integrity of keratin intermediate filament networks in epithelial cells. Studies of the orthologous mouse protein suggest that it accelerates keratinocyte migration during wound healing. [provided by RefSeq, Oct 2013]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
EPPK1-202 ENST00000615648 16005 5088aa ENSP00000484472
EPPK1-201 ENST00000568225 15530 5063aa ENSP00000456124

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
62352Heart Rate1E-1527798624
77465Bronchodilator Agents1E-626634245
77466Forced Expiratory Volume1E-626634245
80570Bronchodilator Agents2E-626634245
80571Forced Expiratory Volume2E-626634245
85077Bronchodilator Agents3E-626634245
85078Forced Expiratory Volume3E-626634245
87093Bronchodilator Agents2E-626634245
87094Forced Expiratory Volume2E-626634245
91583Bronchodilator Agents2E-626634245
91584Forced Expiratory Volume2E-626634245
102024Bronchodilator Agents6E-726634245
102025Forced Expiratory Volume6E-726634245
103518Bronchodilator Agents3E-626634245
103519Forced Expiratory Volume3E-626634245
104151Bronchodilator Agents1E-626634245
104152Forced Expiratory Volume1E-626634245

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000261150homo_sapiensENSP000004508318.904013.82221homo_sapiensENSP0000048447212.08735.18868
ENSG00000261150homo_sapiensENSP0000047452913.86366.59091homo_sapiensENSP000004844722.39781.13994
ENSG00000261150homo_sapiensENSP0000044895513.25655.04323homo_sapiensENSP000004844721.808180.687893
ENSG00000261150homo_sapiensENSP0000034484821.398713.2175homo_sapiensENSP0000048447219.123411.8121
ENSG00000261150homo_sapiensENSP0000036912919.331211.1808homo_sapiensENSP0000048447210.9086.30896
ENSG00000261150homo_sapiensENSP0000032714514.01837.15596homo_sapiensENSP000004844727.507863.83255
ENSG00000261150homo_sapiensENSP0000035886614.09147.0646homo_sapiensENSP000004844727.330983.67531
ENSG00000261150homo_sapiensENSP0000035492311.37045.18318homo_sapiensENSP000004844728.235063.75393
ENSG00000261150homo_sapiensENSP0000046924219.461810.1014homo_sapiensENSP000004844729.807395.09041
ENSG00000261150homo_sapiensENSP0000049590923.238811.3402homo_sapiensENSP0000048447210.63295.18868
ENSG00000261150homo_sapiensENSP0000036182416.55237.10537homo_sapiensENSP000004844728.058183.45912
ENSG00000261150homo_sapiensENSP0000041601518.83129.79021homo_sapiensENSP000004844727.409593.8522
ENSG00000261150homo_sapiensENSP0000031779010.88735.30757homo_sapiensENSP000004844727.861643.83255
ENSG00000261150homo_sapiensENSP000003601588.247423.41188homo_sapiensENSP000004844726.603772.73192
ENSG00000261150homo_sapiensENSP0000050706720.907511.21homo_sapiensENSP000004844724.618712.47642
ENSG00000261150homo_sapiensENSP0000025269920.41719.54994homo_sapiensENSP000004844723.655661.70991
ENSG00000261150homo_sapiensENSP0000038408421.531110.6858homo_sapiensENSP000004844722.65331.31682
ENSG00000261150homo_sapiensENSP0000034925923.688711.0829homo_sapiensENSP0000048447211.00635.14937
ENSG00000261150homo_sapiensENSP000003676558.319583.22885homo_sapiensENSP000004844726.937892.69261
ENSG00000261150homo_sapiensENSP0000040581917.14297.79221homo_sapiensENSP000004844722.594341.17925
ENSG00000261150homo_sapiensENSP0000049521416.16377.06904homo_sapiensENSP000004844727.684753.36085
ENSG00000261150homo_sapiensENSP0000039659325.951613.4948homo_sapiensENSP000004844722.948111.53302
ENSG00000261150homo_sapiensENSP0000043256822.133910.7531homo_sapiensENSP0000048447210.3975.0511
ENSG00000261150homo_sapiensENSP000005050986.433873.04426homo_sapiensENSP000004844729.886014.67767
ENSG00000261150homo_sapiensENSP0000035651513.51595.59278homo_sapiensENSP000004844729.11953.77358
ENSG00000261150homo_sapiensENSP0000037863511.91224.80669homo_sapiensENSP000004844722.240570.904088
ENSG00000261150homo_sapiensENSP0000050750120.820510.8718homo_sapiensENSP000004844723.989782.08333
ENSG00000261150homo_sapiensENSP0000037396419.73979.32755homo_sapiensENSP000004844721.788520.845126
ENSG00000261150homo_sapiensENSP0000035166421.274612.2774homo_sapiensENSP000004844724.461482.57469
ENSG00000261150homo_sapiensENSP0000029595614.52737.22521homo_sapiensENSP000004844727.429253.69497
ENSG00000261150homo_sapiensENSP000004552749.675714.43415homo_sapiensENSP0000048447214.36716.58412
ENSG00000261150homo_sapiensENSP000003562247.775383.58077homo_sapiensENSP0000048447213.44346.19104
ENSG00000261150homo_sapiensENSP0000037794119.58428.86214homo_sapiensENSP000004844723.518081.59198
ENSG00000261150homo_sapiensENSP0000035553720.69359.17226homo_sapiensENSP000004844723.636011.61164
ENSG00000261150homo_sapiensENSP0000042679720.19989.21199homo_sapiensENSP000004844723.577041.63129
ENSG00000261150homo_sapiensENSP0000029891227.744513.1737homo_sapiensENSP000004844725.463842.59434

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000261150homo_sapiensENSP0000048447256.643156.3483pan_paniscusENSPPAP0000003150399.037898.5223
ENSG00000261150homo_sapiensENSP0000048447237.991428.9112ornithorhynchus_anatinusENSOANP0000004584450.4738.4073
ENSG00000261150homo_sapiensENSP0000048447244.870336.6352sarcophilus_harrisiiENSSHAP0000003306466.950154.6628
ENSG00000261150homo_sapiensENSP0000048447238.030732.783dasypus_novemcinctusENSDNOP0000003373083.441171.9276
ENSG00000261150homo_sapiensENSP0000048447243.651737.8734vulpes_vulpesENSVVUP0000003084470.485661.1552
ENSG00000261150homo_sapiensENSP0000048447229.933226.3954mus_spretusMGP_SPRETEiJ_P004038472.009563.4988
ENSG00000261150homo_sapiensENSP0000048447237.44129.6973loxodonta_africanaENSLAFP0000001930044.384935.205
ENSG00000261150homo_sapiensENSP0000048447245.558240.2319ailuropoda_melanoleucaENSAMEP0000004287972.301963.849
ENSG00000261150homo_sapiensENSP0000048447259.669853.5181bos_indicus_hybridENSBIXP0000500081950.356645.165
ENSG00000261150homo_sapiensENSP0000048447235.45631.0731oryctolagus_cuniculusENSOCUP0000004821185.945775.3216
ENSG00000261150homo_sapiensENSP0000048447249.744544.2807panthera_pardusENSPPRP0000000564970.462162.7227
ENSG00000261150homo_sapiensENSP0000048447240.782236.1046marmota_marmota_marmotaENSMMMP0000000733861.408754.3652
ENSG00000261150homo_sapiensENSP0000048447249.783844.4575felis_catusENSFCAP0000005483973.719465.8324
ENSG00000261150homo_sapiensENSP0000048447245.007936.2618monodelphis_domesticaENSMODP0000003950564.271751.7822
ENSG00000261150homo_sapiensENSP0000048447253.675347.9363sus_scrofaENSSSCP0000007706768.790961.4358
ENSG00000261150homo_sapiensENSP0000048447259.473353.4198ovis_aries_rambouilletENSOARP0002001037359.531853.4724
ENSG00000261150homo_sapiensENSP000004844724.913522.96777physeter_catodonENSPCTP0000502172148.638129.3774
ENSG00000261150homo_sapiensENSP0000048447249.606943.5928mus_musculusENSMUSP0000015944072.990264.1411
ENSG00000261150homo_sapiensENSP0000048447245.79444.5362chlorocebus_sabaeusENSCSAP0000000512296.241293.5977
ENSG00000261150homo_sapiensENSP000004844720.2948110.196541panthera_tigris_altaicaENSPTIP000000037805.859383.90625
ENSG00000261150homo_sapiensENSP0000048447249.292543.0031rattus_norvegicusENSRNOP0000009363958.543451.0738
ENSG00000261150homo_sapiensENSP0000048447249.48943.9858rhinolophus_ferrumequinumENSRFEP0001002722873.070264.9449
ENSG00000261150homo_sapiensENSP0000048447250.628945.0668bos_taurusENSBTAP0000005807374.688366.483
ENSG00000261150homo_sapiensENSP0000048447257.763451.5134canis_lupus_dingoENSCAFP0002002384658.371452.0556
ENSG00000261150homo_sapiensENSP0000048447240.801936.1242sciurus_vulgarisENSSVLP0000500022056.459149.9864
ENSG00000261150homo_sapiensENSP0000048447239.209934.5715urocitellus_parryiiENSUPAP0001002987157.675650.8528
ENSG00000261150homo_sapiensENSP000004844725.797963.98978petromyzon_marinusENSPMAP0000000249754.327837.3849
ENSG00000261150homo_sapiensENSP000004844728.608496.4662callorhinchus_miliiENSCMIP0000000138064.697248.5968
ENSG00000261150homo_sapiensENSP0000048447219.673714.1706lepisosteus_oculatusENSLOCP0000001054268.095249.0476
ENSG00000261150homo_sapiensENSP0000048447219.418213.9544clupea_harengusENSCHAP0000002980833.940224.3902
ENSG00000261150homo_sapiensENSP0000048447226.493718.6714astyanax_mexicanusENSAMXP0000005429238.993327.4805
ENSG00000261150homo_sapiensENSP0000048447229.952821.9536esox_luciusENSELUP0000007940846.993534.4434
ENSG00000261150homo_sapiensENSP0000048447224.174517.217electrophorus_electricusENSEEEP0000001153656.42240.1835
ENSG00000261150homo_sapiensENSP0000048447229.068421.364oncorhynchus_kisutchENSOKIP0000507955931.501623.1523
ENSG00000261150homo_sapiensENSP0000048447228.773621.0102salmo_salarENSSSAP0000013697032.168823.4893
ENSG00000261150homo_sapiensENSP0000048447231.210722.6415salmo_truttaENSSTUP0000008678330.184421.897
ENSG00000261150homo_sapiensENSP000004844722.279871.69025gadus_morhuaENSGMOP0000005198073.885454.7771
ENSG00000261150homo_sapiensENSP0000048447213.63999.61085poecilia_reticulataENSPREP0000002181013.42369.45841
ENSG00000261150homo_sapiensENSP0000048447226.690318.9072xiphophorus_maculatusENSXMAP0000004084132.969223.3552
ENSG00000261150homo_sapiensENSP0000048447231.76122.8577cyclopterus_lumpusENSCLMP0000501689250.785736.5493
ENSG00000261150homo_sapiensENSP0000048447231.878922.9756oreochromis_niloticusENSONIP0000007230141.042529.58
ENSG00000261150homo_sapiensENSP0000048447228.852220.7547astatotilapia_callipteraENSACLP0000000149337.487226.9663
ENSG00000261150homo_sapiensENSP0000048447234.217825.3734sparus_aurataENSSAUP0001006697249.306136.5619
ENSG00000261150homo_sapiensENSP0000048447216.470112.3035lates_calcariferENSLCAP0001002984933.333324.9006
ENSG00000261150homo_sapiensENSP0000048447230.562120.9119xenopus_tropicalisENSXETP0000011068825.22317.2587
ENSG00000261150homo_sapiensENSP0000048447235.534626.9458chrysemys_picta_belliiENSCPBP0000000705238.29729.0405
ENSG00000261150homo_sapiensENSP000004844720.1375790.0589623sphenodon_punctatusENSSPUP000000046596.542062.80374
ENSG00000261150homo_sapiensENSP000004844724.343552.51572crocodylus_porosusENSCPRP0000500203547.835527.7056
ENSG00000261150homo_sapiensENSP0000048447234.237425.2555laticauda_laticaudataENSLLTP0000000369056.965342.0209
ENSG00000261150homo_sapiensENSP000004844725.424533.79324notechis_scutatusENSNSUP0000000207461.74543.1767
ENSG00000261150homo_sapiensENSP000004844726.426894.91352notechis_scutatusENSNSUP0000000207373.483156.1798
ENSG00000261150homo_sapiensENSP0000048447238.816828.1447pseudonaja_textilisENSPTXP0000002639555.743740.4177
ENSG00000261150homo_sapiensENSP0000048447217.983512.7555anas_platyrhynchos_platyrhynchosENSAPLP0000002239328.937420.525
ENSG00000261150homo_sapiensENSP0000048447217.767312.7948gallus_gallusENSGALP0001001176226.801119.3003
ENSG00000261150homo_sapiensENSP0000048447217.767312.7358meleagris_gallopavoENSMGAP0000003282537.417226.8212
ENSG00000261150homo_sapiensENSP0000048447236.124226.9458serinus_canariaENSSCAP0000000909162.538346.6485
ENSG00000261150homo_sapiensENSP000004844726.328624.61871parus_majorENSPMJP0000002150459.409643.3579
ENSG00000261150homo_sapiensENSP0000048447232.33122.6415anolis_carolinensisENSACAP0000002022728.583820.0174
ENSG00000261150homo_sapiensENSP000004844727.23275.22799neolamprologus_brichardiENSNBRP0000002118565.132747.0796
ENSG00000261150homo_sapiensENSP0000048447234.257125.3931naja_najaENSNNAP0000001544055.438941.0941
ENSG00000261150homo_sapiensENSP0000048447228.498421.4426podarcis_muralisENSPMRP0000001532227.629620.7889
ENSG00000261150homo_sapiensENSP0000048447224.764217.3546geospiza_fortisENSGFOP0000000406942.567629.8311
ENSG00000261150homo_sapiensENSP0000048447241.784631.3679taeniopygia_guttataENSTGUP0000002077962.713947.0796
ENSG00000261150homo_sapiensENSP0000048447245.086533.864taeniopygia_guttataENSTGUP0000002501546.064334.5984
ENSG00000261150homo_sapiensENSP0000048447232.429223.8011erpetoichthys_calabaricusENSECRP0000001940145.032833.0513
ENSG00000261150homo_sapiensENSP000004844720.1375790.0589623kryptolebias_marmoratusENSKMAP000000033491.015970.435414
ENSG00000261150homo_sapiensENSP000004844728.569185.81761kryptolebias_marmoratusENSKMAP0000000942265.367344.3778
ENSG00000261150homo_sapiensENSP0000048447240.290929.1667salvator_merianaeENSSMRP0000001498952.469937.9831
ENSG00000261150homo_sapiensENSP000004844728.962266.15173amphilophus_citrinellusENSACIP0000002532467.958346.6468
ENSG00000261150homo_sapiensENSP0000048447231.996923.0542dicentrarchus_labraxENSDLAP0000506858143.125831.0728
ENSG00000261150homo_sapiensENSP0000048447235.672225.6879amphiprion_perculaENSAPEP0000002510651.886837.3642
ENSG00000261150homo_sapiensENSP0000048447242.452832.2917gopherus_evgoodeiENSGEVP0000500340756.411642.9094
ENSG00000261150homo_sapiensENSP000004844724.32392.53538chelonoidis_abingdoniiENSCABP0000000268547.61927.9221
ENSG00000261150homo_sapiensENSP0000048447234.669824.7642cottoperca_gobioENSCGOP0000002746437.262426.616
ENSG00000261150homo_sapiensENSP0000048447217.629712.2838struthio_camelus_australisENSSCUP0000000616529.294620.4115
ENSG00000261150homo_sapiensENSP000004844720.864780.727201anser_brachyrhynchusENSABRP000000040449.713028.16777
ENSG00000261150homo_sapiensENSP000004844726.72175.11006cynoglossus_semilaevisENSCSEP0000001460154.285741.2698
ENSG00000261150homo_sapiensENSP0000048447221.678515.0943poecilia_formosaENSPFOP0000003042846.896332.6531
ENSG00000261150homo_sapiensENSP0000048447233.058224.1942myripristis_murdjanENSMMDP0000503232953.379939.067
ENSG00000261150homo_sapiensENSP0000048447227.653319.8899sander_luciopercaENSSLUP0000005663931.610922.7365
ENSG00000261150homo_sapiensENSP0000048447241.332530.8962strigops_habroptilaENSSHBP0000500127246.07834.4435
ENSG00000261150homo_sapiensENSP0000048447233.706824.548amphiprion_ocellarisENSAOCP0000002308955.251340.2384
ENSG00000261150homo_sapiensENSP0000048447222.091215.7429hucho_huchoENSHHUP0000002203328.269620.1459
ENSG00000261150homo_sapiensENSP0000048447230.365621.8553betta_splendensENSBSLP0000002107946.903533.7584
ENSG00000261150homo_sapiensENSP0000048447227.692620.0275anabas_testudineusENSATEP0000005257933.207624.016
ENSG00000261150homo_sapiensENSP000004844721.768871.29717ciona_savignyiENSCSAVP0000001607156.603841.5094
ENSG00000261150homo_sapiensENSP000004844722.260221.63129ciona_savignyiENSCSAVP0000001605151.111136.8889
ENSG00000261150homo_sapiensENSP000004844722.260221.63129ciona_savignyiENSCSAVP0000001603151.111136.8889
ENSG00000261150homo_sapiensENSP000004844722.790881.9261seriola_lalandi_dorsalisENSSLDP0000002096251.449335.5072
ENSG00000261150homo_sapiensENSP000004844727.350635.56211labrus_bergyltaENSLBEP0000001986565.156849.3031
ENSG00000261150homo_sapiensENSP000004844724.893873.125pundamilia_nyerereiENSPNYP0000000746835.982722.9769
ENSG00000261150homo_sapiensENSP000004844725.621074.00943stegastes_partitusENSSPAP0000001623544.548331.7757
ENSG00000261150homo_sapiensENSP000004844720.1768870.137579acanthochromis_polyacanthusENSAPOP000000136995.389224.19162
ENSG00000261150homo_sapiensENSP000004844720.432390.275157acanthochromis_polyacanthusENSAPOP000000301792.528741.6092
ENSG00000261150homo_sapiensENSP000004844720.864780.746855aquila_chrysaetos_chrysaetosENSACCP000200027319.016397.78689
ENSG00000261150homo_sapiensENSP0000048447231.996922.956nothobranchius_furzeriENSNFUP0001503284038.780427.8228
ENSG00000261150homo_sapiensENSP000004844725.129723.91116cyprinodon_variegatusENSCVAP0000001405552.095839.7206
ENSG00000261150homo_sapiensENSP0000048447229.461521.305denticeps_clupeoidesENSDCDP0000005233547.16834.1095
ENSG00000261150homo_sapiensENSP0000048447236.084926.1792takifugu_rubripesENSTRUP0000007814731.792223.0649
ENSG00000261150homo_sapiensENSP0000048447231.525223.2311ficedula_albicollisENSFALP0000001818666.089848.7021
ENSG00000261150homo_sapiensENSP000004844727.606135.46384hippocampus_comesENSHCOP0000000385459.814542.9675
ENSG00000261150homo_sapiensENSP000004844724.245283.10535coturnix_japonicaENSCJPP0000501360845.66633.4038
ENSG00000261150homo_sapiensENSP000004844726.308964.7956poecilia_latipinnaENSPLAP0000001630565.243949.5935
ENSG00000261150homo_sapiensENSP000004844729.257086.87893sinocyclocheilus_grahamiENSSGRP0000010546169.366751.5464
ENSG00000261150homo_sapiensENSP0000048447224.154917.3742maylandia_zebraENSMZEP0000503502634.561324.8594
ENSG00000261150homo_sapiensENSP000004844727.547175.32626tetraodon_nigroviridisENSTNIP0000000870866.43646.8858
ENSG00000261150homo_sapiensENSP0000048447219.339614.544scleropages_formosusENSSFOP0001501476128.646321.5429
ENSG00000261150homo_sapiensENSP0000048447234.807424.5283leptobrachium_leishanenseENSLLEP0000003199542.166729.7143
ENSG00000261150homo_sapiensENSP0000048447228.57720.7744scophthalmus_maximusENSSMAP0000005283742.714531.0517
ENSG00000261150homo_sapiensENSP000004844725.915884.3239oryzias_melastigmaENSOMEP0000003349464.731247.3118

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0003723enables RNA binding1HDAHomo_sapiens(9606)Function
GO:0005198enables structural molecule activity1IBAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005737is_active_in cytoplasm1IBAHomo_sapiens(9606)Component
GO:0005856located_in cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0005882colocalizes_with intermediate filament1IBAHomo_sapiens(9606)Component
GO:0005923located_in bicellular tight junction1IDAHomo_sapiens(9606)Component
GO:0010839involved_in negative regulation of keratinocyte proliferation1ISSHomo_sapiens(9606)Process
GO:0016020is_active_in membrane1IBAHomo_sapiens(9606)Component
GO:0016323located_in basolateral plasma membrane1IEAHomo_sapiens(9606)Component
GO:0016327located_in apicolateral plasma membrane1IEAHomo_sapiens(9606)Component
GO:0019215enables intermediate filament binding1IPIHomo_sapiens(9606)Function
GO:0030054is_active_in cell junction1IBAHomo_sapiens(9606)Component
GO:0030056located_in hemidesmosome1IDAHomo_sapiens(9606)Component
GO:0030336involved_in negative regulation of cell migration1IMPHomo_sapiens(9606)Process
GO:0042060involved_in wound healing2IBA,IMPHomo_sapiens(9606)Process
GO:0042995located_in cell projection1IEAHomo_sapiens(9606)Component
GO:0045095located_in keratin filament2IDA,ISSHomo_sapiens(9606)Component
GO:0045109involved_in intermediate filament organization3IDA,IMP,ISSHomo_sapiens(9606)Process
GO:0045110involved_in intermediate filament bundle assembly1IBAHomo_sapiens(9606)Process
GO:0045111located_in intermediate filament cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0050680involved_in negative regulation of epithelial cell proliferation1IMPHomo_sapiens(9606)Process
GO:0051548involved_in negative regulation of keratinocyte migration1ISSHomo_sapiens(9606)Process
GO:0061045involved_in negative regulation of wound healing1IMPHomo_sapiens(9606)Process
GO:0071944located_in cell periphery1IDAHomo_sapiens(9606)Component
GO:0097356located_in perinucleolar compartment1IDAHomo_sapiens(9606)Component
GO:1905041involved_in regulation of epithelium regeneration1ISSHomo_sapiens(9606)Process
GO:1990254enables keratin filament binding1IBAHomo_sapiens(9606)Function

Expression