RBP Type	Non-canonical_RBPs
Diseases	SARS-COV-2
Drug	Drug
Main interacting RNAs	N.A.
Moonlighting functions	Metabolic enzyme
Localizations	N.A.
BulkPerturb-seq

Ensembl ID	ENSG00000206172	Gene ID	3039	Accession	4823
Symbol	HBA1	Alias	HBH;ECYT7;HBA-T3;METHBA	Full Name	hemoglobin subunit alpha 1
Status	Confidence	Length	843 bases	Strand	Plus strand
Position	16 : 176680 - 177522	RNA binding domain	N.A.
Summary	The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
HBA1-201	ENST00000320868	577	142aa	ENSP00000322421
HBA1-203	ENST00000472694	674	No protein	-
HBA1-202	ENST00000397797	504	110aa	ENSP00000380899
HBA1-204	ENST00000487791	410	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID
76598	Erythrocyte Indices	3E-9	20139978
76599	Hemoglobins	3E-9	20139978

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0004601	contributes_to peroxidase activity	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0005344	enables oxygen carrier activity	1	IBA	Homo_sapiens(9606)	Function
GO:0005506	enables iron ion binding	1	IEA	Homo_sapiens(9606)	Function
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005576	located_in extracellular region	1	TAS	Homo_sapiens(9606)	Component
GO:0005615	located_in extracellular space	1	IDA	Homo_sapiens(9606)	Component
GO:0005829	located_in cytosol	1	TAS	Homo_sapiens(9606)	Component
GO:0005833	part_of hemoglobin complex	4	IBA,IDA,IPI,TAS	Homo_sapiens(9606)	Component
GO:0015670	involved_in carbon dioxide transport	1	NAS	Homo_sapiens(9606)	Process
GO:0015671	involved_in oxygen transport	4	IDA,IMP,NAS,TAS	Homo_sapiens(9606)	Process
GO:0016020	located_in membrane	1	HDA	Homo_sapiens(9606)	Component
GO:0019825	enables oxygen binding	1	IBA	Homo_sapiens(9606)	Function
GO:0020037	enables heme binding	1	IBA	Homo_sapiens(9606)	Function
GO:0030185	involved_in nitric oxide transport	1	IDA	Homo_sapiens(9606)	Process
GO:0031720	contributes_to haptoglobin binding	2	IBA,IDA	Homo_sapiens(9606)	Function
GO:0031838	part_of haptoglobin-hemoglobin complex	2	IBA,IDA	Homo_sapiens(9606)	Component
GO:0042542	involved_in response to hydrogen peroxide	1	IDA	Homo_sapiens(9606)	Process
GO:0042744	involved_in hydrogen peroxide catabolic process	2	IBA,IDA	Homo_sapiens(9606)	Process
GO:0043177	enables organic acid binding	1	IBA	Homo_sapiens(9606)	Function
GO:0070062	located_in extracellular exosome	1	HDA	Homo_sapiens(9606)	Component
GO:0071682	located_in endocytic vesicle lumen	1	TAS	Homo_sapiens(9606)	Component
GO:0072562	located_in blood microparticle	1	HDA	Homo_sapiens(9606)	Component
GO:0098869	involved_in cellular oxidant detoxification	1	IEA	Homo_sapiens(9606)	Process