Ensembl ID ENSG00000204822 Gene ID 116540 Accession 16684
Gene Symbol MRPL53 Alias mL53;L53MT Full Name mitochondrial ribosomal protein L53
Position 2 : 74471982 - 74472687 Length 706 bases Strand Minus strand
Status Confidence Main interacting RNAsrRNARBP type Canonical_RBPs
Summary Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 1p. [provided by RefSeq, Jul 2008]

ENSG00000204822 Expression In 33 Tumors

Ensembl ID Gene symbol Log2 Foldchange Pvaue Cancer
ENSG00000204822 MRPL53 0.88 3.43e-32 KIRC
ENSG00000204822 MRPL53 0.71 4.72e-36 BRCA
ENSG00000204822 MRPL53 0.93 1.85e-40 LUSC
ENSG00000204822 MRPL53 0.54 2.32e-12 PRAD
ENSG00000204822 MRPL53 0.99 1.16e-28 LIHC
ENSG00000204822 MRPL53 0.70 1.67e-20 LUAD
Ensembl ID Gene symbol Cancer types Pubmed ID
Ensembl ID Gene symbol Disease/phenotype Mutation type Mutated / Total samples Literature
Ensembl ID Gene symbol Cancer P-value Which worse show
ENSG00000204822 MRPL53 MESO 0.022 low
ENSG00000204822 MRPL53 PAAD 2e-04 low
ENSG00000204822 MRPL53 LGG 0.022 high
ENSG00000204822 MRPL53 LUSC 0.0023 low
ENSG00000204822 MRPL53 HNSC 0.033 low
ENSG00000204822 MRPL53 READ 0.011 low
ENSG00000204822 MRPL53 BRCA 0.046 high
ENSG00000204822 MRPL53 COAD 0.0073 high
ENSG00000204822 MRPL53 ESCA 0.039 high
ENSG00000204822 MRPL53 OV 0.033 low
ENSG00000204822 MRPL53 BLCA 0.016 low
ENSG00000204822 MRPL53 SKCM 0.001 low
ENSG00000204822 MRPL53 CESC 0.018 low
ENSG00000204822 MRPL53 LIHC 0.00018 high
Ensembl ID Gene symbol Cancer CNV type -log10(q-value) G-score average amplitude frequency