RBP Type	Canonical_RBPs
Diseases	Cancer
Drug	N.A.
Main interacting RNAs	rRNA
Moonlighting functions	N.A.
Localizations	N.A.
BulkPerturb-seq	N.A.

Ensembl ID	ENSG00000204822	Gene ID	116540	Accession	16684
Symbol	MRPL53	Alias	mL53;L53MT	Full Name	mitochondrial ribosomal protein L53
Status	Confidence	Length	706 bases	Strand	Minus strand
Position	2 : 74471982 - 74472687	RNA binding domain	MRP_L53
Summary	Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]

Protein	Domain	Pfam ID	E-value	Domain number
ENSP00000258105	MRP_L53	PF10780	1.9e-14	1

Pubmed ID	Full Name	Cell	Author	Time	Doi

Pubmed ID	Title	Author	Time	Journal

Name	Transcript ID	bp	Protein	Translation ID
MRPL53-201	ENST00000258105	496	112aa	ENSP00000258105
MRPL53-202	ENST00000409710	386	70aa	ENSP00000386920
MRPL53-203	ENST00000467349	451	No protein	-
MRPL53-204	ENST00000468875	574	No protein	-

Pathway ID	Pathway Name	Source

ensgID	Trait	pValue	Pubmed ID

ensgID	SNP	Chromosome	Position	Trait	PubmedID	Or or BEAT	EFO ID

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000204822

Ensembl ID	Source				Target
	Species	Protein ID	Perc_pos	Perc_id	Species	Protein ID	Perc_pos	Perc_id
ENSG00000204822	homo_sapiens	ENSP00000258105	98.2143	97.3214	nomascus_leucogenys	ENSNLEP00000027555	98.2143	97.3214
ENSG00000204822	homo_sapiens	ENSP00000258105	99.1071	99.1071	pan_paniscus	ENSPPAP00000013445	99.1071	99.1071
ENSG00000204822	homo_sapiens	ENSP00000258105	99.1071	99.1071	pan_troglodytes	ENSPTRP00000062041	99.1071	99.1071
ENSG00000204822	homo_sapiens	ENSP00000258105	99.1071	99.1071	gorilla_gorilla	ENSGGOP00000006363	99.1071	99.1071
ENSG00000204822	homo_sapiens	ENSP00000258105	68.75	57.1429	ornithorhynchus_anatinus	ENSOANP00000038607	34.5291	28.6996
ENSG00000204822	homo_sapiens	ENSP00000258105	76.7857	66.0714	notamacropus_eugenii	ENSMEUP00000008132	81.1321	69.8113
ENSG00000204822	homo_sapiens	ENSP00000258105	83.9286	81.25	dasypus_novemcinctus	ENSDNOP00000027389	85.4545	82.7273
ENSG00000204822	homo_sapiens	ENSP00000258105	91.9643	87.5	echinops_telfairi	ENSETEP00000010200	91.1504	86.7257
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	91.9643	callithrix_jacchus	ENSCJAP00000056369	97.3214	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	94.6429	cercocebus_atys	ENSCATP00000002128	97.3214	94.6429
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	94.6429	macaca_fascicularis	ENSMFAP00000005984	61.9318	60.2273
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	94.6429	macaca_mulatta	ENSMMUP00000077929	61.9318	60.2273
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	94.6429	macaca_nemestrina	ENSMNEP00000034349	97.3214	94.6429
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	94.6429	papio_anubis	ENSPANP00000023559	97.3214	94.6429
ENSG00000204822	homo_sapiens	ENSP00000258105	96.4286	93.75	mandrillus_leucophaeus	ENSMLEP00000015927	96.4286	93.75
ENSG00000204822	homo_sapiens	ENSP00000258105	94.6429	93.75	tursiops_truncatus	ENSTTRP00000012066	94.6429	93.75
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.0714	vulpes_vulpes	ENSVVUP00000005709	93.75	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	88.3929	83.9286	mus_spretus	MGP_SPRETEiJ_P0077412	83.8983	79.661
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	90.1786	equus_asinus	ENSEASP00005054452	56.7568	54.5946
ENSG00000204822	homo_sapiens	ENSP00000258105	75	71.4286	capra_hircus	ENSCHIP00000022926	77.7778	74.0741
ENSG00000204822	homo_sapiens	ENSP00000258105	86.6071	84.8214	capra_hircus	ENSCHIP00000023769	75.7812	74.2188
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.0714	capra_hircus	ENSCHIP00000005305	92.8571	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	77.6786	74.1071	loxodonta_africana	ENSLAFP00000006699	87.8788	83.8384
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.0714	panthera_leo	ENSPLOP00000008568	92.8571	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.0714	ailuropoda_melanoleuca	ENSAMEP00000018206	93.75	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	94.6429	89.2857	oryctolagus_cuniculus	ENSOCUP00000013178	93.8053	88.4956
ENSG00000204822	homo_sapiens	ENSP00000258105	83.9286	79.4643	oryctolagus_cuniculus	ENSOCUP00000045773	85.4545	80.9091
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.0714	panthera_pardus	ENSPPRP00000015467	92.8571	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	89.2857	85.7143	marmota_marmota_marmota	ENSMMMP00000004530	89.2857	85.7143
ENSG00000204822	homo_sapiens	ENSP00000258105	91.0714	87.5	marmota_marmota_marmota	ENSMMMP00000005175	91.0714	87.5
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.9643	balaenoptera_musculus	ENSBMSP00010017903	93.75	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	89.2857	83.9286	cavia_porcellus	ENSCPOP00000023137	89.2857	83.9286
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.0714	felis_catus	ENSFCAP00000029046	92.8571	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	72.3214	67.8571	ursus_americanus	ENSUAMP00000028086	67.5	63.3333
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.0714	bison_bison_bison	ENSBBBP00000012936	93.75	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	92.8571	monodon_monoceros	ENSMMNP00015010581	93.75	92.8571
ENSG00000204822	homo_sapiens	ENSP00000258105	94.6429	91.9643	microcebus_murinus	ENSMICP00000049178	94.6429	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	89.2857	83.9286	jaculus_jaculus	ENSJJAP00000007128	89.2857	83.9286
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.9643	ovis_aries_rambouillet	ENSOARP00020002199	92.8571	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	72.3214	67.8571	ursus_maritimus	ENSUMAP00000001702	67.5	63.3333
ENSG00000204822	homo_sapiens	ENSP00000258105	88.3929	83.9286	mus_caroli	MGP_CAROLIEiJ_P0074518	83.8983	79.661
ENSG00000204822	homo_sapiens	ENSP00000258105	88.3929	83.9286	mus_musculus	ENSMUSP00000109571	83.8983	79.661
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.0714	mustela_putorius_furo	ENSMPUP00000007997	92.8571	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	91.9643	aotus_nancymaae	ENSANAP00000028953	97.3214	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	96.4286	91.9643	saimiri_boliviensis_boliviensis	ENSSBOP00000020739	96.4286	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	95.5357	chlorocebus_sabaeus	ENSCSAP00000011700	97.3214	95.5357
ENSG00000204822	homo_sapiens	ENSP00000258105	85.7143	83.0357	tupaia_belangeri	ENSTBEP00000015382	94.1176	91.1765
ENSG00000204822	homo_sapiens	ENSP00000258105	91.9643	86.6071	mesocricetus_auratus	ENSMAUP00000009464	86.5546	81.5126
ENSG00000204822	homo_sapiens	ENSP00000258105	94.6429	93.75	phocoena_sinus	ENSPSNP00000020469	94.6429	93.75
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.0714	camelus_dromedarius	ENSCDRP00005009121	73.9437	71.831
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	92.8571	carlito_syrichta	ENSTSYP00000020721	93.75	92.8571
ENSG00000204822	homo_sapiens	ENSP00000258105	82.1429	76.7857	carlito_syrichta	ENSTSYP00000018517	71.875	67.1875
ENSG00000204822	homo_sapiens	ENSP00000258105	91.9643	91.0714	panthera_tigris_altaica	ENSPTIP00000011118	91.9643	91.0714
ENSG00000204822	homo_sapiens	ENSP00000258105	94.6429	92.8571	prolemur_simus	ENSPSMP00000029305	94.6429	92.8571
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	87.5	microtus_ochrogaster	ENSMOCP00000016196	88.1356	83.0508
ENSG00000204822	homo_sapiens	ENSP00000258105	90.1786	84.8214	sorex_araneus	ENSSARP00000009641	89.3805	84.0708
ENSG00000204822	homo_sapiens	ENSP00000258105	90.1786	84.8214	peromyscus_maniculatus_bairdii	ENSPEMP00000006529	83.4711	78.5124
ENSG00000204822	homo_sapiens	ENSP00000258105	74.1071	70.5357	bos_mutus	ENSBMUP00000017109	54.6053	51.9737
ENSG00000204822	homo_sapiens	ENSP00000258105	88.3929	83.9286	mus_spicilegus	ENSMSIP00000037912	83.8983	79.661
ENSG00000204822	homo_sapiens	ENSP00000258105	89.2857	82.1429	cricetulus_griseus_chok1gshd	ENSCGRP00001010744	84.0336	77.3109
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	90.1786	pteropus_vampyrus	ENSPVAP00000013162	93.75	90.1786
ENSG00000204822	homo_sapiens	ENSP00000258105	89.2857	83.9286	myotis_lucifugus	ENSMLUP00000002407	90.0901	84.6847
ENSG00000204822	homo_sapiens	ENSP00000258105	73.2143	63.3929	vombatus_ursinus	ENSVURP00010026390	80.3922	69.6078
ENSG00000204822	homo_sapiens	ENSP00000258105	91.9643	91.0714	rhinolophus_ferrumequinum	ENSRFEP00010010765	72.028	71.3287
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.0714	neovison_vison	ENSNVIP00000026153	43.5146	42.6778
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.9643	bos_taurus	ENSBTAP00000022082	93.75	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	87.5	81.25	heterocephalus_glaber_female	ENSHGLP00000046437	87.5	81.25
ENSG00000204822	homo_sapiens	ENSP00000258105	96.4286	95.5357	rhinopithecus_bieti	ENSRBIP00000002716	96.4286	95.5357
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.9643	canis_lupus_dingo	ENSCAFP00020017568	93.75	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	90.1786	87.5	sciurus_vulgaris	ENSSVLP00005031427	90.1786	87.5
ENSG00000204822	homo_sapiens	ENSP00000258105	74.1071	63.3929	phascolarctos_cinereus	ENSPCIP00000007115	77.5701	66.3551
ENSG00000204822	homo_sapiens	ENSP00000258105	86.6071	83.0357	procavia_capensis	ENSPCAP00000015734	86.6071	83.0357
ENSG00000204822	homo_sapiens	ENSP00000258105	90.1786	85.7143	nannospalax_galili	ENSNGAP00000001414	87.069	82.7586
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.9643	bos_grunniens	ENSBGRP00000011377	93.75	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	91.0714	87.5	chinchilla_lanigera	ENSCLAP00000007458	91.0714	87.5
ENSG00000204822	homo_sapiens	ENSP00000258105	90.1786	89.2857	cervus_hanglu_yarkandensis	ENSCHYP00000011662	90.1786	89.2857
ENSG00000204822	homo_sapiens	ENSP00000258105	71.4286	69.6429	catagonus_wagneri	ENSCWAP00000022868	66.6667	65
ENSG00000204822	homo_sapiens	ENSP00000258105	91.0714	87.5	ictidomys_tridecemlineatus	ENSSTOP00000000918	91.0714	87.5
ENSG00000204822	homo_sapiens	ENSP00000258105	96.4286	93.75	otolemur_garnettii	ENSOGAP00000000945	96.4286	93.75
ENSG00000204822	homo_sapiens	ENSP00000258105	97.3214	92.8571	cebus_imitator	ENSCCAP00000015895	97.3214	92.8571
ENSG00000204822	homo_sapiens	ENSP00000258105	90.1786	87.5	urocitellus_parryii	ENSUPAP00010021041	90.1786	87.5
ENSG00000204822	homo_sapiens	ENSP00000258105	92.8571	91.9643	moschus_moschiferus	ENSMMSP00000019993	92.8571	91.9643
ENSG00000204822	homo_sapiens	ENSP00000258105	68.75	61.6071	moschus_moschiferus	ENSMMSP00000019767	71.2963	63.8889
ENSG00000204822	homo_sapiens	ENSP00000258105	95.5357	94.6429	rhinopithecus_roxellana	ENSRROP00000045542	95.5357	94.6429
ENSG00000204822	homo_sapiens	ENSP00000258105	87.5	83.0357	mus_pahari	MGP_PahariEiJ_P0050589	83.0508	78.8136
ENSG00000204822	homo_sapiens	ENSP00000258105	93.75	91.0714	propithecus_coquereli	ENSPCOP00000031795	93.75	91.0714

Go ID	Go term	No. evidence	Entries	Species	Category
GO:0005515	enables protein binding	1	IPI	Homo_sapiens(9606)	Function
GO:0005739	located_in mitochondrion	1	IDA	Homo_sapiens(9606)	Component
GO:0005743	located_in mitochondrial inner membrane	2	NAS,TAS	Homo_sapiens(9606)	Component
GO:0005762	part_of mitochondrial large ribosomal subunit	3	IBA,IDA,NAS	Homo_sapiens(9606)	Component
GO:0032543	involved_in mitochondrial translation	1	NAS	Homo_sapiens(9606)	Process