Ensembl ID ENSG00000214274 Gene ID 283 Accession 483
Gene Symbol ANG Alias ALS9;RAA1;HEL168;RNASE4;RNASE5 Full Name angiogenin
Position 14 : 20684177 - 20694186 Length 10010 bases Strand Plus strand
Status Confidence Main interacting RNAsdiverseRBP type Canonical_RBPs
Summary The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]

ENSG00000214274 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000214274 ANG 1.58 1.09e-38 KIRC
ENSG00000214274 ANG -1.1 1.52e-12 HNSC
ENSG00000214274 ANG -3.0 1.25e-41 KICH
ENSG00000214274 ANG -1.8 2.09e-41 LUSC
ENSG00000214274 ANG 3.06 1.61e-13 GBM
ENSG00000214274 ANG -5.0 1.34e-23 CHOL
Ensembl ID Gene symbol Cancer types Pubmed ID
ENSG00000214274 ANG tumor 10072879
ENSG00000214274 ANG tumor 10092530
ENSG00000214274 ANG pancreatic cancer 10206479
ENSG00000214274 ANG colorectal cancer 10353747
ENSG00000214274 ANG tumor 10421268
ENSG00000214274 ANG tumor 10430623
ENSG00000214274 ANG cancer 10589746
ENSG00000214274 ANG tumors 10746455
ENSG00000214274 ANG tumours 10928091
ENSG00000214274 ANG cancer 10961390
ENSG00000214274 ANG colorectal cancer 10999742
ENSG00000214274 ANG tumors 11082997
ENSG00000214274 ANG HNSCC 11123175
ENSG00000214274 ANG Ewing's tumor 11140588
ENSG00000214274 ANG breast cancer 11205216
ENSG00000214274 ANG cancer 11288955
ENSG00000214274 ANG malignant tumors 11299848
ENSG00000214274 ANG tumor 11328412
ENSG00000214274 ANG tumor 11443914
ENSG00000214274 ANG tumor 11461835
ENSG00000214274 ANG tumours 11529846
ENSG00000214274 ANG tumour 11578940
ENSG00000214274 ANG bladder cancer 11579593
ENSG00000214274 ANG prostate tumor 11705882
ENSG00000214274 ANG acute myeloid leukemia (AML) 11815714
ENSG00000214274 ANG acute myeloid leukemia (AML) 11847008
ENSG00000214274 ANG tumor 11882979
ENSG00000214274 ANG HNSCC 11903369
ENSG00000214274 ANG tumor 11919285
ENSG00000214274 ANG prostate cancer 11948474
ENSG00000214274 ANG tumor 12051708
ENSG00000214274 ANG tumors 12058199
ENSG00000214274 ANG tumor 12118120
ENSG00000214274 ANG tumour 12144504
ENSG00000214274 ANG colorectal cancer 12168899
ENSG00000214274 ANG tumor 12187074
ENSG00000214274 ANG tumor 12548285
ENSG00000214274 ANG gastric cancer 12684892
ENSG00000214274 ANG gestational trophoblastic tumors 12705339
ENSG00000214274 ANG tumor 12711394
ENSG00000214274 ANG tumor 12734082
ENSG00000214274 ANG tumor 12740039
ENSG00000214274 ANG tumor 12746434
ENSG00000214274 ANG tumour 12759577
ENSG00000214274 ANG prostate cancer 12799464
ENSG00000214274 ANG tumors 12842050
ENSG00000214274 ANG tumor 14503864
ENSG00000214274 ANG tumor 14581357
ENSG00000214274 ANG cancer 15057644
ENSG00000214274 ANG tumour 15166501
ENSG00000214274 ANG tumors 15182336
ENSG00000214274 ANG tumour 15328513
ENSG00000214274 ANG bladder cancer 15329320
ENSG00000214274 ANG tumor 1544320
ENSG00000214274 ANG tumors 15522168
ENSG00000214274 ANG tumor 15558023
ENSG00000214274 ANG tumor 15652516
ENSG00000214274 ANG tumor 1565609
ENSG00000214274 ANG tumor 15722410
ENSG00000214274 ANG tumour 15725080
ENSG00000214274 ANG cancer 15735021
ENSG00000214274 ANG tumor 15737636
ENSG00000214274 ANG tumors 15757533
ENSG00000214274 ANG tumour 15776477
ENSG00000214274 ANG tumour 15807874
ENSG00000214274 ANG cancer 15816535
ENSG00000214274 ANG tumor 15838381
ENSG00000214274 ANG tumor 1599460
ENSG00000214274 ANG AML 16019534
ENSG00000214274 ANG tumor 16175248
ENSG00000214274 ANG tumor 16293765
ENSG00000214274 ANG prostate cancer 16322296
ENSG00000214274 ANG cancer 16361562
ENSG00000214274 ANG tumor 16391790
ENSG00000214274 ANG tumour 16487436
ENSG00000214274 ANG tumor 16567967
ENSG00000214274 ANG breast cancer 16762098
ENSG00000214274 ANG tumor 16900775
ENSG00000214274 ANG tumor 16937522
ENSG00000214274 ANG prostate cancer 16971483
ENSG00000214274 ANG tumor 17017190
ENSG00000214274 ANG tumour 17082335
ENSG00000214274 ANG tumour 1723310
ENSG00000214274 ANG tumors 17233842
ENSG00000214274 ANG prostate cancer 17270024
ENSG00000214274 ANG AML 17304969
ENSG00000214274 ANG tumor 17869204
ENSG00000214274 ANG cancer 17883850
ENSG00000214274 ANG cancer 17991437
ENSG00000214274 ANG tumors 18049111
ENSG00000214274 ANG breast cancer 18533682
ENSG00000214274 ANG cancer 18604453
ENSG00000214274 ANG tumor 18776656
ENSG00000214274 ANG tumor 18832998
ENSG00000214274 ANG breast cancer 18996696
ENSG00000214274 ANG tumor 19173562
ENSG00000214274 ANG cancer 19212105
ENSG00000214274 ANG prostate cancer 19258415
ENSG00000214274 ANG prostate cancer 19276260
ENSG00000214274 ANG tumor 19423182
ENSG00000214274 ANG tumor 19477431
ENSG00000214274 ANG tumor 19575937
ENSG00000214274 ANG tumor 19625371
ENSG00000214274 ANG tumor 19631914
ENSG00000214274 ANG cancer 19647334
ENSG00000214274 ANG breast cancer 19649207
ENSG00000214274 ANG colon cancer 19689337
ENSG00000214274 ANG GBM 20071465
ENSG00000214274 ANG metastatic tumor 20105109
ENSG00000214274 ANG metastatic tumor 20174961
ENSG00000214274 ANG tumors 20380732
ENSG00000214274 ANG tumour 20461086
ENSG00000214274 ANG breast cancer 20501617
ENSG00000214274 ANG tumour 20584290
ENSG00000214274 ANG tumor 20656548
ENSG00000214274 ANG cancer 20805979
ENSG00000214274 ANG cancer 20827423
ENSG00000214274 ANG tumor 20923443
ENSG00000214274 ANG tumour 20955379
ENSG00000214274 ANG Prostate cancer 21352472
ENSG00000214274 ANG tumor 21364907
ENSG00000214274 ANG cancer 21426933
ENSG00000214274 ANG tumor 21427009
ENSG00000214274 ANG tumour 21439815
ENSG00000214274 ANG tumor 21528671
ENSG00000214274 ANG tumor 21552980
ENSG00000214274 ANG tumour 21703011
ENSG00000214274 ANG prostate cancer 21743803
ENSG00000214274 ANG tumour 21778309
ENSG00000214274 ANG cervical cancer 21778318
ENSG00000214274 ANG metastatic tumor 21842202
ENSG00000214274 ANG breast cancer 21984941
ENSG00000214274 ANG tumors 22018671
ENSG00000214274 ANG tumor 22021078
ENSG00000214274 ANG tumor 22044691
ENSG00000214274 ANG tumour 22048008
ENSG00000214274 ANG cancer 22194915
ENSG00000214274 ANG cancers 22266868
ENSG00000214274 ANG tumor 2229005
ENSG00000214274 ANG tumor 22349830
ENSG00000214274 ANG tumours 22372545
ENSG00000214274 ANG bladder cancer 22386755
ENSG00000214274 ANG tumour 22448202
ENSG00000214274 ANG cancer 22477091
ENSG00000214274 ANG tumor 22531314
ENSG00000214274 ANG tumor 22587902
ENSG00000214274 ANG oral cancer 22694909
ENSG00000214274 ANG breast cancer 22718627
ENSG00000214274 ANG tumor 22945624
ENSG00000214274 ANG tumour 22970115
ENSG00000214274 ANG tumor 23243599
ENSG00000214274 ANG lung cancer 23412843
ENSG00000214274 ANG tumours 23419171
ENSG00000214274 ANG tumor 23576184
ENSG00000214274 ANG colorectal cancer 23683169
ENSG00000214274 ANG tumours 23772376
ENSG00000214274 ANG tumor 23792575
ENSG00000214274 ANG prostate cancer 23851444
ENSG00000214274 ANG cancer 23865486
ENSG00000214274 ANG prostate cancer 23921786
ENSG00000214274 ANG cancer 23977052
ENSG00000214274 ANG tumor 23986578
ENSG00000214274 ANG tumor 23989187
ENSG00000214274 ANG cancer 24179386
ENSG00000214274 ANG tumor 24214914
ENSG00000214274 ANG tumor 2424496
ENSG00000214274 ANG tumour 24386211
ENSG00000214274 ANG tumor 2438646
ENSG00000214274 ANG breast cancer 24419232
ENSG00000214274 ANG breast cancer 24457100
ENSG00000214274 ANG tumor 24561529
ENSG00000214274 ANG tumour 2457389
ENSG00000214274 ANG cancer 24603325
ENSG00000214274 ANG colorectal cancer 24632679
ENSG00000214274 ANG bone tumors 24640099
ENSG00000214274 ANG tumours 24649286
ENSG00000214274 ANG cancers 24659782
ENSG00000214274 ANG bladder cancer 24696417
ENSG00000214274 ANG tumor 24751730
ENSG00000214274 ANG tumors 24769129
ENSG00000214274 ANG cancer 24778013
ENSG00000214274 ANG cancer 25019631
ENSG00000214274 ANG tumors 25068345
ENSG00000214274 ANG bladder cancer 25193113
ENSG00000214274 ANG cancer 25211664
ENSG00000214274 ANG bladder cancer 25387487
ENSG00000214274 ANG tumor 25549350
ENSG00000214274 ANG cervical cancers 25552400
ENSG00000214274 ANG bladder cancer 25564356
ENSG00000214274 ANG cancer 25567797
ENSG00000214274 ANG colorectal cancer 25598043
ENSG00000214274 ANG Liver Cancer 25604905
ENSG00000214274 ANG tumor 25659096
ENSG00000214274 ANG breast cancer 25992213
ENSG00000214274 ANG prostate cancer 26170989
ENSG00000214274 ANG Tumor 26272182
ENSG00000214274 ANG tumor 26285778
ENSG00000214274 ANG tumors 26330923
ENSG00000214274 ANG tumor 26590021
ENSG00000214274 ANG tumors 26618892
ENSG00000214274 ANG cancers 26657107
ENSG00000214274 ANG cancer 26705141
ENSG00000214274 ANG tumour 26809004
ENSG00000214274 ANG cancer 26837255
ENSG00000214274 ANG tumor 26838745
ENSG00000214274 ANG cancer 26843810
ENSG00000214274 ANG cancer 26865839
ENSG00000214274 ANG cancer 26871601
ENSG00000214274 ANG tumor 26877599
ENSG00000214274 ANG tumor 27014725
ENSG00000214274 ANG Head and Neck Cancer 27127118
ENSG00000214274 ANG cancers 27162546
ENSG00000214274 ANG Prostate Cancer 27175049
ENSG00000214274 ANG bladder cancer 27317771
ENSG00000214274 ANG cancers 27490533
ENSG00000214274 ANG cancer 27526633
ENSG00000214274 ANG tumor 27548530
ENSG00000214274 ANG colon cancer 27717848
ENSG00000214274 ANG tumor 27765902
ENSG00000214274 ANG tumors 27878431
ENSG00000214274 ANG tumor 27895461
ENSG00000214274 ANG cancer 27915233
ENSG00000214274 ANG liver cancer 27940282
ENSG00000214274 ANG tumors 27995973
ENSG00000214274 ANG tumor 28120377
ENSG00000214274 ANG bladder cancer 28149930
ENSG00000214274 ANG cancers 28335793
ENSG00000214274 ANG tumor 28507810
ENSG00000214274 ANG tumor 28561015
ENSG00000214274 ANG tumors 28624797
ENSG00000214274 ANG cancer 28645172
ENSG00000214274 ANG tumor 2866794
ENSG00000214274 ANG tumor 2866795
ENSG00000214274 ANG tumors 28744448
ENSG00000214274 ANG tumors 29100074
ENSG00000214274 ANG cancer 29105754
ENSG00000214274 ANG Anaplastic Thyroid Cancer 29190616
ENSG00000214274 ANG ovarian cancer 29221134
ENSG00000214274 ANG tumors 29231847
ENSG00000214274 ANG bladder cancer 29245935
ENSG00000214274 ANG cancer 29261171
ENSG00000214274 ANG tumor 29442906
ENSG00000214274 ANG cancer 29497482
ENSG00000214274 ANG tumor 29507632
ENSG00000214274 ANG Pancreatic Cancer 29606349
ENSG00000214274 ANG tumor 29660846
ENSG00000214274 ANG cancers 29660986
ENSG00000214274 ANG cancer 29736193
ENSG00000214274 ANG colorectal cancer 29763380
ENSG00000214274 ANG tumor 29890464
ENSG00000214274 ANG tumor 29893017
ENSG00000214274 ANG cancer 30008694
ENSG00000214274 ANG tumor 30071515
ENSG00000214274 ANG cancer 30352093
ENSG00000214274 ANG tumor 30449278
ENSG00000214274 ANG cancer 30529768
ENSG00000214274 ANG pancreatic cancer 30534052
ENSG00000214274 ANG cancers 30538719
ENSG00000214274 ANG bladder cancer 30544619
ENSG00000214274 ANG Tumor 30619758
ENSG00000214274 ANG tumor 3064806
ENSG00000214274 ANG tumour 30710110
ENSG00000214274 ANG colorectal cancer 30755821
ENSG00000214274 ANG colorectal cancer 30828790
ENSG00000214274 ANG ovarian cancer 30845964
ENSG00000214274 ANG colon cancer 31057536
ENSG00000214274 ANG tumors 31072237
ENSG00000214274 ANG cancers 31128105
ENSG00000214274 ANG tumor 31159852
ENSG00000214274 ANG tumor 31308149
ENSG00000214274 ANG tumour 31333092
ENSG00000214274 ANG Tumor 31335473
ENSG00000214274 ANG GBM 31428150
ENSG00000214274 ANG Tumours 31500197
ENSG00000214274 ANG tumor 31617104
ENSG00000214274 ANG breast cancer 31619709
ENSG00000214274 ANG tumor 31655854
ENSG00000214274 ANG breast cancer 31673107
ENSG00000214274 ANG bladder cancer 31905599
ENSG00000214274 ANG prostate cancer 31942000
ENSG00000214274 ANG tumor 31949702
ENSG00000214274 ANG tumor 3619929
ENSG00000214274 ANG tumor 3663649
ENSG00000214274 ANG tumor 4074709
ENSG00000214274 ANG tumor 7510698
ENSG00000214274 ANG gastric cancers 7513352
ENSG00000214274 ANG tumour 7528139
ENSG00000214274 ANG tumor 7584854
ENSG00000214274 ANG tumor 7831307
ENSG00000214274 ANG tumors 7925406
ENSG00000214274 ANG tumor 8062244
ENSG00000214274 ANG tumor 8267604
ENSG00000214274 ANG tumour 8448385
ENSG00000214274 ANG pancreatic cancer 8665497
ENSG00000214274 ANG endometrial cancer 9119882
ENSG00000214274 ANG ovarian cancer 9166545
ENSG00000214274 ANG tumor 9288781
ENSG00000214274 ANG tumor 9305884
ENSG00000214274 ANG tumour 9413551
ENSG00000214274 ANG tumor 9464241
ENSG00000214274 ANG breast cancer 9539780
ENSG00000214274 ANG cervical cancer 9541628
ENSG00000214274 ANG tumor 9738585
ENSG00000214274 ANG tumor 9748135
ENSG00000214274 ANG tumour 9764576
ENSG00000214274 ANG tumor 9815846
ENSG00000214274 ANG tumors 9854643
ENSG00000214274 ANG tumour 9918722
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000214274 ANG MESO 0.0052 low
ENSG00000214274 ANG SARC 0.0042 low
ENSG00000214274 ANG STAD 0.004 high
ENSG00000214274 ANG UCEC 0.00028 low
ENSG00000214274 ANG THCA 0.033 high
ENSG00000214274 ANG ACC 0.00016 high
ENSG00000214274 ANG LUSC 0.029 high
ENSG00000214274 ANG READ 0.0082 high
ENSG00000214274 ANG KICH 0.0018 high
ENSG00000214274 ANG THYM 0.0038 high
ENSG00000214274 ANG BRCA 0.024 low
ENSG00000214274 ANG ESCA 0.018 high
ENSG00000214274 ANG OV 0.019 high
ENSG00000214274 ANG DLBC 0.027 low
ENSG00000214274 ANG KIRC 0.0047 low
ENSG00000214274 ANG GBM 0.0082 high
ENSG00000214274 ANG SKCM 0.0077 low
ENSG00000214274 ANG LIHC 0.00038 low
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency
ENSG00000214274 ANG LUSC Del 1.083513 0.071312 0.355895 0.341317
ENSG00000214274 ANG LUAD Amp 1.610736 0.140736 0.431110 0.323643
ENSG00000214274 ANG KIRP Del 1.122031 0.031201 0.551124 0.170139
ENSG00000214274 ANG ACC Amp 0.908712 0.273335 1.099683 0.300000
ENSG00000214274 ANG READ Del 1.003302 0.080707 0.491898 0.418182
ENSG00000214274 ANG GBM Del 5.514048 0.096444 0.599339 0.294627
ENSG00000214274 ANG PAAD Del 0.945689 0.050602 0.405273 0.103261
ENSG00000214274 ANG HNSC Del 0.800630 0.055377 0.414712 0.130268
ENSG00000214274 ANG OV Amp 3.842798 0.424459 0.817972 0.250432