Functions and Diseases

RBP Type Canonical_RBPs
Diseases Cancer Disease
Drug N.A.
Main interacting RNAs diverse
Moonlighting functions Transmemebrane
Localizations Stress granucleNucleoliNucleoli rim
BulkPerturb-seq N.A.

Description

Ensembl ID ENSG00000214274 Gene ID 283 Accession 483
Symbol ANG Alias ALS9;RAA1;HEL168;RNASE4;RNASE5 Full Name angiogenin
Status Confidence Length 10010 bases Strand Plus strand
Position 14 : 20684177 - 20694186 RNA binding domain RnaseA
Summary The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]

RNA binding domains (RBDs)

Protein Domain Pfam ID E-value Domain number
ENSP00000336762 RnaseA PF00074 7.1e-34 1
ENSP00000381077 RnaseA PF00074 7.1e-34 1

RNA binding proteomes (RBPomes)

Pubmed ID Full Name Cell Author Time Doi

Literatures on RNA binding capacity

Pubmed ID Title Author Time Journal

Transcripts

Name Transcript ID bp Protein Translation ID
ANG-201 ENST00000336811 1222 147aa ENSP00000336762
ANG-203 ENST00000554073 251 No protein -
ANG-202 ENST00000397990 748 147aa ENSP00000381077

Gene Model

Pathways

Pathway ID Pathway Name Source

Phenotypes

ensgID Trait pValue Pubmed ID
15809Stroke2.1727993E-004-
54574Cryptoxanthins8.3140000E-005-

GWAS

ensgIDSNPChromosomePosition TraitPubmedIDOr or BEAT EFO ID

Protein-Protein Interaction (PPI)

Paralogs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000214274homo_sapiensENSP0000051286731.292520.4082homo_sapiensENSP0000038107731.292520.4082
ENSG00000214274homo_sapiensENSP0000029869039.743628.8462homo_sapiensENSP0000038107742.176930.6122
ENSG00000214274homo_sapiensENSP0000031139835.714325.3247homo_sapiensENSP0000038107737.41526.5306
ENSG00000214274homo_sapiensENSP0000030204637.333326homo_sapiensENSP0000038107738.095226.5306
ENSG00000214274homo_sapiensENSP0000039299624.074113.8889homo_sapiensENSP0000038107735.374120.4082
ENSG00000214274homo_sapiensENSP0000045131822.110611.5578homo_sapiensENSP0000038107729.93215.6463
ENSG00000214274homo_sapiensENSP0000038468321.904810.9524homo_sapiensENSP0000038107731.292515.6463
ENSG00000214274homo_sapiensENSP0000038105744.230831.4103homo_sapiensENSP0000038107746.938833.3333
ENSG00000214274homo_sapiensENSP0000045224547.61937.415homo_sapiensENSP0000038107747.61937.415
ENSG00000214274homo_sapiensENSP0000037241033.333319.2308homo_sapiensENSP0000038107735.374120.4082
ENSG00000214274homo_sapiensENSP0000030232431.2521.875homo_sapiensENSP0000038107734.013623.8095
ENSG00000214274homo_sapiensENSP0000030327634.161522.3602homo_sapiensENSP0000038107737.41524.4898

Orthologs

Ensembl ID Source Target
Species Protein ID Perc_pos Perc_id Species Protein ID Perc_pos Perc_id
ENSG00000214274homo_sapiensENSP0000038107798.639598.6395pan_paniscusENSPPAP0000001925898.639598.6395
ENSG00000214274homo_sapiensENSP0000038107799.319799.3197pan_troglodytesENSPTRP0000006687599.319799.3197
ENSG00000214274homo_sapiensENSP0000038107710099.3197gorilla_gorillaENSGGOP0000003566710099.3197
ENSG00000214274homo_sapiensENSP0000038107777.55161.2245sarcophilus_harrisiiENSSHAP000000240067660
ENSG00000214274homo_sapiensENSP0000038107771.428658.5034notamacropus_eugeniiENSMEUP0000000062473.943760.5634
ENSG00000214274homo_sapiensENSP0000038107783.673575.5102macaca_fascicularisENSMFAP0000005199684.246676.0274
ENSG00000214274homo_sapiensENSP0000038107784.353776.1905macaca_fascicularisENSMFAP0000006307958.767853.0806
ENSG00000214274homo_sapiensENSP0000038107782.312974.1497macaca_mulattaENSMMUP0000006260682.876774.6575
ENSG00000214274homo_sapiensENSP0000038107776.870863.9456tursiops_truncatusENSTTRP0000000899577.93164.8276
ENSG00000214274homo_sapiensENSP0000038107774.149763.9456mus_spretusMGP_SPRETEiJ_P004329075.172464.8276
ENSG00000214274homo_sapiensENSP0000038107774.149763.9456mus_spretusMGP_SPRETEiJ_P004328975.172464.8276
ENSG00000214274homo_sapiensENSP0000038107783.673572.1088mus_spretusMGP_SPRETEiJ_P003822184.827673.1034
ENSG00000214274homo_sapiensENSP0000038107785.03474.8299equus_asinusENSEASP0000506152385.616475.3425
ENSG00000214274homo_sapiensENSP0000038107777.55164.6258capra_hircusENSCHIP0000000647277.02764.1892
ENSG00000214274homo_sapiensENSP0000038107774.829962.585capra_hircusENSCHIP0000000723274.324362.1622
ENSG00000214274homo_sapiensENSP0000038107787.074876.8708panthera_leoENSPLOP0000001109087.671277.3973
ENSG00000214274homo_sapiensENSP0000038107774.149761.9048bos_indicus_hybridENSBIXP0000501609373.648761.4865
ENSG00000214274homo_sapiensENSP0000038107767.346954.4218bos_indicus_hybridENSBIXP000050159776048.4848
ENSG00000214274homo_sapiensENSP0000038107784.353774.1497equus_caballusENSECAP0000007381284.931574.6575
ENSG00000214274homo_sapiensENSP0000038107787.074877.551panthera_pardusENSPPRP0000002812087.671278.0822
ENSG00000214274homo_sapiensENSP0000038107787.755178.9116marmota_marmota_marmotaENSMMMP0000001693888.356279.4521
ENSG00000214274homo_sapiensENSP0000038107776.190564.6258balaenoptera_musculusENSBMSP0001001215163.276853.6723
ENSG00000214274homo_sapiensENSP0000038107785.03475.5102ursus_americanusENSUAMP0000001510685.616476.0274
ENSG00000214274homo_sapiensENSP0000038107778.231362.585monodelphis_domesticaENSMODP0000000864368.047354.4379
ENSG00000214274homo_sapiensENSP0000038107774.829963.9456bison_bison_bisonENSBBBP0000001621074.324363.5135
ENSG00000214274homo_sapiensENSP0000038107770.06856.4626bison_bison_bisonENSBBBP0000000177870.06856.4626
ENSG00000214274homo_sapiensENSP0000038107773.469460.5442bison_bison_bisonENSBBBP0000001816272.97360.1351
ENSG00000214274homo_sapiensENSP0000038107774.829963.9456bison_bison_bisonENSBBBP0000000177675.862164.8276
ENSG00000214274homo_sapiensENSP0000038107777.55164.6258monodon_monocerosENSMMNP0001501328378.620765.5172
ENSG00000214274homo_sapiensENSP0000038107778.911668.7075sus_scrofaENSSSCP0000003722378.911668.7075
ENSG00000214274homo_sapiensENSP0000038107774.149761.9048ovis_aries_rambouilletENSOARP0002001723173.648761.4865
ENSG00000214274homo_sapiensENSP0000038107777.55164.6258delphinapterus_leucasENSDLEP0000000230150.666742.2222
ENSG00000214274homo_sapiensENSP0000038107772.108859.8639physeter_catodonENSPCTP0000500392774.125961.5385
ENSG00000214274homo_sapiensENSP0000038107775.510263.2653mus_musculusENSMUSP0000015955176.551764.1379
ENSG00000214274homo_sapiensENSP0000038107776.190564.6258mus_musculusENSMUSP0000015410077.241465.5172
ENSG00000214274homo_sapiensENSP0000038107772.789162.585mus_musculusENSMUSP0000007352574.305663.8889
ENSG00000214274homo_sapiensENSP0000038107784.353772.7891mus_musculusENSMUSP0000006743485.517273.7931
ENSG00000214274homo_sapiensENSP0000038107768.027257.1429mus_musculusENSMUSP0000015955268.027257.1429
ENSG00000214274homo_sapiensENSP0000038107776.190565.9864mesocricetus_auratusENSMAUP0000000924677.241466.8966
ENSG00000214274homo_sapiensENSP0000038107773.469461.2245phocoena_sinusENSPSNP0000001688874.482862.069
ENSG00000214274homo_sapiensENSP0000038107777.55162.585camelus_dromedariusENSCDRP0000500254181.428665.7143
ENSG00000214274homo_sapiensENSP0000038107787.074877.551panthera_tigris_altaicaENSPTIP0000000160287.671278.0822
ENSG00000214274homo_sapiensENSP0000038107782.993272.1088rattus_norvegicusENSRNOP0000003438373.053963.4731
ENSG00000214274homo_sapiensENSP0000038107755.782349.6599prolemur_simusENSPSMP0000001745983.673574.4898
ENSG00000214274homo_sapiensENSP0000038107781.632767.3469microtus_ochrogasterENSMOCP0000000079082.191867.8082
ENSG00000214274homo_sapiensENSP0000038107776.870865.3061peromyscus_maniculatus_bairdiiENSPEMP0000001297667.664757.485
ENSG00000214274homo_sapiensENSP0000038107780.952470.068peromyscus_maniculatus_bairdiiENSPEMP0000003029381.506970.5479
ENSG00000214274homo_sapiensENSP0000038107778.231365.3061peromyscus_maniculatus_bairdiiENSPEMP0000003030977.181264.4295
ENSG00000214274homo_sapiensENSP0000038107775.510266.6667peromyscus_maniculatus_bairdiiENSPEMP0000002951376.027467.1233
ENSG00000214274homo_sapiensENSP0000038107778.911668.0272peromyscus_maniculatus_bairdiiENSPEMP0000003447579.452168.4931
ENSG00000214274homo_sapiensENSP0000038107774.829964.6258bos_mutusENSBMUP0000001591674.324364.1892
ENSG00000214274homo_sapiensENSP0000038107770.06855.102bos_mutusENSBMUP0000001592570.06855.102
ENSG00000214274homo_sapiensENSP0000038107773.469460.5442bos_mutusENSBMUP0000002580073.972660.9589
ENSG00000214274homo_sapiensENSP0000038107773.469461.2245mus_spicilegusENSMSIP0000000026573.972661.6438
ENSG00000214274homo_sapiensENSP0000038107784.353772.7891mus_spicilegusENSMSIP0000002308785.517273.7931
ENSG00000214274homo_sapiensENSP0000038107774.829963.9456mus_spicilegusENSMSIP0000000260176.388965.2778
ENSG00000214274homo_sapiensENSP0000038107773.469460.5442mus_spicilegusENSMSIP0000001056856.842146.8421
ENSG00000214274homo_sapiensENSP0000038107775.510264.6258mus_spicilegusENSMSIP0000002315476.551765.5172
ENSG00000214274homo_sapiensENSP0000038107776.870865.9864cricetulus_griseus_chok1gshdENSCGRP0000100519353.051645.5399
ENSG00000214274homo_sapiensENSP0000038107778.911664.6258pteropus_vampyrusENSPVAP0000001279679.452165.0685
ENSG00000214274homo_sapiensENSP0000038107778.231367.3469myotis_lucifugusENSMLUP0000001918279.861168.75
ENSG00000214274homo_sapiensENSP0000038107783.673568.0272myotis_lucifugusENSMLUP0000001627684.246668.4931
ENSG00000214274homo_sapiensENSP0000038107777.55163.9456myotis_lucifugusENSMLUP0000001791378.082264.3836
ENSG00000214274homo_sapiensENSP0000038107784.353767.3469myotis_lucifugusENSMLUP0000001627384.931567.8082
ENSG00000214274homo_sapiensENSP0000038107781.632770.068myotis_lucifugusENSMLUP0000002267781.632770.068
ENSG00000214274homo_sapiensENSP0000038107779.591867.3469myotis_lucifugusENSMLUP0000001681181.2568.75
ENSG00000214274homo_sapiensENSP0000038107782.312968.0272myotis_lucifugusENSMLUP0000002165582.876768.4931
ENSG00000214274homo_sapiensENSP0000038107781.632769.3878rhinolophus_ferrumequinumENSRFEP0001002566178.947467.1053
ENSG00000214274homo_sapiensENSP0000038107760.544251.7007neovison_visonENSNVIP0000001705378.070266.6667
ENSG00000214274homo_sapiensENSP0000038107770.06854.4218bos_taurusENSBTAP0000004972770.06854.4218
ENSG00000214274homo_sapiensENSP0000038107767.346954.4218bos_taurusENSBTAP000000704956048.4848
ENSG00000214274homo_sapiensENSP0000038107772.789160.5442bos_taurusENSBTAP0000004394563.690552.9762
ENSG00000214274homo_sapiensENSP0000038107784.353775.5102sciurus_vulgarisENSSVLP0000500209585.517276.5517
ENSG00000214274homo_sapiensENSP0000038107765.306153.0612procavia_capensisENSPCAP0000000559969.565256.5217
ENSG00000214274homo_sapiensENSP0000038107785.714376.8708nannospalax_galiliENSNGAP0000001828386.301477.3973
ENSG00000214274homo_sapiensENSP0000038107761.904853.0612cervus_hanglu_yarkandensisENSCHYP000000215815042.8571
ENSG00000214274homo_sapiensENSP0000038107772.789159.8639cervus_hanglu_yarkandensisENSCHYP0000002124964.848553.3333
ENSG00000214274homo_sapiensENSP0000038107778.231365.9864catagonus_wagneriENSCWAP0000000845179.861167.3611
ENSG00000214274homo_sapiensENSP0000038107773.469461.9048otolemur_garnettiiENSOGAP0000001668673.972662.3288
ENSG00000214274homo_sapiensENSP0000038107788.435479.5918urocitellus_parryiiENSUPAP0001000227389.041180.137
ENSG00000214274homo_sapiensENSP0000038107770.748359.1837moschus_moschiferusENSMMSP0000001121668.421157.2368
ENSG00000214274homo_sapiensENSP0000038107781.632769.3878mus_pahariMGP_PahariEiJ_P008461982.758670.3448
ENSG00000214274homo_sapiensENSP0000038107781.632769.3878mus_pahariMGP_PahariEiJ_P008462182.758670.3448
ENSG00000214274homo_sapiensENSP0000038107787.074877.551propithecus_coquereliENSPCOP0000000488987.671278.0822
ENSG00000214274homo_sapiensENSP0000038107749.659938.7755chrysemys_picta_belliiENSCPBP0000001251551.04939.8601
ENSG00000214274homo_sapiensENSP0000038107757.823145.5782chrysemys_picta_belliiENSCPBP0000000080753.797542.4051
ENSG00000214274homo_sapiensENSP0000038107757.142946.9388laticauda_laticaudataENSLLTP000000054735041.0714
ENSG00000214274homo_sapiensENSP0000038107749.659938.7755pseudonaja_textilisENSPTXP0000002409050.694439.5833
ENSG00000214274homo_sapiensENSP0000038107753.741540.8163podarcis_muralisENSPMRP0000003407458.955244.7761
ENSG00000214274homo_sapiensENSP0000038107750.340137.415podarcis_muralisENSPMRP0000002511459.244
ENSG00000214274homo_sapiensENSP0000038107749.659937.415podarcis_muralisENSPMRP0000003408054.074140.7407
ENSG00000214274homo_sapiensENSP0000038107757.142942.8571podarcis_muralisENSPMRP0000003408657.534243.1507
ENSG00000214274homo_sapiensENSP0000038107755.10242.8571pelodiscus_sinensisENSPSIP0000000073450.310639.1304
ENSG00000214274homo_sapiensENSP0000038107740.136132.6531gopherus_evgoodeiENSGEVP0000502169148.360739.3443
ENSG00000214274homo_sapiensENSP0000038107759.863948.2993gopherus_evgoodeiENSGEVP0000502117254.658444.0994
ENSG00000214274homo_sapiensENSP0000038107757.823146.9388chelonoidis_abingdoniiENSCABP0000001857454.838744.5161
ENSG00000214274homo_sapiensENSP0000038107752.38138.7755terrapene_carolina_triunguisENSTMTP0000000830653.846239.8601
ENSG00000214274homo_sapiensENSP0000038107757.142944.2177terrapene_carolina_triunguisENSTMTP0000000866953.164641.1392
ENSG00000214274homo_sapiensENSP0000038107755.782342.1769paramormyrops_kingsleyaeENSPKIP0000001261436.771327.8027

Gene Ontology

Go ID Go term No. evidence Entries Species Category
GO:0001525involved_in angiogenesis4IBA,IDA,IMP,TASHomo_sapiens(9606)Process
GO:0001541involved_in ovarian follicle development1NASHomo_sapiens(9606)Process
GO:0001556involved_in oocyte maturation1NASHomo_sapiens(9606)Process
GO:0001666involved_in response to hypoxia2IDA,NASHomo_sapiens(9606)Process
GO:0001890involved_in placenta development1NASHomo_sapiens(9606)Process
GO:0001938involved_in positive regulation of endothelial cell proliferation1IDAHomo_sapiens(9606)Process
GO:0003677enables DNA binding1ICHomo_sapiens(9606)Function
GO:0003779enables actin binding1IDAHomo_sapiens(9606)Function
GO:0004519enables endonuclease activity1TASHomo_sapiens(9606)Function
GO:0004521enables RNA endonuclease activity1TASHomo_sapiens(9606)Function
GO:0004540enables RNA nuclease activity2IBA,IDAHomo_sapiens(9606)Function
GO:0005102enables signaling receptor binding1IDAHomo_sapiens(9606)Function
GO:0005507enables copper ion binding1IDAHomo_sapiens(9606)Function
GO:0005515enables protein binding1IPIHomo_sapiens(9606)Function
GO:0005576located_in extracellular region1TASHomo_sapiens(9606)Component
GO:0005604located_in basement membrane1IDAHomo_sapiens(9606)Component
GO:0005615is_active_in extracellular space2IBA,IDAHomo_sapiens(9606)Component
GO:0005634located_in nucleus1IDAHomo_sapiens(9606)Component
GO:0005694located_in chromosome1IDAHomo_sapiens(9606)Component
GO:0005730located_in nucleolus2IDA,ISSHomo_sapiens(9606)Component
GO:0005829located_in cytosol1TASHomo_sapiens(9606)Component
GO:0006651involved_in diacylglycerol biosynthetic process1IDAHomo_sapiens(9606)Process
GO:0007154involved_in cell communication1NASHomo_sapiens(9606)Process
GO:0007202involved_in activation of phospholipase C activity1IMPHomo_sapiens(9606)Process
GO:0008201enables heparin binding1IDAHomo_sapiens(9606)Function
GO:0009303involved_in rRNA transcription1IMPHomo_sapiens(9606)Process
GO:0009725involved_in response to hormone1IDAHomo_sapiens(9606)Process
GO:0015629located_in actin cytoskeleton1IDAHomo_sapiens(9606)Component
GO:0016078involved_in tRNA catabolic process1TASHomo_sapiens(9606)Process
GO:0016477involved_in cell migration1IMPHomo_sapiens(9606)Process
GO:0017148involved_in negative regulation of translation1IEAHomo_sapiens(9606)Process
GO:0019731involved_in antibacterial humoral response1IBAHomo_sapiens(9606)Process
GO:0019843enables rRNA binding1TASHomo_sapiens(9606)Function
GO:0030041involved_in actin filament polymerization1ISSHomo_sapiens(9606)Process
GO:0030426located_in growth cone1ISSHomo_sapiens(9606)Component
GO:0031410located_in cytoplasmic vesicle1IEAHomo_sapiens(9606)Component
GO:0032148involved_in activation of protein kinase B activity1IMPHomo_sapiens(9606)Process
GO:0032311part_of angiogenin-PRI complex2IDA,IPIHomo_sapiens(9606)Component
GO:0032431involved_in activation of phospholipase A2 activity1IMPHomo_sapiens(9606)Process
GO:0042277enables peptide binding1IDAHomo_sapiens(9606)Function
GO:0042327involved_in positive regulation of phosphorylation1IDAHomo_sapiens(9606)Process
GO:0042592involved_in homeostatic process1NASHomo_sapiens(9606)Process
GO:0042803enables protein homodimerization activity1IDAHomo_sapiens(9606)Function
GO:0043025located_in neuronal cell body1ISSHomo_sapiens(9606)Component
GO:0045087involved_in innate immune response1IBAHomo_sapiens(9606)Process
GO:0048662involved_in negative regulation of smooth muscle cell proliferation1IDAHomo_sapiens(9606)Process
GO:0050714involved_in positive regulation of protein secretion2IDA,ISSHomo_sapiens(9606)Process
GO:0050830involved_in defense response to Gram-positive bacterium1IBAHomo_sapiens(9606)Process
GO:0061844involved_in antimicrobial humoral immune response mediated by antimicrobial peptide1IBAHomo_sapiens(9606)Process

Expression